"37% of patients with LCDD are alive and do not have end stage renal disease. Light chain deposition disease Light chain deposition disease (LCDD) is a rare blood cell disease which is characterized by deposition of fragments of infection-fighting immunoglobulins, called light chains (LCs), in the body. LCs are normally cleared by the kidneys, but in LCDD, these light chain deposits damage organs and cause disease. The kidneys are almost always affected and this often leads to kidney failure. About half of people with light chain deposition disease also have a plasma cell dyscrasia, a spectrum of diseases that includes"
"Bright's disease Bright's disease is a historical classification of kidney diseases that would be described in modern medicine as acute or chronic nephritis. It was characterized by swelling, the presence of albumin in the urine and was frequently accompanied by high blood pressure and heart disease. The symptoms and signs of Bright's disease were first described in 1827 by the English physician Richard Bright, after whom the disease was named. In his ""Reports of Medical Cases"", he described 25 cases of dropsy (edema) which he attributed to kidney disease. Symptoms and signs included: inflammation of serous membranes, hemorrhages, apoplexy, convulsions,"
"Minnesota, died in 1922. Baseball Hall of Famer Ross Youngs died on October 22, 1927. Master of Science Fiction Horror, Howard Phillips “H. P.” Lovecraft, died from a combination of cancer and Bright’s Disease on March 15, 1937, at the age of 46. Albert Carl ""Al"" Ringling (1852–1916), eldest of the Ringling brothers, died of Bright's disease at the age of 63 in Wisconsin. Bright's disease Bright's disease is a historical classification of kidney diseases that would be described in modern medicine as acute or chronic nephritis. It was characterized by swelling, the presence of albumin in the urine and"
"stages of the condition, was dangerous and should be discouraged. Gull states that he formed this opinion after experience of dealing with cases of anoerexia nervosa, having previously himself been inclined to indulge patients' wishes. In 1872, Sir William Gull and Henry G. Sutton, M.B., F.R.C.P. presented a paper that challenged the earlier understanding of the causes of chronic Bright's Disease. The symptoms of Bright's Disease had been described in 1827 by the English physician Richard Bright who, like Gull, was based at Guy's Hospital. Dr. Bright's work characterised the symptoms as caused by a disease centred on the kidney."
"Brights (department store) Brights was a small group of department stores based in the South and South West of England. Frederick John Bright was born in Castle Hedingham, in Essex in 1832 and went onto work for the London Missionary Service in India. During his time in India, his son Percy was born by his wife June in 1864. They returned to England due to the ill health of Frederick's mother, firstly moving to Poole, then Lymington where Frederick ran a small haberdashery business for 6 years. In 1871 he opened a store at no. 9 Bournemouth Arcade selling needlework"
"A bust of Bright is held at the Royal College of Physicians of Edinburgh. Richard Bright (physician) Richard Bright (28 September 1789 – 16 December 1858) was an English physician and early pioneer in the research of kidney disease. He is particularly known for his description of Bright's disease. He was born in Bristol, Gloucestershire, the third son of Sarah and Richard Bright Sr., a wealthy merchant and banker. Bright Sr. shared his interest in science with his son, encouraging him to consider it as a career. In 1808, Bright Jr. joined the University of Edinburgh to study philosophy, economics"
"vital."" ""The bacteria is an innocent feller, and if he carries disease he carries the Simple Substance which causes disease, just as an elephant would."" As a follower of a mystical Christian religious sect headed by Emanuel Swedenborg, Kent believed that illness had spiritual causes: ""You cannot divorce medicine and theology. Man exists all the way down from his innermost spiritual, to his outermost natural."" Kent died of Bright's disease on June 5, 1916, in Stevensville, Montana. He was 67 years old at the time of his death. Not long after his death, Kent was eulogized by one contemporary as"
"Chronic Bright's disease was a more severe variant, where other organs are also affected. In their introduction, Gull and Sutton point out that Dr. Bright and others ""have fully recognised that the granular contracted kidney is usually associated with morbid changes in other organs of the body"" and that these co-existent changes were commonly grouped together and termed ""chronic Bright's disease."" The prevailing opinion at the time was that the kidney was the organ primarily affected, inducing a condition that would spread to other parts of the body and thereby cause other organs to suffer. Gull and Sutton argued that"
"blood pressure and increased resistance to flow was believed to explain the cardiac hypertrophy. It is now known that Bright's disease is caused by a wide and diverse range of kidney diseases; thus, the term ""Bright's disease"" is retained strictly for historical application. The disease was diagnosed frequently in patients with diabetes; at least some of these cases would probably correspond to a modern diagnosis of diabetic nephropathy. Bright's disease was historically treated with warm baths, blood-letting, squill, digitalis, mercuric compounds, opium, diuretics, laxatives, and dietary therapy, including abstinence from alcoholic drinks, cheese and red meat. Arnold Ehret was diagnosed"
