The act of drinking quenches the sensation of thirst, even before enough water is absorbed from the gastrointestinal tract to correct the plasma osmolality. It is worth noting that the thirst sensation is reduced more effectively by cold water. This response involves the oropharyngeal and upper gastrointestinal receptors. However, this relief is short-lived, and thirst is fully satisfied only when the plasma osmolality or blood volume or pressure is corrected.

The AVP and thirst systems work together to maintain water balance. When plasma osmolality increases, it triggers drinking and, through AVP action on the kidneys, water conservation. On the other hand, when plasma osmolality decreases, thirst is suppressed and, in the absence of AVP, renal water excretion is increased. However, fluid intake is mainly influenced by cultural factors and social situations, especially when thirst is not stimulated. In such cases, the kidneys alone are responsible for maintaining normal body fluid osmolality by excreting water. The detailed mechanisms employed by the kidneys for this purpose are discussed in the subsequent sections of this chapter.

The renal mechanisms for the dilution and concentration of urine operate independently from solute excretion. In order to accomplish this, the kidneys must be capable of excreting urine that is either hypoosmotic or hyperosmotic in relation to body fluids. This ability requires the separation of solute from water at some point along the nephron. As previously mentioned, solute reabsorption in the proximal tubule results in the proportional reabsorption of water. Consequently, solute and water are not separated in this segment of the nephron, regardless of whether the kidneys excrete dilute or concentrated urine. The loop of Henle, particularly the thick ascending limb, is the primary site of solute and water separation. Hence, the normal functioning of the loop of Henle is necessary for the excretion of both dilute and concentrated urine.

The excretion of hypoosmotic urine is relatively straightforward. The nephron simply needs to reabsorb solute from the tubular fluid without allowing water reabsorption to occur. As mentioned earlier, this occurs in the ascending limb of Henle's loop. Under appropriate conditions (i.e., in the absence of AVP), the distal tubule and collecting duct also dilute the tubular fluid by reabsorbing solute without water.

The excretion of hyperosmotic urine is more complex and therefore more difficult to comprehend. In essence, this process prevents the development of hyperosmolality when there is adequate access to water. This mechanism is responsible for the excessive thirst (polydipsia) observed in both central and nephrogenic diabetes insipidus, which is a result of the polyuria. In most cases, individuals consume water or other beverages even when not experiencing thirst. Normally, the kidneys can excrete this excess water as they have the capacity to eliminate up to 18 L/day of urine. However, in certain situations, the volume of water ingested surpasses the kidneys' ability to excrete water, especially within short periods of time. As a consequence, body fluids become hypoosmotic.

An example of water intake exceeding the kidneys' excretion capacity is observed in long-distance running. A study of participants in the Boston Marathon revealed that 13% of the runners developed hyponatremia during the race.
The sensation of thirst is satisfied by the act of drinking, even before sufficient water is absorbed from the gastrointestinal tract to correct the plasma osmolality. It is interesting to note that cold water is more effective in reducing the thirst sensation. Oropharyngeal and upper gastrointestinal receptors appear to be involved in this response. However, relief of the thirst sensation via these receptors is short lived, and thirst is only completely satisfied when the plasma osmolality or blood volume or pressure is corrected.
It should be apparent that the AVP and thirst systems work in concert to maintain water balance. An increase in plasma osmolality evokes drinking and, via AVP action on the kidneys, conservation of water. Conversely, when plasma osmolality is decreased, thirst is suppressed and, in the absence of AVP, renal water excretion is enhanced. However, most of the time fluid intake is dictated by cultural factors and social situations. This is especially the case when thirst is not stimulated. In this situation, maintaining normal body fluid osmolality relies solely on the ability of the kidneys to excrete water. How the kidney accomplishes this is discussed in detail in the following sections of this chapter.
Renal Mechanisms for Dilution and Concentration of Urine
As already noted, water excretion is regulated separately from solute excretion. For this to occur the kidneys must be able to excrete urine that is either hypoosmotic or hyper-osmotic with respect to body fluids. This ability to excrete urine of varying osmolality in turn requires that solute be separated from water at some point along the nephron. As discussed in , reabsorption of solute in the proximal tubule results in reabsorption of a proportional amount of water. Hence solute and water are not separated in this portion of the nephron. Moreover, this proportionality between proximal tubule water and solute reabsorption occurs regardless of whether the kidneys excrete dilute or concentrated urine. Thus the proximal tubule reabsorbs a large portion of the filtered amount of solute and water, but it does not produce dilute or concentrated tubular fluid. The loop of Henle, in particular the thick ascending limb, is the major site where solute and water are separated. Thus excretion of both dilute and concentrated urine requires normal function of the loop of Henle.
Excretion of hypoosmotic urine is relatively easy to understand. The nephron must simply reabsorb solute from the tubular fluid and not allow water reabsorption to also occur. As just noted, and as described in greater detail later, reabsorption of solute without concomitant water reabsorption occurs in the ascending limb of Henle’s loop. Under appropriate conditions (i.e., in the absence of AVP) the distal tubule and collecting duct also dilute the tubular fluid by reabsorbing solute but not water.
Excretion of hyperosmotic urine is more complex and thus more difficult to understand. This process in essence
With adequate access to water, the thirst mechanism can prevent development of hyperosmolality. This mechanism is responsible for the polydipsia seen in response to the polyuria of both central and nephrogenic diabetes insipidus. Most individuals ingest water/beverages even in the absence of the thirst sensation. Normally the kidneys are able to excrete this excess water because they can excrete up to 18 L/day of urine. However, in some instances, the volume of water ingested exceeds the kidneys’ capacity to excrete water, especially over short periods of time. When this occurs, body fluids become hypoosmotic.
An example of how water intake can exceed the capacity of the kidneys to excrete water is long-distance running. A study of participants in the Boston Marathon found that 13% of the runners developed hyponatremia during the course of the race.