"on a diet devoid or nearly devoid of vitamin C, had blood levels of vitamin C too low to be accurately measured when they developed signs of scurvy, and in the Iowa study, at this time were estimated (by labeled vitamin C dilution) to have a body pool of less than 300 mg, with daily turnover of only 2.5 mg/day. The vast majority of animals and plants are able to synthesize vitamin C, through a sequence of enzyme-driven steps, which convert monosaccharides to vitamin C. However, some mammals have lost the ability to synthesize vitamin C, notably simians and tarsiers."
"of vitamin C, since without this vitamin, collagen made by the body is too unstable to perform its function. Scurvy leads to the formation of brown spots on the skin, spongy gums, and bleeding from all mucous membranes. The spots are most abundant on the thighs and legs, and a person with the ailment looks pale, feels depressed, and is partially immobilized. In advanced scurvy there are open, suppurating wounds and loss of teeth and, eventually, death. The human body can store only a certain amount of vitamin C, and so the body stores are depleted if fresh supplies are"
"disorders, unusual eating habits, alcoholism, and old people who live alone. Other risk factors include intestinal malabsorption and dialysis. Humans and certain other animals require vitamin C in their diets to make the building blocks for collagen. Diagnosis typically is based on physical signs, X-rays, and improvement after treatment. Treatment is with vitamin C supplements taken by mouth. Improvement often begins in a few days with complete recovery in a few weeks. Sources of vitamin C in the diet include citrus fruit and a number of vegetables such as tomatoes and potatoes. Cooking often decreases vitamin C in foods. Scurvy"
"natural vitamin C content of the milk. Scurvy is one of the accompanying diseases of malnutrition (other such micronutrient deficiencies are beriberi or pellagra) and thus is still widespread in areas of the world depending on external food aid. Although rare, there are also documented cases of scurvy due to poor dietary choices by people living in industrialized nations. Vitamins are essential to the production and use of enzymes that are involved in ongoing processes throughout the human body. Ascorbic acid is needed for a variety of biosynthetic pathways, by accelerating hydroxylation and amidation reactions. In the synthesis of collagen,"
"scurvy while that ship was patrolling the Bay of Biscay. Just after that patrol he left the Navy, wrote his MD thesis on venereal diseases and earned his degree from the University of Edinburgh Medical School, and was granted a licence to practice in Edinburgh. Scurvy is a disease now known to be caused by a vitamin C deficiency, but in Lind's day, the concept of vitamins was unknown. Vitamin C is necessary for the maintenance of healthy connective tissue. In 1740 the catastrophic result of Anson's circumnavigation attracted much attention in Europe; out of 1900 men, 1400 had died,"
"Vitamin deficiency A vitamin deficiency can cause a disease or syndrome known as an avitaminosis or hypovitaminosis. This usually refers to a long-term deficiency of a vitamin. When caused by inadequate nutrition it can be classed as a ""primary deficiency"", and when due to an underlying disorder such as malabsorption it can be classed as a ""secondary deficiency"". An underlying disorder may be metabolic as in a defect converting tryptophan to niacin. It can also be the result of lifestyle choices including smoking and alcohol consumption. Examples are vitamin A deficiency, folate deficiency, scurvy, vitamin D deficiency, vitamin E deficiency,"
"symptoms are malaise and lethargy, progressing to shortness of breath, bone pain, bleeding gums, susceptibility to bruising, poor wound healing, and finally fever, convulsions and eventual death. Until quite late in the disease the damage is reversible, as healthy collagen replaces the defective collagen with vitamin C repletion. Treatment can be orally or by intramuscular or intravenous injection. Scurvy was known to Hippocrates in the classical era. The disease was shown to be prevented by citrus fruit in an early controlled trial by a Royal Navy surgeon, James Lind, in 1747, and from 1796 lemon juice was issued to all"
"pathological disorder concerning the ""tunica externa"" is scurvy, also known as vitamin C deficiency. Scurvy occurs because vitamin C is essential for the synthesis of collagen, and without it, the faulty collagen cannot maintain the vein walls and rupture, leading to a multitude of problems. Tunica externa The tunica externa (New Latin ""outer coat"") — also known as the tunica adventitia (New Latin ""additional coat""), or adventitia for short — is the outermost tunica (layer) of a blood vessel, surrounding the tunica media. It is mainly composed of collagen and, in arteries, is supported by external elastic lamina. The collagen"
"In these experiments, no clinical difference was noted between men given 70 mg vitamin C per day (which produced blood levels of vitamin C of about 0.55 mg/dl, about of tissue saturation levels), and those given 10 mg per day (which produced lower blood levels). Men in the prison study developed the first signs of scurvy about 4 weeks after starting the vitamin C-free diet, whereas in the British study, six to eight months were required, possibly because the subjects were pre-loaded with a 70 mg/day supplement for six weeks before the scorbutic diet was fed. Men in both studies,"
