id stringlengths 11 22 | document_id stringlengths 11 22 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
PMID-8640445 | PMID-8640445 | [
{
"id": "PMID-8640445__text",
"type": "abstract",
"text": [
"Cell surface binding characteristics correlate with consensus type I interferon enhanced activity.\nThe binding characteristics of a genetically engineered consensus interferon with unusually high biologic activity were compared to the c... | [
{
"id": "PMID-8640445_T1",
"type": "Cellular_component",
"text": [
"Cell surface"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "PMID-8640445_T2",
"type": "Cellular_component",
"text": [
"cell surface"
],
"offsets... | [] | [] | [] |
PMC-2988921-caption-02 | PMC-2988921-caption-02 | [
{
"id": "PMC-2988921-caption-02__text",
"type": "caption",
"text": [
"Selective SMA angiography was performed 5 h from onset. Before therapy, the SMA was completely occluded by an embolus at the proximal portion (a), and after the bolus infusion of urokinase (600,000 IU) into the SMA, peripheral b... | [
{
"id": "PMC-2988921-caption-02_T1",
"type": "Organism_substance",
"text": [
"embolus"
],
"offsets": [
[
110,
117
]
],
"normalized": []
},
{
"id": "PMC-2988921-caption-02_T3",
"type": "Organism_substance",
"text": [
"peripheral bloo... | [] | [] | [] |
PMID-14613080 | PMID-14613080 | [
{
"id": "PMID-14613080__text",
"type": "abstract",
"text": [
"Microvascular density and vascular endothelial growth factor immunoreactivity as predictors of regional lymph node metastasis from betel-associated oral squamous cell carcinoma. \nPURPOSE: Neovascularization has profound effects on tumo... | [
{
"id": "PMID-14613080_T1",
"type": "Tissue",
"text": [
"Microvascular"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "PMID-14613080_T3",
"type": "Multi-tissue_structure",
"text": [
"lymph node"
],
"offsets": [
... | [] | [] | [] |
PMID-16720995 | PMID-16720995 | [
{
"id": "PMID-16720995__text",
"type": "abstract",
"text": [
"GDP and AGE receptors: mechanisms of peritoneal damage.\nLong-term peritoneal dialysis (PD) is limited by morphological changes of the peritoneal membrane. Structural changes were promoted by toxicity of glucose degradation products (GD... | [
{
"id": "PMID-16720995_T3",
"type": "Multi-tissue_structure",
"text": [
"peritoneal"
],
"offsets": [
[
37,
47
]
],
"normalized": []
},
{
"id": "PMID-16720995_T4",
"type": "Multi-tissue_structure",
"text": [
"peritoneal"
],
"... | [] | [] | [] |
PMID-17145768 | PMID-17145768 | [
{
"id": "PMID-17145768__text",
"type": "abstract",
"text": [
"p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors. \nMutant mice lacking both cyclin-dependent kinase (CDK) inhibitors p18(Ink4c) and p27(Kip1) develop a tumor spectrum reminiscent of human multip... | [
{
"id": "PMID-17145768_T4",
"type": "Cancer",
"text": [
"neuroendocrine organ tumors"
],
"offsets": [
[
62,
89
]
],
"normalized": []
},
{
"id": "PMID-17145768_T12",
"type": "Cancer",
"text": [
"tumor"
],
"offsets": [
[... | [] | [] | [] |
PMID-3930969 | PMID-3930969 | [
{
"id": "PMID-3930969__text",
"type": "abstract",
"text": [
"The effect of aflatoxin B1 on the utilization of serum calcium.\nThe mathematical analysis for plasma disappearance curve of aflatoxicosed animals, subsequently injected with 45Ca was determined. The analysis showed that the three main c... | [
{
"id": "PMID-3930969_T1",
"type": "Organism_substance",
"text": [
"serum"
],
"offsets": [
[
49,
54
]
],
"normalized": []
},
{
"id": "PMID-3930969_T2",
"type": "Organism_substance",
"text": [
"plasma"
],
"offsets": [
[... | [] | [] | [] |
PMC-2211454-sec-18 | PMC-2211454-sec-18 | [
{
"id": "PMC-2211454-sec-18__text",
"type": "sec",
"text": [
"Acknowledgements\nWe would like to thank our colleague Dr. Nikolaos Papathanasiou for his assistance in performing the statistical analysis.\n"
],
"offsets": [
[
0,
140
]
]
}
] | [] | [] | [] | [] |
PMID-20549676 | PMID-20549676 | [
{
"id": "PMID-20549676__text",
"type": "abstract",
"text": [
"Telomere/telomerase interplay in virus-driven and virus-independent lymphomagenesis: pathogenic and clinical implications. \nTelomerase is a ribonucleoprotein complex critically involved in extending and maintaining telomeres. Unlike th... | [
{
"id": "PMID-20549676_T1",
"type": "Cellular_component",
"text": [
"Telomere"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "PMID-20549676_T4",
"type": "Cellular_component",
"text": [
"telomeres"
],
"offsets": [
... | [] | [] | [] |
PMID-15464487 | PMID-15464487 | [
{
"id": "PMID-15464487__text",
"type": "abstract",
"text": [
"Flow dynamics of the internal thoracic and radial artery T-graft.\nBACKGROUND:\nComplex use of arterial conduits has resurrected concerns about the adequacy of conduit flow. The T-graft is the extreme example of this trend. Our purpose ... | [
{
"id": "PMID-15464487_T2",
"type": "Multi-tissue_structure",
"text": [
"arterial conduits"
],
"offsets": [
[
93,
110
]
],
"normalized": []
},
{
"id": "PMID-15464487_T3",
"type": "Multi-tissue_structure",
"text": [
"conduit"
],
... | [] | [] | [] |
PMID-899346 | PMID-899346 | [
{
"id": "PMID-899346__text",
"type": "abstract",
"text": [
"[Considerations regarding two cases of macromastia (author's transl)].\nTwo cases of macromastia have been shown; one which appeared during puberty, the other during menopause. Histopathological examination has demonstrated for the both c... | [
{
"id": "PMID-899346_T1",
"type": "Tissue",
"text": [
"glandular tissue"
],
"offsets": [
[
269,
285
]
],
"normalized": []
},
{
"id": "PMID-899346_T2",
"type": "Tissue",
"text": [
"conjunctive tissue"
],
"offsets": [
[
... | [] | [] | [] |
PMC-2889408-caption-02 | PMC-2889408-caption-02 | [
{
"id": "PMC-2889408-caption-02__text",
"type": "caption",
"text": [
"The eukaryotic parasite Trypanosoma brucei is able to import inositol from the environment or synthesize it de novo. However, according to the current model, inositol imported from the environment is utilized primarily in bulk p... | [
{
"id": "PMC-2889408-caption-02_T1",
"type": "Cellular_component",
"text": [
"Golgi complex"
],
"offsets": [
[
348,
361
]
],
"normalized": []
},
{
"id": "PMC-2889408-caption-02_T2",
"type": "Cellular_component",
"text": [
"ER"
]... | [] | [] | [] |
PMID-17483295 | PMID-17483295 | [
{
"id": "PMID-17483295__text",
"type": "abstract",
"text": [
"In vivo p53 response and immune reaction underlie highly effective low-dose radiotherapy in follicular lymphoma. \nVery low-dose irradiation (2 x 2 Gy) is a new, effective, and safe local treatment for follicular lymphoma. To understand... | [
