"Eye testing using speckle Laser speckle can be employed as a method for conducting a very sensitive eye test. When a surface is illuminated by a laser beam and is viewed by an observer, a speckle pattern is formed on the retina. If the observer has perfect vision, the image of the surface is also formed on the retina, and movement of the head will result in the speckle pattern and the surface moving together so that the speckle pattern remains stationary with respect to the background. If the observer is near-sighted, the image of the surface is formed in"
"Retina The retina is the innermost, light-sensitive layer, or ""coat"", of shell tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which translates that image into electrical neural impulses to the brain to create visual perception, the retina serving much the same function as film or a CCD in a camera. The retina consists of several layers of neurons interconnected by synapses. The neural retina refers to the three layers of neural cells (photo receptor cells, bipolar cells, and ganglion cells) within"
"the retina, which in its entirety comprises ten distinct layers, including an outer layer of pigmented epithelial cells. The only neural cells that are directly sensitive to light are the photoreceptor cells, which are of two types: rods and cones. Rods function mainly in dim light and provide black-and-white vision while cones are responsible for the perception of colour. A third type of photoreceptor, the photosensitive ganglion cells, is important for entrainment and reflexive responses to the brightness of light. Light striking the retina initiates a cascade of chemical and electrical events that ultimately trigger nerve impulses that are sent"
"eyes and in the deep brain the ciliary photoreceptor cells. The ciliary photoreceptor cells express a ciliary opsin, which is a photopigment maximally sensitive to UV-light (""λ"" = 383 nm). Thus, the ciliary photoreceptor cells react on UV-light and make the larvae swimming down gravitactically. The gravitaxis here is countered by phototaxis, which makes the larvae swimming up to the light coming from the surface. Phototaxis is mediated by the rhabdomeric eyes. The eyes express at least three opsins (at least in the older larvae), and one of them is maximally sensitive to cyan light (""λ"" = 483 nm) so"
"light from its surroundings onto a light-sensitive membrane in the back of the eye, called the retina. The retina is actually part of the brain that is isolated to serve as a transducer for the conversion of light into neuronal signals. Based on feedback from the visual system, the lens of the eye adjusts its thickness to focus light on the photoreceptive cells of the retina, also known as the rods and cones, which detect the photons of light and respond by producing neural impulses. These signals are processed via complex feedforward and feedback processes by different parts of the"
"In the human eye, light enters the pupil and is focused on the retina by the lens. Light-sensitive nerve cells called rods (for brightness), cones (for color) and non-imaging ipRGC (intrinsincally photosensitive retinal ganglion cells) react to the light. They interact with each other and send messages to the brain. The rods and cones enable vision. The ipRGCs enable entrainment to the Earth's 24-hour cycle, resizing of the pupil and acute suppression of the pineal hormone melatonin. The retina contains three forms of photosensitive cells, two of them important to vision, rods and cones, in addition to the subset of"
"not receiving a light signal. Outer plexiform layer The outer plexiform layer (external plexiform layer) is a layer of neuronal synapses in the retina of the eye. It consists of a dense network of synapses between dendrites of horizontal cells from the inner nuclear layer, and photoreceptor cell inner segments from the outer nuclear layer. It is much thinner than the inner plexiform layer, where amacrine cells synapse with retinal ganglion cells. The synapses in the outer plexiform layer are between the rod cell endings or cone cell branched foot plates and horizontal cells. Unlike in most systems, rod and"
"the lens which controls the amount of light entering the eye. At the centre of the iris is the pupil, the variable circular area through which the light passes into the eye. The retina is a relatively smooth curved multi-layered structure containing the photosensitive rod and cone cells with the associated neurons and blood vessels. The density of the photoreceptors is critical in determining the maximum attainable visual acuity. Humans have about 200,000 receptors per mm, but the house sparrow has 400,000 and the common buzzard 1,000,000. The photoreceptors are not all individually connected to the optic nerve, and the"
"melatonin. The retinohypothalamic tract consists of retinal ganglion cells. A distinct population of ganglion cells, known as intrinsically photosensitive retinal ganglion cells (ipRGCs), is critically responsible for providing non-image-forming visual signals to the brain. Only about two percent of all retinal ganglion cells are ipRGCs, whose cell bodies are in mainly the ganglion cell layer (and some are displaced in the inner nuclear layer of the retina). The photopigment melanopsin is present on the dendrites of ipRGCs, giving ipRGCs sensitivity to light in the absence of rod or cone input. The dendrites spread outwards from ipRGCs within the inner plexiform"
