FIG. 6. Confocal images showing cytochrome c diffusely localized to the cytoplasm but not significantly to the mitochondria in palmitic acid-treated islets. Islets were plated on extracellular matrix-coated dishes and were exposed for 4 days to media containing 11.1 mmol/l glucose alone (A) and with 0.5 mmol/l palmitic acid (B) and stained with anti-cytochrome c antibody.