id stringlengths 24 24 | type stringclasses 4
values | body stringlengths 13 215 | ideal_answer listlengths 1 12 | exact_answer listlengths 0 44 | snippets listlengths 0 121 | documents listlengths 1 157 | triples listlengths 0 537 | concepts listlengths 0 99 |
|---|---|---|---|---|---|---|---|---|
58815f26713cbdfd3d000002 | summary | What is the role of the Ctf4-interacting-peptide or CIP-box? | [
"Crystallographic analysis classifies CIP-boxes into two related groups that target different sites on Ctf4. Mutations in the CIP-box motifs of the Dna2 nuclease or the rDNA-associated protein Tof2 do not perturb DNA synthesis genome-wide, but instead lead to a dramatic shortening of chromosome 12 that contains the... | [] | [
" Here, we identify new Ctf4 partners in addition to Pol α and helicase, all of which contain a \"Ctf4-interacting-peptide\" or CIP-box. Crystallographic analysis classifies CIP-boxes into two related groups that target different sites on Ctf4. Mutations in the CIP-box motifs of the Dna2 nuclease or the rDNA-associ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27397685"
] | [] | [
"http://www.biosemantics.org/jochem#4264134",
"http://www.biosemantics.org/jochem#4265011"
] |
58f3c4b970f9fc6f0f00000a | factoid | What type of genome, (RNA or DNA, double stranded single stranded) is found in the the virus that causes blue tongue disease? | [
"The Bluetongue virus (BTV) genome contains ten double-stranded RNA segments.",
"Bluetongue virus (BTV) genome contains ten double-stranded RNA segments. ",
"Bluetongue virus (BTV) genome contains ten double-stranded RNA segments.",
"Bluetongue virus (BTV) genome contains ten double-stranded RNA segments",
... | [
"double stranded, segmented RNA"
] | [
"Bluetongue virus (BTV) genome contains ten double-stranded RNA segments"
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/22549161"
] | [
{
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"s": "http://linkedlifedata.com/resource/umls/id/C0042776",
"o": "http://linkedlifedata.com/resource/umls/label/A0491591"
},
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"s": "http://linkedlifedata.com/resource/umls/label/A04915... | [
"http://www.disease-ontology.org/api/metadata/DOID:1301",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012330",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001820",
"http://www.disease-ontology.org/api/metadata/DOID:0050498"
] |
58efa1b870f9fc6f0f000003 | factoid | What is a "chemobrain"? | [
"The term \"chemobrain\" is sometimes used to denote deficits in neuropsychological functioning that may occur as a result of cancer treatment."
] | [
"The term \"chemobrain\" is sometimes used to denote deficits in neuropsychological functioning that may occur as a result of cancer treatment."
] | [
"Frequency of chemotherapy-related cognitive impairment or \"chemobrain\" is mentioned to be significant in literature, although very little is known about the chemotherapy-caused chemobrain and its connection with metal homeostasis alteration.",
"Cognitive decline or dementia is a debilitating problem of neurolo... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25176562",
"http://www.ncbi.nlm.nih.gov/pubmed/26653737",
"http://www.ncbi.nlm.nih.gov/pubmed/25687405",
"http://www.ncbi.nlm.nih.gov/pubmed/27041861",
"http://www.ncbi.nlm.nih.gov/pubmed/27709283"
] | [] | [] |
5890fde5621ea6ff7e000009 | factoid | Borden classification is used for which disease? | [
"Borden classification systems is used for the prediction of clinical behavior of cranial dural arteriovenous fistulas."
] | [
"cranial dural arteriovenous fistula",
"DAVF"
] | [
"The locations of DAVFs were the transverse-sigmoid sinus in 11, tentorium in 10, cranial vault in 9, and superior sagittal sinus, jugular bulb, foramen magnum, and middle cranial fossa in 1 each. Borden classification was type I in 7, type II in 3, and type III in 24.",
"Transarterial glue embolization is highly... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22107858",
"http://www.ncbi.nlm.nih.gov/pubmed/20678361",
"http://www.ncbi.nlm.nih.gov/pubmed/20678360",
"http://www.ncbi.nlm.nih.gov/pubmed/22374275",
"http://www.ncbi.nlm.nih.gov/pubmed/20849795",
"http://www.ncbi.nlm.nih.gov/pubmed/23570149",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002965",
"http://www.disease-ontology.org/api/metadata/DOID:4",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004194",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Ex... |
58c27b7102b8c60953000021 | factoid | Which effects create neighborhoods of transcriptional regulation in eukaryotes? | [
"Enhancer Sharing Promotes Neighborhoods of Transcriptional Regulation Across Eukaryotes. Here, we present cross-organismic evidence suggesting that most EP pairs are compatible, largely determined by physical proximity rather than specific interactions. we find that the transcription of gene neighbors is correlate... | [
"the sharing of enhancer elements",
"enhancer sharing"
] | [
"Enhancer Sharing Promotes Neighborhoods of Transcriptional Regulation Across Eukaryotes",
"Here, we present cross-organismic evidence suggesting that most EP pairs are compatible, largely determined by physical proximity rather than specific interactions.",
"we find that the transcription of gene neighbors is ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22084256",
"http://www.ncbi.nlm.nih.gov/pubmed/27799341",
"http://www.ncbi.nlm.nih.gov/pubmed/17025153"
] | [] | [] |
5881e8e8713cbdfd3d000003 | yesno | Is Pfh1 a component of the replisome? | [
"No. Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity. DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase."
] | [
"no"
] | [
"Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity",
"Although the Schizosaccharomyces pombe 5'-to-3' DNA helicase Pfh1 is known to promote fork progression, its genomic targets, dynamics, and mechanisms of action are largely u... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22426534",
"http://www.ncbi.nlm.nih.gov/pubmed/27611590"
] | [
{
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"s": "http://linkedlifedata.com/resource/umls/id/C1325592",
"o": "replisome"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#prefLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C1325592",
"o": "http://linkedlifedata.com/resource/... | [] |
58f3c8f470f9fc6f0f00000c | summary | What is the function of mTOR? | [
"The mTOR protein regulates assembly of the translation initiation machinery and are master regulators of cellular survival, growth and metabolism."
] | [] | [
"Protein synthesis regulation via mammalian target of rapamycin complex 1 (mTORC1) signaling pathway has key roles in neural development and function,",
"mTOR regulates assembly of the translation initiation machinery by interacting with the eukaryotic initiation factor eIF3 complex and by controlling phosphoryla... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21871173",
"http://www.ncbi.nlm.nih.gov/pubmed/12864941",
"http://www.ncbi.nlm.nih.gov/pubmed/27889578",
"http://www.ncbi.nlm.nih.gov/pubmed/25898924",
"http://www.ncbi.nlm.nih.gov/pubmed/25893295"
] | [] | [
"http://amigo.geneontology.org/amigo/term/GO:0065009"
] |
58f0b0c070f9fc6f0f000006 | factoid | What is the indication for valbenazine? | [
"Valbenazine granted breakthrough drug status for treating tardive dyskinesia."
