"Hydrocodone/ibuprofen The drug combination hydrocodone/ibuprofen (INNs, trade name Vicoprofen) is an analgesic medication used in short-term therapy to relieve severe pain. Vicoprofen combines the analgesic and antitussive properties of hydrocodone with the analgesic, anti-inflammatory, and antipyretic properties of ibuprofen. In contrast to hydrocodone/acetaminophen combination analgesics such as Vicodin, this hydrocodone/ibuprofen avoids some of the liver toxicity which may occur from acetaminophen, but still presents significant dangers in hydrocodone overdose, namely respiratory depression. Vicoprofen is supplied in a fixed dose combination tablet which contains hydrocodone bitartrate, USP 7.5 mg with ibuprofen, USP 200 mg. Additional strengths of generic Vicoprofen are now"
"pain relief options, particularly within the grocery environment where there is no healthcare professional to assist decision making"". The ACCC said that the products were found to be ""no more effective at treating the type of pain described on its packaging than any of the other Nurofen specific pain products"", and sold for almost twice the price. Specific pain range painkillers include Nurofen Back Pain, Nurofen Period Pain, Nurofen Migraine Pain and Nurofen Tension; and all contain the ""same active ingredient, 342 milligrams of ibuprofen lysine"". In April 2016, the Federal Court imposed a $1.7 million fine on Reckitt Benckiser."
"Baclofen Baclofen, sold under the brand name Lioresal among others, is a medication used to treat spasticity. It is used as a central nervous system depressant and skeletal muscle relaxant. It is also used in topical creams to help with pain. Chemically it is a derivative of the neurotransmitter γ-aminobutyric acid (GABA). It is believed to work by activating (or agonizing) GABA receptors, specifically the GABA receptors. Its beneficial effects in spasticity result from its actions in the brain and spinal cord. As of 2015 the cost for a typical course of treatment in the United States is less than"
"Naproxen Naproxen (brand names: Aleve, Naprosyn, among others) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, swelling, and stiffness. It is available in both an immediate release and extended release formulation. Common side effects include dizziness, headache, bruising, allergic reactions, heartburn, and stomach pain. It has an intermediate risk of stomach ulcers compared to others drugs in the same class (NSAIDs). NSAIDs appear to increase the risk of serious cardiovascular events, though this risk appears to be less with naproxen compared to other NSAIDs. Serious drug interactions may occur in combinations with other drugs that affect the"
"Nortriptyline Nortriptyline, sold under the brand names Allegron, Aventyl, Noritren, Nortrilen, and Pamelor among others, is a tricyclic antidepressant (TCA) used to treat clinical depression. Another licensed use for it is in the treatment of childhood bedwetting. Off-label uses include chronic pain and migraine and labile affect in some neurological disorders. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a second-generation TCA. Nortriptyline has less anticholinergic (like dry mouth, constipation, blurred vision, ""etc.""), antihistamine (like sedation and possibly weight gain), antiadrenergic (like orthostatic hypotension), and cardiotoxic (heart-toxic, namely the capacity of these drugs to interfere"
"marketed and sold in the United Kingdom, other parts of Europe, South Africa, Australia and New Zealand. In 2016 it was the biggest selling branded over-the-counter medication sold in Great Britain, with sales of £116.8 million. There are 11 variants of Nurofen, all of which contain ibuprofen as an active ingredient. The ibuprofen is variously formulated as the free acid, or the lysine salt. For oral formulations, i.e., taken by mouth, it is available in the conventional solid round tablet, a torpedo-shaped solid caplet, or may alternatively be in the form of a soft gel cap. It is also available"
