"blood flow activates the renin–angiotensin–aldosterone system (RAAS), causing fluid retention and mild hypertension. As the kidneys inflame, they begin to excrete needed protein from the affected individual's body into the urine stream. This condition is called proteinuria. Loss of necessary protein due to nephritis can result in several life-threatening symptoms. The most serious complication of nephritis can occur if there is significant loss of the proteins that keep blood from clotting excessively. Loss of these proteins can result in blood clots, causing sudden stroke. The diagnosis depends on the cause of the nephritis, in the case of lupus nephritis, blood"
"Intestinal neuronal dysplasia Intestinal neuronal dysplasia (or neuronal intestinal dysplasia or NID) is an inherited disease of the intestine that affects one in 3000 children and adults. The intestine uses peristalsis to push its contents toward the anus; IND sufferers have a problem with the motor neurons that lead to the intestine, inhibiting this process and thus preventing digestion. It can often be confused for Hirschsprung's disease, as both have similar symptoms. IND can be grouped into NID A and NID B, with the ""A"" form affecting the sympathetic innervation, and the ""B"" version affecting the parasympathetic innervation. In 2002"
"IgA nephropathy IgA nephropathy (IgAN), also known as IgA nephritis, Berger's disease () (and variations), or synpharyngitic glomerulonephritis, is a disease of the kidney (or nephropathy) and the immune system; specifically it is a form of glomerulonephritis or an inflammation of the glomeruli of the kidney. Aggressive Berger's disease (a rarer form of the disease) can attack other major organs, such as the liver, skin and heart. IgA nephropathy is the most common glomerulonephritis worldwide, however aggressive Berger's disease is on the NORD list of rare diseases. Primary IgA nephropathy is characterized by deposition of the IgA antibody in the"
"have evidence of pancreatic involvement at autopsy. Symptomatic kidney involvement occurs in just 0.7% of cases, although evidence of kidney involvement at autopsy has been reported in up to 22% of people and occurs exclusively in cases of chronic disease. Symptomatic kidney involvement is usually nephrocalcinosis, although granulomatous interstitial nephritis that presents with reduced creatinine clearance and little proteinuria is a close second. Less commonly, the epididymis, testicles, prostate, ovaries, fallopian tubes, uterus, or the vulva may be affected, the latter may cause vulva itchiness. Testicular involvement has been reported in about 5% of people at autopsy. In males, sarcoidosis"
"be seen on cystoscopy. Other conditions which can produce similar symptoms include urinary tract infection (UTI), overactive bladder, sexually transmitted infections, endometriosis, bladder cancer, and prostatitis. There is no cure for interstitial cystitis. Treatments that may improve symptoms include lifestyle changes, medications, or procedures. Lifestyle changes may include stopping smoking and reducing stress. Medications may include ibuprofen, pentosan polysulfate, or amitriptyline. Procedures may include bladder distention, nerve stimulation, or surgery. Pelvic floor exercises and long term antibiotics are not recommended. In the United States and Europe it is estimated that around 0.5% of people are affected. Women are affected about"
"therefore it is sometimes called Berger’s disease. IgA nephropathy IgA nephropathy (IgAN), also known as IgA nephritis, Berger's disease () (and variations), or synpharyngitic glomerulonephritis, is a disease of the kidney (or nephropathy) and the immune system; specifically it is a form of glomerulonephritis or an inflammation of the glomeruli of the kidney. Aggressive Berger's disease (a rarer form of the disease) can attack other major organs, such as the liver, skin and heart. IgA nephropathy is the most common glomerulonephritis worldwide, however aggressive Berger's disease is on the NORD list of rare diseases. Primary IgA nephropathy is characterized by"
"ear lobe, nipple, or scrotum. Various acute neurological problems, termed neuroborreliosis, appear in 10–15% of untreated people. These include facial palsy, which is the loss of muscle tone on one or both sides of the face, as well as meningitis, which involves severe headaches, neck stiffness, and sensitivity to light. Inflammation of the spinal cord's nerve roots can cause shooting pains that may interfere with sleep, as well as abnormal skin sensations. Mild encephalitis may lead to memory loss, sleep disturbances, or mood changes. In addition, some case reports have described altered mental status as the only symptom seen in"
"known as nephrotic syndrome). If emboli have spread to the digestive tract, reduced appetite, nausea and vomiting may occur, as well as nonspecific abdominal pain, gastrointestinal hemorrhage (vomiting blood, or admixture of blood in the stool), and occasionally acute pancreatitis (inflammation of the pancreas). Both the central nervous system (brain and spinal cord) and the peripheral nervous system may be involved. Emboli to the brain may cause stroke-like episodes, headache and episodes of loss of vision in one eye (known as amaurosis fugax). Emboli to the eye can be seen by ophthalmoscopy and are known as plaques of Hollenhorst. Emboli"