{
"id": "PMID-17483295_T2",
"type": "Cancer",
"text": [
"follicular lymphoma"
],
"offsets": [
[
92,
111
]
],
"normalized": []
},
{
"id": "PMID-17483295_T3",
"type": "Cancer",
"text": [
"follicular lymphoma"
],
"offsets": [
... | [] | [] | [] |
PMID-19622586 | PMID-19622586 | [
{
"id": "PMID-19622586__text",
"type": "abstract",
"text": [
"EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation.\nPURPOSE: Antiangiogenic therapy is considered as an effective strategy for controlling the growth and metastasis of tumors. Among a myriad of biological activ... | [
{
"id": "PMID-19622586_T4",
"type": "Cancer",
"text": [
"tumors"
],
"offsets": [
[
193,
199
]
],
"normalized": []
},
{
"id": "PMID-19622586_T6",
"type": "Cancer",
"text": [
"cancer"
],
"offsets": [
[
285,
... | [] | [] | [] |
PMC-2024775-sec-01 | PMC-2024775-sec-01 | [
{
"id": "PMC-2024775-sec-01__text",
"type": "sec",
"text": [
"Images\nFig. 1\nFig. 2\nFig. 3\n"
],
"offsets": [
[
0,
28
]
]
}
] | [] | [] | [] | [] |
PMID-15623598 | PMID-15623598 | [
{
"id": "PMID-15623598__text",
"type": "abstract",
"text": [
"Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. \nPURPOSE: The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes involved in tumor invasio... | [
{
"id": "PMID-15623598_T1",
"type": "Cancer",
"text": [
"colorectal cancers"
],
"offsets": [
[
107,
125
]
],
"normalized": []
},
{
"id": "PMID-15623598_T2",
"type": "Cancer",
"text": [
"tumor"
],
"offsets": [
[
... | [] | [] | [] |
PMID-11835401 | PMID-11835401 | [
{
"id": "PMID-11835401__text",
"type": "abstract",
"text": [
"Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors.\nInteractions among growth factors, cells, and... | [
{
"id": "PMID-11835401_T2",
"type": "Cellular_component",
"text": [
"matrix"
],
"offsets": [
[
34,
40
]
],
"normalized": []
},
{
"id": "PMID-11835401_T4",
"type": "Cell",
"text": [
"vascular smooth muscle cells"
],
"offsets"... | [] | [] | [] |
PMID-8398065 | PMID-8398065 | [
{
"id": "PMID-8398065__text",
"type": "abstract",
"text": [
"Vitamins regulate gene expression and induce differentiation and growth inhibition in cancer cells. Their relevance in cancer prevention. \nAlthough several hypotheses for human carcinogenesis have been proposed, the specific genetic cha... | [
{
"id": "PMID-8398065_T2",
"type": "Cell",
"text": [
"cancer cells"
],
"offsets": [
[
86,
98
]
],
"normalized": []
},
{
"id": "PMID-8398065_T3",
"type": "Cancer",
"text": [
"cancer"
],
"offsets": [
[
119,
... | [] | [] | [] |
PMID-15331370 | PMID-15331370 | [
{
"id": "PMID-15331370__text",
"type": "abstract",
"text": [
"Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation.\nThe functional benefit of cell transplantation after a myocardial infarction is diminished by early cell losses. IGF-1 enhances cell prolifer... | [
{
"id": "PMID-15331370_T2",
"type": "Cell",
"text": [
"smooth muscle cell"
],
"offsets": [
[
35,
53
]
],
"normalized": []
},
{
"id": "PMID-15331370_T3",
"type": "Cell",
"text": [
"cell"
],
"offsets": [
[
72,
... | [] | [] | [] |
PMC-2739198-caption-20 | PMC-2739198-caption-20 | [
{
"id": "PMC-2739198-caption-20__text",
"type": "caption",
"text": [
"Click here for file\n"
],
"offsets": [
[
0,
20
]
]
}
] | [] | [] | [] | [] |
PMID-16374459 | PMID-16374459 | [
{
"id": "PMID-16374459__text",
"type": "abstract",
"text": [
"Regulation of skin microvasculature angiogenesis, cell migration, and permeability by a specific inhibitor of PKCalpha.\nActivation of protein kinase C (PKC) induces phenotypic changes in the morphology of microvascular endothelial cell... | [
{
"id": "PMID-16374459_T1",
"type": "Tissue",
"text": [
"skin microvasculature"
],
"offsets": [
[
14,
35
]
],
"normalized": []
},
{
"id": "PMID-16374459_T2",
"type": "Cell",
"text": [
"cell"
],
"offsets": [
[
5... | [] | [] | [] |
PMC-2782986-sec-02 | PMC-2782986-sec-02 | [
{
"id": "PMC-2782986-sec-02__text",
"type": "sec",
"text": [
"RESEARCH DESIGN AND METHODS\nFor this study, 20 individuals (mean age 39.5 +/- 11.1 years) with long-standing type 1 diabetes (21.3 +/- 10.7 years) were enrolled in this prospective open-label crossover trial. After achieving optimal bl... | [
{
"id": "PMC-2782986-sec-02_T1",
"type": "Organism_substance",
"text": [
"blood"
],
"offsets": [
[
233,
238
]
],
"normalized": []
},
{
"id": "PMC-2782986-sec-02_T2",
"type": "Organism_substance",
"text": [
"serum"
],
"offset... | [] | [] | [] |
PMID-16650140 | PMID-16650140 | [
{
"id": "PMID-16650140__text",
"type": "abstract",
"text": [
"The ictal bradycardia syndrome: localization and lateralization.\nPURPOSE:\nPrevious studies have established the importance of the insular cortex and temporal lobe in cardiovascular autonomic modulation. Some investigators, based on th... | [
{
"id": "PMID-16650140_T1",
"type": "Multi-tissue_structure",
"text": [
"insular cortex"
],
"offsets": [
[
130,
144
]
],
"normalized": []
},
{
"id": "PMID-16650140_T2",
"type": "Multi-tissue_structure",
"text": [
"temporal lobe"
... | [] | [] | [] |
PMID-14555793 | PMID-14555793 | [
{
"id": "PMID-14555793__text",
"type": "abstract",
"text": [
"Therapeutic angiogenesis: a complex problem requiring a sophisticated approach.\nBlood and vascular disorders underlie a plethora of pathologic conditions and are the single most frequent cause of human disease. Ischemia, involving rest... | [
{
"id": "PMID-14555793_T1",
"type": "Organism_substance",
"text": [
"Blood"
],
"offsets": [
[
80,
85
]
],
"normalized": []
},
{
"id": "PMID-14555793_T2",
"type": "Multi-tissue_structure",
"text": [
"vascular"
],
"offsets": [... | [] | [] | [] |
PMC-2690976-sec-05 | PMC-2690976-sec-05 | [
{
"id": "PMC-2690976-sec-05__text",
"type": "sec",
"text": [
"Efficacy of MMF in current immunosuppressive regimens after kidney transplantation\nCurrent established immunosuppressive strategies in kidney transplantation often include an induction agent (monoclonal or polyclonal anti-T-cell antibo... | [
{
"id": "PMC-2690976-sec-05_T1",
"type": "Organ",
"text": [
"kidney"
],
"offsets": [
[
60,
66
]
],
"normalized": []
},
{
"id": "PMC-2690976-sec-05_T2",
"type": "Organ",
"text": [
"kidney"
],
"offsets": [
[
135,... | [] | [] | [] |
PMID-16907772 | PMID-16907772 | [
{
"id": "PMID-16907772__text",
"type": "abstract",
"text": [
"Formation of new bone during vertical distraction osteogenesis of the human mandible is related to the presence of blood vessels.\nWe examined the effect of distraction rate on blood vessel growth in intramembraneous ossification after ... | [
{
"id": "PMID-16907772_T1",
"type": "Tissue",
