"eye appearance. Further tests like ELISA can be used to detect the antigen. The cells of the infected organ show intranuclear inclusion giving the nucleus classical owls eye appearance. Further tests like ELISA can be used to detect the antigen.Virus can be grown in cell culture also. Cytomegalic inclusion body disease Cytomegalic inclusion body disease (CIBD) is a series of signs and symptoms caused by cytomegalovirus infection, toxoplasmosis or other rare infections such as herpes or rubella viruses. It can produce massive calcification of the central nervous system, and often the kidneys. Cytomegalic inclusion body disease is the most common"
"Bright's disease Bright's disease is a historical classification of kidney diseases that would be described in modern medicine as acute or chronic nephritis. It was characterized by swelling, the presence of albumin in the urine and was frequently accompanied by high blood pressure and heart disease. The symptoms and signs of Bright's disease were first described in 1827 by the English physician Richard Bright, after whom the disease was named. In his ""Reports of Medical Cases"", he described 25 cases of dropsy (edema) which he attributed to kidney disease. Symptoms and signs included: inflammation of serous membranes, hemorrhages, apoplexy, convulsions,"
"Chronic Bright's disease was a more severe variant, where other organs are also affected. In their introduction, Gull and Sutton point out that Dr. Bright and others ""have fully recognised that the granular contracted kidney is usually associated with morbid changes in other organs of the body"" and that these co-existent changes were commonly grouped together and termed ""chronic Bright's disease."" The prevailing opinion at the time was that the kidney was the organ primarily affected, inducing a condition that would spread to other parts of the body and thereby cause other organs to suffer. Gull and Sutton argued that"
"Minnesota, died in 1922. Baseball Hall of Famer Ross Youngs died on October 22, 1927. Master of Science Fiction Horror, Howard Phillips “H. P.” Lovecraft, died from a combination of cancer and Bright’s Disease on March 15, 1937, at the age of 46. Albert Carl ""Al"" Ringling (1852–1916), eldest of the Ringling brothers, died of Bright's disease at the age of 63 in Wisconsin. Bright's disease Bright's disease is a historical classification of kidney diseases that would be described in modern medicine as acute or chronic nephritis. It was characterized by swelling, the presence of albumin in the urine and"
"this assumption was incorrect. They presented evidence to show that the diseased state could also originate in other organs, and that the deterioration of the kidney is part of the general morbid change, rather than the primary cause. In some cases examined by Gull and Sutton, the kidney was only marginally affected while the condition was far more advanced in other organs. Gull and Sutton's main conclusion was that the morbid change in the arteries and capillaries was the primary and essential condition of the morbid state known as chronic Bright's disease with contracted kidney. They stated that the clinical"
"blindness and coma. Many of these cases were found to have albumin in their urine (detected by the spoon and candle-heat coagulation), and showed striking morbid changes of the kidneys at autopsy. The triad of dropsy, albumin in the urine and kidney disease came to be regarded as characteristic of Bright's disease. Subsequent work by Bright and others indicated an association with cardiac hypertrophy, which was attributed by Bright to stimulation of the heart. Subsequent work by Frederick Akbar Mahomed showed that a rise in blood pressure could precede the appearance of albumin in the urine, and the rise in"
"A bust of Bright is held at the Royal College of Physicians of Edinburgh. Richard Bright (physician) Richard Bright (28 September 1789 – 16 December 1858) was an English physician and early pioneer in the research of kidney disease. He is particularly known for his description of Bright's disease. He was born in Bristol, Gloucestershire, the third son of Sarah and Richard Bright Sr., a wealthy merchant and banker. Bright Sr. shared his interest in science with his son, encouraging him to consider it as a career. In 1808, Bright Jr. joined the University of Edinburgh to study philosophy, economics"
"vital."" ""The bacteria is an innocent feller, and if he carries disease he carries the Simple Substance which causes disease, just as an elephant would."" As a follower of a mystical Christian religious sect headed by Emanuel Swedenborg, Kent believed that illness had spiritual causes: ""You cannot divorce medicine and theology. Man exists all the way down from his innermost spiritual, to his outermost natural."" Kent died of Bright's disease on June 5, 1916, in Stevensville, Montana. He was 67 years old at the time of his death. Not long after his death, Kent was eulogized by one contemporary as"
"blood pressure and increased resistance to flow was believed to explain the cardiac hypertrophy. It is now known that Bright's disease is caused by a wide and diverse range of kidney diseases; thus, the term ""Bright's disease"" is retained strictly for historical application. The disease was diagnosed frequently in patients with diabetes; at least some of these cases would probably correspond to a modern diagnosis of diabetic nephropathy. Bright's disease was historically treated with warm baths, blood-letting, squill, digitalis, mercuric compounds, opium, diuretics, laxatives, and dietary therapy, including abstinence from alcoholic drinks, cheese and red meat. Arnold Ehret was diagnosed"
"stages of the condition, was dangerous and should be discouraged. Gull states that he formed this opinion after experience of dealing with cases of anoerexia nervosa, having previously himself been inclined to indulge patients' wishes. In 1872, Sir William Gull and Henry G. Sutton, M.B., F.R.C.P. presented a paper that challenged the earlier understanding of the causes of chronic Bright's Disease. The symptoms of Bright's Disease had been described in 1827 by the English physician Richard Bright who, like Gull, was based at Guy's Hospital. Dr. Bright's work characterised the symptoms as caused by a disease centred on the kidney."
