2010 US Open – Mixed Doubles

Carly Gullickson and Travis Parrott were the defending champions, but lost in the first round to Gisela Dulko and Pablo Cuevas 2–6, 4–6.
Liezel Huber and Bob Bryan won in the final 6–4, 6–4, against Květa Peschke and Aisam-ul-Haq Qureshi.