] | [
"Valbenazine granted breakthrough drug status for treating tardive dyskinesia."
] | [
"VMAT2 inhibitors (e.g. deutetrabenazine and valbenazine) have been studied in the treatment of HD-related chorea, tardive dyskinesia and tics associated with Tourette syndrome.",
"Valbenazine granted breakthrough drug status for treating tardive dyskinesia.",
"The FDA lowered approval hurdles for valbenazine d... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25809133",
"http://www.ncbi.nlm.nih.gov/pubmed/27819145"
] | [] | [] |
5895b7157d9090f353000009 | list | List features of the Kaufman Oculocerebrofacial Syndrome. | [
"Clinical features of the Kaufman Oculocerebrofacial Syndrome include hypotonia, developmental delay, intellectual disability, low cholesterol levels, microcephaly, long narrow face, ocular anomalies, and long thin hands and feet."
] | [
"hypotonia",
"developmental delay",
"intellectual disability",
"low cholesterol levels",
"microcephaly",
"long narrow face",
"ocular anomalies",
"long thin hands and feet"
] | [
"A pair of sisters was ascertained for multiple congenital defects, including marked craniofacial dysmorphisms with blepharophimosis, and severe psychomotor delay. ",
"Genetic syndromes involving both brain and eye abnormalities are numerous and include syndromes such as Warburg micro syndrome, Kaufman oculocereb... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8275567",
"http://www.ncbi.nlm.nih.gov/pubmed/23687348",
"http://www.ncbi.nlm.nih.gov/pubmed/7573151",
"http://www.ncbi.nlm.nih.gov/pubmed/24615390",
"http://www.ncbi.nlm.nih.gov/pubmed/25691420",
"http://www.ncbi.nlm.nih.gov/pubmed/25792360"
] | [] | [] |
58853c56e56acf5176000018 | factoid | What is the role of DNA Repair Cofactors ATMIN and NBS1? | [
"The DNA double-strand break signaling kinase ATM and its cofactor NBS1 are required during T cell development and for the maintenance of genomic stability. The role of a second ATM cofactor, ATMIN (also known as ASCIZ) in T cells is much less clear, and whether ATMIN and NBS1 function in synergy in T cells is unkn... | [
"Suppresion of T Cell Activation."
] | [
"DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation.",
"Here, we investigate the roles of ATMIN and NBS1, either alone or in combination, using murine models. We show loss of NBS1 led to a developmental block at the double-positive stage of T cell development, as well as reduced TCRα r... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26544571"
] | [
{
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"s": "http://linkedlifedata.com/resource/umls/id/C0012899",
"o": "DNA repair"
},
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"s": "http://linkedlifedata.com/resource/umls/id/C0012899",
"o": "http://linkedlifedata.com/resource/... | [
"http://www.uniprot.org/uniprot/NBS1_SCHPO",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004260",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D045643",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&t... |
58f4b73b70f9fc6f0f000014 | list | The MMR vaccine protects against what 3 viruses? | [
"The MMR vaccine provides immunity to measles, mumps and rubella.",
" measles, mumps and rubella (mmr) vaccine ."
] | [
"Measles",
"Mumps",
"Rubella"
] | [
" measles, mumps and rubella (MMR) vaccine ",
"Measles, mumps, rubella (MMR) vaccine is a live vaccine preparation containing attenuated strains of all 3 viruses."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/7686463",
"http://www.ncbi.nlm.nih.gov/pubmed/26265115"
] | [
{
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"s": "http://linkedlifedata.com/resource/umls/id/C0065828",
"o": "http://linkedlifedata.com/resource/umls/label/A18558018"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A1855... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012411",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012412",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008458",
"https://www.nlm.nih.gov/cgi/me... |
5895bfdc7d9090f35300000c | list | List cardinal features of the Triple A syndrome. | [
"Triple A syndrome, also known as Allgrove syndrome, is a rare disease, and presents mainly in children. Its cardinal symptoms are achalasia, alacrima, and adrenal insufficiency."
] | [
"achalasia",
"alacrima",
"adrenal insufficiency"
] | [
"UNLABELLED: Triple A syndrome (alacrima, achalasia, adrenal failure, progressive neurodegenerative disease) is caused by mutations in the AAAS gene which encodes the protein alacrima achalasia adrenal insufficiency neurologic disorder (ALADIN).",
"Triple A syndrome, also known as Allgrove syndrome, is a rare dis... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26354489",
"http://www.ncbi.nlm.nih.gov/pubmed/27411173",
"http://www.ncbi.nlm.nih.gov/pubmed/27385299",
"http://www.ncbi.nlm.nih.gov/pubmed/16938764",
"http://www.ncbi.nlm.nih.gov/pubmed/20200814",
"http://www.ncbi.nlm.nih.gov/pubmed/12752575",
"http://www.ncbi.nlm.n... | [
{
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"s": "http://linkedlifedata.com/resource/umls/id/C0326926",
"o": "cardinal"
},
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"s": "http://linkedlifedata.com/resource/umls/id/C0326926",
"o": "http://linkedlifedata.com/resource/um... | [
"http://www.disease-ontology.org/api/metadata/DOID:0050602"
] |
5891c2e7621ea6ff7e00000f | summary | Describe the applicability of Basset in the context of deep learning | [
"Basset is an open source package which applies CNNs to learn the functional activity of DNA sequences from genomics data. Basset was trained on a compendium of accessible genomic sites mapped in 164 cell types by DNase-seq, and demonstrated greater predictive accuracy than previous methods. Basset predictions for ... | [] | [
"Basset: learning the regulatory code of the accessible genome with deep convolutional neural networks.",
"We introduce the open source package Basset to apply CNNs to learn the functional activity of DNA sequences from genomics data. We trained Basset on a compendium of accessible genomic sites mapped in 164 cel... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27197224"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000069553",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000069550"
] |
58db94948acda34529000017 | yesno | Does the Abelson-related gene (ARG) gene encode for a serine kinase? | [
"No, the ARG gene encodes for a nonreceptor tyrosine kinase."
