"spaces for more details. The choice of primary colors is related to the physiology of the human eye; good primaries are stimuli that maximize the difference between the responses of the cone cells of the human retina to light of different wavelengths, and that thereby make a large color triangle. The normal three kinds of light-sensitive photoreceptor cells in the human eye (cone cells) respond most to yellow (long wavelength or L), green (medium or M), and violet (short or S) light (peak wavelengths near 570 nm, 540 nm and 440 nm, respectively). The difference in the signals received from"
"the retina, which in its entirety comprises ten distinct layers, including an outer layer of pigmented epithelial cells. The only neural cells that are directly sensitive to light are the photoreceptor cells, which are of two types: rods and cones. Rods function mainly in dim light and provide black-and-white vision while cones are responsible for the perception of colour. A third type of photoreceptor, the photosensitive ganglion cells, is important for entrainment and reflexive responses to the brightness of light. Light striking the retina initiates a cascade of chemical and electrical events that ultimately trigger nerve impulses that are sent"
"the three kinds allows the brain to differentiate a wide gamut of different colors, while being most sensitive (overall) to yellowish-green light and to differences between hues in the green-to-orange region. As an example, suppose that light in the orange range of wavelengths (approximately 577 nm to 597 nm) enters the eye and strikes the retina. Light of these wavelengths would activate both the medium and long wavelength cones of the retina, but not equally—the long-wavelength cells will respond more. The difference in the response can be detected by the brain, and this difference is the basis of our perception"
"is based upon the varying sensitivity of different cells in the retina to light of different wavelengths. Humans are trichromatic—the retina contains three types of color receptor cells, or cones. One type, relatively distinct from the other two, is most responsive to light that is perceived as blue or blue-violet, with wavelengths around 450 nm; cones of this type are sometimes called ""short-wavelength cones"", ""S cones"", or ""blue cones"". The other two types are closely related genetically and chemically: ""middle-wavelength cones"", ""M cones"", or ""green cones"" are most sensitive to light perceived as green, with wavelengths around 540 nm, while"
"of 2018 there is no medical entity offering this treatment, and no clinical trials available for volunteers. The retina of the human eye contains photoreceptive cells called cones that allow color vision. A normal trichromat individual possesses three different types of cones to distinguish different colors within the visible spectrum from 380 nm to 740 nm. The three types of cones are designated L, M, and S cones, and each type is sensitive to a certain range of wavelength of light depending on what photopigment it contains. More specifically, the L cone absorbs around 560 nm, the M cone absorbs"
"In the human eye, light enters the pupil and is focused on the retina by the lens. Light-sensitive nerve cells called rods (for brightness), cones (for color) and non-imaging ipRGC (intrinsincally photosensitive retinal ganglion cells) react to the light. They interact with each other and send messages to the brain. The rods and cones enable vision. The ipRGCs enable entrainment to the Earth's 24-hour cycle, resizing of the pupil and acute suppression of the pineal hormone melatonin. The retina contains three forms of photosensitive cells, two of them important to vision, rods and cones, in addition to the subset of"
"still the standard elsewhere. The human eye's detection system, which is in the retina, consists primarily of two types of light detectors: rod cells that capture light, dark, and shapes/figures, and the cone cells that detect color. A typical retina contains 120 million rods and 4.5 million to 6 million cones, which are divided among three groups that are sensitive to red, green, and blue light. This means that the eye has far more resolution in brightness, or ""luminance"", than in color. However, post-processing of the optic nerve and other portions of the human visual system combine the information from"
"The retina is where a group of light-sensing cells, called photoreceptors are located. There are two types of photoreceptors: rods and cones. Rods are sensitive to dim light and cones are better able to transduce bright light. Photoreceptors connect to bipolar cells, which induce action potentials in retinal ganglion cells. These retinal ganglion cells form a bundle at the optic disc, which is a part of the optic nerve. The two optic nerves from each eye meet at the optic chiasm, where nerve fibers from each nasal retina cross which results in the right half of each eye's visual field"
"cell differentiation; amongst these are the differentiation of human embryonic stem cells to posterior foregut lineages and also to functional motor neurons. Vitamin A is converted by the protein RPE65 within the retinal pigment epithelium into 11-cis-retinal. This molecule is then transported into the photoreceptor cells of the retina, where it acts as a light-activated molecular switch within opsin proteins that activates a complex cascade called the visual cycle. This cycle begins with 11-cis retinal absorbing light and isomerizing into all-trans retinal. The change in shape of the molecule after absorbing light in turn changes the configuration of the complex"
