Valproate

Valproate (VPA) is a drug. It has different forms, such as valproic acid, sodium valproate and valproate semisodium. It is mostly used to treat epilepsy and bipolar disorder. It is also used to stop migraines. It is useful to stop some types of seizures. It can be given intravenously or by mouth.
Common side effects of this medication are sleepiness, dry mouth, weakness, vomiting and nausea. Serious side effects can include liver problems, pancreatitis and an increased suicide risk. Valproate is known to cause birth defects and miscarriages in pregnant women who use the medicine, so it is not recommended for women who are pregnant or able to become pregnant to take Valproate.
Overdose and poisoning.
Too much valproic acid can result in wanting to sleep, shaking, near unconsciousness, less breathing, coma, metabolic acidosis, and death. Normal amounts of valproic acid levels in blood plasma are from 20–100 milligrams per liter. 150–1500 milligrams of valproic acid per liter of blood plasma is very dangerous.
Brand names.
Brand names of valproic acid.
Branded products include:
Brand names of sodium valproate.
New Zealand.
All the above formulations are Pharmac-subsidised.
Europe.
In much of Europe, Dépakine and Depakine Chrono (tablets) are equivalent to Epilim and Epilim Chrono above.