] | [
"no"
] | [
"One isoform of Arg/Abl2 tyrosine kinase is nuclear and the other seven cytosolic isoforms differently modulate cell morphology, motility and the cytoskeleton.",
"The non-receptor tyrosine kinase Abelson related gene (Arg/Abl2) regulates cell migration and morphogenesis by modulating the cytoskeleton. ",
"The h... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18411439",
"http://www.ncbi.nlm.nih.gov/pubmed/25849507",
"http://www.ncbi.nlm.nih.gov/pubmed/15987940",
"http://www.ncbi.nlm.nih.gov/pubmed/12220663",
"http://www.ncbi.nlm.nih.gov/pubmed/1923513",
"http://www.ncbi.nlm.nih.gov/pubmed/23707396",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.uniprot.org/uniprot/ABL2_HUMAN",
"http://www.uniprot.org/uniprot/ABL2_MOUSE"
] |
58f4b9d470f9fc6f0f000016 | factoid | What organism causes tularemia? | [
"Francisella tularensis, the agent of tularemia, is a Gram-negative coccobacillus primarily pathogen for animals and occasionally for humans. F. tularensis is the causative agent of zoonotic tularemia. ",
"francisella tularensis, the agent of tularemia, is a gram-negative coccobacillus primarily pathogen for anim... | [
"Francisella tularensis"
] | [
"Francisella tularensis, the agent of tularemia, is a Gram-negative coccobacillus primarily pathogen for animals and occasionally for humans. ",
"F. tularensis is the causative agent of zoonotic tularemia",
"Tularemia is a zoonosis caused by Francisella tularensis that can be transmitted by several ways to huma... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23473220",
"http://www.ncbi.nlm.nih.gov/pubmed/21607086",
"http://www.ncbi.nlm.nih.gov/pubmed/26189939",
"http://www.ncbi.nlm.nih.gov/pubmed/18304778",
"http://www.ncbi.nlm.nih.gov/pubmed/21687806",
"http://www.ncbi.nlm.nih.gov/pubmed/25494920",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0041351",
"o": "Tularemia"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0041351",
"o": "http://linkedlifedata.com/resource/u... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=diseases_category",
"http://www.disease-ontology.org/api/metadata/DOID:14239",
"http://www.disease-ontology.org/api/metadata/DOID:13226",
"http://www.biosemantics.org/jochem#4244019",
"http://www.disease-ontology.org/api/meta... |
58ea659c3e8b6dc87c000013 | yesno | Is Prochlorococcus the most abundant photosynthetic organism? | [
"Yes, the marine cyanobacterium Prochlorococcus is the smallest and most abundant photosynthetic organism on Earth."
] | [
"yes"
] | [
"The marine cyanobacterium Prochlorococcus is the smallest and most abundant photosynthetic organism on Earth.",
"The marine cyanobacterium Prochlorococcus is the numerically dominant photosynthetic organism in the oligotrophic oceans, and a model system in marine microbial ecology.",
"The marine cyanobacterium... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25977791",
"http://www.ncbi.nlm.nih.gov/pubmed/19549842",
"http://www.ncbi.nlm.nih.gov/pubmed/11595938",
"http://www.ncbi.nlm.nih.gov/pubmed/25435307"
] | [] | [] |
5895dd6a7d9090f35300000f | list | List 3 features of IRVAN syndrome. | [
"Idiopathic retinal vasculitis, aneurysms, and neuroretinitis is coined as IRVAN syndrome."
] | [
"Idiopathic retinal vasculitis",
"Aneurysms",
"Neuroretinitis"
] | [
"Fluorescein photodiagnosis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome: A case report and long-term outcome of photocoagulation therapy.",
"Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is a disease characterized by multiple retinal macroaneury... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24221466",
"http://www.ncbi.nlm.nih.gov/pubmed/22454754",
"http://www.ncbi.nlm.nih.gov/pubmed/15348989",
"http://www.ncbi.nlm.nih.gov/pubmed/26922651",
"http://www.ncbi.nlm.nih.gov/pubmed/9121757",
"http://www.ncbi.nlm.nih.gov/pubmed/24766157",
"http://www.ncbi.nlm.ni... | [] | [] |
58dbb3f18acda34529000019 | list | Which are the Proprotein Convertase Subtilisin Kexin 9 (PCSK9) inhibitors that are FDA approved? | [
"The PCSK9 inhibitors that are FDA approved are:\n1) Alirocumab and \n2) Evolocumab."
] | [
"Alirocumab",
"Praluent",
"Evolocumab",
"Repatha"
] | [
"Inhibition of the PCSK9 protein by monoclonal antibodies results in a dramatic 40%-60% lowering of serum low-density lipoprotein cholesterol (LDL-C). ",
"Alirocumab and evolocumab have been approved by the FDA for the treatment of patients with heterozygous familial hypercholesterolemia and patients with clinica... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26548330",
"http://www.ncbi.nlm.nih.gov/pubmed/27086681",
"http://www.ncbi.nlm.nih.gov/pubmed/26785741",
"http://www.ncbi.nlm.nih.gov/pubmed/27533159",
"http://www.ncbi.nlm.nih.gov/pubmed/27661220",
"http://www.ncbi.nlm.nih.gov/pubmed/26345307",
"http://www.ncbi.nlm.n... | [
{
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"s": "http://linkedlifedata.com/resource/umls/id/C0243077",
"o": "inhibitors"
},
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"s": "http://linkedlifedata.com/resource/umls/id/C0243077",
"o": "http://linkedlifedata.com/resource... | [
"http://www.uniprot.org/uniprot/PCSK9_MACMU",
"http://www.uniprot.org/uniprot/PCSK9_PANTR",
"http://www.uniprot.org/uniprot/PCSK9_COLGU",
"http://www.uniprot.org/uniprot/PCSK9_CALJA",
"http://www.uniprot.org/uniprot/PCSK9_SAGLB",
"http://www.uniprot.org/uniprot/PCSK9_PONPY",
"http://www.uniprot.org/unip... |
58df5efbc784871774000001 | yesno | Is dupilumab an antibody targeting the IL-1 receptor? | [
"No, Dupilumab is a fully human monoclonal antibody directed against the IL-4 receptor α subunit that blocks the signaling of IL-4 and IL-13, both key cytokines in Th2-mediated pathways."
] | [
"no"
] | [
"Atopic dermatitis (AD) is characterized by type 2 helper T (Th2) cell-driven inflammation. Dupilumab is a fully human monoclonal antibody directed against the IL-4 receptor α subunit that blocks the signaling of IL-4 and IL-13, both key cytokines in Th2-mediated pathways.",
"Dupilumab, a humanized monoclonal ant... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26440137",
"http://www.ncbi.nlm.nih.gov/pubmed/27130691",
"http://www.ncbi.nlm.nih.gov/pubmed/27690741",
"http://www.ncbi.nlm.nih.gov/pubmed/26598956",
"http://www.ncbi.nlm.nih.gov/pubmed/23688323",
"http://www.ncbi.nlm.nih.gov/pubmed/27497276",
"http://www.ncbi.nlm.n... | [] | [] |
5895dfc97d9090f353000010 | list | List active ingredients of the Stribild polypill. | [
"Active ingredients of Stribild are elvitegravir, cobicistat, emtricitabine and tenofovir. It is used for treatment of HIV infection."
