"sweat, and ""congenital"" indicates that the condition is present from birth. People with this disorder are very likely to injure themselves in ways that would normally be prevented by feeling pain. For example, a patient could burn themselves severely and not even notice. The main features of the disorder are lack of pain sensation, painless injuries of the arms, legs, and oral structures, hyperthermia during hot weather because of inability to sweat, syndromic intellectual disability as a result of hyperthermia, infection and scarring of the tongue, lips and gums, chronic infections of bones and joints, bone fractures, multiple scars, osteomyelitis"
"Hyperhidrosis Hyperhidrosis is a condition characterized by abnormally increased sweating, in excess of that required for regulation of body temperature. Although primarily a physical burden, hyperhidrosis can deteriorate quality of life from a psychological, emotional, and social perspective. It has been called by some 'the silent handicap'. Both the words diaphoresis and hidrosis can mean either perspiration (in which sense they are synonymous with ""sweating"") or ""excessive"" perspiration, in which case they refer to a specific, narrowly defined, clinical disorder. Hyperhidrosis can either be ""generalized"", or ""localized"" to specific parts of the body. Hands, feet, armpits, groin, and the facial"
"Hypohidrosis Hypohidrosis is disorder in which a person exhibits diminished sweating in response to appropriate stimuli. In contrast with hyp""er""hidrosis, which is a socially troubling yet benign condition, the consequences of untreated hypohidrosis include hyperthermia, heat stroke and death. An extreme case of hypohydrosis in which there is a complete absence of sweating and the skin is dry is termed anhidrosis. Sweat is readily visualized by a topical indicator such as iodinated starch (Minor test) or sodium alizarin sulphonate, both of which undergo a dramatic colour change when moistened by sweat. A thermoregulatory sweat test can evaluate the body’s response"
"Congenital insensitivity to pain with anhidrosis Congenital insensitivity to pain with anhidrosis (CIPA), also called hereditary sensory and autonomic neuropathy type IV, is an extremely rare inherited disorder of the nervous system which prevents the sensation of pain, heat, cold, or ""any"" real nerve-related sensations (including feeling the need to urinate); however, patients can still feel pressure. CIPA is the fourth type of hereditary sensory and autonomic neuropathy (HSAN), known as HSAN IV. (It is also referred to as HSAN Type IV). A person with CIPA cannot feel pain or differentiate even extreme temperatures. ""Anhidrosis"" means the body does not"
"bacterial infection. Miliaria pustulosa is preceded by another dermatitis that has produced injury, destruction, or blocking of the sweat duct. ""Postmiliarial hypohidrosis"" is a skin condition that results from occlusion of sweat ducts and pores, and may be severe enough to impair an individual's ability to perform sustained work in a hot environment. ""Tropical anhidrotic asthenia"" is a skin condition, a rare form of miliaria, with long-lasting poral occlusion, which produces anhidrosis and heat retention. ""Occlusion miliaria"" is a skin condition that is accompanied by anhidrosis and increased heat-stress susceptibility, all after the application of extensive polyethylene film occlusion for"
"neurological diseases, the primary pathology is often irreversible. In these instances, prevention of further neurological damage, such as good glycaemic control in diabetes, is the cornerstone of management. In acquired generalized anhidrosis, spontaneous remission may be observed in some cases. Numerous cases have been reported to respond effectively to systemic corticosteroids. Although an optimum dose and regime has not been established, pulse methylprednisolone (up to 1000 mg ⁄ day) has been reported to have good effect. Hypohidrosis Hypohidrosis is disorder in which a person exhibits diminished sweating in response to appropriate stimuli. In contrast with hyp""er""hidrosis, which is a socially"
"""playing"" outside the mother inspected them of injuries as they did not feel pain. The Peacock family was inbred since around the civil war. Congenital insensitivity to pain with anhidrosis Congenital insensitivity to pain with anhidrosis (CIPA), also called hereditary sensory and autonomic neuropathy type IV, is an extremely rare inherited disorder of the nervous system which prevents the sensation of pain, heat, cold, or ""any"" real nerve-related sensations (including feeling the need to urinate); however, patients can still feel pressure. CIPA is the fourth type of hereditary sensory and autonomic neuropathy (HSAN), known as HSAN IV. (It is also"
"the severe hardening of the arteries (arteriosclerosis). There is currently no treatment available. Individuals with HGPS typically appear normal at birth, but their growth is severely retarded, resulting in short stature, a very low body weight and delayed tooth eruption. Their facial/cranial proportions and facial features are abnormal, characterized by larger-than-normal eyes, a thin, beaked nose, thin lips, small chin and jaw (micrognathia), protruding ears, scalp hair, eyebrows, and lashes, hair loss, large head, large fontanelle and generally appearing aged. Other features include skeletal alterations (osteolysis, osteoporosis), amyotrophy (wasting of muscle), lipodystrophy and skin atrophy (loss of subcutaneous tissue and"
"Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND) or Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles. Some also use the term motor neuron disease for a group of conditions of which ALS is the most common. ALS is characterized by stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size. This results in difficulty speaking, swallowing, and eventually breathing. The cause is not known in 90% to 95% of cases. The remaining 5–10% of cases are inherited from a person's parents."