"Richard Bright (physician) Richard Bright (28 September 1789 – 16 December 1858) was an English physician and early pioneer in the research of kidney disease. He is particularly known for his description of Bright's disease. He was born in Bristol, Gloucestershire, the third son of Sarah and Richard Bright Sr., a wealthy merchant and banker. Bright Sr. shared his interest in science with his son, encouraging him to consider it as a career. In 1808, Bright Jr. joined the University of Edinburgh to study philosophy, economics and mathematics, but switched to medicine the following year. In 1810, he accompanied Sir"
"seems he had an episode of acute heart failure following running for a train. As a result, he discovered that he had Bright's disease (or hypertension) with a dilated heart, a condition with a poor prognosis at the time. As a consequence he changed his diet, discontinued coffee and stopped smoking. His condition improved, he lost weight and his blood pressure fell. Over the next 4 years he developed a dietary system based on this experience. The dietary system he developed involved fasting and promoted the idea that certain foods require an acid pH environment in digestion, and other foods"
"can affect many other organ systems. Inflammation of the interior portion of the eye, known as uveitis, can cause blurred vision and eye pain, especially when exposed to light (photophobia). Inflammation may also involve the white part of the eye (sclera), a condition called episcleritis. Both episcleritis and uveitis can lead to loss of vision if untreated. Crohn's disease that affects the ileum may result in an increased risk of gallstones. This is due to a decrease in bile acid resorption in the ileum and the bile gets excreted in the stool. As a result, the cholesterol/bile ratio increases in"
"1859. He was elected assistant-physician to St. Bartholomew's Hospital in 1860, was secretary to the medical council of the hospital from 14 January 1865 to 9 February 1867, and was in 1866 elected lecturer on forensic medicine in the medical school. He also held the office of medical registrar, and was elected physician to the hospital 23 January 1867, but did not long enjoy that office. One day, while going round the wards, he fell down in an uræmic convulsion, was moved to his own house, a victim of chronic Bright's disease. He grew blind so gradually that he did"
"was already suffering from an inflammation of the kidneys for sometime and diagnosed with Bright's disease (a type of kidney disease). At the onstart of the voyage in early May, he became very weak, and had to be carried aboard a ship in a wheelchair. He reached London on 10 May, and checked into Bailey's Hotel but was bedridden throughout his remaining days. He was not allowed to receive many visitors, though the Duke of Connaught and Strathearn, Prince Arthur paid two visits. Queen Victoria sent her personal physician, Douglas Powell to attend to his medical needs upon receiving news"
"Johnson suggested that the thickened blood vessels seen in the kidney in Bright's disease might be an adaptation to elevated blood pressure. William Senhouse Kirkes in 1855 and Ludwig Traube in 1856 also proposed, based on pathological observations, that elevated pressure could account for the association between left ventricular hypertrophy to kidney damage in Bright's disease. Samuel Wilks observed that left ventricular hypertrophy and diseased arteries were not necessarily associated with diseased kidneys, implying that high blood pressure might occur in people with healthy kidneys; however the first report of elevated blood pressure in a person without evidence of kidney"
"in the esophagus (esophageal varices) and stomach (gastric varices) and severe fluid retention in the abdomen (ascites). Toxins may accumulate in the blood and eventually affect mental functioning. This can lead to confusion or even coma (hepatic encephalopathy). Liver cancer: Cirrhosis and haemochromatosis together will increase the risk of liver cancer. (Nearly one-third of people with haemochromatosis and cirrhosis eventually develop liver cancer.) Diabetes: The pancreas which also stores iron is very important in the body’s mechanisms for sugar metabolism. Diabetes affects the way the body uses blood sugar (glucose). Diabetes is in turn the leading cause of new blindness"
"his name to Bright's disease) when Bright suggested that the source of the problem in oedema was the kidneys. Addison preferred to believe that the condition was caused by intemperance or some other external factor, and that since the whole body had been disrupted, it could not be localised to a specific organ. Addison further challenged Bright's student, Snow, when in 1839 Snow suggested from case studies and laboratory analysis that oedema was associated with an increase in albumin in the blood. Addison dismissed this as a mere epiphenomenon. Bird disagreed with Snow's proposed treatment, but his arguments clearly show"