"Labyrinthitis Labyrinthitis, also known as vestibular neuritis, is the inflammation of the inner ear. It results in a sensation of the world spinning and also possible hearing loss or ringing in the ears. It can occur as a single attack, a series of attacks, or a persistent condition that diminishes over three to six weeks. It may be associated with nausea, vomiting, and eye nystagmus. The cause is often not clear. It may be due to a virus, but it can also arise from bacterial infection, head injury, extreme stress, an allergy, or as a reaction to medication. 30% of"
"perineal hygiene should be stressed. This includes avoiding use of vaginal deodorant sprays and proper wiping after urination and bowel movements. Intercourse should be avoided until symptoms subside. Urethritis Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. It is usually caused by infection with bacteria. The bacterial infection is often sexually transmitted, but not in every instance; it can be idiopathic, for example. The disease is classified as either gonococcal urethritis, caused by ""Neisseria gonorrhoeae"", or non-gonococcal urethritis (NGU), most commonly caused by ""Chlamydia trachomatis"". NGU, sometimes called nonspecific urethritis (NSU), has both"
"interstitial nephritis, vascular injury, and diabetic nephropathy. In these situations, PTECs may be directly affected by protein (e.g., proteinuria in glomerulonephritis), glucose (in diabetes mellitus), or cytokines (e.g., interferon-γ and tumor necrosis factors). There are several ways in which PTECs may respond: producing cytokines, chemokines, and collagen; undergoing epithelial mesenchymal trans-differentiation; necrosis or apoptosis. Proximal tubule The proximal tubule is the portion of the duct system of the nephron of the kidney which leads from Bowman's capsule to the loop of Henle. It is conventionally divided into the proximal convoluted tubule (PCT) and the proximal straight tubule (PST). The most"
"affected people had a common cold prior to developing the disease. Either bacterial or viral labyrinthitis can cause a permanent hearing loss in rare cases. This appears to result from an imbalance of neuronal input between the left and right inner ears. Vestibular neuritis affects approximately 35 people per million per year. It typically occurs in those between 30 and 60 years of age. There is no significant gender difference. It derives its name from the labyrinths that house the vestibular system, which senses changes in head position. The main symptom of labyrinthitis is severe vertigo. Rapid and undesired eye"
"Infrapatellar bursitis Infrapatellar bursitis is the inflammation of one or both of the infrapatellar bursa, which are located just below the kneecap. Symptoms of bursitis commonly include swelling and knee pain. Bursitis often develops gradually over a period of days to even months but may develop more rapidly, especially in the event of trauma or infection. Bursitis affecting the superficial infrapatellar bursa is an occupational hazard of persons whose work involves kneeling on hard surfaces. Depending on the occupation affected it is known by a variety of nicknames, most commonly floor layers' knee, but also plumbers' knee, clergyman's knee, hoe's"
"Enteric neuropathy Enteric neuropathy is a degenerative neuromuscular condition of the digestive system. In simple terms the gut stops functioning, due to degradation of the nerves and muscles. The condition affects all parts of the digestive tract. There is no known cure or treatment for enteric neuropathy at this time; it is only possible to work on symptom management. The name enteric neuropathy only seems to be used for diagnosis within the UK. The most common name worldwide for this condition is Intestinal pseudoobstruction. The main symptom of enteric neuropathy is severe and constant pain. Other symptoms include nausea, vomiting,"
"a stress-free environment should decrease the amount of clinical disease seen in flocks. Avian nephritis virus Avian nephritis virus is an astrovirus which causes 'avian nephritis' in chickens. Causes: Infectious Stunting Syndrome — ISS — Baby Chick Nephritis — BCN. The virus has been reported in Japan, Europe, USA and New Zealand. The disease is mainly transmitted horizontally by the oro-faecal route, but rarely vertical transmission may occur. Clinical signs of the disease are normally only seen in chicks less than two weeks old, and these signs should be mild unless the chick is immunosuppressed. In mild cases diarrhea, stunted"
"reasons that are unclear, it occasionally occurs in people with an apparently normal general condition. Necrotizing fasciitis can occur at any part of the body, but it is more commonly seen at the extremities, perineum, and genitals. Only a few of such cases arise from the chest and abdomen. Trauma is the usual cause of the infection such as intravenous drug injection, insulin injection, animals and insect bites, catheter insertion over the skin, or a fistula connecting skin to the internal body organs. Skin infections such as abscess and ulcers can also complicate necrotizing fasciitis. Spreading of infection through blood"
"3,000 deaths down from 4,000 in 1990. A URI may be classified by the area inflamed. Rhinitis affects the nasal mucosa, while rhinosinusitis or sinusitis affects the nose and paranasal sinuses, including frontal, ethmoid, maxillary, and sphenoid sinuses. Nasopharyngitis (rhinopharyngitis or the common cold) affects the nares, pharynx, hypopharynx, uvula, and tonsils generally. Without involving the nose, pharyngitis inflames the pharynx, hypopharynx, uvula, and tonsils. Similarly, epiglottitis (supraglottitis) inflames the superior portion of the larynx and supraglottic area; laryngitis is in the larynx; laryngotracheitis is in the larynx, trachea, and subglottic area; and tracheitis is in the trachea and subglottic"