"text": [
"bone"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "PMID-16907772_T3",
"type": "Organ",
"text": [
"mandible"
],
"offsets": [
[
76,
8... | [] | [] | [] |
PMID-21878661 | PMID-21878661 | [
{
"id": "PMID-21878661__text",
"type": "abstract",
"text": [
"Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD. \nSunitinib is an oral multitargeted receptor tyrosine kinase inhibitor with antiangiogenic and... | [
{
"id": "PMID-21878661_T2",
"type": "Cell",
"text": [
"pheochromocytoma tumor cells"
],
"offsets": [
[
31,
59
]
],
"normalized": []
},
{
"id": "PMID-21878661_T10",
"type": "Organism_subdivision",
"text": [
"oral"
],
"offsets... | [] | [] | [] |
PMID-9088383 | PMID-9088383 | [
{
"id": "PMID-9088383__text",
"type": "abstract",
"text": [
"Procedural memory stimulation in Alzheimer's disease: impact of a training programme.\nThe study evaluates the efficacy of a procedural memory stimulation programme in mild and mild-moderate Alzheimer's disease (AD). Twenty basic and ins... | [] | [] | [] | [] |
PMC-2713402-sec-09 | PMC-2713402-sec-09 | [
{
"id": "PMC-2713402-sec-09__text",
"type": "sec",
"text": [
"Statistical Analysis\nMitochondrial DNA haplogroup frequencies were calculated by counting from the observed genotypes. The Pearson chi-square test and the chi-square test for linear-by-linear association were used to analyze the signif... | [
{
"id": "PMC-2713402-sec-09_T1",
"type": "Cellular_component",
"text": [
"Mitochondrial"
],
"offsets": [
[
21,
34
]
],
"normalized": []
}
] | [] | [] | [] |
PMID-14981916 | PMID-14981916 | [
{
"id": "PMID-14981916__text",
"type": "abstract",
"text": [
"Full sequencing analysis of estrogen receptor-alpha gene polymorphism and its association with breast cancer risk.\nBACKGROUND:\nThe estrogen receptor plays a critical role in breast cancer development and progression. So the genetic po... | [
{
"id": "PMID-14981916_T1",
"type": "Cancer",
"text": [
"breast cancer"
],
"offsets": [
[
95,
108
]
],
"normalized": []
},
{
"id": "PMID-14981916_T2",
"type": "Cancer",
"text": [
"breast cancer"
],
"offsets": [
[
... | [] | [] | [] |
PMID-16204028 | PMID-16204028 | [
{
"id": "PMID-16204028__text",
"type": "abstract",
"text": [
"The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. \nThe adenomatous polyposis coli (APC) gene, whose mutations are responsible for familial adenomatous polyposis, is a major negative controlle... | [
{
"id": "PMID-16204028_T3",
"type": "Multi-tissue_structure",
"text": [
"intestinal"
],
"offsets": [
[
68,
78
]
],
"normalized": []
},
{
"id": "PMID-16204028_T9",
"type": "Multi-tissue_structure",
"text": [
"intestinal"
],
"... | [] | [] | [] |
PMC-2646243-sec-01 | PMC-2646243-sec-01 | [
{
"id": "PMC-2646243-sec-01__text",
"type": "sec",
"text": [
"Background\n\n"
],
"offsets": [
[
0,
12
]
]
}
] | [] | [] | [] | [] |
PMID-21196400 | PMID-21196400 | [
{
"id": "PMID-21196400__text",
"type": "abstract",
"text": [
"MTSS1: a multifunctional protein and its role in cancer invasion and metastasis. \nMTSS1 (metastasis suppressor-1) was first identified as a metastasis suppressor missing in metastatic bladder carcinoma cell lines. The down-regulation o... | [
{
"id": "PMID-21196400_T2",
"type": "Cancer",
"text": [
"cancer"
],
"offsets": [
[
49,
55
]
],
"normalized": []
},
{
"id": "PMID-21196400_T5",
"type": "Cell",
"text": [
"metastatic bladder carcinoma cell lines"
],
"offsets":... | [] | [] | [] |
PMID-14729736 | PMID-14729736 | [
{
"id": "PMID-14729736__text",
"type": "abstract",
"text": [
"Antibiotic-induced persistence of cytotoxic Staphylococcus aureus in non-phagocytic cells.\nOBJECTIVES:\nAfter infection of non-phagocytic cells, some Staphylococcus aureus strains are able to survive and kill their host cells. The purp... | [
{
"id": "PMID-14729736_T1",
"type": "Cell",
"text": [
"non-phagocytic cells"
],
"offsets": [
[
69,
89
]
],
"normalized": []
},
{
"id": "PMID-14729736_T2",
"type": "Cell",
"text": [
"non-phagocytic cells"
],
"offsets": [
... | [] | [] | [] |
PMID-19695243 | PMID-19695243 | [
{
"id": "PMID-19695243__text",
"type": "abstract",
"text": [
"Metronomic 5-fluorouracil, oxaliplatin and irinotecan in colorectal cancer.\nMetronomic chemotherapy (the frequent, long term, low dose administration of chemotherapeutic drugs) is a promising therapy because it enhances the anti-endoth... | [
{
"id": "PMID-19695243_T4",
"type": "Cancer",
"text": [
"colorectal cancer"
],
"offsets": [
[
57,
74
]
],
"normalized": []
},
{
"id": "PMID-19695243_T5",
"type": "Cell",
"text": [
"endothelial"
],
"offsets": [
[
... | [] | [] | [] |
PMID-21743150 | PMID-21743150 | [
{
"id": "PMID-21743150__text",
"type": "abstract",
"text": [
"[Expression of Merlin protein in non-small cell lung carcinoma and the clinical significance]. \nOBJECTIVE: To determine the expression and clinical significance of Merlin protein in non-small cell lung cancer (NSCLC). METHODS: The expr... | [
{
"id": "PMID-21743150_T2",
"type": "Cancer",
"text": [
"non-small cell lung carcinoma"
],
"offsets": [
[
33,
62
]
],
"normalized": []
},
{
"id": "PMID-21743150_T4",
"type": "Cancer",
"text": [
"non-small cell lung cancer"
],
... | [] | [] | [] |
PMID-15015551 | PMID-15015551 | [
{
"id": "PMID-15015551__text",
"type": "abstract",
"text": [
"Morphogenesis of embryonic CNS vessels.\nThis chapter focuses on the morphology of blood vessel formation in and around the early central nervous system (CNS, i.e., brain and spinal cord) of avian embryos. We discuss cell lineages, prol... | [
{
"id": "PMID-15015551_T1",
"type": "Multi-tissue_structure",
"text": [
"embryonic CNS vessels"
],
"offsets": [
[
17,
38
]
],
"normalized": []
},
{
"id": "PMID-15015551_T2",
"type": "Multi-tissue_structure",
"text": [
"blood vessel"... | [] | [] | [] |
PMID-11957196 | PMID-11957196 | [
{
"id": "PMID-11957196__text",
"type": "abstract",
"text": [
"Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias. \nGranulocyte colony-stimulating factor (G-CSF) has had a major impact on the management of \"severe chronic neutropenia\" (SCN), a collective term ... | [
{
"id": "PMID-11957196_T1",
"type": "Cancer",
"text": [
"acute myeloid leukemia"
],
"offsets": [
[
37,
59
]
],
"normalized": []
},
{
"id": "PMID-11957196_T6",
"type": "Cell",
"text": [
"neutrophils"
],
"offsets": [
[
... | [] | [] | [] |
PMID-12344153 | PMID-12344153 | [
{
"id": "PMID-12344153__text",
"type": "abstract",
"text": [
"Act No. 16.045 of 2 June 1989 prohibiting all discrimination that violates the principle of equality of treatment and opportunities for both sexes in all sectors of labor activity.\nThis Uruguayan Act prohibits discrimination in employ... | [] | [] | [] | [] |