] | [
"elvitegravir",
"cobicistat",
"emtricitabine",
"tenofovir"
] | [
"PURPOSE: The purpose of this study is to assess postmarketing safety and tolerability of Stribild (elvitegravir [EVG]/cobicistat [COBI]/tenofovir disoproxil fumarate [TDF]/emtricitabine [FTC]).",
"INTRODUCTION: Co-formulated elvitegravir, cobicistat, emtricitabine and tenofovir (EVG/COBI/FTC/TDF or Stribild™) is... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24338165",
"http://www.ncbi.nlm.nih.gov/pubmed/25553805",
"http://www.ncbi.nlm.nih.gov/pubmed/27225853",
"http://www.ncbi.nlm.nih.gov/pubmed/26286337",
"http://www.ncbi.nlm.nih.gov/pubmed/23136357",
"http://www.ncbi.nlm.nih.gov/pubmed/26045359",
"http://www.ncbi.nlm.n... | [] | [] |
5895e4637d9090f353000012 | list | List clinical features of the IMAGe syndrome. | [
"Clinical features of IMAGe syndrome include intra-uterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita and genital abnormalities. It is s caused by gain-of-function mutations of maternally expressed gene CDKN1C on chromosome 11p15.5."
] | [
"intra-uterine growth restriction",
"metaphyseal dysplasia",
"adrenal hypoplasia congenita",
"genital abnormalities"
] | [
"Recently, our group described gain-of-function mutations in the PCNA-binding site of CDKN1C that result in an undergrowth syndrome called IMAGe Syndrome (Intrauterine Growth Restriction, Metaphyseal dysplasia, Adrenal hypoplasia, and Genital anomalies), with life-threatening consequences. ",
"IMAGe syndrome is a... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25517553",
"http://www.ncbi.nlm.nih.gov/pubmed/25861374",
"http://www.ncbi.nlm.nih.gov/pubmed/16835919",
"http://www.ncbi.nlm.nih.gov/pubmed/25258553",
"http://www.ncbi.nlm.nih.gov/pubmed/22634751",
"http://www.ncbi.nlm.nih.gov/pubmed/25541901",
"http://www.ncbi.nlm.n... | [
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58e7a1393e8b6dc87c00000b | list | Which gene mutations are predictive of response to anti-TNF therapy in Rheumatoid Arthritis patients? | [
"Μutations in TLR5 and TLR1 genes contribute to differential response to anti-TNF treatment in RA. Variation at FCGR2A and functionally related genes such as DHX32 and RGS12 is also associated with the response to anti-TNF therapy in rheumatoid arthritis."
] | [
"TLR5",
"TLR1",
"FCGR2A",
"DHX32",
"RGS12"
] | [
"Genetic Variations in Pattern Recognition Receptor Loci Are Associated with Anti-TNF Response in Patients with Rheumatoid Arthritis",
"Six of twenty successfully genotyped polymorphisms were nominally associated with EULAR treatment response. Three of these were in weak to moderate linkage disequilibrium with po... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26440629",
"http://www.ncbi.nlm.nih.gov/pubmed/22044414",
"http://www.ncbi.nlm.nih.gov/pubmed/25848939"
] | [] | [] |
5895f18ce370baff39000001 | factoid | Which method is used for prediction of novel microRNA genes in cancer-associated genomic regions? | [
"SSCprofiler is a computational tool utilizing a probabilistic method based on Profile Hidden Markov Models to predict novel miRNA precursors. Via the simultaneous integration of biological features such as sequence, structure and conservation, SSCprofiler achieves a performance accuracy of 88.95% sensitivity and 8... | [
"SSCprofiler"
] | [
" In this work we present a new computational tool (SSCprofiler) utilizing a probabilistic method based on Profile Hidden Markov Models to predict novel miRNA precursors. Via the simultaneous integration of biological features such as sequence, structure and conservation, SSCprofiler achieves a performance accuracy... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19324892"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D035683"
] |
58dcbb8c8acda34529000021 | yesno | Does the histone chaperone ASF1 interact with histones H1/H2? | [
"No, the histone chaperone ASF1 interacts with histones H3/H4."
] | [
"no"
] | [
"The C terminus of the histone chaperone Asf1 cross-links to histone H3 in yeast and promotes interaction with histones H3 and H4.",
"The central histone H3/H4 chaperone Asf1 comprises a highly conserved globular core and a divergent C-terminal tail. ",
"The histone H3-H4 chaperone Asf1 is involved in chromatin... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22291963",
"http://www.ncbi.nlm.nih.gov/pubmed/21329878",
"http://www.ncbi.nlm.nih.gov/pubmed/18096807",
"http://www.ncbi.nlm.nih.gov/pubmed/17690098",
"http://www.ncbi.nlm.nih.gov/pubmed/19172748",
"http://www.ncbi.nlm.nih.gov/pubmed/16229457",
"http://www.ncbi.nlm.n... | [
{
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"http://www.uniprot.org/uniprot/ASF1_CANGA",
"http://www.uniprot.org/uniprot/ASF1_CRYNJ",
"http://www.uniprot.org/uniprot/ASF1_ASPFU",
"http://www.uniprot.org/uniprot/ASF1_ENCCU",
"http://www.uniprot.org/uniprot/ASF1_DEBHA",
"http://www.uniprot.org/uniprot/ASF1_ASHGO",
"https://www.nlm.nih.gov/cgi/mesh/... |
58f3cd1470f9fc6f0f00000e | yesno | Is Hepatic mesenchymal hamartoma usually a malignant tumor? | [
"Mesenchymal hamartoma of the liver (MHL) is an uncommon benign hepatic tumor typically affecting children under 2 years of age.",
"Mesenchymal hamartoma of the liver (MHL) is a benign and rare hepatic lesion, ",
"mesenchymal hamartoma of the liver (mhl) is an uncommon benign hepatic tumor typically affecting c... | [
"no"
] | [
"Mesenchymal hamartoma of the liver (MHL) is a benign and rare hepatic lesion, ",
"Mesenchymal hamartoma of the liver (MHL) is an uncommon benign hepatic tumor typically affecting children under 2 years of age",
"This review on the pathology of hepatic tumors in childhood, from a personal series of 245 tumors, ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23164031",
"http://www.ncbi.nlm.nih.gov/pubmed/16833000",
"http://www.ncbi.nlm.nih.gov/pubmed/19365132",
"http://www.ncbi.nlm.nih.gov/pubmed/18022426",
"http://www.ncbi.nlm.nih.gov/pubmed/23351454",
"http://www.ncbi.nlm.nih.gov/pubmed/17493912",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006223",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006222",
"http://www.disease-ontology.org/api/metadata/DOID:3467",
"http://www.disease-ontology.org/api/metadata/DOID:6108",
"http:... |
5895e9977d9090f353000013 | list | List clinical features of EEM syndrome. | [
"EEM syndrome is characterized by ectodermal dysplasia, ectrodactyly and macular dystrophy."