"Richard Bright (physician) Richard Bright (28 September 1789 – 16 December 1858) was an English physician and early pioneer in the research of kidney disease. He is particularly known for his description of Bright's disease. He was born in Bristol, Gloucestershire, the third son of Sarah and Richard Bright Sr., a wealthy merchant and banker. Bright Sr. shared his interest in science with his son, encouraging him to consider it as a career. In 1808, Bright Jr. joined the University of Edinburgh to study philosophy, economics and mathematics, but switched to medicine the following year. In 1810, he accompanied Sir"
"Bright's Disease. It was soon released to the public that Mayo was ill. Originally, the newspapers reported that Mayo had pneumonia and was resting at his mansion. Mayo didn't stay resting for long. A week later, Mayo conducted business as usual, but citizens of Paintsville could tell he was seriously ill. Specialists were soon called in from Cincinnati. Mayo had been experiencing periods of unconsciousness according to reports. Bright's Disease had attacked the function of the liver, but news reports were still hopeful for a quick recovery. On March 1, 1914, Mayo was taken by special train to the Jewish"
"blindness and coma. Many of these cases were found to have albumin in their urine (detected by the spoon and candle-heat coagulation), and showed striking morbid changes of the kidneys at autopsy. The triad of dropsy, albumin in the urine and kidney disease came to be regarded as characteristic of Bright's disease. Subsequent work by Bright and others indicated an association with cardiac hypertrophy, which was attributed by Bright to stimulation of the heart. Subsequent work by Frederick Akbar Mahomed showed that a rise in blood pressure could precede the appearance of albumin in the urine, and the rise in"
"newborn son, Buford. After Cadle was diagnosed with Bright’s disease in the spring of 1914, his doctor gave him six months to live. Cadle returned to his mother’s home in Fredericksburg, where she and his family welcomed him. Cadle later described his conversion experience which began after a long prayer session through an afternoon and night. Cadle awoke feeling unchanged, so his mother encouraged him to lay down again. The next time he awoke, ""[A]ll the beauty of heaven seemed to burst into the windows. The old, dead apple tree seemed to be in full bloom and I could hear"
"for languages and could speak German, French, Italian, and English. In 1887, aged 21, he graduated as a Professor of Design from a college in Baden, and was drafted into the military only to be discharged after 9 months of service, because of heart disease. After studying in Frankfurt, he then taught there at a technical school for 15 years. At 31, he was diagnosed with Bright's disease (inflammation of the kidneys) by Dr Gustav Riedlin, and pronounced incurable by 24 of Europe's most respected doctors. He visited several sanitariums in Europe to learn holistic methods and philosophies including the"
"days; usually the crusts fall off and the skin heals, but sometimes, after severe blistering, scarring and discolored skin remain. Shingles may have additional symptoms, depending on the dermatome involved. The trigeminal nerve is the most commonly involved nerve, of which the ophthalmic division is the most commonly involved branch. When the virus is reactivated in this nerve branch it is termed ""zoster ophthalmicus"". The skin of the forehead, upper eyelid and orbit of the eye may be involved. Zoster ophthalmicus occurs in approximately 10% to 25% of cases. In some people, symptoms may include conjunctivitis, keratitis, uveitis, and optic"
"this assumption was incorrect. They presented evidence to show that the diseased state could also originate in other organs, and that the deterioration of the kidney is part of the general morbid change, rather than the primary cause. In some cases examined by Gull and Sutton, the kidney was only marginally affected while the condition was far more advanced in other organs. Gull and Sutton's main conclusion was that the morbid change in the arteries and capillaries was the primary and essential condition of the morbid state known as chronic Bright's disease with contracted kidney. They stated that the clinical"
"manner and childlike in some respects."" After her death, ""The Australian Star"" named her as the most favored journalist in Australia at the time. The Mitchell Library of the State Library of New South Wales holds eight of the poems she wrote throughout her life. Wildman became infected with nephritis, a kidney disease which at the time was classified as Bright's disease, beginning in 1894. She travelled to Queensland, in hope that upon return she could then travel all the way to Europe to improve her health; however, her health declined quickly, causing her to be unable to journey to"
"a limited form of eugenics by suggesting that human carriers of defective genes be given a compulsory visible mark - such as a forehead tattoo - to discourage potential mates with the same defect, in order to reduce the number of babies with diseases such as sickle cell anemia. In 1941, at age 40, Pauling was diagnosed with Bright's disease, a renal disease. Following the recommendations of Thomas Addis, who actively recruited Ava Helen Pauling as ""nutritionist, cook, and eventually as deputy 'doctor'"", Pauling was able to control the disease with Addis's then-unusual low-protein salt-free diet and vitamin supplements. Thus"