PMID-18565374 | PMID-18565374 | [
{
"id": "PMID-18565374__text",
"type": "abstract",
"text": [
"Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists.\nThe purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy sympos... | [
{
"id": "PMID-18565374_T1",
"type": "Tissue",
"text": [
"pulp"
],
"offsets": [
[
35,
39
]
],
"normalized": []
},
{
"id": "PMID-18565374_T2",
"type": "Tissue",
"text": [
"pulp"
],
"offsets": [
[
216,
220... | [] | [] | [] |
PMID-18469146 | PMID-18469146 | [
{
"id": "PMID-18469146__text",
"type": "abstract",
"text": [
"Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells.\nPhysiological angiogenesis is regulated by various factors, including signaling through vascular endothelial growth factor (VEGF) receptors. We previous... | [
{
"id": "PMID-18469146_T3",
"type": "Cell",
"text": [
"cell"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "PMID-18469146_T4",
"type": "Cell",
"text": [
"endothelial cells"
],
"offsets": [
[
64,
... | [] | [] | [] |
PMID-7684185 | PMID-7684185 | [
{
"id": "PMID-7684185__text",
"type": "abstract",
"text": [
"Comparative immunohistochemical study of primary and metastatic carcinomas of the liver.\nDistinguishing primary hepatocellular carcinoma (HCC) from metastatic carcinomas to the liver is often difficult, if not impossible, particularly i... | [
{
"id": "PMID-7684185_T1",
"type": "Cancer",
"text": [
"primary"
],
"offsets": [
[
41,
48
]
],
"normalized": []
},
{
"id": "PMID-7684185_T2",
"type": "Cancer",
"text": [
"metastatic carcinomas"
],
"offsets": [
[
... | [] | [] | [] |
PMID-8874381 | PMID-8874381 | [
{
"id": "PMID-8874381__text",
"type": "abstract",
"text": [
"Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.\nVascular endothelial growth factor (VEGF) is a naturally secreted endothelial cell-specific mitogen.... | [
{
"id": "PMID-8874381_T3",
"type": "Multi-tissue_structure",
"text": [
"collateral"
],
"offsets": [
[
104,
114
]
],
"normalized": []
},
{
"id": "PMID-8874381_T6",
"type": "Cell",
"text": [
"endothelial cell"
],
"offsets": [
... | [] | [] | [] |
PMC-2268729-sec-08 | PMC-2268729-sec-08 | [
{
"id": "PMC-2268729-sec-08__text",
"type": "sec",
"text": [
"Ovariectomy\nBased on the uterine weight, we determined seven unsuccessful OVXs. The rats concerned were removed from further analyses, which left nine rats in the control group, five in the OVX group, seven in the OVX and late ZOL grou... | [
{
"id": "PMC-2268729-sec-08_T1",
"type": "Organ",
"text": [
"uterine"
],
"offsets": [
[
25,
32
]
],
"normalized": []
},
{
"id": "PMC-2268729-sec-08_T2",
"type": "Tissue",
"text": [
"bone"
],
"offsets": [
[
1040... | [] | [] | [] |
PMID-12727857 | PMID-12727857 | [
{
"id": "PMID-12727857__text",
"type": "abstract",
"text": [
"Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression.\nThe expression of endothelial cell (EC) adhesion molecules involved in leukocyte-vessel wall interactions is ... | [
{
"id": "PMID-12727857_T1",
"type": "Cancer",
"text": [
"Tumor"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "PMID-12727857_T2",
"type": "Cell",
"text": [
"leukocyte"
],
"offsets": [
[
29,
38... | [] | [] | [] |
PMID-6325250 | PMID-6325250 | [
{
"id": "PMID-6325250__text",
"type": "abstract",
"text": [
"Molecular events leading to enhanced glucose transport in Rous sarcoma virus-transformed cells. \nTransformation by Rous sarcoma virus results in a dramatic increase in the rate at which the transformed cells transport glucose across the... | [
{
"id": "PMID-6325250_T3",
"type": "Cell",
"text": [
"cells"
],
"offsets": [
[
89,
94
]
],
"normalized": []
},
{
"id": "PMID-6325250_T5",
"type": "Cell",
"text": [
"cells"
],
"offsets": [
[
202,
207
... | [] | [] | [] |
PMID-19806573 | PMID-19806573 | [
{
"id": "PMID-19806573__text",
"type": "abstract",
"text": [
"[Effect of osteopontin silencing by lentivirus-mediated delivery of siRNA on glioma cell invasion and apoptosis]. \nOBJECTIVE: To investigate the effect of osteopontin silencing on the invasion and apoptosis of U251 cells. METHODS: The ... | [
{
"id": "PMID-19806573_T3",
"type": "Cell",
"text": [
"glioma cell"
],
"offsets": [
[
77,
88
]
],
"normalized": []
},
{
"id": "PMID-19806573_T5",
"type": "Cell",
"text": [
"U251 cells"
],
"offsets": [
[
210,
... | [] | [] | [] |
PMC-2535566-caption-18 | PMC-2535566-caption-18 | [
{
"id": "PMC-2535566-caption-18__text",
"type": "caption",
"text": [
"Click here for additional data file.\n"
],
"offsets": [
[
0,
37
]
]
}
] | [] | [] | [] | [] |
PMID-22172720 | PMID-22172720 | [
{
"id": "PMID-22172720__text",
"type": "abstract",
"text": [
"beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. \nMalignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. ... | [
{
"id": "PMID-22172720_T4",
"type": "Cancer",
"text": [
"melanomas"
],
"offsets": [
[
76,
85
]
],
"normalized": []
},
{
"id": "PMID-22172720_T5",
"type": "Cancer",
"text": [
"Malignant melanoma"
],
"offsets": [
[
... | [] | [] | [] |
PMID-21506108 | PMID-21506108 | [
{
"id": "PMID-21506108__text",
"type": "abstract",
"text": [
"Induction of Id-1 by FGF-2 involves activity of EGR-1 and sensitizes neuroblastoma cells to cell death. \nInhibitor of differentiation-1 (Id-1) is a member of helix-loop-helix (HLH) family of proteins that regulate gene transcription th... | [
{
"id": "PMID-21506108_T4",
"type": "Cell",
"text": [
"neuroblastoma cells"
],
"offsets": [
[
69,
88
]
],
"normalized": []
},
{
"id": "PMID-21506108_T5",
"type": "Cell",
"text": [
"cell"
],
"offsets": [
[
92,
... | [] | [] | [] |
PMID-10978248 | PMID-10978248 | [
{
"id": "PMID-10978248__text",
"type": "abstract",
"text": [
"Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells.\nVasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been imp... | [
{
"id": "PMID-10978248_T2",
"type": "Cellular_component",
"text": [
"stress-fiber"
],
"offsets": [
[
53,
65
]
],
"normalized": []
},
{
"id": "PMID-10978248_T3",
"type": "Cellular_component",
"text": [
"membrane ruffle"
],
"o... | [] | [] | [] |
PMID-9843597 | PMID-9843597 | [
{
"id": "PMID-9843597__text",
"type": "abstract",
"text": [
"Glucagon induces suppression of ATP-sensitive K+ channel activity through a Ca2+/calmodulin-dependent pathway in mouse pancreatic beta-cells.\nGlucagon is known to increase intracellular cAMP levels and enhance glucose-induced electrical... | [
{
"id": "PMID-9843597_T1",
"type": "Cell",
"text": [
"pancreatic beta-cells"
],
"offsets": [
[
119,
140
]
],
"normalized": []
},
{
