Maria, Queen of Hungary. She was born in Brussels to Philip I of Castile &quot;The Handsome&quot; and Joanna &quot;The Mad&quot; of Castile. Her paternal grandparents were Maximilian I, Holy Roman Emperor and his first wife Mary of Burgundy. Her maternal grandparents were Ferdinand II of Aragon and Isabella of Castile. She was the niece of Catherine of Aragon.