"1859. He was elected assistant-physician to St. Bartholomew's Hospital in 1860, was secretary to the medical council of the hospital from 14 January 1865 to 9 February 1867, and was in 1866 elected lecturer on forensic medicine in the medical school. He also held the office of medical registrar, and was elected physician to the hospital 23 January 1867, but did not long enjoy that office. One day, while going round the wards, he fell down in an uræmic convulsion, was moved to his own house, a victim of chronic Bright's disease. He grew blind so gradually that he did"
"was already suffering from an inflammation of the kidneys for sometime and diagnosed with Bright's disease (a type of kidney disease). At the onstart of the voyage in early May, he became very weak, and had to be carried aboard a ship in a wheelchair. He reached London on 10 May, and checked into Bailey's Hotel but was bedridden throughout his remaining days. He was not allowed to receive many visitors, though the Duke of Connaught and Strathearn, Prince Arthur paid two visits. Queen Victoria sent her personal physician, Douglas Powell to attend to his medical needs upon receiving news"
"many years. He never practised extensively, having a private fortune. He died 1 February 1870, aged 87. Bright married Elizabeth Mynors; John Edward Bright the barrister and Mynors Bright were their sons. John Bright (physician) John Bright (1783–1870) was an English physician. Bright was born in Derbyshire, and educated at Wadham College, Oxford, where he graduated B.A. 1801, and M.D. 1808. He at first practised in Birmingham, and was appointed physician to the General Hospital in 1810; but before long he moved to London. He was elected fellow of the Royal College of Physicians in 1809, was several times censor,"
"treated, because the infection area is limited to the skin, preventing the lethal factor, edema factor, and protective antigen from entering and destroying a vital organ. Without treatment, about 20% of cutaneous skin infection cases progress to toxemia and death. Respiratory infection in humans is relatively rare and presents as two stages. It infects the lymph nodes in the chest first, rather than the lungs themselves, a condition called hemorrhagic mediastinitis, causing bloody fluid to accumulate in the chest cavity, therefore causing shortness of breath. The first stage causes cold and flu-like symptoms. Symptoms include fever, shortness of breath, cough,"
"seems he had an episode of acute heart failure following running for a train. As a result, he discovered that he had Bright's disease (or hypertension) with a dilated heart, a condition with a poor prognosis at the time. As a consequence he changed his diet, discontinued coffee and stopped smoking. His condition improved, he lost weight and his blood pressure fell. Over the next 4 years he developed a dietary system based on this experience. The dietary system he developed involved fasting and promoted the idea that certain foods require an acid pH environment in digestion, and other foods"
"his name to Bright's disease) when Bright suggested that the source of the problem in oedema was the kidneys. Addison preferred to believe that the condition was caused by intemperance or some other external factor, and that since the whole body had been disrupted, it could not be localised to a specific organ. Addison further challenged Bright's student, Snow, when in 1839 Snow suggested from case studies and laboratory analysis that oedema was associated with an increase in albumin in the blood. Addison dismissed this as a mere epiphenomenon. Bird disagreed with Snow's proposed treatment, but his arguments clearly show"
"form of Bright's disease. He died, at his home in Cambridge, December 9, 1885, in his 53rd year. He married, September 17, 1862, Rachel P. Carmalt, of Lakeside, Pa, who survived him, with four of their six children, two daughters and two sons. Elisha Mulford Elisha Mulford (November 19, 1833 – December 9, 1885) was an American religious minister and author of ""The Nation: the Foundation of Civil Order and Political life in the United States"" and ""The Republic of God, an Institute of Theology"". Mulford was born in Montrose, Pa., November 19, 1833, and was prepared for Yale College"
"joint pains. The most commonly affected joints are those of the hands, particularly the knuckles of the second and third fingers. Bronzing of the skin. This deep tan color, in concert with insulin insufficiency due to pancreatic damage, is the source of a nickname for this condition: ""bronze diabetes"". The causes can be distinguished between primary cases (hereditary or genetically determined) and less frequent secondary cases (acquired during life). People of Celtic (Irish, Scottish, Welsh, Cornish, Breton etc.), English, and Scandinavian origin have a particularly high incidence, with about 10% being carriers of the principal genetic variant, the C282Y mutation"
"between 28% and 50%. Uveitis is estimated to be responsible for approximately 10%-20% of the blindness in the United States. Uveitis Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the outer fibrous layer composed of the sclera and cornea. The uvea consists of the middle layer of pigmented vascular structures of the eye and includes the iris, ciliary body, and choroid. Uveitis is an ophthalmic emergency and requires a thorough examination by an optometrist or ophthalmologist and urgent treatment to control the inflammation. It is often associated with other ocular problems."