"id": "PMID-9843597_T2",
"type": "Immaterial_anatomical_entity",
"text": [
"intracellular"
],
... | [] | [] | [] |
PMC-1971061-sec-09 | PMC-1971061-sec-09 | [
{
"id": "PMC-1971061-sec-09__text",
"type": "sec",
"text": [
"Etiology\nAnorectal malformations (ARM) represent a spectrum of abnormalities ranging from mild anal anomalies to complex cloacal malformations. The etiology of such malformations remains unclear and is likely multifactorial. There are ... | [
{
"id": "PMC-1971061-sec-09_T1",
"type": "Organism_subdivision",
"text": [
"Anorectal"
],
"offsets": [
[
9,
18
]
],
"normalized": []
},
{
"id": "PMC-1971061-sec-09_T2",
"type": "Immaterial_anatomical_entity",
"text": [
"anal"
],... | [] | [] | [] |
PMID-11909360 | PMID-11909360 | [
{
"id": "PMID-11909360__text",
"type": "abstract",
"text": [
"Novel method for multiturn extraction: trapping charged particles in islands of phase space.\nA novel method for multiturn extraction from a circular particle accelerator is presented, based on trapping particles into islands of phase s... | [] | [] | [] | [] |
PMC-2217075-caption-07 | PMC-2217075-caption-07 | [
{
"id": "PMC-2217075-caption-07__text",
"type": "caption",
"text": [
"Anion to cation selectivity ratio determined from the relative rates of reaction of MTSES- and MTSET+ with the water exposed residues in the M6 segment. The anion selectivity ratio is calculated as described in Table II, column ... | [] | [] | [] | [] |
PMID-9394578 | PMID-9394578 | [
{
"id": "PMID-9394578__text",
"type": "abstract",
"text": [
"[Extra-anatomic bypass from the ascending aorta to the supraceliac abdominal aorta--surgical option applied to reoperation for aortic coarctation or interruption].\nThe optimal approach for reoperation following repair of aortic coarctat... | [
{
"id": "PMID-9394578_T1",
"type": "Multi-tissue_structure",
"text": [
"abdominal aorta"
],
"offsets": [
[
67,
82
]
],
"normalized": []
},
{
"id": "PMID-9394578_T2",
"type": "Multi-tissue_structure",
"text": [
"aortic"
],
"o... | [] | [] | [] |
PMID-15623651 | PMID-15623651 | [
{
"id": "PMID-15623651__text",
"type": "abstract",
"text": [
"2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma.\nPURPOSE: Head and neck squamous cell carcinomas have been reported t... | [
{
"id": "PMID-15623651_T3",
"type": "Cancer",
"text": [
"tumor"
],
"offsets": [
[
61,
66
]
],
"normalized": []
},
{
"id": "PMID-15623651_T5",
"type": "Cancer",
"text": [
"head and neck squamous cell carcinoma"
],
"offsets": ... | [] | [] | [] |
PMID-1683740 | PMID-1683740 | [
{
"id": "PMID-1683740__text",
"type": "abstract",
"text": [
"Changes of lymphocyte subsets in leukemia patients who received allogenic bone marrow transplantation.\nProportional changes of lymphocyte subsets in the peripheral blood were monitored by two-color flow-cytometry in seven leukemia patie... | [
{
"id": "PMID-1683740_T1",
"type": "Cell",
"text": [
"lymphocyte"
],
"offsets": [
[
11,
21
]
],
"normalized": []
},
{
"id": "PMID-1683740_T2",
"type": "Multi-tissue_structure",
"text": [
"bone marrow"
],
"offsets": [
[... | [] | [] | [] |
PMID-3609047 | PMID-3609047 | [
{
"id": "PMID-3609047__text",
"type": "abstract",
"text": [
"Torsade de pointes during loading with amiodarone.\nTorsade de pointes represents a potential complication of chronic amiodarone therapy. Several reports have emphasized the need for a loading dose in order to achieve therapeutic blood l... | [
{
"id": "PMID-3609047_T1",
"type": "Organism_substance",
"text": [
"blood"
],
"offsets": [
[
229,
234
]
],
"normalized": []
},
{
"id": "PMID-3609047_T2",
"type": "Immaterial_anatomical_entity",
"text": [
"intravenous"
],
"of... | [] | [] | [] |
PMID-19292679 | PMID-19292679 | [
{
"id": "PMID-19292679__text",
"type": "abstract",
"text": [
"The effect of perfluorocarbon-based artificial oxygen carriers on tissue-engineered trachea.\nThe biological effect of the perfluorocarbon-based artificial oxygen carrier (Oxygent) was investigated in tissue-engineered trachea (TET) con... | [
{
"id": "PMID-19292679_T3",
"type": "Multi-tissue_structure",
"text": [
"tissue-engineered trachea"
],
"offsets": [
[
66,
91
]
],
"normalized": []
},
{
"id": "PMID-19292679_T7",
"type": "Multi-tissue_structure",
"text": [
"tissue-en... | [] | [] | [] |
PMID-19679742 | PMID-19679742 | [
{
"id": "PMID-19679742__text",
"type": "abstract",
"text": [
"Aging affects the cardiovascular responses to cold stress in humans.\nCardiovascular-related mortality peaks during cold winter months, particularly in older adults. Acute physiological responses, such as increases in blood pressure, in... | [
{
"id": "PMID-19679742_T1",
"type": "Anatomical_system",
"text": [
"cardiovascular"
],
"offsets": [
[
18,
32
]
],
"normalized": []
},
{
"id": "PMID-19679742_T2",
"type": "Anatomical_system",
"text": [
"Cardiovascular"
],
"of... | [] | [] | [] |
PMID-16850045 | PMID-16850045 | [
{
"id": "PMID-16850045__text",
"type": "abstract",
"text": [
"Fluoroscopically guided cervical prolotherapy for instability with blinded pre and post radiographic reading.\nBACKGROUND:\nSeveral authors have postulated that cervical instability is a major cause of traumatic spinal pain.\nOBJECTIVE:... | [
{
"id": "PMID-16850045_T1",
"type": "Organism_subdivision",
"text": [
"cervical"
],
"offsets": [
[
24,
32
]
],
"normalized": []
},
{
"id": "PMID-16850045_T2",
"type": "Organism_subdivision",
"text": [
"cervical"
],
"offsets"... | [] | [] | [] |
PMID-1553573 | PMID-1553573 | [
{
"id": "PMID-1553573__text",
"type": "abstract",
"text": [
"Granulocyte-macrophage colony-stimulating factor and interleukin-3 enhance the incorporation of cytosine arabinoside into the DNA of leukemic blasts and the cytotoxic effect on clonogenic cells from patients with acute myeloid leukemia. ... | [
{
"id": "PMID-1553573_T5",
"type": "Cell",
"text": [
"leukemic blasts"
],
"offsets": [
[
133,
148
]
],
"normalized": []
},
{
"id": "PMID-1553573_T6",
"type": "Cell",
"text": [
"clonogenic cells"
],
"offsets": [
[
... | [] | [] | [] |
PMID-11425277 | PMID-11425277 | [
{
"id": "PMID-11425277__text",
"type": "abstract",
"text": [
"Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs.\nIn animal or cell culture studies, the growth and spread of cancer can be slowed by many nutrie... | [
{
"id": "PMID-11425277_T1",
"type": "Cancer",
"text": [
"cancer"
],
"offsets": [
[
34,
40
]
],
"normalized": []
},
{
"id": "PMID-11425277_T2",
"type": "Cell",
"text": [
"cell culture"
],
"offsets": [
[
153,
... | [] | [] | [] |
PMC-2959883-sec-06 | PMC-2959883-sec-06 | [
{
"id": "PMC-2959883-sec-06__text",
