Top 10 Nutritional Supplements for Menopause. The menopause marks the time in a woman’s life when her menstruation stops and it signals the end of fertility . Menopause typically occurs in women in midlife, during their late 40s or early 50s.  It has physical and emotional symptoms which may disrupt your sleep, cause hot flashes, lower your energy or trigger anxiety or feelings of sadness and loss. Menopause is a natural biological process, and although it ends fertility, you