] | [
"ectodermal dysplasia",
"ectrodactyly",
"macular dystrophy"
] | [
"Hypotrichosis with juvenile macular dystrophy (HJMD) and ectodermal dysplasia, ectrodactyly and macular dystrophy (EEM) are both caused by mutations in the CDH3 gene. ",
"Loss-of-function mutations in CDH3, which encodes P-cadherin, result in two allelic autosomal recessive disorders: hypotrichosis with juvenile... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25707507",
"http://www.ncbi.nlm.nih.gov/pubmed/10420194",
"http://www.ncbi.nlm.nih.gov/pubmed/11424132",
"http://www.ncbi.nlm.nih.gov/pubmed/22140374",
"http://www.ncbi.nlm.nih.gov/pubmed/15805154",
"http://www.ncbi.nlm.nih.gov/pubmed/2628819",
"http://www.ncbi.nlm.ni... | [
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... | [] |
58f6295a70f9fc6f0f000019 | factoid | How many times is CLAST faster than BLAST? | [
"was capable of identifying sequence similarities ~80.8 times faster than blast and 9.6 times faster than blat . ",
"CLAST was capable of identifying sequence similarities ~80.8 times faster than BLAST and 9.6 times faster than BLAT",
"clast was capable of identifying sequence similarities ~80.8 times faster th... | [
"80.8 times",
"80.8"
] | [
"CLAST was capable of identifying sequence similarities ~80.8 times faster than BLAST and 9.6 times faster than BLAT",
"First, CLAST was capable of identifying sequence similarities ~80.8 times faster than BLAST and 9.6 times faster than BLAT.",
"First, CLAST was capable of identifying sequence similarities ~80... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25495907"
] | [] | [] |
58e640573e8b6dc87c000003 | list | Which are the most common methods for circular RNA detection from RNASeq? | [
"The main algorithms are circRNA_finder, find_circ, CIRCexplorer, CIRI, and MapSplice.",
"Here, we use common RNAseq datasets to scrutinize and compare the output from five different algorithms; circRNA_finder, find_circ, CIRCexplorer, CIRI, and MapSplice and evaluate the levels of bona fide and false positive ci... | [
"circRNA_finder",
"find_circ",
"CIRCexplorer",
"CIRI",
"MapSplice"
] | [
"Here, we use common RNAseq datasets to scrutinize and compare the output from five different algorithms; circRNA_finder, find_circ, CIRCexplorer, CIRI, and MapSplice and evaluate the levels of bona fide and false positive circRNAs based on RNase R resistance."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/26657634",
"http://www.ncbi.nlm.nih.gov/pubmed/27167008"
] | [] | [] |
58ee0dd5eda5a57672000013 | factoid | From which cell type is leptin secreted? | [
"leptin is mainly produced and secreted by adipocytes, but other tissues and gastric glands have also recently been shown to produce it in a dual (endocrine and exocrine) mode.",
" Although leptin is produced mainly by white adipose tissue, several laboratories have shown low levels of leptin production by a grow... | [
"adipocytes"
] | [
" Although leptin is produced mainly by white adipose tissue, several laboratories have shown low levels of leptin production by a growing number of tissues including the anterior pituitary gland.",
"Lipolysis (stimulated by beta-adrenergic agents) and leptin secretion by adipocytes are down-regulated by neurons ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12242022",
"http://www.ncbi.nlm.nih.gov/pubmed/11606782",
"http://www.ncbi.nlm.nih.gov/pubmed/23376443",
"http://www.ncbi.nlm.nih.gov/pubmed/22692856",
"http://www.ncbi.nlm.nih.gov/pubmed/10443698",
"http://www.ncbi.nlm.nih.gov/pubmed/12448771",
"http://www.ncbi.nlm.n... | [] | [] |
589635dd78275d0c4a000009 | factoid | Which tool is used for the identification of recurrent variants in noncoding regions? | [
"LARVA is an integrative framework for large-scale analysis of recurrent variants in noncoding annotations. It integrates variants with a comprehensive set of noncoding functional elements, modeling the mutation counts of the elements with a β-binomial distribution to handle overdispersion. LARVA, moreover, uses re... | [
"LARVA"
] | [
"LARVA: an integrative framework for large-scale analysis of recurrent variants in noncoding annotations.",
"In cancer research, background models for mutation rates have been extensively calibrated in coding regions, leading to the identification of many driver genes, recurrently mutated more than expected. Nonc... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26304545"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000071184",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012045"
] |
58f3c62970f9fc6f0f00000b | factoid | What body parts are also known as phalanges? | [
"The anatomical structure of each finger is comprised of four phalanges (distal, middle, proximal, and metacarpal phalange). Toes are also known as phalages"
] | [
"bones of the digits, fingers or toes"
] | [
"Metacarpal and phalangeal fractures of the long fingers a",
" The anatomical structure of each finger is comprised of four phalanges (distal, middle, proximal, and metacarpal phalange).",
"arious features of the toes, humps in the toe line, phalange marks, flatfoot condition, pits, cracks, corns, etc., were st... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19700363",
"http://www.ncbi.nlm.nih.gov/pubmed/22250842",
"http://www.ncbi.nlm.nih.gov/pubmed/2187446",
"http://www.ncbi.nlm.nih.gov/pubmed/24486016",
"http://www.ncbi.nlm.nih.gov/pubmed/16965880"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D050278",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D050277"
] |
58f0b40d70f9fc6f0f000008 | yesno | Are selenium supplements recommended for prostate cancer prevention? | [
"No. The SELECT study failed to show any significant risk reduction for prostate cancers ascribable to selenium and vitamin E supplementations."
] | [
"no"
] | [
"Our meta-analysis in prospective studies demonstrated a significant inverse association between selenium status and CVD risk within a narrow selenium range and a null effect of selenium supplementation on CVD was observed in RCTs. These findings indicate the importance of considering selenium status, dose and safe... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26957512",
"http://www.ncbi.nlm.nih.gov/pubmed/25990689",
"http://www.ncbi.nlm.nih.gov/pubmed/25854337",
"http://www.ncbi.nlm.nih.gov/pubmed/25505227"
] | [] | [] |
5896271178275d0c4a000004 | factoid | Which disease is treated with lucinactant? | [
"Lucinactant us used for the prevention of respiratory distress syndrome in premature infants."
