Mesothelioma, a rare form of cancer that develops from the protective lining of the body's internal organs (the mesothelium) is usually caused by exposure to what substance?
"express high levels of calretinin. Other morphological subtypes have been described: Staging of mesothelioma is based on the recommendation by the International Mesothelioma Interest Group. TNM classification of the primary tumor, lymph node involvement, and distant metastasis is performed. Mesothelioma is staged Ia–IV (one-A to four) based on the TNM status. Mesothelioma can be prevented in most cases by preventing exposure to asbestos. The US National Institute for Occupational Safety and Health maintains a recommended exposure limit of 0.1 asbestos fiber per cubic centimeter. There is no universally agreed protocol for screening people who have been exposed to asbestos. Screening"
"Mesothelioma Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs (known as the mesothelium). The most common area affected is the lining of the lungs and chest wall. Less commonly the lining of the abdomen and rarely the sac surrounding the heart, or the sac surrounding the testis may be affected. Signs and symptoms of mesothelioma may include shortness of breath due to fluid around the lung, a swollen abdomen, chest wall pain, cough, feeling tired, and weight loss. These symptoms typically come on slowly. More than 80%"
"be useful sign in differentiating pseudomyxoma peritonei from ascites. Mesothelioma is a rare primary tumour of the connective tissue, originates in the serous membranes of the pleura, peritoneum or pericardium. Peritoneal involvement is reported in 25% of cases. Imaging features include ascites, diffuse irregular nodular peritoneal thickening, invasion of omenta and mesentery with the formation of omental cakes, and mesenteric masses and bowel wall thickening. Coexistence of pleural abnormalities with positive occupational asbestos exposure history in absence detectable primary tumour goes more in favor of mesothelioma. The extent of carcinomatosis represents one of the most important prognostic factors. In patients"
"Mesothelium The mesothelium is a membrane composed of simple squamous epithelium that forms the lining of several body cavities: the pleura (thoracic cavity), peritoneum (abdominal cavity including the mesentery), mediastinum and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). Mesothelium that covers the internal organs is called visceral mesothelium, while the layer that covers the body walls is called the parietal mesothelium. Mesothelium is the epithelial component of serosa. Mesothelium derives from the embryonic mesoderm cell layer, that lines the"
"Peritoneal mesothelioma Peritoneal mesothelioma is the name given to the cancer that attacks the lining of the abdomen. This type of cancer affects the lining that protects the contents of the abdomen and which also provides a lubricating fluid to enable the organs to move and work properly. The peritoneum is made of two parts, the visceral and parietal peritoneum. The visceral peritoneum covers the internal organs and makes up most of the outer layer of the intestinal tract. Covering the abdominal cavity is the parietal peritoneum. Symptoms of peritoneal mesothelioma include weight loss and abdominal pain and swelling due"
"the disposition and clearance of fibrin (such as plasminogen). Mesothelial cells are capable of phagocytosis and are antigen presenting cells. Furthermore, the secretion of glycosaminoglycans and lubricants may protect the body against infection and tumor dissemination. Mesothelium The mesothelium is a membrane composed of simple squamous epithelium that forms the lining of several body cavities: the pleura (thoracic cavity), peritoneum (abdominal cavity including the mesentery), mediastinum and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). Mesothelium that covers the internal"
"by pseudomembranes of dead epithelial cells, white blood cells, red blood cells, and fibrin that form around the tonsils and back of the throat. In developed countries, it is an uncommon illness that tends to occur in unvaccinated individuals, especially school-aged children, elderly, neutropenic or immunocompromised patients, and those with prosthetic devices such as prosthetic heart valves, shunts, or catheters. It is more common in developing countries It can occasionally infect wounds, the vulva, the conjunctiva, and the middle ear. It can be spread within a hospital. The virulent and toxigenic strains are lysogenic, and produce an exotoxin formed by"
"Evidence supporting the effectiveness of chemotherapy is, in many cases, unclear due to a wide variety of prognostic factors and small sample size. However, there is some evidence to suggest that drugs such as paclitaxel, doxorubicin, ifosfamide, and gemcitabine exhibit antitumor activity. Lymphangiosarcoma Lymphangiosarcoma is a rare cancer which occurs in long-standing cases of primary or secondary lymphedema. It involves either the upper or lower lymphedematous extremities but is most common in upper extremities. Although its name implies lymphatic origin, it is believed to arise from endothelial cells and may be more accurately referred to as angiosarcoma. Lymphangiosarcoma may present"