"is delivered through a demand-valve inhaler over the nose, which will only release gas when the patient inhales through it. Nitronox was a registered trademark of BOC between 1966 and 1999, and was reregistered by Hs Tm Inc since 2005 It is also colloquially known as ""gas and air"". Investigational trials show potential for antidepressant applications of NO, especially for treatment-resistant forms of depression, and it is rapid-acting. Nitrous oxide (medication) Nitrous oxide, sold under the brand name Entonox among others, is an inhaled gas used as a pain medication and together with other medications for anesthesia. Common uses include"
"Fenoprofen Fenoprofen is a nonsteroidal anti-inflammatory drug (NSAID). Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the USA as Nalfon. As of 2015 the cost for a typical month of medication in the United States is 50 to 100 USD. Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase (COX-2 inhibitor) activity and prostaglandin synthesis. History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment"
"of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery. False elevation in free and total serum T 3 as measured by Amerlex-M kit. Fenoprofen Fenoprofen is a nonsteroidal anti-inflammatory drug (NSAID). Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the USA as Nalfon. As of 2015 the cost for a typical month of medication in the United States is 50 to 100 USD. Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase (COX-2 inhibitor) activity and prostaglandin synthesis. History of significantly impaired renal"
"Dextropropoxyphene Dextropropoxyphene is an analgesic in the opioid category, patented in 1955 and manufactured by Eli Lilly and Company. It is an optical isomer of levopropoxyphene. It is intended to treat mild pain and also has antitussive (cough suppressant) and local anaesthetic effects. The drug has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias. Its onset of analgesia (pain relief) is said to be 20–30 minutes and peak effects are seen about 1.5–2.0 hours after oral administration. Dextropropoxyphene is sometimes combined with acetaminophen. Trade names include Darvocet-N and Di-Gesic,"
"the Crookes Products division was Nurofen (Ibuprofen or Brufen), which Boots had patented in 1962, developed by Stewart Adams (chemist) and launched on 8 August 1983. By the late 1980s Nurofen had a 12% share of the analgesics market. Gold Greenlees Trott (GGT), who later bought BBDP then were bought by Omnicom Group in 1998 and made part of TBWA Worldwide, were commissioned to make an advert to markedly increase Nurofen's market share. Analgesics are mainly purchased by 25- to 40-year-old women. The 30 second TV advert, launched on 3 May 1989, used the voice instrumental section by Clare Torry"
"in June 2012. Phenibut, marketed under the brand names Anvifen, Fenibut, and Noofen, was introduced in Russia in the 1960s for the treatment of anxiety, insomnia, and a variety of other conditions. It was not discovered to act as a gabapentinoid until 2015. As of 2017, mirogabalin, under the developmental code name DS-5565, is in phase III clinical trials for the treatment of neuropathic pain and postherpetic neuralgia. Gabapentinoids produce euphoria at high doses, with effects similar to GABAergic central nervous system depressants such as alcohol, γ-hydroxybutyric acid (GHB), and benzodiazepines, and are used as recreational drugs (at 3–20 times"
"effective for myositis than the commonly used NSAID phenylbutazone, and has shown especially good results for treatment of equine exertional rhabdomyolysis, a disease of muscle breakdown, but is less commonly used for musculoskeletal disease. Naproxen Naproxen (brand names: Aleve, Naprosyn, among others) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, swelling, and stiffness. It is available in both an immediate release and extended release formulation. Common side effects include dizziness, headache, bruising, allergic reactions, heartburn, and stomach pain. It has an intermediate risk of stomach ulcers compared to others drugs in the same class (NSAIDs). NSAIDs appear"
"of semen in all subjects, 12 out of the 15 patients reported mild discomfort upon orgasm. The men also reported the psychosexual side effect of being strongly dissatisfied by their lack of ejaculation. Silodosin Silodosin (trade names Rapaflo (USA), Silodyx (Europe and South Africa), Rapilif (India), Silodal (India), Sildoo(India) Urief (Japan), Thrupas (South Korea), Urorec (Russia) is a medication for the symptomatic treatment of benign prostatic hyperplasia. It acts as an α-adrenoceptor antagonist with high uroselectivity (selectivity for the prostate). Silodosin received its first marketing approval in Japan in May 2006 under the tradename Urief, which is jointly marketed by"