] | [
"respiratory distress syndrome"
] | [
"Lucinactant for the prevention of respiratory distress syndrome in premature infants.",
"Lucinactant is a synthetic surfactant containing sinapultide, a bioengineered peptide mimic of surfactant-associated protein B. A meta-analysis of clinical trials demonstrates that lucinactant is as effective as animal-deriv... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15813666",
"http://www.ncbi.nlm.nih.gov/pubmed/18822258",
"http://www.ncbi.nlm.nih.gov/pubmed/22791092",
"http://www.ncbi.nlm.nih.gov/pubmed/16896079",
"http://www.ncbi.nlm.nih.gov/pubmed/23473590",
"http://www.ncbi.nlm.nih.gov/pubmed/16452346",
"http://www.ncbi.nlm.n... | [
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"http://www.disease-ontology.org/api/metadata/DOID:4"
] |
58adca6d9ef3c34033000007 | list | Which proteins control the degradation of cryptic unstable transcripts (CUTs) in yeast? | [
"Termination of cryptic unstable transcripts is directed by yeast RNA-binding proteins Nrd1 and Nab3. These cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome. Key substrates for exosomal degradation include aberrant functional RNAs and cryptic unstable transcripts (CUTs). Yeast RNA bin... | [
"Rrp6",
"Nrd1",
"Nab3",
"TRAMP complex",
"Trf4/5-Air1/2-Mtr4 polyadenylation",
"Sen1"
] | [
"Termination of cryptic unstable transcripts is directed by yeast RNA-binding proteins Nrd1 and Nab3",
"These cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome. Yeast RNA binding proteins Nrd1 and Nab3 direct termination of sn/snoRNAs and recently have also been implicated in prematu... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25210768",
"http://www.ncbi.nlm.nih.gov/pubmed/19169244",
"http://www.ncbi.nlm.nih.gov/pubmed/25680078",
"http://www.ncbi.nlm.nih.gov/pubmed/16973436",
"http://www.ncbi.nlm.nih.gov/pubmed/21878619"
] | [] | [] |
58965a4178275d0c4a00000e | yesno | Is there any involvement of L1 retrotransposition in the Rett syndrome? | [
"Yes. Recent studies indicate that long interspersed nuclear element-1 (L1) are mobilized in the genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia telangiectasia."
] | [
"yes"
] | [
"Using neuronal progenitor cells derived from human induced pluripotent stem cells and human tissues, we revealed that patients with Rett syndrome (RTT), carrying MeCP2 mutations, have increased susceptibility for L1 retrotransposition. Our data demonstrate that L1 retrotransposition can be controlled in a tissue-s... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23057747",
"http://www.ncbi.nlm.nih.gov/pubmed/24389010",
"http://www.ncbi.nlm.nih.gov/pubmed/22159035",
"http://www.ncbi.nlm.nih.gov/pubmed/21085180"
] | [
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"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020084",
"http://www.disease-ontology.org/api/metadata/DOID:1206"
] |
58f3d85170f9fc6f0f00000f | yesno | Is Downs syndrome associated with decreased risk of leukemia? | [
"No, multiple studies have established the incidence of leukemia in Down's syndrome patients to be 10- to 20-fold higher than that in the general population."
] | [
"no"
] | [
"The association of Down's syndrome and leukemia has been documented for over 50 years. Multiple studies have established the incidence of leukemia in Down's syndrome patients to be 10- to 20-fold higher than that in the general population.",
"We present a case of congenital acute myeloid leukemia manifesting fro... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19332933",
"http://www.ncbi.nlm.nih.gov/pubmed/25332567",
"http://www.ncbi.nlm.nih.gov/pubmed/16321814",
"http://www.ncbi.nlm.nih.gov/pubmed/2955886"
] | [] | [] |
589630f378275d0c4a000007 | factoid | Which enzyme is inhibited by ixazomib? | [
"Ixazomib is proteasome inhibitor. It is used for treatment of multiple myeloma."
] | [
"proteasome"
] | [
"Over the past decade, MM therapy is significantly improved by the introduction of novel therapeutics such as immunomodulatory agents (thalidomide, lenalidomide, and pomalidomide), proteasome inhibitors (bortezomib, carfilzomib, and ixazomib), monoclonal antibodies (daratumumab and elotuzumab), histone deacetylase ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27119237",
"http://www.ncbi.nlm.nih.gov/pubmed/26667773",
"http://www.ncbi.nlm.nih.gov/pubmed/27121262",
"http://www.ncbi.nlm.nih.gov/pubmed/26846321",
"http://www.ncbi.nlm.nih.gov/pubmed/25377318",
"http://www.ncbi.nlm.nih.gov/pubmed/26988986",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004791"
] |
58db9aa28acda34529000018 | yesno | Does PCSK9 (Proprotein convertase subtilisin/kexin type 9) binds with HDL-receptor (HDL-R)? | [
"No, Proprotein Convertase Subtilisin Kexin 9 (PCSK9) binds with LDL-receptor (LDL-R) causing its degradation in the lysosome with the result of LDL-C accumulating in the blood."
] | [
"no"
] | [
"Recently it was revealed that the secreted Proprotein Convertase Subtilisin Kexin 9 (PCSK9) binds with LDL-receptor (LDL-R) causing its degradation in the lysosome with the result of LDL-C accumulating in the blood.",
"The major goal of this study is to identify peptide/s from the catalytic domain of hPCSK9 that... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27284008",
"http://www.ncbi.nlm.nih.gov/pubmed/26040332",
"http://www.ncbi.nlm.nih.gov/pubmed/20529551",
"http://www.ncbi.nlm.nih.gov/pubmed/23675525",
"http://www.ncbi.nlm.nih.gov/pubmed/26318398",
"http://www.ncbi.nlm.nih.gov/pubmed/23400816",
"http://www.ncbi.nlm.n... | [
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"http://www.uniprot.org/uniprot/PCSK9_PANTR",
"http://www.uniprot.org/uniprot/PCSK9_COLGU",
"http://www.uniprot.org/uniprot/PCSK9_CALJA",
"http://www.uniprot.org/uniprot/PCSK9_LAGLA",
"http://www.uniprot.org/unip... |
58f4b25e70f9fc6f0f000011 | factoid | Hy's law measures failure for what organ? | [
"Hy's law correlates enzyme elevations with liver injury ad subsequent failure."
] | [
"liver"
] | [
" Hy's Law of drug-induced hepatocellular jaundice causing a case-fatality rate or need for transplant of 10% or higher has been validated in several large national registries, including the ongoing, prospective U.S. Drug-Induced Liver Injury Network. ",
"Enzyme elevations alone may not be harmful, but if caused ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24203912",
"http://www.ncbi.nlm.nih.gov/pubmed/26116527",
"http://www.ncbi.nlm.nih.gov/pubmed/23874514",
"http://www.ncbi.nlm.nih.gov/pubmed/22928730",
"http://www.ncbi.nlm.nih.gov/pubmed/24704526",
"http://www.ncbi.nlm.nih.gov/pubmed/26159259",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D065290",
"http://www.disease-ontology.org/api/metadata/DOID:2044",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D056486",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find... |
5896e22078275d0c4a000014 | yesno | Is apremilast effective for psoriatic arthritis? | [
"Yes, apremilast, an oral phosphodiesterase 4 inhibitor, is effective for psoriatic arthritis."
