"three types of cells: The most common type of grouping is the ABO blood group system. The varieties of glycoprotein and glycolipid coating on red blood cells divides blood into four groups: Another antigen, the Rh factor, plays an important part in the grouping of blood. If this is present, the particular blood type is called Rh-positive. If it is absent, it is called Rh-negative. In addition to the ABO and Rh blood group systems, there are more than two hundred minor blood groups that can complicate blood transfusions. These are known as rare blood types. Whereas common blood types"
"alleles in white individuals of the ABO gene that produce one's blood type: The same study also identified 18 rare alleles, which generally have a weaker glycosylation activity. People with weak alleles of A can sometimes express anti-A antibodies, though these are usually not clinically significant as they do not stably interact with the antigen at body temperature. Cis AB is another rare variant, in which A and B genes are transmitted together from a single parent. The distribution of the blood groups A, B, O and AB varies across the world according to the population. There are also variations"
"pregnancy or occasionally a blood transfusion with D positive RBCs. Rh disease can develop in these cases. Rh negative blood types are much less common in Asian populations (0.3%) than they are in European populations (15%). The presence or absence of the Rh(D) antigen is signified by the + or − sign, so that, for example, the A− group is ABO type A and does not have the Rh (D) antigen. As with many other genetic traits, the distribution of ABO and Rh blood groups varies significantly between populations. 28 blood-group systems have been identified by the International Society for"
"each parent; each has a 25% chance, but some occur more than once. Historically, ABO blood tests were used in paternity testing, but in 1957 only 50% of American men falsely accused were able to use them as evidence against paternity. Occasionally, the blood types of children are not consistent with expectations—for example, a type O child can be born to an AB parent—due to rare situations, such as Bombay phenotype and cis AB. The A blood type contains about 20 subgroups, of which A1 and A2 are the most common (over 99%). A1 makes up about 80% of all"
"Rh blood group system The Rh blood group system is one of thirty-five known human blood group systems. It is the second most important blood group system, after the ABO blood group system. The Rh blood group system consists of 49 defined blood group antigens, among which the five antigens D, C, c, E, and e are the most important. There is no d (""little d"") antigen. Rh(D) status of an individual is normally described with a ""positive"" or ""negative"" suffix after the ABO type. e.g. Someone who is A Positive has the A antigen and the Rh(D) antigen, whereas"
"A-type blood, with A2 making up almost all of the rest. These two subgroups are not always interchangeable as far as transfusion is concerned, as some A2 individuals produce antibodies against the A1 antigen. Complications can sometimes arise in rare cases when typing the blood. With the development of DNA sequencing, it has been possible to identify a much larger number of alleles at the ABO locus, each of which can be categorized as A, B, or O in terms of the reaction to transfusion, but which can be distinguished by variations in the DNA sequence. There are six common"
"group systems, 308 different blood-group antigens have been found. Almost always, an individual has the same blood group for life, but very rarely an individual's blood type changes through addition or suppression of an antigen in infection, malignancy, or autoimmune disease. Another more common cause in blood type change is a bone marrow transplant. Bone-marrow transplants are performed for many leukemias and lymphomas, among other diseases. If a person receives bone marrow from someone who is a different ABO type (e.g., a type A patient receives a type O bone marrow), the patient's blood type will eventually convert to the"
"only three groups; and was for this (blood types) discovery awarded the Nobel Prize in Physiology or Medicine in 1930). Janský's classification remains in use today. A similar classification was described by William Lorenzo Moss, except the I and IV of Moss were the opposite to that of Janský's, leading to confusion in blood transfusion until the use of A, B and O became standard. Jan Janský Prof. MUDr. Jan Janský () (3 April 1873 in Prague – 8 September 1921 in Černošice, near Prague) was a Czech serologist, neurologist and psychiatrist. He is credited with the first classification of"