"Intermittent hydrarthrosis Intermittent hydrarthrosis (IH), also known as ""periodic synoviosis"", ""periodic benign synovitis"", or ""periodic hydrarthritis"", is a chronic condition of unknown cause characterized by recurring, temporary episodes of fluid accumulation (effusion) in the knee. While the knee is mainly involved, occasionally other joints such as the elbow or ankle can additionally be affected. Fluid accumulation in the joint can be extensive causing discomfort and impairing movement, although affected joints are not usually very painful. While the condition is chronic, it does not appear to progress to more destructive damage of the joint. It seems to affect slightly more women"
"itself is overactive—so overactive that they may sweat four or five times more than is typical. Millions of people are affected by this condition, but more than half never receive treatment due to embarrassment or lack of awareness. While it most commonly affects the armpits, feet, and hands, it is possible for someone to experience this condition over their whole body. The face is another common area for hyperhidrosis to be an issue. Sweating uncontrollably is not always expected and may be embarrassing to sufferers of the condition. It can cause both physiological and emotional problems in patients. It is"
"the findings of the primary dermatological disorder. The treatment options for hypohidrosis and anhidrosis is limited. Those with hypohidrosis should avoid drugs that can aggravate the condition (see medication-causes). They should limit activities that raise the core body temperature and if exercises are to be performed, they should be supervised and be performed in a cool, sheltered and well-ventilated environment. In instances where the cause is known, treatment should be directed at the primary pathology. In autoimmune diseases, such as Sjogren syndrome and systemic sclerosis, treatment of the underlying disease using immunosuppressive drugs may lead to improvement in hypohidrosis. In"
"hemisphere stroke yet denied that there were any problems with their left arm or leg. This condition is known as anosognosia for hemiplegia (AHP). This condition has evolved throughout the years and is now used to describe people who lack subjective experience in both neurological and neuropsychological cases. A wide variety of disorders are associated with anosognosia. For example, patients who are blind from cortical lesions might in fact be unaware that they are blind and may state that they do not suffer from any visual disturbances. Individuals with aphasia and other cognitive disorders may also suffer from anosognosia as"
"Anuria Anuria, sometimes called anuresis, is nonpassage of urine, in practice is defined as passage of less than 100 milliliters of urine in a day. Anuria is often caused by failure in the function of kidneys. It may also occur because of some severe obstruction like kidney stones or tumours. It may occur with end stage renal disease. It is a more extreme reduction than oliguria (hypouresis), with 100 mL/day being the conventional (albeit slightly arbitrary) cutoff point between the two. Failure of kidney function, which can have multiple causes including medications or toxins (e.g., antifreeze, cephalosporins, ACEIs); diabetes; high"
"open-toe shoes, as the feet slide around in the shoe because of sweat. Some careers present challenges for people with hyperhidrosis. For example, careers that require the use of a knife may not be safely performed by people with excessive sweating of the hands. The risk of dehydration can limit the ability of some to function in extremely hot (especially if also humid) conditions. Even the playing of musical instruments can be uncomfortable or difficult because of sweaty hands. It is estimated that the incidence of focal hyperhidrosis may be as high as 2.8% of the population of the United"
"Most have delayed development of mental abilities and motor skills such as sitting and walking. Other neurological problems can include intellectual disability, seizures, weak muscle tone (hypotonia), poor coordination, and difficulty walking. Some affected individuals have abnormal brain structures, such as underdevelopment of the tissue connecting the left and right halves of the brain (corpus callosum), wasting away (atrophy) of the exterior part of the brain known as the cerebral cortex, or patches of damaged tissue (lesions) on some parts of the brain. Because of the severe health effects, many individuals with pyruvate dehydrogenase deficiency do not survive past childhood,"
"and can become a danger to others and himself. The syndrome of ""Amok"" is found in the DSM-IV TR. Anhedonia refers to an inability to experience pleasure, and may be described as a feeling of emotional emptiness. It can be a negative symptom of schizophrenia. It also may be seen in severe depressive states and schizoid personality disorder. Anosognosia is a condition in which a person who suffers certain disability seems unaware of the existence of his or her disability. Hemiasomatognosia is a subtype of anosognosia in which the person suffering from hemiplegia neglects one half of his body. Anton"