". Its generic name in Spanish and Italian and its are ""nortriptilina"", in German is ""nortriptylin"", and in Latin is ""nortriptylinum"". Brand names of nortriptyline include Allegron, Aventyl, Noritren, Norpress, Nortrilen, Norventyl, Norzepine, Pamelor, and Sensoval, among many others. Nortriptyline Nortriptyline, sold under the brand names Allegron, Aventyl, Noritren, Nortrilen, and Pamelor among others, is a tricyclic antidepressant (TCA) used to treat clinical depression. Another licensed use for it is in the treatment of childhood bedwetting. Off-label uses include chronic pain and migraine and labile affect in some neurological disorders. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it"
"Phenibut Phenibut, sold under the brand names Anvifen, Fenibut, and Noofen among others, is a central nervous system depressant with anxiolytic and stimulant effects which is used in the treatment of anxiety, insomnia, and for a variety of other indications. It is usually taken by mouth as a tablet, but can also be given as an intravenous infusion. Side effects of phenibut include sedation, sleepiness, nausea, irritability, agitation, dizziness, and headache, among others. Overdose of phenibut can produce marked central nervous system depression including unconsciousness, although no deaths have been reported. The medication is structurally related to the neurotransmitter γ-aminobutyric"
"Oxymorphone Oxymorphone, sold under the brand names Numorphan among others, is a powerful semi-synthetic opioid analgesic (painkiller) developed in Germany in 1914. Pain relief after injection begins after about 5–10 minutes and 15–30 minutes after rectal administration, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets. It is highly addictive and in June 2017 the FDA asked the manufacturer to remove its product from the US market. This was in part due to the opioid epidemic in the US, and the fact that the 2012 reformulation led to a shift in the route of abuse"
"Benoxaprofen Benoxaprofen, also known as Benoxaphen, is a chemical compound with the formula CHClNO. It is a nonsteroidal anti-inflammatory drug (NSAID) and was marketed under the brand name Oraflex in the United States and as Opren in Europe by Eli Lilly and Company. Lilly suspended sales of Oraflex in 1982 after reports from the British government and the U.S. Food and Drug Administration (FDA) of adverse effects and deaths linked to the drug. Benoxaprofen was discovered by a team of Lilly chemists at its British laboratory. This laboratory was assigned to explore new anti-arthritic compounds in 1966. Lilly applied for"
"Nalbuphine Nalbuphine, sold under the brand names Nubain and Nalpain among others, is a opioid analgesic which is used in the treatment of pain. It is given by injection into a vein, muscle, or fat. Side effects of nalbuphine include sedation, sweatiness, clamminess, nausea, vomiting, dizziness, vertigo, dry mouth, and headache. Unlike other opioids, it has little to no capacity for euphoria or respiratory depression. It also has little to no incidence of dysphoria, dissociation, hallucinations, and related side effects at typical therapeutic doses. Nalbuphine is a mixed agonist/antagonist opioid modulator. Specifically, it acts as a moderate-efficacy partial agonist agonist"
"Nitrous oxide (medication) Nitrous oxide, sold under the brand name Entonox among others, is an inhaled gas used as a pain medication and together with other medications for anesthesia. Common uses include during childbirth, following trauma, and as part of end of life care. Onset of effect is typically within half a minute and lasts for about a minute. There are few side effects, other than vomiting, with short term use. With long term use anemia or numbness may occur. It should always be given with at least 21% oxygen. It is not recommended in people with a bowel obstruction"
