EEG and Brain Imaging Data for Individuals with SIK1 Mutations.  (A) Representative EEG tracings from subject DB13-001 at 10 days of age showing burst suppression pattern with myoclonic activity, consistent with a diagnosis of early myoclonic encephalopathy.  (B) At 8 monthsof age,the EEG hadnot improved, with continued burst suppression pattern associated with both myoclonic and tonic seizures. (C–J) MRI scans of subjects with SIK1 mutations showed subtle abnormalities. (C and D) Subject DB13-001 (p.Pro287Thr) at age 1 week showed normal morphology. (E and F) Subject IS13-013 (p.Gln614*) at age 12 years showed low forehead, mild shortening of the corpus callosum, and mild atrophy of the cerebellar vermis. (G and H) Subject LR05-086 (p.Gly636Ser) at 3 days of age with increased extra-axial spaces and simplified gyral pattern in the frontal lobes. (I and J) Subject LR05-086 at age 16 months showed thinning of the corpus callosumand asymmetricthinning of the white matter.  De Novo Mutations in SIK1 Cause a Spectrum of Developmental Epilepsies.  Paciorkowski et al 2015.