] | [
"yes"
] | [
"Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement: a phase III, randomised, controlled trial (PALACE 3).",
"OBJECTIVE: To evaluate apremilast treatment in patients with active psoriatic arthritis, including current skin involvement, despite prior... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26220911",
"http://www.ncbi.nlm.nih.gov/pubmed/25633241",
"http://www.ncbi.nlm.nih.gov/pubmed/27272887",
"http://www.ncbi.nlm.nih.gov/pubmed/26644232",
"http://www.ncbi.nlm.nih.gov/pubmed/27022911",
"http://www.ncbi.nlm.nih.gov/pubmed/26806620",
"http://www.ncbi.nlm.n... | [
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"http://www.disease-ontology.org/api/metadata/DOID:9008"
] |
58965ed478275d0c4a000010 | yesno | Is there any role of TBR1 in autism? | [
"Yes. Exome sequencing studies have identified multiple genes harboring de novo loss-of-function (LoF) variants in individuals with autism spectrum disorders (ASD), including T-Brain-1 (TBR1), a master regulator of cortical development. T-brain-1 (TBR1) is a brain-specific T-box transcription factor. In 1995, Tbr1 ... | [
"yes"
] | [
"TBR1 regulates autism risk genes in the developing neocortex",
"Exome sequencing studies have identified multiple genes harboring de novo loss-of-function (LoF) variants in individuals with autism spectrum disorders (ASD), including TBR1, a master regulator of cortical development. We performed ChIP-seq for TBR1... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24441682",
"http://www.ncbi.nlm.nih.gov/pubmed/26578866",
"http://www.ncbi.nlm.nih.gov/pubmed/27325115",
"http://www.ncbi.nlm.nih.gov/pubmed/25600067",
"http://www.ncbi.nlm.nih.gov/pubmed/25309323",
"http://www.ncbi.nlm.nih.gov/pubmed/23431145",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0004352",
"o": "http://linkedlifedata.com/resource/umls/label/A18645844"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A1864... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000067877",
"http://www.uniprot.org/uniprot/TBR1_MOUSE",
"http://www.disease-ontology.org/api/metadata/DOID:12849",
"http://www.disease-ontology.org/api/metadata/DOID:0060042",
"http://www.disease-ontology.org/api/metadata/D... |
58dcd0338acda34529000022 | summary | What is the role of the MCM2-7 complex? | [
"The MCM2-7 complex is a ring-shaped heterohexamer helicase, that unwinds the DNA double helix ahead of the other replication machinery. During pre-replication complex (pre-RC) formation, origin recognition complex (ORC), Cdc6, and Cdt1 cooperatively load a double-hexameric MCM2-7 complex onto DNA. Loading of MCM2-... | [] | [
"The role of the MCM2-7 helicase complex during Arabidopsis seed development.",
"The MINICHROMOSOME MAINTENANCE 2-7 (MCM2-7) complex, a ring-shaped heterohexamer, unwinds the DNA double helix ahead of the other replication machinery. ",
"MCM7 is one of the subunits of the MCM2-7 complex that plays a critical ro... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19805216",
"http://www.ncbi.nlm.nih.gov/pubmed/23817338",
"http://www.ncbi.nlm.nih.gov/pubmed/22045335",
"http://www.ncbi.nlm.nih.gov/pubmed/24234446",
"http://www.ncbi.nlm.nih.gov/pubmed/23376927",
"http://www.ncbi.nlm.nih.gov/pubmed/17314092",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/MCM2_YEAST",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D064111",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D064110",
"http://www.uniprot.org/uniprot/MCM2_HUMAN",
"https://www.nlm.nih.gov/cgi/mes... |
58eb6061eda5a57672000005 | list | In which fields of DNA sequencing are Bloom filters applied? | [
"A novel algorithm, fast and accurate classification of sequences (FACSs), is introduced that can accurately and rapidly classify sequences as belonging or not belonging to a reference sequence. Classification of DNA sequences using Bloom filters Lighter is a fast, memory-efficient tool for correcting sequencing e... | [
"storage",
"compression",
"alignment-free comparisons"
] | [
"A novel algorithm, fast and accurate classification of sequences (FACSs), is introduced that can accurately and rapidly classify sequences as belonging or not belonging to a reference sequence. ",
"Classification of DNA sequences using Bloom filters",
"Lighter is a fast, memory-efficient tool for correcting se... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26539459",
"http://www.ncbi.nlm.nih.gov/pubmed/27412092",
"http://www.ncbi.nlm.nih.gov/pubmed/25252952",
"http://www.ncbi.nlm.nih.gov/pubmed/24565280",
"http://www.ncbi.nlm.nih.gov/pubmed/27828710",
"http://www.ncbi.nlm.nih.gov/pubmed/20472541",
"http://www.ncbi.nlm.n... | [] | [] |
589a246c78275d0c4a000032 | list | Which 2 medications are included in the Qsymia pill? | [
"Qsymia pill includes phentermine and topiramate. It is used for treatment of obesity."
] | [
"phentermine",
"topiramate"
] | [
"OBJECTIVE: To quantify the incremental cost-effectiveness of Qsymia (phentermine and topiramate extended-release) for health-related quality of life improvements.",
"The intervention was diet and lifestyle advice plus the recommended dose of Qsymia (phentermine 7.5 mg plus topiramate 46.0 mg) vs. control, which ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23590816",
"http://www.ncbi.nlm.nih.gov/pubmed/23531960",
"http://www.ncbi.nlm.nih.gov/pubmed/24222976",
"http://www.ncbi.nlm.nih.gov/pubmed/23565717",
"http://www.ncbi.nlm.nih.gov/pubmed/25826792",
"http://www.ncbi.nlm.nih.gov/pubmed/25661549",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0013227",
"o": "http://linkedlifedata.com/resource/umls/label/A18591068"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A1859... | [] |
589a246f78275d0c4a000034 | yesno | Is sonidegib effective for basal cell carcinoma? | [
"Yes. Sonidegib, an oral smoothened antagonist, is indicated for the treatment of adults with locally advanced basal cell carcinoma (laBCC) who are not candidates for surgery or radiation therapy, or adults with recurrent laBCC following surgery or radiation therapy."