"health consequences of abuse."" By July 6, 2017, Endo International voluntarily complied with the FDA removal request. Oxymorphone Oxymorphone, sold under the brand names Numorphan among others, is a powerful semi-synthetic opioid analgesic (painkiller) developed in Germany in 1914. Pain relief after injection begins after about 5–10 minutes and 15–30 minutes after rectal administration, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets. It is highly addictive and in June 2017 the FDA asked the manufacturer to remove its product from the US market. This was in part due to the opioid epidemic in the"
"chlorproethazine. Chlorproethazine Chlorproethazine, sold under the brand name Neuriplege, is a drug of the phenothiazine group described as a muscle relaxant or tranquilizer which is or has been marketed in Europe as a topical cream for the treatment of muscle pain. It has been associated with photoallergic contact dermatitis. Chlorproethazine can be synthesized from a diphenylsulfide derivative. The general scheme is sufficiently flexible to permit the interchange of the order of some of the steps. Thus alkylation of aniline thioether () with 3-chloro-1-diethylaminopropane leads to the intermediate (). Ring closure as above by nucleophilic aromatic displacement leads to the antipsychotic"
"Carprofen Carprofen, marketed under many brand names worldwide, is a nonsteroidal anti-inflammatory drug (NSAID) that veterinarians prescribe as a supportive treatment for various conditions in animals. It provides day-to-day treatment for pain and inflammation from various kinds of joint pain as well as post-operative pain. Carprofen reduces inflammation by inhibition of COX-1 and COX-2; its specificity for COX-2 varies from species to species. Most dogs respond well to carprofen use, but like all NSAIDs, it may cause gastrointestinal, liver and kidney problems in some patients. After introduction, significant anecdotal reports of sudden animal deaths from its use arose. To date"
"business of Boots Group, Boots Healthcare International, for £1.9 billion. The three main brands acquired were Nurofen's analgesics, Strepsils sore throat lozenges, and Clearasil anti-acne treatments. In January 2008, RB acquired Adams Respiratory Therapeutics, Inc., a pharmaceutical company, for $2.3 billion; one of the major brands acquired was Mucinex. In July 2010, RB agreed to buy SSL International, the makers of Durex condoms and Scholl's footcare products, in a £2.5 billion deal. On 27 August 2011, RB recalled all remaining stock of its major analgesic product, Nurofen Plus, after packs were found to contain an antipsychotic drug. It turned out"
"part would contain the 12.8 mg of codeine phosphate, and the other part contained 200 mg of ibuprofen. The tablets could be forcefully split into their two constituent active ingredients; for recreational use of codeine. Such drugs have a potential for misuse because they are available freely to the public. On 25 August 2011, it was reported that several packs of Nurofen Plus were found to contain Seroquel XR — an anti-psychotic drug used to treat schizophrenia — in Boots stores across London. The next day, a safety alert was issued by the Medicines and Healthcare Products Regulatory Agency (MHRA)."
"mg/200 mg strength to be $356.62 and a 100 count of 10 mg/200 mg strength to be $470.35. These prices are all for generic equivalents of Vicoprofen. In 2003, at the time of the approval announcement for the first generic equivalent, it was reported that annual sales of brand name Vicoprofen totaled $104 million. According to IMS, the Hydrocodone/Ibuprofen tablets 7.5 mg/200 mg, had an estimated market size of $15.7 million for the 12 months preceding May 2016. Hydrocodone/ibuprofen The drug combination hydrocodone/ibuprofen (INNs, trade name Vicoprofen) is an analgesic medication used in short-term therapy to relieve severe pain. Vicoprofen"
"March 4, 2011. Fexofenadine is marketed under many brand names worldwide as of January 2017, including: Agimfast, Alafree, Alanil, Alercas, Alerfedine, Alerix, Alertam, Alexia, Allegix, Allegra, Allegratab, Allemax, Allerfast, Allerfen, Allerfexo, Allergo, Allergyna, Allerphast, Alrin, Alterfast, Altifex, Altiva, Aspen, Axodin, Axofen, BiXin, Bosnum, Dinafex, Ewofex, Fastel, Fastofen, Fastway, Fe Min, Feksine, Fenadex, Fenadin, Fenafex, Fenax, Fenofex, Fentradol, Fesler, Fexadyne, Fexal, Fexalar, Fexaway, Fexet, Fexgen, Fexidine, Fexigra, Fexine, Fexo, Fexodane, Fexodine, Fexodis, Fexofast, Fexofen, Fexofenaderm, Fexofenadin, Fexofenadina, Fexofenadine, Fexofénadine, Fexofep, Fexofin, Fexogen, Fexomin, Fexon, Fexona, Fexonadinea, Fexoquit, Fexoral, Fexoril, Fexostad, Fexotine, Fexovid, Fixal, Fixit, Fixodin, Flexofen, Foxin, Fynadin, Glodas, Hasalfast, Histafree,"
