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Human skin
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This article is about skin in humans. For other animals, see skin.
Skin
Epidermis, dermis, and subcutis, showing a hair follicle, gland, and sebaceous gland
Details
System
Integumentary system
Identifiers
Latin
cutis
MeSH
D020405, D012867
TA
A16.0.00.002
TH
H3.12.00.1.00001
FMA
7163
Anatomical terminology
[edit on Wikidata]
The human skin is the outer covering of the body. In humans, it is the largest organ of the integumentary system. The skin has up to seven layers of ectodermal tissue and guards the underlying muscles, bones, ligaments and internal organs.[1] Human skin is similar to most of the other mammals skin, and human skin is very similar to pig skin.[2][3] Though nearly all human skin is covered with hair follicles, it can appear hairless. There are two general types of skin, hairy and glabrous skin (hairless).[4] The adjective cutaneous literally means "of the skin" (from Latin cutis, skin).
Because it interfaces with the environment, skin plays an important immunity role in protecting the body against pathogens[5] and excessive water loss.[6] Its other functions are insulation, temperature regulation, sensation, synthesis of vitamin D, and the protection of vitamin B folates. Severely damaged skin will try to heal by forming scar tissue. This is often discolored and depigmented.
In humans, skin pigmentation varies among populations, and skin type can range from dry to oily. Such skin variety provides a rich and diverse habitat for bacteria that number roughly 1000 species from 19 phyla, present on the human skin.[7][8]
Contents
1 Structure
1.1 Epidermis
1.1.1 Components
1.1.2 Layers
1.1.3 Sublayers
1.1.4 Genes and proteins expressed in the epidermis
1.2 Dermis
1.2.1 Papillary region
1.2.2 Reticular region
1.3 Subcutaneous tissue
1.4 Cross-section
2 Development
2.1 Skin color
2.2 Aging
2.2.1 Photoaging
3 Functions
3.1 Skin flora
4 Clinical significance
5 Society and culture
5.1 Hygiene and skin care
5.1.1 Oily skin
6 Permeability
6.1 Nanoparticles
6.2 Increasing permeability
6.3 Applications
6.4 Sunblock and sunscreen
6.5 Diet
7 See also
8 References
9 External links
Structure[edit]
Skin has mesodermal cells, pigmentation, such as melanin provided by melanocytes, which absorb some of the potentially dangerous ultraviolet radiation (UV) in sunlight. It also contains DNA repair enzymes that help reverse UV damage, such that people lacking the genes for these enzymes suffer high rates of skin cancer. One form predominantly produced by UV light, malignant melanoma, is particularly invasive, causing it to spread quickly, and can often be deadly. Human skin pigmentation varies among populations in a striking manner. This has led to the classification of people(s) on the basis of skin color.[9]
In terms of surface area, the skin is the second largest organ in the human body (the inside of the small intestine is 15 to 20 times larger). For the average adult human, the skin has a surface area of between 1.5-2.0 square meters (16.1-21.5 sq ft.). The thickness of the skin varies considerably over all parts of the body, and between men and women and the young and the old. An example is the skin on the forearm which is on average 1.3 mm in the male and 1.26 mm in the female.[10] The average square inch (6.5 cm²) of skin holds 650 sweat glands, 20 blood vessels, 60,000 melanocytes, and more than 1,000 nerve endings.[11][better source needed] The average human skin cell is about 30 micrometers in diameter, but there are variants. A skin cell usually ranges from 25-40 micrometers (squared), depending on a variety of factors.
Skin is composed of three primary layers: the epidermis, the dermis and the hypodermis.[10]
Layers, Receptors, and Appendages of Human Skin
Epidermis[edit]
Main article: Epidermis
Epidermis, "epi" coming from the Greek meaning "over" or "upon", is the outermost layer of the skin. It forms the waterproof, protective wrap over the body's surface which also serves as a barrier to infection and is made up of stratified squamous epithelium with an underlying basal lamina.
The epidermis contains no blood vessels, and cells in the deepest layers are nourished almost exclusively by diffused oxygen from the surrounding air[12] and to a far lesser degree by blood capillaries extending to the outer layers of the dermis. The main type of cells which make up the epidermis are Merkel cells, keratinocytes, with melanocytes and Langerhans cells also present. The epidermis can be further subdivided into the following strata (beginning with the outermost layer): corneum, lucidum (only in palms of hands and bottoms of feet), granulosum, spinosum, basale. Cells are formed through mitosis at the basale layer. The daughter cells (see cell division) move up the strata changing shape and composition as they die due to isolation from their blood source. The cytoplasm is released and the protein keratin is inserted. They eventually reach the corneum and slough off (desquamation). This process is called "keratinization". This keratinized layer of skin is responsible for keeping water in the body and keeping other harmful chemicals and pathogens out, making skin a natural barrier to infection.