"whereas deuterostomes allow less through. This suggests that when the two lineages diverged in the Precambrian, they had only very primitive light receptors, which developed into more complex eyes independently. The basic light-processing unit of eyes is the photoreceptor cell, a specialized cell containing two types of molecules in a membrane: the opsin, a light-sensitive protein, surrounding the chromophore, a pigment that distinguishes colors. Groups of such cells are termed ""eyespots"", and have evolved independently somewhere between 40 and 65 times. These eyespots permit animals to gain only a very basic sense of the direction and intensity of light, but"
"the deuterostomes (chordates and echinoderms). The functional unit of the eye is the photoreceptor cell, which contains the opsin proteins and responds to light by initiating a nerve impulse. The light sensitive opsins are borne on a hairy layer, to maximise the surface area. The nature of these ""hairs"" differs, with two basic forms underlying photoreceptor structure: microvilli and cilia. In the eyes of protostomes, they are microvilli: extensions or protrusions of the cellular membrane. But in the eyes of deuterostomes, they are derived from cilia, which are separate structures. However, outside the eyes an organism may use the other"
"the vitreous body. It contains the ciliary muscle, vessels, and fibrous connective tissue. Folds on the inner ciliary epithelium are called ciliary processes, and these secrete aqueous humor into the posterior chamber. The aqueous humor then flows through the pupil into the anterior chamber. The ciliary body is attached to the lens by connective tissue called the zonular fibers (fibers of Zinn). Relaxation of the ciliary muscle puts tension on these fibers and changes the shape of the lens in order to focus light on the retina. The inner layer is transparent and covers the vitreous body, and is continuous"
"of 2018 there is no medical entity offering this treatment, and no clinical trials available for volunteers. The retina of the human eye contains photoreceptive cells called cones that allow color vision. A normal trichromat individual possesses three different types of cones to distinguish different colors within the visible spectrum from 380 nm to 740 nm. The three types of cones are designated L, M, and S cones, and each type is sensitive to a certain range of wavelength of light depending on what photopigment it contains. More specifically, the L cone absorbs around 560 nm, the M cone absorbs"
"cornea must be continuously moist. They keep the eyes from drying out when asleep. Moreover, the blink reflex protects the eye from foreign bodies. The eyelid is made up of several layers; from superficial to deep, these are: skin, subcutaneous tissue, orbicularis oculi, orbital septum and tarsal plates, and palpebral conjunctiva. The meibomian glands lie within the eyelid and secrete the lipid part of the tear film. The skin is similar to areas elsewhere, but is relatively thin and has more pigment cells. In diseased persons these may wander and cause a discoloration of the lids. It contains sweat glands"
"Conjunctiva The conjunctiva lines the inside of the eyelids and covers the sclera (the white of the eye). It is composed of non-keratinized, stratified squamous epithelium with goblet cells, and also stratified columnar epithelium. The conjunctiva is highly vascularised, with many microvessels easily accessible for imaging studies. The conjunctiva is typically divided into three parts: Blood to the bulbar conjunctiva is primarily derived from the ophthalmic artery. The blood supply to the palpebral conjunctiva (the eyelid) is derived from the external carotid artery. However, the circulation of the bulbar conjunctiva and palpebral conjunctiva are linked, so both bulbar conjunctival and"
"Ocular immune system The ocular immune system protects the eye from infection and regulates healing processes following injuries. The interior of the eye lacks lymph vessels but is highly vascularized, and many immune cells reside in the uvea, including mostly macrophages, dendritic cells, and mast cells. These cells fight off intraocular infections, and intraocular inflammation can manifest as uveitis (including iritis) or retinitis. The cornea of the eye is immunologically a very special tissue. Its constant exposure to the exterior world means that it is vulnerable to a wide range of microorganisms while its moist mucosal surface makes the cornea"
"the sclera, a thick, hard membrane which protects the inner parts of the nerves from injury. The chorioid, a thin and soft structure filled with veins and arteries, follows next and provides nourishment to the overall structure. Finally, the retina transmits nutrients to the lenses themselves. Hunayn then presents the system responsible for protecting the eye. From the outermost level, these are the conjunctiva, cornea, and uvea. While both the conjuctiva and cornea provide protection with minimizing hindrance to the lenses, the uvea has an extra function of concentrating the pneuma exiting out of the eye to prevent it from"