] | [
"yes"
] | [
"This review of the literature aims to describe previous and current treatment options for oral therapy in locally advanced and metastatic NMSC otherwise unamenable to standard treatment. Oral Smoothened (Smo) inhibitors Vismodegib, Sonidegib, and Taladegib have shown to be effective in several trials. ",
"Sonide... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26867946",
"http://www.ncbi.nlm.nih.gov/pubmed/27189494",
"http://www.ncbi.nlm.nih.gov/pubmed/27636236",
"http://www.ncbi.nlm.nih.gov/pubmed/26566923",
"http://www.ncbi.nlm.nih.gov/pubmed/26780190",
"http://www.ncbi.nlm.nih.gov/pubmed/26546616",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0007117",
"o": "http://linkedlifedata.com/resource/umls/label/A18627521"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A1862... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002280",
"http://www.disease-ontology.org/api/metadata/DOID:2513"
] |
587e2300fc7e8dd84f000004 | factoid | Which R package could be used for the identification of pediatric brain tumors? | [
"MethPed",
"The MethPed R package efficiently classifies pediatric brain tumors using the developed MethPed classifier. MethPed is available via Bioconductor: http://bioconductor.org/packages/MethPed/",
"The MethPed classifier, which is a multiclass random forest algorithm, based on DNA methylation profiles fro... | [
"MethPed"
] | [
"MethPed: an R package for the identification of pediatric brain tumor subtypes",
"We have therefore developed the MethPed classifier, which is a multiclass random forest algorithm, based on DNA methylation profiles from many subgroups of pediatric brain tumors",
"The MethPed R package efficiently classifies pe... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27370569"
] | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0220603",
"o": "childhood brain tumor"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#prefLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0220603",
"o": "http://linkedlifedata.c... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010372"
] |
5880b036c872c95565000002 | summary | Describe the usefulness of CAMUR in The Cancer Genome Atlas (TCGA) | [
"CAMUR is a new method that extracts multiple and equivalent classification models. CAMUR iteratively computes a rule-based classification model, calculates the power set of the genes present in the rules, iteratively eliminates those combinations from the data set, and performs again the classification procedure u... | [] | [
"CAMUR: Knowledge extraction from RNA-seq cancer data through equivalent classification rules",
"CAMUR, a new method that extracts multiple and equivalent classification models. CAMUR iteratively computes a rule-based classification model, calculates the power set of the genes present in the rules, iteratively el... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26519501"
] | [] | [] |
58da2a348acda34529000014 | list | Which markers are screened with the triple test for the detection of syndromes in fetus? | [
"The markers that are screened with the triple test for the detection of syndromes in fetus are:\n1) alpha-fetoprotein (AFP), \n2) beta-chorionic gonadotrophin (beta-CG) and \n3) unconjugated oestriol (uE3)."
] | [
"alpha-fetoprotein",
"AFP",
"α-fetoprotein",
"beta-chorionic gonadotrophin",
"beta-CG",
"unconjugated oestriol",
"uE3"
] | [
"Our study aimed at calculation and validation of the triple marker medians used in screening Egyptian females as well as to recommend programme conventions to unify screening in this country.",
"Chorionic gonadotropin (CG), α-fetoprotein (AFP) and unconjugated oestriol (uE3) were measured on Siemens Immulite ana... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21699408",
"http://www.ncbi.nlm.nih.gov/pubmed/10585342",
"http://www.ncbi.nlm.nih.gov/pubmed/8624312",
"http://www.ncbi.nlm.nih.gov/pubmed/7544745",
"http://www.ncbi.nlm.nih.gov/pubmed/18839465",
"http://www.ncbi.nlm.nih.gov/pubmed/15512289",
"http://www.ncbi.nlm.nih... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0015965",
"o": "Fetus"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0015965",
"o": "http://linkedlifedata.com/resource/umls/... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013577",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005333",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D062145",
"https://www.nlm.nih.gov/cgi/me... |
58dcb47c8acda34529000020 | factoid | What is the role of TAD protein domain? | [
"TAD domain is a transcription activation domain found in transcription factors."
] | [
"transcription activation domain",
"transactivation domain",
"trans-activating domain"
] | [
" Thus, nuclear ERK5 activates transcription factors by either direct phosphorylation or acting as co-activator thanks to a unique transcriptional activation TAD domain located at its C-terminal tail. ",
"Although lacking kinase activity, these forms activate transcription by interacting with transcription factor... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26537679",
"http://www.ncbi.nlm.nih.gov/pubmed/17404593",
"http://www.ncbi.nlm.nih.gov/pubmed/17332356",
"http://www.ncbi.nlm.nih.gov/pubmed/27196604",
"http://www.ncbi.nlm.nih.gov/pubmed/9826771",
"http://www.ncbi.nlm.nih.gov/pubmed/27713878",
"http://www.ncbi.nlm.ni... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0280090",
"o": "TAD"
}
] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012380"
] |
58f4c09f70f9fc6f0f000017 | summary | What is the function of lncRNA? | [
"Long noncoding RNAs (lncRNAs) are involved in a variety of biological processes, including the epigenetic control of gene expression, post-transcriptional regulation of mRNA, and cellular proliferation and differentiation"
] | [] | [
"long noncoding RNAs (lncRNAs) have mainly been studied using cultured cell lines, and this approach has revealed the involvement of lncRNAs in a variety of biological processes, including the epigenetic control of gene expression, post-transcriptional regulation of mRNA, and cellular proliferation and differentiat... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27582466",
"http://www.ncbi.nlm.nih.gov/pubmed/26117798",
"http://www.ncbi.nlm.nih.gov/pubmed/24757148",
"http://www.ncbi.nlm.nih.gov/pubmed/25994219",
"http://www.ncbi.nlm.nih.gov/pubmed/26362525",
"http://www.ncbi.nlm.nih.gov/pubmed/25855606",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D062085",
"http://amigo.geneontology.org/amigo/term/GO:0065009"
] |
58f4b3ee70f9fc6f0f000013 | summary | What is the function of the exosome? | [
"Exosomes are 40-100-nm vesicles released by most cell types after fusion of multivesicular endosomes with the plasma membrane. Exosomes contain proteins and RNA species and can mediate communication and immune responses."
] | [] | [
"Exosomes-secreted microRNAs play an important role in metastatic spread",
"Exosome-mediated communication",
"Cells are able to produce and release different types of vesicles, such as microvesicles and exosomes, in the extracellular microenvironment. According to the scientific community, both microvesicles an... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27583248",
"http://www.ncbi.nlm.nih.gov/pubmed/26794715",
"http://www.ncbi.nlm.nih.gov/pubmed/23719940",
"http://www.ncbi.nlm.nih.gov/pubmed/16939780",
"http://www.ncbi.nlm.nih.gov/pubmed/14727085",
"http://www.ncbi.nlm.nih.gov/pubmed/23143101",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/amigo/term/GO:0070062",
"http://amigo.geneontology.org/amigo/term/GO:0000178",
"http://amigo.geneontology.org/amigo/term/GO:0071971",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D063326",
"http://amigo.geneontology.org/amigo/term/GO:19905... |
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