"malignancy, mesothelioma tumors have been found to be polyclonal in origin, by performing a X-inactivation based assay on epitheloid and biphasic tumors obtained from female patients. These results suggest that an environmental factor, most likely asbestos exposure, may damage and transform a group of cells in the tissue, resulting in a population of tumor cells that are, albeit only slightly, genetically different. Asbestos fibers have been shown to alter the function and secretory properties of macrophages, ultimately creating conditions which favour the development of mesothelioma. Following asbestos phagocytosis, macrophages generate increased amounts of hydroxyl radicals, which are normal by-products of"
"one another. The mesothelium is composed of an extensive monolayer of specialized cells (mesothelial cells) that line the body's serous cavities and internal organs. The main purpose of these cells is to produce a lubricating fluid that is released between layers, providing a slippery, non-adhesive, and protective surface to facilitate intracoelomic movement. The mesothelium is also implicated in the transport and movement of fluid and particulate matter across the serosal cavities, leukocyte migration in response to inflammatory mediators, synthesis of pro-inflammatory cytokines, growth factors, and extracellular matrix proteins to aid in serosal repair, and the release of factors to promote"
"carcinomatosis index (39) can be completely reduced to a PCI of 0 with adequate surgery. This article includes text from the U.S. National Cancer Institute's public domain Dictionary of Cancer Terms. Peritoneal mesothelioma Peritoneal mesothelioma is the name given to the cancer that attacks the lining of the abdomen. This type of cancer affects the lining that protects the contents of the abdomen and which also provides a lubricating fluid to enable the organs to move and work properly. The peritoneum is made of two parts, the visceral and parietal peritoneum. The visceral peritoneum covers the internal organs and makes"
"Lymphangiosarcoma Lymphangiosarcoma is a rare cancer which occurs in long-standing cases of primary or secondary lymphedema. It involves either the upper or lower lymphedematous extremities but is most common in upper extremities. Although its name implies lymphatic origin, it is believed to arise from endothelial cells and may be more accurately referred to as angiosarcoma. Lymphangiosarcoma may present as a purple discoloration or a tender skin nodule in the extremity, typically on the anterior surface. It progresses to an ulcer with crusting to an extensive necrotic focus involving the skin and subcutaneous tissue. It metastasizes quickly. It was previously a"
"safely. Mesotheliomas appear usually 30–50 years after exposure but this can be prolonged, very rarely, to 70 years. Thus, since the use of ""louto"" stopped between 1980-1985, a decreasing incidence of mesothelioma may be expected until 2020-2030 and possibly 2040. Metsovo Lung Metsovo lung was an epidemic of lung disease resulting from domestic exposure to asbestos in the village of Metsovo in northwest Greece. Most of the inhabitants had previously been exposed to a whitewash derived from local soils containing tremolite asbestos. This caused an epidemic of malignant mesothelioma (MM) that reached an incidence 300 times that expected in populations"
"very easily treated and rarely result in death. The condition did, however, take the life of Scottish golfer Willie Dunn, Sr. in 1878 at a time when the ailment was likely not fully understood. Epithelioma Epithelioma is an abnormal growth of the epithelium, which is the layer of tissue that covers the surfaces of organs and other structures of the body. Epitheliomas can be benign growths or malignant carcinomas. They are classified according to the specific type of epithelial cells that are affected. The most common epitheliomas are basal cell carcinoma and squamous cell carcinoma (skin cancers). Treatment usually involves"
"long-term exposure to asbestos. Asbestos-related fibrosis is progressive because it continues to progress in the lung even if no further asbestos is inhaled. The scar tissue causes the alveolar walls to thicken, reducing the lung capacity which leads to the patient experiencing shortness of breath (dyspnea). Sufferers are at an increased risk for heart failure and certain malignancies. Malignant mesothelioma is an aggressive and incurable tumour caused by asbestos arising from mesothelial cells of the pleura, peritoneum (the lining of the abdominal cavity) and rarely elsewhere. Pleural mesothelioma is the most common type of mesothelioma, representing about 75 percent of"
"cell mitogens such as platelet-derived growth factor (PDGF) and transforming growth factor-β (TGF-β) which in turn, may induce the chronic stimulation and proliferation of mesothelial cells after injury by asbestos fibres. Diagnosis of mesothelioma can be suspected with imaging but is confirmed with biopsy. It must be clinically and histologically differentiated from other pleural and pulmonary malignancies, including reactive pleural disease, primary lung carcinoma, pleural metastases of other cancers, and other primary pleural cancers. Primary pericardial mesothelioma is often diagnosed after it has metastasized to lymph nodes or the lungs. Diagnosing mesothelioma is often difficult because the symptoms are similar"