"considered the ""father of nephrology"". He was elected a Fellow of the Royal Society in 1821. Bright had a special affection for Hungary and in 1815 he lived in Festetics Castle in Keszthely, where there is a large plaque: “To the memory of the English physician scientist and traveller who was one of the pioneers in the accurate description of Lake Balaton.” He delivered the Lumleian Lectures in 1837 on ""Disorders of the Brain"" and the Gulstonian lectures in 1833 on the ""Function of the Abdominal Viscera"" at the Royal College of Physicians. On 11 December 1858, Bright became severely"
"also the brain. The cause of this is somewhat unclear but may relate to very low levels of creatine often found in this population. Treatment may include vitamin B6, Lysine or dramatic dietary change to minimise Arginine from patients diet. Research has indicated that these treatments may be somewhat effective in lowering ornithine blood concentration levels in some patients, either in combination or individually. Vitamin B6 has been found to be very effective in a small proportion of patients. Quite often, the presenting symptom of ornithine aminotransferase (OAT) deficiency is myopia which progresses to night blindness. The onset of myopia"
"for languages and could speak German, French, Italian, and English. In 1887, aged 21, he graduated as a Professor of Design from a college in Baden, and was drafted into the military only to be discharged after 9 months of service, because of heart disease. After studying in Frankfurt, he then taught there at a technical school for 15 years. At 31, he was diagnosed with Bright's disease (inflammation of the kidneys) by Dr Gustav Riedlin, and pronounced incurable by 24 of Europe's most respected doctors. He visited several sanitariums in Europe to learn holistic methods and philosophies including the"
"suffered serious injuries in 1978 when struck by a city bus, the accident severely damaged his kidneys. He told his family very little of the accident. Diagnosed with Bright's disease during the late 1980s, he would die of a heart attack on November 21, 1990 at the Hart family mansion. He was cremated. Dean's death had severe effect on his brother Bret, making him extremely distraught as he felt that they had grown apart too much in their later years. He was unsatisfied with how their last interactions ended up, leaving him feeling like their relationship never got to recover"
"form of Bright's disease. He died, at his home in Cambridge, December 9, 1885, in his 53rd year. He married, September 17, 1862, Rachel P. Carmalt, of Lakeside, Pa, who survived him, with four of their six children, two daughters and two sons. Elisha Mulford Elisha Mulford (November 19, 1833 – December 9, 1885) was an American religious minister and author of ""The Nation: the Foundation of Civil Order and Political life in the United States"" and ""The Republic of God, an Institute of Theology"". Mulford was born in Montrose, Pa., November 19, 1833, and was prepared for Yale College"
"hospital. The strain led to a period of serious illness, but she insisted on returning to duty once she recovered. Her work fed over into her personal life when she met French ambulance driver, Daniel Mistrick, marrying him on the Verdun battlefield according to French genealogy sources. She remained in Europe, working at a feeding station in Germany after the war ended with the French army of occupation. In 1921, she returned to Newport to nurse her ailing mother at 23 West Street, but was herself seriously ill and died of kidney disease, Bright’s disease, on 30 January 1921 aged"
"many years. He never practised extensively, having a private fortune. He died 1 February 1870, aged 87. Bright married Elizabeth Mynors; John Edward Bright the barrister and Mynors Bright were their sons. John Bright (physician) John Bright (1783–1870) was an English physician. Bright was born in Derbyshire, and educated at Wadham College, Oxford, where he graduated B.A. 1801, and M.D. 1808. He at first practised in Birmingham, and was appointed physician to the General Hospital in 1810; but before long he moved to London. He was elected fellow of the Royal College of Physicians in 1809, was several times censor,"