"type": "sec",
"text": [
"Data collection: CrystalClear (Rigaku/MSC, 2005 >); cell refinement: CrystalClear; data reduction: CrystalClear; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 >); program(s) used to refine structure: SHELXL97 (Sheldrick,... | [
{
"id": "PMC-2959883-sec-06_T1",
"type": "Cell",
"text": [
"cell"
],
"offsets": [
[
52,
56
]
],
"normalized": []
}
] | [] | [] | [] |
PMC-2845033-sec-09 | PMC-2845033-sec-09 | [
{
"id": "PMC-2845033-sec-09__text",
"type": "sec",
"text": [
"Applying A1C cut offs to the AusDiab population (4.6% undiagnosed diabetes)\nApplying the same cut offs, a total 75.9% of the AusDiab population had diabetes ruled in or ruled out (Fig. 1B), while the remaining 24.1% had impaired A1C. F... | [] | [] | [] | [] |
PMID-15012488 | PMID-15012488 | [
{
"id": "PMID-15012488__text",
"type": "abstract",
"text": [
"Covariance structure analysis: statistical practice, theory, and directions.\nAlthough covariance structure analysis is used increasingly to analyze nonexperimental data, important statistical requirements for its proper use are frequen... | [] | [] | [] | [] |
PMID-11836604 | PMID-11836604 | [
{
"id": "PMID-11836604__text",
"type": "abstract",
"text": [
"Prognostic significance of heat shock protein 27 (HSP27) in patients with oral squamous cell carcinoma. \nHeat shock proteins (HSPs) have been defined as proteins induced by heat shock and other environmental and pathophysiologic stress... | [
{
"id": "PMID-11836604_T4",
"type": "Cancer",
"text": [
"oral squamous cell carcinoma"
],
"offsets": [
[
74,
102
]
],
"normalized": []
},
{
"id": "PMID-11836604_T11",
"type": "Cancer",
"text": [
"cancers"
],
"offsets": [
... | [] | [] | [] |
PMID-15355640 | PMID-15355640 | [
{
"id": "PMID-15355640__text",
"type": "abstract",
"text": [
"[Altered expression of PTEN gene and LOH of its epigenetic microsatellite in gastric carcinoma]. \nOBJECTIVE: To investigate the expression of PTEN and loss of heterozygosity (LOH) of its epigenetic microsatellite in gastric carcinoma a... | [
{
"id": "PMID-15355640_T2",
"type": "Cancer",
"text": [
"gastric carcinoma"
],
"offsets": [
[
77,
94
]
],
"normalized": []
},
{
"id": "PMID-15355640_T4",
"type": "Cancer",
"text": [
"gastric carcinoma"
],
"offsets": [
... | [] | [] | [] |
PMID-707591 | PMID-707591 | [
{
"id": "PMID-707591__text",
"type": "abstract",
"text": [
"Subretinal neovascularization following rubella retinopathy.\nA 17-year-old girl and an 11-year-old girl with rubella retinopathy had decreased vision in one eye secondary to subretinal neovascularization and hemorrhage. In both cases a d... | [
{
"id": "PMID-707591_T2",
"type": "Organ",
"text": [
"eye"
],
"offsets": [
[
157,
160
]
],
"normalized": []
},
{
"id": "PMID-707591_T4",
"type": "Pathological_formation",
"text": [
"scar"
],
"offsets": [
[
246,... | [] | [] | [] |
PMID-3993849 | PMID-3993849 | [
{
"id": "PMID-3993849__text",
"type": "abstract",
"text": [
"Management of the tortuous internal carotid artery.\nThe tortuous internal carotid artery as the basis of cerebral vascular insufficiency is a controversial entity, as such lesions frequently occur without neurologic symptoms. However, s... | [
{
"id": "PMID-3993849_T1",
"type": "Multi-tissue_structure",
"text": [
"tortuous internal carotid artery"
],
"offsets": [
[
18,
50
]
],
"normalized": []
},
{
"id": "PMID-3993849_T2",
"type": "Multi-tissue_structure",
"text": [
"tort... | [] | [] | [] |
PMID-10816661 | PMID-10816661 | [
{
"id": "PMID-10816661__text",
"type": "abstract",
"text": [
"Alpha-melanocyte-stimulating hormone modulates activation of NF-kappa B and AP-1 and secretion of interleukin-8 in human dermal fibroblasts.\nAlpha-melanocyte-stimulating hormone (alpha-MSH) has evolved as a mediator of diverse biologic... | [
{
"id": "PMID-10816661_T6",
"type": "Cell",
"text": [
"dermal fibroblasts"
],
"offsets": [
[
121,
139
]
],
"normalized": []
},
{
"id": "PMID-10816661_T9",
"type": "Cell",
"text": [
"non-melanocytic cell"
],
"offsets": [
... | [] | [] | [] |
PMID-11381168 | PMID-11381168 | [
{
"id": "PMID-11381168__text",
"type": "abstract",
"text": [
"Effects of morphological patterning on endothelial cell migration.\nThe migration of vascular endothelial cells (ECs) plays an important role in vascular remodeling. Here we studied the effects of cell morphology on the migration of bov... | [
{
"id": "PMID-11381168_T1",
"type": "Cell",
"text": [
"endothelial cell"
],
"offsets": [
[
39,
55
]
],
"normalized": []
},
{
"id": "PMID-11381168_T2",
"type": "Cell",
"text": [
"vascular endothelial cells"
],
"offsets": [
... | [] | [] | [] |
PMID-11107120 | PMID-11107120 | [
{
"id": "PMID-11107120__text",
"type": "abstract",
"text": [
"p75 mediated apoptosis in neuroblastoma cells is inhibited by expression of TrkA. \nBACKGROUND: Neurotrophins mediate their effects by binding to members of the Trk family of receptor tyrosine kinases and to the low-affinity nerve growt... | [
{
"id": "PMID-11107120_T2",
"type": "Cell",
"text": [
"neuroblastoma cells"
],
"offsets": [
[
26,
45
]
],
"normalized": []
},
{
"id": "PMID-11107120_T9",
"type": "Cell",
"text": [
"neuroblastoma (NB) cells"
],
"offsets": [
... | [] | [] | [] |
PMID-12920663 | PMID-12920663 | [
{
"id": "PMID-12920663__text",
"type": "abstract",
"text": [
"Proliferative diabetic retinopathy is associated with a low level of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor. a pilot study.\nRetinopathy is the most common microvascular diabet... | [
{
"id": "PMID-12920663_T1",
"type": "Organ",
"text": [
"ocular"
],
"offsets": [
[
81,
87
]
],
"normalized": []
},
{
"id": "PMID-12920663_T4",
"type": "Organism_substance",
"text": [
"aqueous humor"
],
"offsets": [
[
... | [] | [] | [] |
PMID-8691230 | PMID-8691230 | [
{
"id": "PMID-8691230__text",
"type": "abstract",
"text": [
"Referral bias among health workers in studies using hospitalization as a proxy measure of the underlying incidence rate.\nContacts with health services like hospitals or general practitioners are usually the only available proxy measure ... | [
{
"id": "PMID-8691230_T1",
"type": "Organ",
"text": [
"heart"
],
"offsets": [
[
1065,
1070
]
],
"normalized": []
}
] | [] | [] | [] |
PMID-11255762 | PMID-11255762 | [
{
"id": "PMID-11255762__text",
"type": "abstract",
"text": [
"[Study of fungus polysaccharides compounds (FPC) in inducing the apoptosis of liver cancer cell Bel-7402]. \nTo observe the influence of fungus polysaccharides compounds (FPC) in inducing human liver cancer cell Bel-7402 apoptosis in ce... | [
{
"id": "PMID-11255762_T3",