"Intertrigo Intertrigo refers to a type of inflammatory rash (dermatitis) of the superficial skin that occurs within a person's body folds. These areas are more susceptible to irritation and subsequent infection due to factors that promote skin breakdown such as moisture, friction, and exposure to bodily secretions such as sweat, urine or feces. Areas of the body which are more likely to be affected by intertrigo include the inframammary fold, intergluteal cleft, armpits, and spaces between the fingers or toes. Skin affected by intertrigo is more prone to infection than intact skin. The term ""intertrigo"" commonly refers to a secondary"
"in the stools. The joints involved tend to be the ankles, knees, and elbows, but arthritis in the hands and feet is possible; the arthritis is nonerosive and hence causes no permanent deformity. Forty percent have evidence of kidney involvement, mainly in the form of hematuria (blood in the urine), but only a quarter will have this in sufficient quantities to be noticeable without laboratory tests. Problems in other organs, such as the central nervous system (brain and spinal cord) and lungs may occur, but is much less common than in the skin, bowel and kidneys. Of the 40% of"
"Intermittent hydrarthrosis Intermittent hydrarthrosis (IH), also known as ""periodic synoviosis"", ""periodic benign synovitis"", or ""periodic hydrarthritis"", is a chronic condition of unknown cause characterized by recurring, temporary episodes of fluid accumulation (effusion) in the knee. While the knee is mainly involved, occasionally other joints such as the elbow or ankle can additionally be affected. Fluid accumulation in the joint can be extensive causing discomfort and impairing movement, although affected joints are not usually very painful. While the condition is chronic, it does not appear to progress to more destructive damage of the joint. It seems to affect slightly more women"
"can affect many other organ systems. Inflammation of the interior portion of the eye, known as uveitis, can cause blurred vision and eye pain, especially when exposed to light (photophobia). Inflammation may also involve the white part of the eye (sclera), a condition called episcleritis. Both episcleritis and uveitis can lead to loss of vision if untreated. Crohn's disease that affects the ileum may result in an increased risk of gallstones. This is due to a decrease in bile acid resorption in the ileum and the bile gets excreted in the stool. As a result, the cholesterol/bile ratio increases in"
"Avian nephritis virus Avian nephritis virus is an astrovirus which causes 'avian nephritis' in chickens. Causes: Infectious Stunting Syndrome — ISS — Baby Chick Nephritis — BCN. The virus has been reported in Japan, Europe, USA and New Zealand. The disease is mainly transmitted horizontally by the oro-faecal route, but rarely vertical transmission may occur. Clinical signs of the disease are normally only seen in chicks less than two weeks old, and these signs should be mild unless the chick is immunosuppressed. In mild cases diarrhea, stunted growth and skin lesions are the common clinical signs. Clinical signs are more"
"Intrahepatic cholestasis of pregnancy Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of pregnancy, jaundice of pregnancy, and prurigo gravidarum, is a medical condition in which cholestasis occurs during pregnancy. It typically presents with troublesome itching and can lead to complications for both mother and fetus. Pruritus (itching) has long been considered to be a common symptom of pregnancy. The vast majority of times, itching is a minor annoyance caused by changes to the skin, especially that of the abdomen. However, there are instances when itching is a symptom of ICP. This is usually most intense on"
"(which if significant enough may require the insertion of a pacemaker). It can affect the musculoskeletal system causing non-inflammatory transient arthritis and / or arthralgias. It can affect the nervous system manifesting as facial paralysis (Bell's palsy, classically bilateral), fatigue, and loss of memory. Stage 3 is known as the Late Disseminated stage and occurs months - years after the initial infection. Effects of the 3 stage include encephalitis or meningitis.. as well as migratory arthropathies (most commonly of the knee). Anaplasmosis and babesiosis are also common tick-borne pathogens carried by the Ixodes tick that infect humans similarly to Borrelia"
"Enteritis Enteritis is inflammation of the small intestine. It is most commonly caused by food or drink contaminated with pathogenic microbes, such as ""serratia"", but may have other causes such as NSAIDs, cocaine, radiation therapy as well as autoimmune conditions like Crohn's disease and coeliac disease. Symptoms include abdominal pain, cramping, diarrhoea, dehydration, and fever. Related diseases of the gastrointestinal system include inflammation of the stomach and large intestine. Duodenitis, jejunitis and ileitis are subtypes of enteritis which are only localised to a specific part of the small intestine. Inflammation of both the stomach and small intestine is referred to"