"the bone marrow is affected. Diagnosis is typically by blood, urine, and stool tests. Genetic testing may be done to determine the specific mutation. Treatment depends on the type of porphyria and a person's symptoms. The treatment of porphyria of the skin generally involves the avoidance of sunlight. The treatment for acute porphyria may involve giving intravenous heme or a glucose solution. Rarely a liver transplant may be carried out. The frequency of porphyria is unclear. It is estimated that it affects 1 to 100 per 50,000 people. Rates vary around the world. Porphyria cutanea tarda is believed to be"
"urine encouraged phosphate precipitation and the consequent encrustation and stone formation. The last edition of ""Urinary Deposits"" was updated after Bird's death by Edmund Lloyd Birkett. Bird was the first to recognise that urinary casts are an indication of Bright's disease. Casts were first discovered by Henry Bence Jones. They are microscopic cylinders of Tamm-Horsfall protein that have been precipitated in the kidneys and then released into the urine. A prevalent idea in the 18th and early 19th centuries was that illness was a result of the condition of the whole body. The environment and the activity of the patient"
"Argyria Argyria or argyrosis is a condition caused by excessive exposure to chemical compounds of the element silver, or to silver dust. The most dramatic symptom of argyria is that the skin turns purple or purple-grey. It may take the form of ""generalized argyria"" or ""local argyria"". Generalized argyria affects large areas over much of the visible surface of the body. Local argyria shows in limited regions of the body, such as patches of skin, parts of the mucous membrane or the conjunctiva. The terms argyria and argyrosis have long been used interchangeably, with argyria being used more frequently. Argyrosis"
"hospital. The strain led to a period of serious illness, but she insisted on returning to duty once she recovered. Her work fed over into her personal life when she met French ambulance driver, Daniel Mistrick, marrying him on the Verdun battlefield according to French genealogy sources. She remained in Europe, working at a feeding station in Germany after the war ended with the French army of occupation. In 1921, she returned to Newport to nurse her ailing mother at 23 West Street, but was herself seriously ill and died of kidney disease, Bright’s disease, on 30 January 1921 aged"
"scarring. This maculopapular rash can recur every 4–6 weeks and predominantly affect the upper chest and arms. Erythema nodosum-like skin lesions can affect the legs. When a skin biopsy is examined under the microscope, there can be signs of a neutrophilic dermatosis. The joint pains in BADAS are typically episodic, migratory and affecting multiple joints. They can affect the small joints (e.g. interphalangeal joints of the fingers) and there can be associated tenosynovitis, but there is no erosion or deformation in the long term. Diarrhea may also occur. Immune complexes are thought to cause blood vessel damage, attracting neutrophils into"
"of the severest forms have difficulties with eating due to the rawness in their mouths and often have to have a feeding tube fitted. EB has a number of distinct forms: in the least severe form, blistering is confined to the hands and feet. In more severe cases, the whole body is affected and wounds heal very slowly, giving rise to scarring, physical deformity and significant disability. DEBRA UK is the national charity that supports individuals and families affected by EB. There are at least 5,000 people living with this devastating condition in the UK and 500,000 people worldwide. DEBRA"