"stage. Recently Ader and colleagues in Dublin showed, using the electron microscope, that transplanted photoreceptors formed synaptic connections. In 2012, Sebastian Seung and his laboratory at MIT have launched EyeWire, an online Citizen science game where players trace neurons in the retina. The goals of the EyeWire project are to identify specific cell types within the known broad classes of retinal cells, and to map the connections between neurons in the retina, which will help to determine how vision works. Retina The retina is the innermost, light-sensitive layer, or ""coat"", of shell tissue of the eye of most vertebrates and"
"a light-dark cycle. This observation led to the conclusion that neither rods nor cones, located in the outer retina, are necessary for circadian entrainment and that a third class of photoreceptor exists in the mammalian eye. Provencio and colleagues then found in 2000 that melanopsin is also present in mouse retina, specifically in ganglion cells, and that it mediates non-visual photoreceptive tasks. Melanopsin was found to be encoded by Opn4 with orthologs in a variety of organisms. These retinal ganglion cells were found to be innately photosensitive, since they responded to light even while isolated, and were thus named intrinsically"
"percentage of the ganglion cells in the retina contain melanopsin and, thus, are themselves photosensitive. The light information from these cells is not involved in vision and it reaches the brain not directly via the optic nerve but via the retinohypothalamic tract, the RHT. By way of this light information, the body clock's inherent approximate 24-hour cycling is adjusted daily to nature's light/dark cycle. Signals from these photosensitive ganglion cells have at least two other roles in addition. They exercise control over the size of the pupil, and they lead to acute suppression of melatonin secretion by the pineal gland."
"two of synapses, including the unique ribbon synapse. The optic nerve carries the ganglion cell axons to the brain, and the blood vessels that supply the retina. The ganglion cells lie innermost in the eye while the photoreceptive cells lie beyond. Because of this counter-intuitive arrangement, light must first pass through and around the ganglion cells and through the thickness of the retina, (including its capillary vessels, not shown) before reaching the rods and cones. Light is absorbed by the retinal pigment epithelium or the choroid (both of which are opaque). The white blood cells in the capillaries in front"
"in front of the retina of the eye. Blue light (optimal wavelength: 430 nm) is absorbed by the red blood cells that fill the capillaries. The eye and brain ""edit out"" the shadow lines of the capillaries, partially by dark adaptation of the photoreceptors lying beneath the capillaries. The white blood cells, which are much rarer than the red ones and do not absorb blue light, create gaps in the blood column, and these gaps appear as bright dots. The gaps are elongated because a spherical white blood cell is too wide for the capillary. Red blood cells pile up"
"Tapetum lucidum The tapetum lucidum (Latin: ""bright tapestry; coverlet"", plural tapeta lucida) is a layer of tissue in the eye of many vertebrates. Lying immediately behind the retina, it is a retroreflector. It reflects visible light back through the retina, increasing the light available to the photoreceptors (although slightly blurring the image). The tapetum lucidum contributes to the superior night vision of some animals. Many of these animals are nocturnal, especially carnivores, while others are deep sea animals. Similar adaptations occur in some species of spiders. Most primates, including humans, lack a ""tapetum lucidum"", and compensate for this using perceptive"
"tapetum lucidum. Enhanced intensity range is achieved via technological means through the use of an image intensifier, gain multiplication CCD, or other very low-noise and high-sensitivity array of photodetectors. All photoreceptor cells in the vertebrate eye contain molecules of photoreceptor protein which is a combination of the protein photopsin in color vision cells, rhodopsin in night vision cells, and retinal (a small photoreceptor molecule). Retinal undergoes an irreversible change in shape when it absorbs light; this change causes an alteration in the shape of the protein which surrounds the retinal, and that alteration then induces the physiological process which results"
"μm) in thickness near its center. The posterior chamber constitutes the remaining five-sixths; its diameter is typically about 24 mm. The cornea and sclera are connected by an area termed the limbus. The iris is the pigmented circular structure concentrically surrounding the center of the eye, the pupil, which appears to be black. The size of the pupil, which controls the amount of light entering the eye, is adjusted by the iris' dilator and sphincter muscles. Light energy enters the eye through the cornea, through the pupil and then through the lens. The lens shape is changed for near focus"