"identical p53 and KRAS mutations have been identified in both epithelial and mesenchymal components of carcinosarcoma, findings that suggest an early alteration in the histogenesis of the tumor with late transformation or degeneration of the epithelial component into the sarcomatous component. Carcinosarcoma Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/connective tissue cancer). Carcinosarcomas are rare tumors, and can arise in diverse organs, such as the skin, salivary glands, lungs, the esophagus, pancreas, colon, uterus and ovaries. Four main hypotheses have been proposed for the cellular origins of carcinosarcoma, based largely"
"Epigenetics and melanoma Melanoma is a rare but aggressive malignant cancer that originates from melanocytes. These melanocytes are cells found in the basal layer of the epidermis that produce melanin under the control of melanocyte-stimulating hormone. Despite the fact that melanoma represents only a small number of all skin cancers, it is the cause of more than 50% of cancer-related deaths. The high metastatic qualities and death rate, and also its prevalence among people of younger ages have caused melanoma to become a highly researched malignant cancer. Epigenetic modifications are suspected to influence the emergence of many types of cancer-related"
"Mensacarcin Mensacarcin is a highly oxygenated polyketide first isolated from soil-dwelling ""Streptomyces bottropensis"" bacteria. The molecule is a secondary metabolite, and can be obtained in large amounts from its producing organism. Due to its unique properties it is an important model for drug development against melanoma and other cancers. In NCI-60 anti-cancer compound screening mensacarcin has a high cytostatic effect against almost all cell lines (mean of 50% growth inhibition) and a relatively selective cytotoxic effect against melanoma cells. Low COMPARE correlation with standard antitumor agents indicate a unique mechanism of action. Further examinations reveal mensacarcin effecting the mitochondria. With"
"mucoepidermoid carcinoma and adenoid cystic carcinoma, while extremely uncommon, occur far more often than does EMECL. A number of now-obsolete terms have been used to describe EMECL in past literature, including adenomyoepithelioma, myoepithelioma, epithelial-myoepithelial tumor, epimyoepithelial carcinoma, and malignant mixed tumor containing epithelial and myoepithelial cells. Epithelial-myoepithelial carcinoma of the lung Epithelial-myoepithelial carcinoma of the lung (EMECL) is a very rare histologic form of malignant epithelial neoplasm (""carcinoma"") arising from lung tissue. Lung cancer is an extremely heterogeneous family of malignant neoplasms, with well over 50 different histological variants recognized under the 4th revision of the World Health Organization (WHO)"
"an important role in immunology of infants in human milk feeding. Whereas the skin is a protective barrier due to its dryness and acidity, the conjunctiva (membrane covering the eye) is, instead, protected by secreted enzymes, mainly lysozyme and defensin. However, when these protective barriers fail, conjunctivitis results. In certain cancers (especially myelomonocytic leukemia) excessive production of lysozyme by cancer cells can lead to toxic levels of lysozyme in the blood. High lysozyme blood levels can lead to kidney failure and low blood potassium, conditions that may improve or resolve with treatment of the primary malignancy. Serum lysozyme is much"
"Melanoma Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes. Melanomas typically occur in the skin, but may rarely occur in the mouth, intestines, or eye. In women, they most commonly occur on the legs, while in men they are most common on the back. Sometimes they develop from a mole with changes such as an increase in size, irregular edges, change in color, itchiness, or skin breakdown. The primary cause of melanoma is ultraviolet light (UV) exposure in those with low levels of skin pigment. The UV light"
"cases. Peritoneal mesothelioma is the second most common type, consisting of about 10 to 20 percent of cases. Mesothelioma appears from 20 to 50 years after the initial exposure to asbestos. The symptoms include shortness of breath, chronic chest pain, cough, and weight loss. Diagnosing mesothelioma is often difficult and can include physical examination, chest X-ray and lung function tests, followed by CT scan and MRI. A biopsy is needed to confirm a diagnosis of malignant mesothelioma. Mesothelioma has a poor prognosis, with most patients dying within 1 year of diagnosis. The treatment strategies include surgery, radiotherapy, chemotherapy or multimodality"
"mesenchyme appears as an embryologically primitive ""soup"". This ""soup"" exists as a combination of the mesenchymal cells plus serous fluid plus the many different tissue proteins. Serous fluid is typically stocked with the many serous elements, such as sodium and chloride. The mesenchyme develops into the tissues of the lymphatic and circulatory systems, as well as the musculoskeletal system. This latter system is characterized as connective tissues throughout the body, such as bone, muscle and cartilage. A malignant cancer of mesenchymal cells is a type of sarcoma. The first emergence of mesenchyme occurs during gastrulation from the epithelial–mesenchymal transition (EMT)"
"of virotherapy, where oncolytic viruses are used to treat diseases; viruses can increase metabolism, reduce anti-tumor immunity and disorganize vasculature. Talimogene laherparepvec (T-VEC) (which is a herpes simplex virus type 1–derived oncolytic immunotherapy), was shown to be useful against metastatic melanoma in 2015 with an increased survival of 4.4 months. Melanoma Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes. Melanomas typically occur in the skin, but may rarely occur in the mouth, intestines, or eye. In women, they most commonly occur on the legs, while in men they"