"vitamins and minerals can lead to diseases that can have far-reaching effects on health. For instance, 30% of the world's population either has, or is at risk for developing, iodine deficiency. It is estimated that at least 3 million children are blind due to vitamin A deficiency. Vitamin C deficiency results in scurvy. Calcium, Vitamin D, and phosphorus are inter-related; the consumption of each may affect the absorption of the others. Kwashiorkor and marasmus are childhood disorders caused by lack of dietary protein. Many individuals limit what foods they eat for reasons of morality, or other habit. For instance, vegetarians"
"associated with a 10% reduction in odds of developing breast cancer. Oranges were historically used for their high content of vitamin C, which prevents scurvy. Scurvy is caused by vitamin C deficiency, and can be prevented by having 10 milligrams of vitamin C a day. An early sign of scurvy is fatigue. If ignored, later symptoms are bleeding and bruising easily. British sailors were given a ration of citrus fruits on long voyages to prevent the onset of scurvy, hence the British nickname of Limey. Pectin is a structural heteropolysaccharide contained in the primary cell walls of plants. Limes and"
"the essential vitamin thiamine, causing beri-beri. Another example is the development of scurvy among infants in the late 19th century in the United States. It turned out that the vast majority of sufferers were being fed milk that had been heat-treated (as suggested by Pasteur) to control bacterial disease. Pasteurisation was effective against bacteria, but it destroyed the vitamin C. As mentioned, lifestyle- and obesity-related diseases are becoming increasingly prevalent all around the world. There is little doubt that the increasingly widespread application of some modern food processing technologies has contributed to this development. The food processing industry is a"
"time, and often lacked fresh fruit and vegetables. Without knowing the precise cause, Captain James Cook suspected scurvy was caused by the lack of vegetables in the diet. Based on his suspicion, he forced his crew to eat sauerkraut, a cabbage preparation, every day, and based upon the positive outcomes, he inferred that it prevented scurvy, even though he did not know precisely why. It took about another two hundred years to discover the precise etiology: the lack of vitamin C in a sailor's diet. An etiological myth, or origin myth, is a myth intended to explain the origins of"
"1912 Casimir Funk coined the term vitamin to label a vital factor in the diet: from the words ""vital"" and ""amine,"" because these unknown substances preventing scurvy, beriberi, and pellagra, were thought then to derive from ammonia. The vitamins were studied in the first half of the 20th century. In 1913 Elmer McCollum discovered the first vitamins, fat-soluble vitamin A and water-soluble vitamin B (in 1915; later identified as a complex of several water-soluble vitamins) and named vitamin C as the then-unknown substance preventing scurvy. Lafayette Mendel (1872-1935) and Thomas Osborne (1859–1929) also performed pioneering work on vitamins A and"
"advancement of ocean voyages during the Renaissance resulted in prolonged periods without access to fresh fruits and vegetables, and made illnesses from vitamin deficiency common among ships' crews. In 1747, the Scottish surgeon James Lind discovered that citrus foods helped prevent scurvy, a particularly deadly disease in which collagen is not properly formed, causing poor wound healing, bleeding of the gums, severe pain, and death. In 1753, Lind published his ""Treatise on the Scurvy"", which recommended using lemons and limes to avoid scurvy, which was adopted by the British Royal Navy. This led to the nickname ""limey"" for British sailors."
"vitamin C supplementation of only 10 mg a day. In these experiments, there was no clinical difference noted between men given 70 mg vitamin C per day (which produced a blood level of vitamin C of about 0.55 mg/dl, about 1/3 of tissue saturation levels) and those given 10 mg per day. Men in the prison study developed the first signs of scurvy about four weeks after starting the vitamin C-free diet, whereas in the British study, six to eight months were required, possibly due to the pre-loading of this group with a 70 mg/day supplement for six weeks before"
"due to a genetic inability to effectively kill pathogens by ROS, versus supplementation induced inability caused by antioxidative stress. Nearly all living creatures consume antioxidants in some quantity. Inadequate consumption of dietary antioxidants can be detrimental. For example, a deficiency of vitamin C is a primary cause of scurvy. Vitamin C can be ingested by eating certain fruits. A dietary balance of oxidants and antioxidants are critical in maintaining optimal health. There have been studies on antioxidant capacities of various supplements and compounds. However, there has not been a dietary system devised to quantify what levels of oxidants or antioxidants"
"people in the developing world and the homeless. There have been outbreaks of the condition in refugee camps. Case reports in the developing world of those with poorly healing wounds have occurred. Notable human dietary studies of experimentally induced scurvy have been conducted on conscientious objectors during World War II in Britain and on Iowa state prisoner volunteers in the late 1960s. These studies both found that all obvious symptoms of scurvy previously induced by an experimental scorbutic diet with extremely low vitamin C content could be completely reversed by additional vitamin C supplementation of only 10 mg per day."