"group tattoos during World War II. Rare blood types can cause supply problems for blood banks and hospitals. For example, Duffy-negative blood occurs much more frequently in people of African origin, and the rarity of this blood type in the rest of the population can result in a shortage of Duffy-negative blood for these patients. Similarly for RhD negative people, there is a risk associated with travelling to parts of the world where supplies of RhD negative blood are rare, particularly East Asia, where blood services may endeavor to encourage Westerners to donate blood. Pregnant women may carry a fetus"
"represent contributions from both parents. A total of 36 human blood group systems and 346 antigens are now recognized by the International Society of Blood Transfusion (ISBT). The two most important ones are ABO and the Rh blood group systems; they determine someone's blood type (A, B, AB and O, with +, − or null denoting RhD status) for suitability in blood transfusion. A complete blood type would describe a full set of 30 substances on the surface of red blood cells, and an individual's blood type is one of many possible combinations of blood-group antigens. Across the 36 blood"
"group. Compared to O group individuals, non-O group (A, AB, and B) individuals have a 14% reduced risk of squamous cell carcinoma and 4% reduced risk of basal cell carcinoma. Conversely, type O blood is associated with a reduced risk of pancreatic cancer. The B antigen links with increased risk of ovarian cancer. Gastric cancer has reported to be more common in blood group A and least in group O. According to Glass, Holmgren, et al., those in the O blood group have an increased risk of infection with cholera, and those O-group individuals who are infected have more severe"
"namely group A, group B, and group C. He defined that group A blood agglutinates with group B, but never with its own type. Similarly, group B blood agglutinates with group A. Group C blood is different in that it agglutinates with both A and B. This was the discovery of blood groups for which Landsteiner was awarded the Nobel Prize in Physiology or Medicine in 1930. (C was later renamed to O after the German ""Ohne"", meaning without, or zero, or null.) The group AB was discovered a year later by Landsteiner's students Adriano Sturli, and Alfred von Decastello."
"most resistant. Between these two extremes are the A and B blood types, with type A being more resistant than type B. This suggests that the pleiotropic effects of the genes set up opposing selective forces, thus maintaining a balance. Geographical distribution of blood groups (the differences in gene frequency between populations) is broadly consistent with the classification of ""races"" developed by early anthropologists on the basis of visible features. Sickle-cell anaemia is found mostly in tropical populations in Africa and India. An individual homozygous for the recessive sickle hemoglobin, HgbS, has a short expectancy of life, whereas the life"
"blood group A nor of blood group B. Therefore, the immune systems of persons with blood group A, B or AB do not refuse the donation. Further, because persons with blood group AB do not form antibodies against either the antigens of blood group A or B, they can accept blood from persons with these blood groups, besides from persons with blood group O-negative. In today's blood transfusions only concentrates of red blood cells without serum are transmitted, which is of great importance in surgical practice. In 1930 Landsteiner was awarded the Nobel Prize in Physiology or Medicine in recognition"
"blood. Two categories of blood groups, human-type and simian-type, have been found in apes and monkeys, and can be tested by methods established for grouping human blood. The rhesus system is named after the rhesus monkey, following experiments by Karl Landsteiner and Alexander S. Wiener, which showed that rabbits, when immunised with rhesus monkey red cells, produce an antibody that also agglutinates the red blood cells of many humans. Data on blood groups of chimpanzees, baboons, and macaques. Two complex chimpanzee blood group systems, V-A-B-D and R-C-E-F systems, proved to be counterparts of the human MNS and Rh-Hr blood group"
"very low. However, in low-income countries the risk of a blood donation being positive for HIV, hepatitis C, or syphilis is approximately 1%, and the risk of it being hepatitis B positive is approximately 4%. Although the World Health Organization recommends that all donated blood is screened for these infections, at least 13 low-income countries are unable to screen all their donated blood for at least one of these infections. To avoid transfusion reactions, the donor and recipient blood are tested, typically ordered as a ""type and screen"" for the recipient. The ""type"" in this case is the ABO and"
"red cells with both are called AB. Except in unusual cases like infants or seriously immunocompromised individuals, all people will have antibodies to any ABO blood type that isn't present on their own red blood cells, and will have an immediate hemolytic reaction to a unit that is not compatible with their ABO type. In addition to the A and B antigens, there are rare variations which can further complicate transfusions, such as the Bombay phenotype. The Rh blood group system consists of nearly around 50 different antigens, but the one of the greatest clinical interest is the ""D"" antigen,"