"manage antibiotic resistance. Achlorhydria Achlorhydria or hypochlorhydria refers to states where the production of hydrochloric acid in gastric secretions of the stomach and other digestive organs is absent or low, respectively. It is associated with various other medical problems. Irrespective of the cause, achlorhydria can result as known complications of bacterial overgrowth and intestinal metaplasia and symptoms are often consistent with those diseases: Since acidic pH facilitates the absorption of iron, achlorhydric patients often develop iron deficiency anemia. Acidic environment of stomach helps conversion of pepsinogen into pepsin which is most important to digest the protein into smaller component like"
"well. Most have delayed development of mental abilities and motor skills such as sitting and walking. Other neurological problems can include intellectual disability, seizures, weak muscle tone (hypotonia), poor coordination, and difficulty walking. Some affected individuals have abnormal brain structures, such as underdevelopment of the tissue connecting the left and right halves of the brain (corpus callosum), wasting away (atrophy) of the exterior part of the brain known as the cerebral cortex, or patches of damaged tissue (lesions) on some parts of the brain. Because of the severe health effects, many individuals with pyruvate dehydrogenase deficiency do not survive past"
"been posited over the years. These included ""Brucella"", gonorrhoea, and syphilis. Adrenaline injections, mercury, various hormone treatments (ovarian extracts, growth hormone, stilboestrol), and ergotamine tartrate are among other treatments at some time used without significant or long-term benefit. Physiotherapy, surgery, exclusion diets (following allergen testing) have similarly shown no particular success in early reports of IH. Intermittent hydrarthrosis Intermittent hydrarthrosis (IH), also known as ""periodic synoviosis"", ""periodic benign synovitis"", or ""periodic hydrarthritis"", is a chronic condition of unknown cause characterized by recurring, temporary episodes of fluid accumulation (effusion) in the knee. While the knee is mainly involved, occasionally other joints"
"Bedridden Being bedridden is a form of immobility that can present as the inability to move or even sit upright. It differs from bed-rest, a form of non-invasive treatment that is usually part of recovery or the limitation of activities. Some of the more serious consequences of being bedridden is the high risk of developing thrombosis and muscle wasting (atrophy). Its meaning is derived from a middle English term (bedrid) from a 1300s past tense form of riding a bed. This is a voluntary medical treatment still used today to help cure illness. Current views regarding this treatment are that"
"in atherosclerosis. Atherosclerosis is a disease marked by the hardening of arteries. This is caused by an atheroma or plaque in the artery wall and is a build-up of cell debris, that contain lipids, (cholesterol and fatty acids), calcium and a variable amount of fibrous connective tissue. Accidental intraarterial injection either iatrogenically or through recreational drug use can cause symptoms such as intense pain, paresthesia and necrosis. It usually causes permanent damage to the limb; often amputation is necessary. Among the Ancient Greeks, the arteries were considered to be ""air holders"" that were responsible for the transport of air to"
"Astasis """"Astasia"" redirects here. This term was also applied to chlorophyll-less ""Euglena. Astasis is a lack of motor coordination marked by an inability to stand, walk or even sit without assistance due to disruption of muscle coordination. The term ""astasia"" is interchangeable with ""astasis"" and is most commonly referred to as ""astasia"" in the literature describing it. Astasis is the inability to stand or sit up without assistance in the absence of motor weakness or sensory loss (although the inclusion of 'the lack of motor weakness' has been debated by some physicians). It is categorized more as a symptom than"
"is when there is greater functional use of the lower limbs than the upper limbs. Hemiplegia, is a type of paralysis that effects one side of the body. Monoplegia is a condition that impacts only one limb. Spasticity limits muscle movement as a result of tightness in muscle. Athetosis is a condition that has resulted in damage to the basal ganglia. People with this have involuntary movements in their limbs, with these involuntary movements being worse when the person is under stress. Athetosis may co-present with Dysarthria. Ataxia involves a lack of coordination, and an inability to engage in rapid,"
"Huntington's disease Huntington's disease (HD), also known as Huntington's chorea, is an inherited disorder that results in death of brain cells. The earliest symptoms are often subtle problems with mood or mental abilities. A general lack of coordination and an unsteady gait often follow. As the disease advances, uncoordinated, jerky body movements become more apparent. Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk. Mental abilities generally decline into dementia. The specific symptoms vary somewhat between people. Symptoms usually begin between 30 and 50 years of age, but can start at any age."