"type": "Cell",
"text": [
"liver cancer cell Bel-7402]"
],
"offsets": [
[
78,
105
]
],
"normalized": []
},
{
"id": "PMID-11255762_T7",
"type": "Cell",
"text": [
"liver cancer cell Bel-7402"
],
"of... | [] | [] | [] |
PMID-18319331 | PMID-18319331 | [
{
"id": "PMID-18319331__text",
"type": "abstract",
"text": [
"Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma.\nWe hypothesized that signaling through multiple mitogen-activated protein kinase (MAPK) kinase (MKK) pathways is essential for the g... | [
{
"id": "PMID-18319331_T2",
"type": "Cancer",
"text": [
"fibrosarcoma"
],
"offsets": [
[
89,
101
]
],
"normalized": []
},
{
"id": "PMID-18319331_T5",
"type": "Cancer",
"text": [
"soft-tissue sarcomas"
],
"offsets": [
[... | [] | [] | [] |
PMID-19080335 | PMID-19080335 | [
{
"id": "PMID-19080335__text",
"type": "abstract",
"text": [
"Effect of transplanted mesenchymal stem cells from rats of different ages on the improvement of heart function after acute myocardial infarction.\nBACKGROUND: Mesenchymal stem cells (MSCs) transplantation is of therapeutic potential aft... | [
{
"id": "PMID-19080335_T1",
"type": "Cell",
"text": [
"mesenchymal stem cells"
],
"offsets": [
[
23,
45
]
],
"normalized": []
},
{
"id": "PMID-19080335_T3",
"type": "Organ",
"text": [
"heart"
],
"offsets": [
[
... | [] | [] | [] |
PMID-15574223 | PMID-15574223 | [
{
"id": "PMID-15574223__text",
"type": "abstract",
"text": [
"Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study. \nOBJECTIVE: Dependence on glycolysis is a hallmark of malignant tumors.... | [
{
"id": "PMID-15574223_T2",
"type": "Cell",
"text": [
"cell"
],
"offsets": [
[
113,
117
]
],
"normalized": []
},
{
"id": "PMID-15574223_T3",
"type": "Cancer",
"text": [
"malignant glioma"
],
"offsets": [
[
127,... | [] | [] | [] |
PMID-19389366 | PMID-19389366 | [
{
"id": "PMID-19389366__text",
"type": "abstract",
"text": [
"Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. \nThe polycomb gene Bmi-1 is required for the self-renewal of stem cells from di... | [
{
"id": "PMID-19389366_T2",
"type": "Cell",
"text": [
"neural stem/progenitor cells"
],
"offsets": [
[
25,
53
]
],
"normalized": []
},
{
"id": "PMID-19389366_T4",
"type": "Cell",
"text": [
"stem cells"
],
"offsets": [
... | [] | [] | [] |
PMC-2861602-sec-09 | PMC-2861602-sec-09 | [
{
"id": "PMC-2861602-sec-09__text",
"type": "sec",
"text": [
"Discussion\nThis is the first study to employ such a large number of replicated samples in order to assess the bacterial communities of healthy and diseased corals, and the first culture-independent assessment of bacterial communities o... | [
{
"id": "PMC-2861602-sec-09_T1",
"type": "Cell",
"text": [
"communities"
],
"offsets": [
[
120,
131
]
],
"normalized": []
},
{
"id": "PMC-2861602-sec-09_T2",
"type": "Cell",
"text": [
"communities"
],
"offsets": [
[
... | [] | [] | [] |
PMID-17523137 | PMID-17523137 | [
{
"id": "PMID-17523137__text",
"type": "abstract",
"text": [
"Characterization of transferrin glycoforms in human serum by CE-UV and CE-ESI-MS.\nHuman transferrin (Tf) is a model glycoprotein for congenital disorders of glycosylation (CDG) diagnosis. In the last few years, new CE-UV methods for in... | [
{
"id": "PMID-17523137_T1",
"type": "Organism_substance",
"text": [
"sera"
],
"offsets": [
[
725,
729
]
],
"normalized": []
},
{
"id": "PMID-17523137_T2",
"type": "Organism_substance",
"text": [
"serum samples"
],
"offsets":... | [] | [] | [] |
PMC-1698941-caption-09 | PMC-1698941-caption-09 | [
{
"id": "PMC-1698941-caption-09__text",
"type": "caption",
"text": [
"Comparison of the Predicted Irr Regulon and ICE Motifs with the Published Expression Microarray Data for Iron- and Irr-Affected Genes in Bradyrhizobium japonicum\n"
],
"offsets": [
[
0,
162
]
... | [] | [] | [] | [] |
PMID-12419822 | PMID-12419822 | [
{
"id": "PMID-12419822__text",
"type": "abstract",
"text": [
"Identification of Dss1 as a 12-O-tetradecanoylphorbol-13-acetate-responsive gene expressed in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesis. \nThis study identifies genes expressed early in 12-O-te... | [
{
"id": "PMID-12419822_T3",
"type": "Cell",
"text": [
"keratinocyte progenitor cells"
],
"offsets": [
[
94,
123
]
],
"normalized": []
},
{
"id": "PMID-12419822_T4",
"type": "Organ",
"text": [
"skin"
],
"offsets": [
[
... | [] | [] | [] |
PMC-2792620-sec-33 | PMC-2792620-sec-33 | [
{
"id": "PMC-2792620-sec-33__text",
"type": "sec",
"text": [
"Surgery\nTrabeculectomy should be considered in all patients, when the 'target IOP' is not achieved with glaucoma medications and if the expected rate of visual loss could affect the patient during their lifetime. In this procedure, an ... | [
{
"id": "PMC-2792620-sec-33_T1",
"type": "Organism_substance",
"text": [
"aqueous humor"
],
"offsets": [
[
287,
300
]
],
"normalized": []
},
{
"id": "PMC-2792620-sec-33_T2",
"type": "Multi-tissue_structure",
"text": [
"sclera"
]... | [] | [] | [] |
PMID-11943784 | PMID-11943784 | [
{
"id": "PMID-11943784__text",
"type": "abstract",
"text": [
"Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. \nCancer cells display high rates of aerobic glycolysis, a phenomenon known historically as the Warburg effect. Lactate and pyr... | [
{
"id": "PMID-11943784_T2",
"type": "Cell",
"text": [
"Cancer cells"
],
"offsets": [
[
110,
122
]
],
"normalized": []
},
{
"id": "PMID-11943784_T5",
"type": "Cell",
"text": [
"cancer cells"
],
"offsets": [
[
29... | [] | [] | [] |
PMID-19351864 | PMID-19351864 | [
{
"id": "PMID-19351864__text",
"type": "abstract",
"text": [
"PTTG overexpression promotes lymph node metastasis in human esophageal squamous cell carcinoma. \nHuman pituitary tumor transforming gene (PTTG) overexpression correlates with metastasis in multiple tumors, and yet its molecular mechani... | [
{
"id": "PMID-19351864_T2",
"type": "Multi-tissue_structure",
"text": [
"lymph node"
],
"offsets": [
[
29,
39
]
],
"normalized": []
},
{
"id": "PMID-19351864_T4",
"type": "Cancer",
"text": [
"esophageal squamous cell carcinoma"
... | [] | [] | [] |
PMID-7504687 | PMID-7504687 | [
{
"id": "PMID-7504687__text",
"type": "abstract",
"text": [
"Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human br... | [
{
"id": "PMID-7504687_T2",
"type": "Cell",
"text": [
"breast cancer cell"
],
"offsets": [
[
62,
80
]
],
"normalized": []
},
{
"id": "PMID-7504687_T4",
"type": "Cell",
"text": [
"spleen natural killer cell"
],
"offsets": [
... | [] | [] | [] |
PMID-19509166 | PMID-19509166 | [
{
"id": "PMID-19509166__text",
"type": "abstract",
"text": [
"Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma.\nPURPOSE: Tumor fibroblasts (TF) have been suggested to play an essential role i... | [
{
"id": "PMID-19509166_T1",
"type": "Cell",
"text": [
"Fibroblast growth factor receptor 2-positive fibroblasts"
],
"offsets": [
[
0,
56
]
],
"normalized": []
},
{
"id": "PMID-19509166_T3",
"type": "Cancer",
"text": [
"tumor"
],... | [] | [] | [] |
PMID-3109978 | PMID-3109978 | [
{
"id": "PMID-3109978__text",
"type": "abstract",
"text": [
"Epidermal growth factor and its receptor. \nEpidermal growth factor (EGF) binds with high affinity and specificity to a single site on the external domain of its transmembrane receptor to activate the tyrosine protein kinase activity of ... | [
{
"id": "PMID-3109978_T4",
"type": "Cellular_component",
"text": [
"transmembrane"
],
"offsets": [
[
161,
174
]
],
"normalized": []
},
{
"id": "PMID-3109978_T5",
"type": "Organism_substance",
"text": [
"cytoplasmic"
],
"offs... | [] | [] | [] |
PMC-3203455-sec-04 | PMC-3203455-sec-04 | [
{
"id": "PMC-3203455-sec-04__text",
"type": "sec",
"text": [
"4.\nThe kinetochore\nThe arguments built in the previous section lead to the conclusion that it is essential to understand error correction and spindle checkpoint signalling in the context of the complex structural organization of the k... | [
{
"id": "PMC-3203455-sec-04_T1",
"type": "Cellular_component",
"text": [
"kinetochore"
],
"offsets": [
[
7,
18
]
],
"normalized": []
},
{
"id": "PMC-3203455-sec-04_T2",
"type": "Cellular_component",
"text": [
"kinetochore"
],
... | [] | [] | [] |
PMID-12154044 | PMID-12154044 | [
{
"id": "PMID-12154044__text",
"type": "abstract",
"text": [
"Inhibition of angiogenesis by the cancer chemopreventive agent conjugated linoleic acid.\nDietary conjugated linoleic acid (CLA) has been shown previously to inhibit rat mammary carcinogenesis. In addition to direct effects on mammary e... | [
{
"id": "PMID-12154044_T1",
"type": "Cancer",
"text": [
"cancer"
],
"offsets": [
[
34,
40
]
],
"normalized": []
},
{
"id": "PMID-12154044_T6",
"type": "Organ",
"text": [
"mammary"
],
"offsets": [
[
169,
... | [] | [] | [] |
PMID-2028342 | PMID-2028342 | [
{
"id": "PMID-2028342__text",
"type": "abstract",
"text": [
"Posterior stabilization of the cervical spine with hook plates.\nHook-plate fixation is designed for posterior cervical stabilization from C2 to C7. Indications remain the same as for standard posterior fixations. The prime indications a... | [
{
"id": "PMID-2028342_T1",
"type": "Organism_subdivision",
"text": [
"cervical spine"
],
"offsets": [
[
31,
45
]
],
"normalized": []
},
{
"id": "PMID-2028342_T2",
"type": "Multi-tissue_structure",
"text": [
"lower laminas"
],
... | [] | [] | [] |
PMC-2885393-caption-01 | PMC-2885393-caption-01 | [
{
"id": "PMC-2885393-caption-01__text",
"type": "caption",
"text": [
"Comparison of the molecular organisation of the tra-2 of A. obliqua (A), C. capitata (B) and D. melanogaster (C) and their proteins. Exons (boxes) and introns (dashed lines) are not drawn to scale. The numbers inside the boxes i... | [
{
"id": "PMC-2885393-caption-01_T1",
"type": "Organ",
"text": [
"ovaries"
],
"offsets": [
[
444,
451
]
],
"normalized": []
},
{
"id": "PMC-2885393-caption-01_T2",
"type": "Developing_anatomical_structure",
"text": [
"embryos"
],... | [] | [] | [] |
PMC-1828719-sec-06 | PMC-1828719-sec-06 | [
{
"id": "PMC-1828719-sec-06__text",
"type": "sec",
"text": [
"Mass casualty estimation on a geographic basis\nThe Defense Threat Reduction Agency (DTRA) has expended considerable effort to develop models for calculating mass casualties from a nuclear detonation. In order to specifically evaluate u... | [] | [] | [] | [] |
PMID-19082449 | PMID-19082449 | [
{
"id": "PMID-19082449__text",
"type": "abstract",
"text": [
"Clinical significance of chicken ovalbumin upstream promoter-transcription factor II expression in human colorectal cancer.\nChicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) plays an essential role in angiogenesis... | [
{
"id": "PMID-19082449_T3",
"type": "Cancer",
"text": [
"colorectal cancer"
],
"offsets": [
[
105,
122
]
],
"normalized": []
},
{
"id": "PMID-19082449_T8",
"type": "Cell",
"text": [
"lung carcinoma cells"
],
"offsets": [
... | [] | [] | [] |
PMID-9663607 | PMID-9663607 | [
{
"id": "PMID-9663607__text",
"type": "abstract",
"text": [
"SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. I. Mechanisms responsible for hyperinvasiveness and resistance to anti-invasive action of TGFbeta. \nInvasion of the uterus by first trimeste... | [
{
"id": "PMID-9663607_T3",
"type": "Cell",
"text": [
"trophoblast"
],
"offsets": [
[
47,
58
]
],
"normalized": []
},
{
"id": "PMID-9663607_T5",
"type": "Organ",
"text": [
"uterus"
],
"offsets": [
[
212,
... | [] | [] | [] |
PMID-2992384 | PMID-2992384 | [
{
"id": "PMID-2992384__text",
"type": "abstract",
"text": [
"On the mechanism of glycolysis stimulation by neutral detergents in 3T3 and Ehrlich ascites tumor cells. \nGlycolysis of 3T3 and Ehrlich ascites tumor cells was greatly enhanced by Nonidet P-40 or Triton X-100 at about 100 micrograms/mg ... | [
{
"id": "PMID-2992384_T1",
"type": "Cell",
"text": [
"3T3"
],
"offsets": [
[
68,
71
]
],
"normalized": []
},
{
"id": "PMID-2992384_T2",
"type": "Cell",
"text": [
"Ehrlich ascites tumor cells"
],
"offsets": [
[
... | [] | [] | [] |
PMID-20157600 | PMID-20157600 | [
{
"id": "PMID-20157600__text",
"type": "abstract",
"text": [
"Further Characterization of Activin A-induced IgA Response in Murine B Lymphocytes.\nWe have recently shown that activin A, a member of TGF-beta superfamily, stimulates mouse B cells to express IgA isotype but other isotypes. In the pre... | [
{
"id": "PMID-20157600_T1",
"type": "Cell",
"text": [
"B Lymphocytes"
],
"offsets": [
[
69,
82
]
],
"normalized": []
},
{
"id": "PMID-20157600_T2",
"type": "Cell",
"text": [
"B cells"
],
"offsets": [
[
174,
... | [] | [] | [] |
PMC-3266646-sec-09 | PMC-3266646-sec-09 | [
{
"id": "PMC-3266646-sec-09__text",
"type": "sec",
"text": [
"Origins of Acquired Antibiotic Resistance Mechanisms\nRecently, D'Costa et al. (2011) have reported a metagenomic analysis of the Beringian permafrost, which is 30,000 years old. They showed molecular evidences of the ancient origins of... | [
{
"id": "PMC-3266646-sec-09_T1",
"type": "Cellular_component",
"text": [
"ribosomal"
],
"offsets": [
[
397,
406
]
],
"normalized": []
},
{
"id": "PMC-3266646-sec-09_T2",
"type": "Cellular_component",
"text": [
"ribosomal"
],
... | [] | [] | [] |
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