"in adults. Perthes is a form of osteochondritis which only affects the hip, although other forms of osteochondritis can affect elbows, knees, ankles, and feet. Bilateral Perthes, which means both hips are affected, should always be investigated thoroughly to rule out multiple epiphyseal dysplasia. Common symptoms include pain in the hip, knee, ankle (hip pathology can refer pain to a normal knee or ankle), or groin, exacerbated by hip or leg movement, especially internal hip rotation (with the knee flexed 90°, twisting the lower leg away from the center of the body). The range of motion is reduced, particularly in"
"Neutropenic enterocolitis Neutropenic enterocolitis, also known as typhlitis or typhlenteritis, and less commonly called caecitis or cecitis, is inflammation of the cecum (part of the large intestine) that may be associated with infection. It is particularly associated with neutropenia, a low level of neutrophil granulocytes (the most common form of white blood cells) in the blood. Signs and symptoms of typhlitis may include diarrhea, a distended abdomen, fever, chills, nausea, vomiting, and abdominal pain or tenderness. The condition is usually caused by Gram-positive enteric commensal bacteria of the gut (gut flora). ""Clostridium difficile"" is a species of Gram-positive bacteria that"
"by pelvic floor dysfunction and tension), and discomfort and difficulty driving, working, exercising, or traveling. Pelvic pain experienced by those with IC typically worsens with filling of the urinary bladder and may improve with urination. During cystoscopy, 5–10% of people with IC are found to have Hunner's ulcers. A person with IC may have discomfort only in the urethra, while another might struggle with pain in the entire pelvis. Interstitial cystitis symptoms usually fall into one of two patterns: significant suprapubic pain with little frequency or a lesser amount of suprapubic pain but with increased urinary frequency. Some people with"
"be the first symptom of digestive disturbances and may lead to malnutrition. 20–50% of individuals with intestinal involvement also exhibit cardiac involvement. Up to 10% of chronically infected individuals develop neuritis that results in altered tendon reflexes and sensory impairment. Isolated cases exhibit central nervous system involvement, including dementia, confusion, chronic encephalopathy and sensory and motor deficits. The clinical manifestations of Chagas disease are due to cell death in the target tissues that occurs during the infective cycle, by sequentially inducing an inflammatory response, cellular lesions, and fibrosis. For example, intracellular amastigotes destroy the intramural neurons of the autonomic nervous"
"been posited over the years. These included ""Brucella"", gonorrhoea, and syphilis. Adrenaline injections, mercury, various hormone treatments (ovarian extracts, growth hormone, stilboestrol), and ergotamine tartrate are among other treatments at some time used without significant or long-term benefit. Physiotherapy, surgery, exclusion diets (following allergen testing) have similarly shown no particular success in early reports of IH. Intermittent hydrarthrosis Intermittent hydrarthrosis (IH), also known as ""periodic synoviosis"", ""periodic benign synovitis"", or ""periodic hydrarthritis"", is a chronic condition of unknown cause characterized by recurring, temporary episodes of fluid accumulation (effusion) in the knee. While the knee is mainly involved, occasionally other joints"
"system, bones, eyes, and heart. Neurosyphilis at this point can cause several damages to the body, including tabes dorsalis. When the nervous system is infected at this particular stage, the individual is at risk for meningeal syphilis, which in turn slowly shuts down the entire body. The tertiary stages can also cause the growth of many tumors, and lead to cancerous effects in the body. This stage can be diagnosed through specific tests in serology. The nonspecific tests may be negative. At this point, there is little treatment the individual can pursue, and the body shuts down as a whole."
"necrotizing mediastinitis (infection of the soft tissues that encase the heart) and cervical necrotizing fasciitis (infection of the soft tissues along the throat and cervical spine). The mortality rate of mouth infections that affect the deep neck space and lead to necrotizing mediastinitis or necrotizing fasciitis is high at around a 40-60% mortality rate. Mouth infection Mouth infections, also known as oral infections, are a group of infections that occur around the oral cavity. They include dental infection, dental abscess, and Ludwig's angina. Mouth infections typically originate from dental caries at the root of molars and premolars that spread to"
"like the brain, the eye, muscles, and the nervous system (called neurocysticercosis). At these sites, the parasites lodge and form cysts, producing inflammatory reactions and clinical issues when they die, sometimes causing serious or fatal damage. In the eye, the parasites can cause visual loss, and infection of the spine and adjacent leptomeninges can cause paresthesias, pain, or paralysis. Neurocysticercosis (nervous system infection) can cause headaches, seizures, vomiting, visual disturbances, behavioral abnormalities, focal neurological deficits, and signs of increased intracranial pressure like papilledema and altered alertness. Hydrocephalus can occur, and larvae can threaten the host’s life by obstructing ventricles in"