Milwaukee - largest city in the U.S. state of Wisconsin &amp; 39th most populous region in the country. The first Europeans to pass through the area were French Catholic missionaries and fur traders. In 1818, the French-Canadian explorer Solomon Juneau settled in the area, &amp; in 1846 Juneau&#x27;s town combined with 2 neighboring towns to incorporate as the City of Milwaukee.  Large numbers of German and other immigrants helped increase the city&#x27;s population during the 1840s and the following decades.