"light from its surroundings onto a light-sensitive membrane in the back of the eye, called the retina. The retina is actually part of the brain that is isolated to serve as a transducer for the conversion of light into neuronal signals. Based on feedback from the visual system, the lens of the eye adjusts its thickness to focus light on the photoreceptive cells of the retina, also known as the rods and cones, which detect the photons of light and respond by producing neural impulses. These signals are processed via complex feedforward and feedback processes by different parts of the"
"cones differ in function. Rods are found primarily in the periphery of the retina and are used to see at low levels of light. Cones are found primarily in the center (or fovea) of the retina. There are three types of cones that differ in the wavelengths of light they absorb; they are usually called short or blue, middle or green, and long or red. Cones are used primarily to distinguish color and other features of the visual world at normal levels of light. In the retina, the photoreceptors synapse directly onto bipolar cells, which in turn synapse onto ganglion"
"they have evolved a method called image defocus instead. Of the four photoreceptor layers in the retina, the first two closest to the surface contain ultraviolet-sensitive pigments while the two deepest contain green-sensitive pigments. The incoming green light is only focused on the deepest layer, while the other one receives defocused or fuzzy images. By measuring the amount of defocus from the fuzzy layer, it is possible to calculate the distance to the objects in front of them. In addition to receptor cells, also red filters have been detected, located in front of the cells that normally register green light."
"together are called rhodopsin. In cone cells, there are different types of opsins that combine with retinal to form pigments called photopsins. Three different classes of photopsins in the cones react to different ranges of light frequency, a differentiation that allows the visual system to calculate color. The function of the photoreceptor cell is to convert the light energy of the photon into a form of energy communicable to the nervous system and readily usable to the organism: This conversion is called signal transduction. The opsin found in the photosensitive ganglion cells of the retina is called melanopsin. These cells"
"percentage of the ganglion cells in the retina contain melanopsin and, thus, are themselves photosensitive. The light information from these cells is not involved in vision and it reaches the brain not directly via the optic nerve but via the retinohypothalamic tract, the RHT. By way of this light information, the body clock's inherent approximate 24-hour cycling is adjusted daily to nature's light/dark cycle. Signals from these photosensitive ganglion cells have at least two other roles in addition. They exercise control over the size of the pupil, and they lead to acute suppression of melatonin secretion by the pineal gland."
"Retinal ganglion cell A retinal ganglion cell (RGC) is a type of neuron located near the inner surface (the ganglion cell layer) of the retina of the eye. It receives visual information from photoreceptors via two intermediate neuron types: bipolar cells and retina amacrine cells. Retina amacrine cells, particularly narrow field cells, are important for creating functional subunits within the ganglion cell layer and making it so that ganglion cells can observe a small dot moving a small distance. Retinal ganglion cells collectively transmit image-forming and non-image forming visual information from the retina in the form of action potential to"
"a specific object, and thus can only send achromatic information. There is approximately the same density of parasol ganglion cells in the fovea as in the rest of the retina, another property that distinguishes them from midget cells. Parasol and midget retinal cells begin the parallel magnocellular and parvocellular pathways, respectively. While both parasol cells and midget cells play an important role in the visual system, their anatomies and functional contributions differ. Retinal ganglion cells cannot provide finely detailed or colored information, but still provide useful static, depth, and motion information. Parasol ganglion cells have high light/dark contrast detection, and"
"melatonin. The retinohypothalamic tract consists of retinal ganglion cells. A distinct population of ganglion cells, known as intrinsically photosensitive retinal ganglion cells (ipRGCs), is critically responsible for providing non-image-forming visual signals to the brain. Only about two percent of all retinal ganglion cells are ipRGCs, whose cell bodies are in mainly the ganglion cell layer (and some are displaced in the inner nuclear layer of the retina). The photopigment melanopsin is present on the dendrites of ipRGCs, giving ipRGCs sensitivity to light in the absence of rod or cone input. The dendrites spread outwards from ipRGCs within the inner plexiform"
"Retina The retina is the innermost, light-sensitive layer, or ""coat"", of shell tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which translates that image into electrical neural impulses to the brain to create visual perception, the retina serving much the same function as film or a CCD in a camera. The retina consists of several layers of neurons interconnected by synapses. The neural retina refers to the three layers of neural cells (photo receptor cells, bipolar cells, and ganglion cells) within"
"those living in low light environments. Colour vision is more useful in environments with a broader range of wavelengths available, ""e.g."", near the surface in clear waters rather than in deeper water where only a narrow band of wavelengths persist. The distribution of photoreceptors across the retina is not uniform. Some areas have higher densities of cone cells, for example (see fovea). Fish may have two or three areas specialized for high acuity (e.g. for prey capture) or sensitivity (e.g. from dim light coming from below). The distribution of photoreceptors may also change over time during development of the individual."