"Vitamin A deficiency Vitamin A deficiency (VAD) or hypovitaminosis A is a lack of vitamin A in blood and tissues. It is common in poorer countries, but rarely is seen in more developed countries. Nyctalopia (night blindness) is one of the first signs of VAD. Xerophthalmia, keratomalacia, and complete blindness can also occur since vitamin A has a major role in phototransduction. The three forms of vitamin A include retinols, beta-carotenes, and carotenoids. Vitamin A deficiency is the leading cause of preventable childhood blindness, and is critical to achieving Millennium Development Goal 4 to reduce child mortality. About 250,000 to"
"shaken baby syndrome may result from vitamin C deficiency. This contested hypothesis is based upon a speculated marginal, near scorbutic condition or lack of essential nutrient(s) repletion and a potential elevated histamine level. However, symptoms consistent with increased histamine levels, such as low blood pressure and allergic symptoms, are not commonly associated with scurvy as clinically significant vitamin C deficiency. A literature review of this hypothesis in the journal ""Pediatrics International"" concluded the following: ""From the available information in the literature, concluded that there was no convincing evidence to conclude that vitamin C deficiency can be considered to be a"
"not consumed. The time frame for onset of symptoms of scurvy in unstressed adults on a completely vitamin C free diet, however, may range from one month to more than six months, depending on previous loading of vitamin C. Notable human dietary studies of experimentally induced scurvy have been conducted on conscientious objectors during World War II in Britain and on Iowa state prisoners in the late 1960s to the 1980s. These studies both found that all obvious symptoms of scurvy previously induced by an experimental scorbutic diet with extremely low vitamin C content could be completely reversed by additional"
"vegetables), which may have desirable properties including antioxidant activity (see below); experimental demonstration has been suggestive but inconclusive. Other essential nutrients not classed as vitamins include essential amino acids (see above), essential fatty acids (see above), and the minerals discussed in the preceding section. Vitamin deficiencies may result in disease conditions: goiter, scurvy, osteoporosis, impaired immune system, disorders of cell metabolism, certain forms of cancer, symptoms of premature aging, and poor psychological health (including eating disorders), among many others. Malnutrition refers to insufficient, excessive, or imbalanced consumption of nutrients. In developed countries, the diseases of malnutrition are most often associated"
"found in cases of Vitamin C deficiency, the cause of scurvy. After returning to Edmonton, he compared notes from the survey with James Savelle, an Arctic archaeologist, and noticed skeletal patterns suggesting cannibalism. Seeking information about the Franklin crew's health and diet, he sent bone samples to the Alberta Soil and Feed Testing Laboratory for trace element analysis and assembled another team to visit King William Island. The analysis would find an unexpected level of 226 parts per million (ppm) of lead in the crewman's bones, which was 10 times higher than the control samples, taken from Inuit skeletons from"
"vaccine were equally conceptually flawed. The first proper clinical trial was conducted by the physician James Lind. The disease scurvy, now known to be caused by a Vitamin C deficiency, would often have terrible effects on the welfare of the crew of long distance ocean voyages. In 1740, the catastrophic result of Anson's circumnavigation attracted much attention in Europe; out of 1900 men, 1400 had died, most of them allegedly from having contracted scurvy. John Woodall, an English military surgeon of the British East India Company, had recommended the consumption of citrus fruit (it has an antiscorbutic effect) from the"
"wrote that: scurvy is solely owing to a total abstinence from fresh vegetable food, and greens; which is alone the primary cause of the disease. Lind's essay on the most effectual means of preserving the health of seamen appeared in 1762. It was Gilbert Blane who implemented a longer trial of citrus fruit. In an experiment in 1794, lemon juice was issued on board on a twenty-three-week, non-stop voyage to India. The daily ration of two-thirds of an ounce mixed in grog contained just about the minimum daily intake of 10 mg vitamin C. There was no serious outbreak of"
"became hemorrhagic, but the study found that a daily dose of ten milligrams was sufficient to prevent or reverse scurvy in several cases. The vitamin C research led to the issue of free orange juice for children. The Medical Research Council established recommended daily intakes of vitamins A and C on the basis of the institute's research. Scabies is a skin disease caused by the burrowing of the mite ""Sarcoptes scabiei"". It leads to what sufferers have described as an ""almost intolerable"" itching. The experiment was carried out in 1941 and its purpose was to investigate the mode of transmission"