"Iris (anatomy) In humans and most mammals and birds, the iris (plural: irides or irises) is a thin, circular structure in the eye, responsible for controlling the diameter and size of the pupil and thus the amount of light reaching the retina. Eye color is defined by that of the iris. In optical terms, the pupil is the eye's aperture, while the iris is the diaphragm. The iris consists of two layers: the front pigmented layer known as a stroma and, beneath the stroma, pigmented epithelial cells. The stroma connects to a sphincter muscle (sphincter pupillae), which contracts the pupil"
"loss of transparency. The lens blocks most ultraviolet light in the wavelength range of 300–400 nm; shorter wavelengths are blocked by the cornea. High intensity ultraviolet light can harm the retina, and artificial intraocular lenses are therefore manufactured to also block ultraviolet light. People lacking a lens (a condition known as aphakia) perceive ultraviolet light as whitish blue or whitish-violet. The lens is metabolically active and requires nourishment in order to maintain its growth and transparency. Compared to other tissues in the eye, however, the lens has considerably lower energy demands. By nine weeks into human development, the lens is"
"of the external eye muscles) may be less complete, however. Tenon's capsule The fascia bulbi (also known as the capsule of Tenon and the bulbar sheath) is a thin membrane which envelops the eyeball from the optic nerve to the limbus, separating it from the orbital fat and forming a socket in which it moves. Its inner surface is smooth, and is separated from the outer surface of the sclera by the periscleral lymph space. This lymph space is continuous with the subdural and subarachnoid cavities, and is traversed by delicate bands of connective tissue which extend between the fascia"
"path called the visual axis. The eye's tissues and structures that are in the visual axis (and also the tissues adjacent to it) affect the quality of the image. These structures are: tear film, cornea, anterior chamber, pupil, lens, vitreous, and finally the retina. The posterior part of the retina, called the retinal pigment epithelium (RPE) is responsible for, among many other things, absorbing light that crosses the retina so it cannot bounce to other parts of the retina. In many vertebrates, such as cats, where high visual acuity is not a priority, there is a reflecting tapetum layer that"
"still the standard elsewhere. The human eye's detection system, which is in the retina, consists primarily of two types of light detectors: rod cells that capture light, dark, and shapes/figures, and the cone cells that detect color. A typical retina contains 120 million rods and 4.5 million to 6 million cones, which are divided among three groups that are sensitive to red, green, and blue light. This means that the eye has far more resolution in brightness, or ""luminance"", than in color. However, post-processing of the optic nerve and other portions of the human visual system combine the information from"
"the dolphin effectively blind, but the eye may still serve as a light receptor. The retina contains a densely packed receptor layer, a very thin bipolar and ganglion cell layer, and a tiny optic nerve (with only a few hundred optic fibers) that are sufficient for the retina to act as a light-gathering component. The dense pigmentation in the skin overlying the eye prevents light from reaching the retina from any entrance except for a pinhole sphincter-like structure. This structure is controlled by a cone-shaped muscle layer that extends from the posterior eye orbit to the overlying eye skin layer."
"amacrine cells in the retina. The final result is differing populations of ganglion cells in the retina, a sub-population of which is also intrinsically photosensitive, using the photopigment melanopsin. A non-rod non-cone photoreceptor in the eyes of mice, which was shown to mediate circadian rhythms, was discovered in 1991 by Foster ""et al."" These neuronal cells, called intrinsically photosensitive retinal ganglion cells (ipRGC), are a small subset (≈1–3%) of the retinal ganglion cells located in the inner retina, that is, in front of the rods and cones located in the outer retina. These light sensitive neurons contain a photopigment, melanopsin,"
"radially to enlarge the pupil, pulling it in folds. The back surface is covered by a commonly, heavily pigmented epithelial layer that is two cells thick (the iris pigment epithelium), but the front surface has no epithelium. This anterior surface projects as the muscles dilate. Stroma of iris The stroma of the iris is a layer of tissue. It is the upper layer of two in the iris. The stroma is a delicate interlacement of fibres. Some circle the circumference of the iris and the majority radiate toward the pupil. Blood vessels and nerves intersperse this mesh. In dark eyes,"