"by the interactions with other types of neurons in the retina. The five basic classes of neurons within the retina are photoreceptor cells, bipolar cells, ganglion cells, horizontal cells, and amacrine cells. The basic circuitry of the retina incorporates a three-neuron chain consisting of the photoreceptor (either a rod or cone), bipolar cell, and the ganglion cell. The first action potential occurs in the retinal ganglion cell. This pathway is the most direct way for transmitting visual information to the brain. There are three primary types of photoreceptors: Cones are photoreceptors that respond significantly to color. In humans the three"
"A tenth class of visual pigment is found in the upper and lower hemispheres of the eye. Some species have at least 16 photoreceptor types, which are divided into four classes (their spectral sensitivity is further tuned by colour filters in the retinas), 12 for colour analysis in the different wavelengths (including six which are sensitive to ultraviolet light) and four for analysing polarised light. By comparison, most humans have only four visual pigments, of which three are dedicated to see colour, and human lenses block ultraviolet light. The visual information leaving the retina seems to be processed into numerous"
"cells used for vision: the rods and the cones. Rods cannot distinguish colours, but are responsible for low-light (scotopic) monochrome (black-and-white) vision; they work well in dim light as they contain a pigment, rhodopsin (visual purple), which is sensitive at low light intensity, but saturates at higher (photopic) intensities. Rods are distributed throughout the retina but there are none at the fovea and none at the blind spot. Rod density is greater in the peripheral retina than in the central retina. Cones are responsible for colour vision. They require brighter light to function than rods require. In humans, there are"
"two of synapses, including the unique ribbon synapse. The optic nerve carries the ganglion cell axons to the brain, and the blood vessels that supply the retina. The ganglion cells lie innermost in the eye while the photoreceptive cells lie beyond. Because of this counter-intuitive arrangement, light must first pass through and around the ganglion cells and through the thickness of the retina, (including its capillary vessels, not shown) before reaching the rods and cones. Light is absorbed by the retinal pigment epithelium or the choroid (both of which are opaque). The white blood cells in the capillaries in front"
"amacrine cells in the retina. The final result is differing populations of ganglion cells in the retina, a sub-population of which is also intrinsically photosensitive, using the photopigment melanopsin. A non-rod non-cone photoreceptor in the eyes of mice, which was shown to mediate circadian rhythms, was discovered in 1991 by Foster ""et al."" These neuronal cells, called intrinsically photosensitive retinal ganglion cells (ipRGC), are a small subset (≈1–3%) of the retinal ganglion cells located in the inner retina, that is, in front of the rods and cones located in the outer retina. These light sensitive neurons contain a photopigment, melanopsin,"
"and scarred corneas, which affect the optical path, diseases that affect the retina, such as macular degeneration and diabetes, diseases affecting the optic pathway to the brain such as tumors and multiple sclerosis, and diseases affecting the visual cortex such as tumors and strokes. Though the resolving power depends on the size and packing density of the photoreceptors, the neural system must interpret the receptors’ information. As determined from single-cell experiments on the cat and primate, different ganglion cells in the retina are tuned to different spatial frequencies, so some ganglion cells at each location have better acuity than others."