"A and B antigens, but contains anti-A and anti-B. The following year, his students Adriano Sturli and Alfred von Decastello discovered the fourth type (but not naming it, and simply referred to it as ""no particular type”). In 1910, Ludwik Hirszfeld and Emil Freiherr von Dungern introduced the term 0 (null) for the group Landsteiner designated as C, and AB for the type discovered by Sturli and von Decastello. They were also the first to explain the genetic inheritance of the blood groups.) Czech serologist Jan Janský independently introduced blood type classification in 1907 in a local journal. He used"
"Hh blood group The h/h blood group, also known as Oh or the Bombay blood group, is a rare blood type. This blood phenotype was first discovered in Bombay, now known as Mumbai, in India, by Dr. Y. M. Bhende in 1952. It is mostly found in India, Pakistan, and Iran. The first person found to have the Bombay phenotype had an interesting blood type that reacted to other blood types in a way never seen before. The serum contained antibodies that reacted with all red blood cells' normal ABO phenotypes. The red blood cells appeared to lack all of"
"are expressed in a letter or two, which may be a plus or a minus, a smaller number of people express their blood type in an extensive series of letters in addition to their ""AB±"" type designation. For example, the h/h blood group, also known as Oh or the Bombay blood group, is a rare blood type. Human blood group systems The term human blood group systems is defined by International Society of Blood Transfusion as systems in the human species where cell-surface antigens—in particular, those on blood cells—are ""controlled at a single gene locus or by two or more"
"A is associated with high frequencies in Europe, especially in Scandinavia and Central Europe, although its highest frequencies occur in some Australian Aboriginal populations and the Blackfoot Indians of Montana, the US. Blood type distribution by country Blood group B has its highest frequency in South Asia where it ranks first as the largest share of the earth's population. In Southeast Asia the share of the population is high, especially in Thailand and Indonesia, then in East Asia, Northern Asia and neighboring Central Asia, and its incidence diminishes both towards the east and the west, falling to single digit percentages"
"Blood type distribution by country Blood group B has its highest frequency in South Asia where it ranks first as the largest share of the earth's population. In Southeast Asia the share of the population is high, especially in Thailand and Indonesia, then in East Asia, Northern Asia and neighboring Central Asia, and its incidence diminishes both towards the east and the west, falling to single digit percentages in Netherlands, Norway, Portugal and Switzerland. It is believed to have been entirely absent from Native American and Australian Aboriginal populations prior to the arrival of Europeans in those areas. Blood group"
"Rh type, specifically the phenotype, and the ""screen"" refers to testing for atypical antibodies that might cause transfusion problems. The typing and screening are also performed on donor blood. The blood groups represent antigens on the surface of the red blood cells which might react with antibodies in the recipient. The ABO blood group system has four basic phenotypes: O, A, B, and AB. In the former Soviet Union these were called I, II, III, and IV, respectively. There are two important antigens in the system: A and B. Red cells without A or B are called type O, and"
"are generally administered. Typically higher ratios of fresh frozen plasma and platelets are given relative to packed red blood cells. Because blood type O negative is compatible with anyone, it is often overused and in short supply. According to the American Association of Blood Banks, the use of this blood should be restricted to persons with O negative blood, as nothing else is compatible with them, and women who might be pregnant and for whom it would be impossible to do blood group testing before giving them emergency treatment. Whenever possible, the AABB recommends that O negative blood be conserved"
"do not have an antibody, since the greatest risk of Rh incompatible blood is to current or future pregnancies. For RBCs, type O negative blood is considered a ""universal donor"" as recipients with types A, B, or AB can almost always receive O negative blood safely. Type AB positive is considered a ""universal recipient"" because they can receive the other ABO/Rh types safely. These are not truly universal, as other red cell antigens can further complicate transfusions. There are many other human blood group systems and most of them are only rarely associated with transfusion problems. A screening test is"