"manner and childlike in some respects."" After her death, ""The Australian Star"" named her as the most favored journalist in Australia at the time. The Mitchell Library of the State Library of New South Wales holds eight of the poems she wrote throughout her life. Wildman became infected with nephritis, a kidney disease which at the time was classified as Bright's disease, beginning in 1894. She travelled to Queensland, in hope that upon return she could then travel all the way to Europe to improve her health; however, her health declined quickly, causing her to be unable to journey to"
"his estranged wife $75,000 in exchange for her dropping all financial claims upon him and dismissing a suit for divorce which had been previously filed. During his final years Platt suffered from a palsy of his legs which confined him to a wheelchair for a majority of the time. He was stricken by what was diagnosed as an acute attack of Bright's disease on May 28, 1909, a case so severe that his doctor publicly predicted his patient's eminent demise. Platt recovered, however, convalescing until late in January 1910, when he was deemed well enough to return home to his"
"intestine lesions, abdominal pain, diarrhea, and bowel perforation. If the central nervous system is involved, symptoms can include headaches, dizziness, seizures, paralysis of cranial nerves, weakness, stroke, damage to small areas of the brain due to artery blockage (cerebral infarcts, and cerebral hemorrhage). Additional organs commonly impacted include the heart, lungs, and kidneys. Symptoms that may develop from damage to these organs include double vision (diploplia), clouding of lenses of eyes, swelling of the optic disc (papilledema), partial loss of vision, shortness of breath, chest pain, epilepsy,and thickening of pericardium. Someone with the benign form may suddenly develop symptoms of"
"Bright's Disease. It was soon released to the public that Mayo was ill. Originally, the newspapers reported that Mayo had pneumonia and was resting at his mansion. Mayo didn't stay resting for long. A week later, Mayo conducted business as usual, but citizens of Paintsville could tell he was seriously ill. Specialists were soon called in from Cincinnati. Mayo had been experiencing periods of unconsciousness according to reports. Bright's Disease had attacked the function of the liver, but news reports were still hopeful for a quick recovery. On March 1, 1914, Mayo was taken by special train to the Jewish"
"in Edmonton, Alberta. He was head coach at Edmonton's Bonnie Doon High School in the 1960s when the Lancers were a champion football team. He became a Canadian citizen in 1962. Bright died of a massive heart attack on December 14, 1983, at the University of Alberta Hospital in Edmonton, while undergoing elective surgery to correct a knee injury suffered during his football career. He was survived by his wife and four children. Bright is buried at Holy Cross Cemetery, in Edmonton. Despite irrefutable evidence of the incident, Oklahoma A&M officials denied anything had happened. Indeed, Oklahoma A&M/State refused to"
"a 45-year-old female, but in the ""Star"" newspaper the same day Openshaw denied the report strongly, saying it was impossible to tell its age or gender, or how long it had been preserved in spirits. Major Smith claimed in his memoirs that the sent kidney matched the one missing from Eddowes, because the length of renal artery attached to the kidney matched the missing length from the body, and both the body and kidney showed signs of Bright's disease. Smith's later recollection does not match the medical reports submitted by the examining pathologists or the police records. Police surgeon Dr"
"regulate the concentration of ions including K+, Na+, and Ca2+ using ATP. Without sufficient levels of ATP, these concentration gradients are not maintained and this can lead to cell death in both the stria vascularis and the hair cells, causing hearing loss. Table 1: Metabolically active organs that can be affected by the 3243A>G mitochondrial point mutation and the associated complication: Initially, the person is treated by dietary changes and hypoglycaemic agents. This doesn't last very long before the person has to be started on insulin (within 2 years of diagnosis). Diabetes mellitus and deafness Diabetes mellitus and deafness (DAD)"
"(which if significant enough may require the insertion of a pacemaker). It can affect the musculoskeletal system causing non-inflammatory transient arthritis and / or arthralgias. It can affect the nervous system manifesting as facial paralysis (Bell's palsy, classically bilateral), fatigue, and loss of memory. Stage 3 is known as the Late Disseminated stage and occurs months - years after the initial infection. Effects of the 3 stage include encephalitis or meningitis.. as well as migratory arthropathies (most commonly of the knee). Anaplasmosis and babesiosis are also common tick-borne pathogens carried by the Ixodes tick that infect humans similarly to Borrelia"