"Photoreceptor cell A photoreceptor cell is a specialized type of neuroepithelial cell found in the retina that is capable of visual phototransduction. The great biological importance of photoreceptors is that they convert light (visible electromagnetic radiation) into signals that can stimulate biological processes. To be more specific, photoreceptor proteins in the cell absorb photons, triggering a change in the cell's membrane potential. There are currently three known types of photoreceptor cells in mammalian eyes: rods, cones, and photosensitive retinal ganglion cells. The two classic photoreceptor cells are rods and cones, each contributing information used by the visual system to form"
"ability to target cone photoreceptors. The vertebrate neural retina composed of several layers and distinct cell types (see anatomy of the human retina). A number of these cell types are implicated in retinal diseases, including retinal ganglion cells, which degenerate in glaucoma, the rod and cone photoreceptors, which are responsive to light and degenerate in retinitis pigmentosa, macular degeneration, and other retinal diseases, and the retinal pigment epithelium (RPE), which supports the photoreceptors and is also implicated in retinitis pigmentosa and macular degeneration. In retinal gene therapy, AAV is capable of ""transducing"" these various cell types by entering the cells"
"the rods' peak sensitivity (blue-green). Rod cell Rod cells are photoreceptor cells in the retina of the eye that can function in less intense light than the other type of visual photoreceptor, cone cells. Rods are usually found concentrated at the outer edges of the retina and are used in peripheral vision. On average, there are approximately 90 million rod cells in the human retina. Rod cells are more sensitive than cone cells and are almost entirely responsible for night vision. However, rods have little role in color vision, which is the main reason why colors are much less apparent"
"across different cone types. The process of phototransduction occurs in the retina. The retina has many layers of various cell types. The best-known photoreceptor cells (""rods"" and ""cones"") form the outermost layer. They are the photoreceptors responsible for sight. The middle layer contains bipolar cells, which collect neural signals from the rods and the cones and then transmit them to the innermost layer of the retina, where the neurons called retinal ganglion cells (RGCs), a small percentage of which are themselves photosensitive, organize the signals and send them to the brain. Activation of rods and cones is actually hyperpolarization; when"
"in front of the retina of the eye. Blue light (optimal wavelength: 430 nm) is absorbed by the red blood cells that fill the capillaries. The eye and brain ""edit out"" the shadow lines of the capillaries, partially by dark adaptation of the photoreceptors lying beneath the capillaries. The white blood cells, which are much rarer than the red ones and do not absorb blue light, create gaps in the blood column, and these gaps appear as bright dots. The gaps are elongated because a spherical white blood cell is too wide for the capillary. Red blood cells pile up"
"brain: A 2006 University of Pennsylvania study calculated the approximate bandwidth of human retinas to be about 8960 kilobits per second, whereas guinea pig retinas transfer at about 875 kilobits. In 2007 Zaidi and co-researchers on both sides of the Atlantic studying patients without rods and cones, discovered that the novel photoreceptive ganglion cell in humans also has a role in conscious and unconscious visual perception. The peak spectral sensitivity was 481 nm. This shows that there are two pathways for sight in the retina – one based on classic photoreceptors (rods and cones) and the other, newly discovered, based"
"tests can this be deduced. Most organisms with colour vision are able to detect ultraviolet light. This high energy light can be damaging to receptor cells. With a few exceptions (snakes, placental mammals), most organisms avoid these effects by having absorbent oil droplets around their cone cells. The alternative, developed by organisms that had lost these oil droplets in the course of evolution, is to make the lens impervious to UV light – this precludes the possibility of any UV light being detected, as it does not even reach the retina. The retina contains two major types of light-sensitive photoreceptor"
"photopigment, which are embedded in the membrane of the lamellae; a single human rod contains approximately 10 million of them. The photopigment molecules consist of two parts: an opsin (a protein) and retinal (a lipid). There are 3 specific photopigments (each with their own color) that respond to specific wavelengths of light. When the appropriate wavelength of light hits the photoreceptor, its photopigment splits into two, which sends a message to the bipolar cell layer, which in turn sends a message to the ganglion cells, which then send the information through the optic nerve to the brain. If the appropriate"