"are used in these situations, since they are unlikely to cause a reaction. A potentially fatal reaction is possible if the recipient has pre-existing antibodies, and uncrossmatched blood is only used in dire circumstances. Since O negative blood is not common, other blood types may be used if the situation is desperate. Most frequently, whole blood is collected from a blood donation and is spun in a centrifuge. The red blood cells are denser and settle to the bottom, and the majority of the liquid blood plasma remains on the top. The plasma is separated and the red blood cells"
"Blood type A blood type (also called a blood group) is a classification of blood, based on the presence and absence of antibodies and inherited antigenic substances on the surface of red blood cells (RBCs). These antigens may be proteins, carbohydrates, glycoproteins, or glycolipids, depending on the blood group system. Some of these antigens are also present on the surface of other types of cells of various tissues. Several of these red blood cell surface antigens can stem from one allele (or an alternative version of a gene) and collectively form a blood group system. Blood types are inherited and"
"ways. Two pairs of broadest categories classify them either by structure (granulocytes or agranulocytes) or by cell lineage (myeloid cells or lymphoid cells). These broadest categories can be further divided into the five main types: neutrophils, eosinophils (acidophiles), basophils, lymphocytes, and monocytes. These types are distinguished by their physical and functional characteristics. Monocytes and neutrophils are phagocytic. Further subtypes can be classified; for example, among lymphocytes, there are B cells, T cells, and NK cells. The number of leukocytes in the blood is often an indicator of disease, and thus the ""white blood cell count"" is an important subset of"
"systems, respectively. Two blood group systems have been defined in Old World monkeys: the Drh system of macaques and the Bp system of baboons, both linked by at least one species shared by either of the blood group systems. Over 13 canine blood groups have been described. Eight DEA (dog erythrocyte antigen) types are recognized as international standards. Of these DEA types, DEA 4 and DEA 6 appear on the red blood cells of ~98% of dogs. Dogs with only DEA 4 or DEA 6 can thus serve as blood donors for the majority of the canine population. Any of"
"occurred between persons of different blood groups. Based on his findings, the first successful blood transfusion was performed by Reuben Ottenberg at Mount Sinai Hospital in New York in 1907. Today it is well known that persons with blood group AB can accept donations of the other blood groups, and that persons with blood group O-negative can donate to all other groups. Individuals with blood group AB are referred to as ""universal recipients"" and those with blood group O-negative are known as ""universal donors"". These donor-recipient relationships arise due to the fact that type O-negative blood possesses neither antigens of"
"blood cell antigens and 33 platelet antigens, as defined serologically. The genetic basis for most of these antigens lie in 45 red blood cell and 6 platelet genes. An individual, for example, can be AB RhD positive, and at the same time M and N positive in the MNS system, K positive in the Kell system, and Le or Le positive in the Lewis system, where these and many of the systems are named for patients in whom the corresponding antibodies were first detected. Blood is composed of cells suspended in a liquid called plasma. Suspended in the plasma are"
"type after neutrophils. In young children under age 8, lymphocytes are more common than neutrophils. Monocytes: May be raised in bacterial infection, tuberculosis, malaria, Rocky Mountain spotted fever, monocytic leukemia, chronic ulcerative colitis and regional enteritis Eosinophils: Increased in parasitic infections, asthma, or allergic reaction. Basophils: May be increased in bone marrow related conditions such as leukemia or lymphoma. Total red blood cells: The number of red cells is given as an absolute number per litre. Iron deficiency anemia is one condition that shows up as a Low RBC count. Hemoglobin: The amount of hemoglobin in the blood, expressed in"
"ABO blood group system The ABO blood group system is used to denote the presence of one, both, or neither of the A and B antigens on erythrocytes. In human blood transfusions it is the most important of the 36 different blood type (or group) classification systems currently recognized. A very rare (in modern medicine) mismatch in this, or any other serotype, can cause a serious, potentially fatal, adverse reaction after a transfusion, or a contra-indicated immune response to an organ transplant. The associated anti-A and anti-B antibodies are usually IgM antibodies, which are produced in the first years of"