Association of the -1082G/A polymorphism in the interleukin-10 gene with systemic lupus erythematosus: a meta-analysis.
A great many studies have investigated the -1082G/A polymorphism (rs1800896) in the interleukin-10 gene (IL10) with SLE susceptibility, but the results are inconsistent and inconclusive. The aim of this meta-analysis was in order to more precisely estimate the relationship. The databases of Pubmed and Web of Science updated to Oct, 2012 were retrieved. Odds ratio (OR) and corresponding 95% confidence interval (95%CI.) as effect size were calculated by fixed-effect model. Analysis for allele contrast of stratification by ethnicity in either Asian or Caucasian, as well as in overall population indicated no significant association (Overall: OR 1.096, 95%CI. 0.995-1.207; Asian: OR 1.204, 95%CI.: 0.944-1.535; Caucasian: OR 1.075, 95%CI.: 0.961-1.202). Analysis for recessive model showed no association in overall populations and in Caucasian (Overall: OR 1.135, 95%CI.: 0.945-1.362; Caucasian: OR 1.069, 95%CI.: 0.882-1.296), but significant association in Asian (OR: 2.848; 95%CI.: 1.194-6.791). Analysis for dominant model indicated that the variant G allele carriers (GG+GA) may have increased the risk of SLE when compared with the homozygote AA in overall populations and in Caucasian (Overall: OR 1.203, 95%CI.: 1.029-1.407; Caucasian: OR 1.233, 95%CI.: 1.014-1.499), but not in Asian (OR: 1.154; 95%CI.: 0.856-1.557). Significant association was found by using homozygote contrast model in overall populations and Asian (Overall: OR 1.303, 95%CI.: 1.031-1.648; Asian: OR 3.206, 95%CI.: 1.241-8.284), while no association was found in Caucasian (OR: 1.209; 95%CI.: 0.940-1.556). The results provided evidence for the association between the IL10 -1082G/A polymorphism and the risk of SLE. To confirm these findings, more case-control studies with subtle study design based on adequately sized populations are required.