"public-private Healthy Bodegas Initiative has aimed to encourage bodegas to carry milk and fresh produce and local residents to purchase and consume them. Regardless of daily calorie intake, if a person does not eat foods that are rich in vitamins and nutrients they are susceptible to malnourishment related diseases. These diseases include scurvy which results from low vitamin C levels, rickets from low vitamin D levels, and pellagra from insufficient nicotinic acid. Nutrient imbalances can affect a person, especially a developing child in a multitude of ways. Studies show that malnutrition in children can cause problems with academic performance, attention"
"osteoporosis in the elderly populations. Low levels of Vitamin D have also been associated with other conditions such as heart disease, cancer and kidney disease but further research is required. Recent evidence suggests Vitamin D is also linked to many other health diseases such as cardiovascular disease, chronic kidney disease, diabetes mellitus, multiple sclerosis and some form of cancer. Rickets can be traced back to the 1600s, where a pandemic arose with children around the globe from Vitamin D deficiency. The inadequate intake of UV exposure consequently lead children to numerous health problems such as, growth retardation, muscle weakness, skeletal"
"the oxidation, and use ascorbic acid (vitamin C) to return the iron to its reduced state. Deprivation of ascorbate leads to deficiencies in proline hydroxylation, which leads to less stable collagen, which can manifest itself as the disease scurvy. Since citrus fruits are rich in vitamin C, British sailors were given limes to combat scurvy on long ocean voyages; hence, they were called ""limeys"". Hydroxylation Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step in the oxidative degradation"
"Vitamin D deficiency Vitamin D deficiency, or hypovitaminosis D, most commonly results from inadequate sunlight exposure (in particular sunlight with adequate ultraviolet B rays). Vitamin D deficiency can also be caused by inadequate nutritional intake of vitamin D, disorders limiting vitamin D absorption, and conditions impairing vitamin D conversion into active metabolites—including certain liver, kidney, and hereditary disorders. Deficiency impairs bone mineralization, leading to bone softening diseases such as rickets in children. It can also worsen osteomalacia and osteoporosis in adults, leading to an increased risk of bone fractures. Muscle weakness is also a common symptom of vitamin D deficiency,"
"birth, stillbirth and cretinism, or nutrient excess health-threatening conditions such as obesity and metabolic syndrome; and such common chronic systemic diseases as cardiovascular disease, diabetes, and osteoporosis. Undernutrition can lead to wasting in acute cases, and the stunting of marasmus in chronic cases of malnutrition. The first recorded dietary advice, carved into a Babylonian stone tablet in about 2500 BC, cautioned those with pain inside to avoid eating onions for three days. Scurvy, later found to be a vitamin C deficiency, was first described in 1500 BC in the Ebers Papyrus. According to Walter Gratzer, the study of nutrition probably"
"thought to correlated with cardiovascular disease, type 1 diabetes, type 2 diabetes, and some cancers. Review studies have also seen associations between vitamin D deficiency and preeclampsia. Vitamin D deficiency Vitamin D deficiency, or hypovitaminosis D, most commonly results from inadequate sunlight exposure (in particular sunlight with adequate ultraviolet B rays). Vitamin D deficiency can also be caused by inadequate nutritional intake of vitamin D, disorders limiting vitamin D absorption, and conditions impairing vitamin D conversion into active metabolites—including certain liver, kidney, and hereditary disorders. Deficiency impairs bone mineralization, leading to bone softening diseases such as rickets in children. It"
"had proven this, but published the result without giving Szent-Györgyi credit for it. This led to a bitter dispute over priority. In 1933, Walter Norman Haworth chemically identified the vitamin as -hexuronic acid, proving this by synthesis in 1933. Haworth and Szent-Györgyi proposed that L-hexuronic acid be named a-scorbic acid, and chemically -ascorbic acid, in honor of its activity against scurvy. The term's etymology is from Latin, ""a-"" meaning away, or off from, while -scorbic is from Medieval Latin ""scorbuticus"" (pertaining to scurvy), cognate with Old Norse ""skyrbjugr"", French ""scorbut"", Dutch ""scheurbuik"" and Low German ""scharbock"". Partly for this discovery,"