"increased between 147%-160% and the AUC increased between 64%-85% of vilazodone when it was administered with either a fatty or light meal. Vilazodone Vilazodone (United States trade name Viibryd) is a serotonergic antidepressant developed by Merck KGaA and licensed by Clinical Data, a biotech company purchased by Forest Laboratories in 2011. Vilazodone was approved in 2011 by the FDA for use in the United States to treat major depressive disorder. Its mechanism of action is believed to be a combination of SSRI-like activity (SERT inhibition) and 5HT1AR partial agonism, like the structurally related anxiolytic buspirone. As such it can be"
"Buprenorphine/naloxone Buprenorphine/naloxone, sold under the brand name Suboxone among others, is a combination medication that includes buprenorphine and naloxone. In combination with counselling, it is used to treat opioid use disorder. It decreases withdrawal symptoms for about 24 hours. Buprenorphine/naloxone is available for use in two different forms, under the tongue or in the cheek. Side effects may include respiratory depression (decreased breathing), small pupils, sleepiness, and low blood pressure. The risk of overdose is lower with buprenorphine/naloxone than with methadone. However, people are more likely to stop treatment on buprenorphine/naloxone than methadone. Methadone, or buprenorphine alone, are generally preferred"
"NSAIDs that can be given parenteral routes. It was originally brought to market by Pfizer under the tradename Feldene in 1980, became generic in 1992, and is marketed worldwide under many brandnames. It used in the treatment of rheumatoid and osteoarthritis, primary dysmenorrhoea, postoperative pain; and act as an analgesic, especially where there is an inflammatory component. The European Medicines Agency issued a review of its use in 2007 and recommended that its use be limited to the treatment of chronic inflammatory conditions, as it is only in these circumstances that its risk-benefit ratio proves to be favourable. As with"
"Rofecoxib Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that has now been withdrawn over safety concerns. It was marketed by Merck & Co. to treat osteoarthritis, acute pain conditions, and dysmenorrhea. Rofecoxib was approved by the U.S. Food and Drug Administration (FDA) on May 20, 1999, and was marketed under the brand names Vioxx, Ceoxx, and Ceeoxx. Rofecoxib gained widespread acceptance among physicians treating patients with arthritis and other conditions causing chronic or acute pain. Worldwide, over 80 million people were prescribed rofecoxib at some time. On September 30, 2004, Merck withdrew rofecoxib from the market because of concerns about"
"Pharmacists were told to check each package of Nurofen Plus to look for anti-psychotic drugs. There were three batches of Nurofen Plus which were affected by the alert. Reckitt Benckiser, manufacturer of Nurofen Plus, said that it did not know where the drugs had been switched. The product was re-released in October in cellophane-sealed packs. Christopher McGuire was later found guilty of one count of contaminating goods, and two of administering a noxious substance, and jailed for 18 months. McGuire cost the manufacturers £2.4m, and saved himself £7, when he put anti-psychotic drugs in empty packets of the painkiller. The"
"Pizotifen Pizotifen (INN) or pizotyline (USAN), trade name Sandomigran, is a benzocycloheptene-based drug used as a medicine, primarily as a preventative to reduce the frequency of recurrent migraine headaches. The main medical use for pizotifen is for the prevention of migraine and cluster headache. Pizotifen is one of a range of medications used for this purpose, other options include propranolol, topiramate, valproic acid and amitriptyline. While pizotifen is reasonably effective, its use is limited by side effects, principally drowsiness and weight gain, and it is usually not the first choice medicine for preventing migraines, instead being used as an alternative"