"States. It affects men and women equally, and most commonly occurs among people aged 25–64 years, though some may have been affected since early childhood. About 30–50% of people have another family member afflicted, implying a genetic predisposition. In 2006, researchers at Saga University in Japan reported that primary palmar hyperhidrosis maps to gene locus 14q11.2–q13. Hyperhidrosis Hyperhidrosis is a condition characterized by abnormally increased sweating, in excess of that required for regulation of body temperature. Although primarily a physical burden, hyperhidrosis can deteriorate quality of life from a psychological, emotional, and social perspective. It has been called by some"
"Hyperhydricity Hyperhydricity (previously known as vitrification) is a physiological malformation that results in excessive hydration, low lignification, impaired stomatal function and reduced mechanical strength of tissue culture-generated plants. The consequence is poor regeneration of such plants without intensive greenhouse acclimation for outdoor growth. Additionally, it may also lead to leaf-tip and bud necrosis in some cases, which often leads to loss of apical dominance in the shoots. In general, the main symptom of hyperhydricity is translucent characteristics signified by a shortage of chlorophyll and high water content. Specifically, the presence of a thin or absent cuticular layer, reduced number of"
"medical texts as early as 1550 BC. Enuresis Enuresis (from the Ancient Greek ἐνούρησις ""enoúrēsis"") is a repeated inability to control urination. Use of the term is usually limited to describing people old enough to be expected to exercise such control. Involuntary urination is also known as urinary incontinence. Types of enuresis include: Classification Nocturnal enuresis usually presents with voiding of a lot urine during sleep in a child in whom it is difficult to awake. It also may be accompanied by bladder dysfunction during the day which is termed non-mono symptomatic enuresis. Day time enuresis also known as urinary"
"Anhedonia Anhedonia is a diverse array of deficits in hedonic function, including reduced motivation or ability to experience pleasure. While earlier definitions of anhedonia emphasized the inability to experience pleasure, anhedonia is used by researchers to refer to reduced motivation, reduced anticipatory pleasure (wanting), reduced consummatory pleasure (liking), and deficits in reinforcement learning. In the DSM-V, anhedonia is a component of depressive disorders, substance related disorders, psychotic disorders, and personality disorders, where it is defined by either a reduced ability to experience pleasure, or a diminished interest in engaging in pleasurable activities. While the ICD-10 does not explicitly mention anhedonia,"
"Dysdiadochokinesia Dysdiadochokinesia, dysdiadochokinesis, dysdiadokokinesia, dysdiadokokinesis (from Greek ""δυς"" ""dys"" ""bad"", ""διάδοχος"" ""diadochos"" ""succeeding"", ""κίνησις"" ""kinesis"" ""movement""), often abbreviated as DDK, is the medical term for an impaired ability to perform rapid, alternating movements (i.e., diadochokinesia). Complete inability is called adiadochokinesia. Dysdiadochokinesia is a feature of cerebellar ataxia and may be the result of lesions to either the cerebellar hemispheres or the frontal lobe (of the cerebrum), it can also be a combination of both. It is thought to be caused by the inability to switch on and switch off antagonising muscle groups in a coordinated fashion due to hypotonia, secondary"
"Histotoxic hypoxia Histotoxic hypoxia (also called histoxic hypoxia) is the inability of cells to take up or use oxygen from the bloodstream, despite physiologically normal delivery of oxygen to such cells and tissues. Histotoxic hypoxia results from tissue poisoning, such as that caused by cyanide (which acts by inhibiting cytochrome oxidase) and certain other poisons like hydrogen sulfide (byproduct of sewage and used in leather tanning). Histotoxic hypoxia refers to a reduction in ATP production by the mitochondria due to a defect in the cellular usage of oxygen. An example of histotoxic hypoxia is cyanide poisoning. There is a profound"
"with this disorder. Intellectual disability is usually present. Type 4, congenital insensitivity to pain with anhidrosis (CIPA), is an autosomal recessive condition and affected infants present with episodes of hyperthermia unrelated to environmental temperature, anhidrosis and insensitivity to pain. Palmar skin is thickened and charcot joints are commonly present. NCV shows motor and sensory nerve action potentials to be normal. The histopathology of peripheral nerve biopsy reveals absent small unmyelinated fibers and mitochondria are abnormally enlarged. Management of Hereditary sensory and autonomic neuropathy Type 4: Treatment of manifestations: Treatment is supportive and is best provided by specialists in pediatrics, orthopedics,"
"Madarosis Madarosis is a condition that results in the loss of eyelashes, and sometimes eyebrows. The term ""madarosis"" is Greek for the word ""madao"" which means ""to fall off."" It originally was a disease of only losing eyelashes but it currently is the loss of both eyelashes and eyebrows. Eyebrows and eyelashes are both important in the prevention of bacteria and other foreign objects from entering the eye. A majority of patients with madarosis have leprosy, and it was reported that 76% of patients with varying types of leprosy had madarosis. Madarosis is not a critical or severe condition. The"