"Epithelioma Epithelioma is an abnormal growth of the epithelium, which is the layer of tissue that covers the surfaces of organs and other structures of the body. Epitheliomas can be benign growths or malignant carcinomas. They are classified according to the specific type of epithelial cells that are affected. The most common epitheliomas are basal cell carcinoma and squamous cell carcinoma (skin cancers). Treatment usually involves surgically removing the tumor and affected tissue. Also used is cryosurgery and radiotherapy. The prognosis varies dramatically, depending on the type and stage at the time of treatment. However, the most common epitheliomas are"
"adults, the known causes are natural and artificial ionizing radiation, a few viruses such as human T-lymphotropic virus, and some chemicals, notably benzene and alkylating chemotherapy agents for previous malignancies. Use of tobacco is associated with a small increase in the risk of developing acute myeloid leukemia in adults. Cohort and case-control studies have linked exposure to some petrochemicals and hair dyes to the development of some forms of leukemia. Diet has very limited or no effect, although eating more vegetables may confer a small protective benefit. Viruses have also been linked to some forms of leukemia. For example, human"
"constituted by mesenchymal cells and extracellular matrix, plays a key role in tumor invasiveness and metastasis, at the same time being a physical barrier that prevents anti-cancer agents from reaching tumor cells. Oncomatryx is developing a new generation of biological anti-tumor drugs, combining cytotoxic molecules and monoclonal antibodies specifically directed towards tumor associated stroma. Oncomatryx collaborates with the Institut für Zell Biologie und Immunologie of the University of Stuttgart, the University of Valladolid, Hospital Universitario Marqués de Valdecilla, Hospital Universitario Central de Asturias, the Centro Nacional de Investigaciones Oncológicas, National Jewish Health and Breast Cancer Research among others. Currently, invasive"
"of action is as an inducer of immunogenic cell death, and it has been suggested that immune response contributes to its overall anti-tumor activity. Doxorubicin has been shown to increase adenoviral replication in soft tissue sarcoma cells as well, potentially contributing to the observed synergistic effect in the virus/doxorubicin combination. Epithelioid sarcoma Epithelioid sarcoma is a rare soft tissue sarcoma arising from mesenchymal tissue and characterized by epithelioid-like features. It accounts for less than 1% of all soft tissue sarcomas. It was first clearly characterized by F.M. Enzinger in 1970. It commonly presents itself in the distal limbs (fingers, hands,"
"is common with in the tumors. Pilomatricoma is associated with high levels of beta-catenin caused by either a mutation in the APC gene or a stabilizing mutation in the beta-catenin gene, CTNNB1. High levels of beta-catenin increases cell proliferation, inhibit cell death, and ultimately leads to neoplastic growth. Pilomatricoma Pilomatricoma, also known as a calcifying epithelioma of Malherbe, Malherbe calcifying epithelioma, and Pilomatrixoma, is a benign skin tumor derived from the hair matrix. These neoplasms are relatively uncommon and typically occur on the scalp, face, and upper extremities. Clinically, pilomatricomas present as a subcutaneous nodule or cyst with unremarkable overlying"
"the World Health Organization, 2016. It is an extremely rare disease that occurs in immunologically competent individuals. It is due to the infiltration of large B cells into long-standing, avascular fibrin-based masses that develop in, on, or around long-standing hamartomas, pseudocysts, cardiac myxommas, prosthetic heart valves, thrombus-laden in endovascular grafts, hematomas, hydroceles, and prosthetic implants of the hip. The infiltrations consist of sheets, ribbons, or clusters of proliferating large B cells within avascular tissue that are coated with or contain abundant fibrin plus a paucity or absence of other types of inflammatory cells. The large B cells are infected with"
"may be from either the sun or from other sources, such as tanning devices. About 25% develop from moles. Those with many moles, a history of affected family members, and who have poor immune function are at greater risk. A number of rare genetic defects such as xeroderma pigmentosum also increase risk. Diagnosis is by biopsy and analysis of any skin lesion that has signs of being potentially cancerous. Using sunscreen and avoiding UV light may prevent melanoma. Treatment is typically removal by surgery. In those with slightly larger cancers, nearby lymph nodes may be tested for spread. Most people"
"contrast to adults, carcinomas are exceptionally rare in children.. The two biggest risk factors for ovarian carcinoma are age and family history. Carcinoma Carcinoma is a category of types of cancer that develop from epithelial cells. Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal, mesodermal or ectodermal germ layer during embryogenesis. Carcinomas occur when the DNA of a cell is damaged or altered and the cell begins to grow uncontrollably and become malignant. It is from the Greek,"