2D projection of a 3D OCT-tomogram of the skin at the fingertip, depicting the stratum corneum (~500 µm thick) with the stratum disjunctum on top and the stratum lucidum in the middle. At the bottom are the superficial parts of the dermis. The sweatducts are clearly visible. (See also: Rotating 3D Version)
Components[edit]
The epidermis contains no blood vessels, and is nourished by diffusion from the dermis. The main type of cells which make up the epidermis are keratinocytes, melanocytes, Langerhans cells and Merkel cells. The epidermis helps the skin to regulate body temperature.
Layers[edit]
Epidermis is divided into several layers where cells are formed through mitosis at the innermost layers. They move up the strata changing shape and composition as they differentiate and become filled with keratin. They eventually reach the top layer called stratum corneum and are sloughed off, or desquamated. This process is called keratinization and takes place within weeks. The outermost layer of the epidermis consists of 25 to 30 layers of dead cells.
Sublayers[edit]
Epidermis is divided into the following 5 sublayers or strata:
Stratum corneum
Stratum lucidum
Stratum granulosum
Stratum spinosum
Stratum germinativum (also called "stratum basale").
Blood capillaries are found beneath the epidermis, and are linked to an arteriole and a venule. Arterial shunt vessels may bypass the network in ears, the nose and fingertips.
Genes and proteins expressed in the epidermis[edit]
About 70% of all human protein-coding genes are expressed in the skin.[13][14] Almost 500 genes have an elevated pattern of expression in the skin. There are less than 100 genes that are specific for the skin and these are expressed in the epidermis.[15] An analysis of the corresponding proteins show that these are mainly expressed in keratinocytes and have functions related to squamous differentiation and cornification.
Dermis[edit]
Main article: Dermis
The dermis is the layer of skin beneath the epidermis that consists of connective tissue and cushions the body from stress and strain. The dermis is tightly connected to the epidermis by a basement membrane. It also harbors many nerve endings that provide the sense of touch and heat. It contains the hair follicles, sweat glands, sebaceous glands, apocrine glands, lymphatic vessels and blood vessels. The blood vessels in the dermis provide nourishment and waste removal from its own cells as well as from the Stratum basale of the epidermis.
The dermis is structurally divided into two areas: a superficial area adjacent to the epidermis, called the papillary region, and a deep thicker area known as the reticular region.
Papillary region[edit]
The papillary region is composed of loose areolar connective tissue. It is named for its fingerlike projections called papillae, that extend toward the epidermis. The papillae provide the dermis with a "bumpy" surface that interdigitates with the epidermis, strengthening the connection between the two layers of skin.
In the palms, fingers, soles, and toes, the influence of the papillae projecting into the epidermis forms contours in the skin's surface. These epidermal ridges occur in patterns (see: fingerprint) that are genetically and epigenetically determined and are therefore unique to the individual, making it possible to use fingerprints or footprints as a means of identification.
Reticular region[edit]
The reticular region lies deep in the papillary region and is usually much thicker. It is composed of dense irregular connective tissue, and receives its name from the dense concentration of collagenous, elastic, and reticular fibers that weave throughout it. These protein fibers give the dermis its properties of strength, extensibility, and elasticity.
Also located within the reticular region are the roots of the hairs, sebaceous glands, sweat glands, receptors, nails, and blood vessels.
Tattoo ink is held in the dermis. Stretch marks often from pregnancy and obesity, are also located in the dermis.
Subcutaneous tissue[edit]
The subcutaneous tissue (also hypodermis and subcutis) is not part of the skin, and lies below the dermis of the cutis. Its purpose is to attach the skin to underlying bone and muscle as well as supplying it with blood vessels and nerves. It consists of loose connective tissue, adipose tissue and elastin. The main cell types are fibroblasts, macrophages and adipocytes (subcutaneous tissue contains 50% of body fat). Fat serves as padding and insulation for the body.
Cross-section[edit]
Skin layers, of both hairy and hairless skin
Development[edit]
Further information: Human embryogenesis § Integumentary system
Skin color[edit]
Main article: Human skin color
Human skin shows high skin color variety from the darkest brown to the lightest pinkish-white hues. Human skin shows higher variation in color than any other single mammalian species and is the result of natural selection. Skin pigmentation in humans evolved to primarily regulate the amount of ultraviolet radiation (UVR) penetrating the skin, controlling its biochemical effects.[16]
The actual skin color of different humans is affected by many substances, although the single most important substance determining human skin color is the pigment melanin. Melanin is produced within the skin in cells called melanocytes and it is the main determinant of the skin color of darker-skinned humans. The skin color of people with light skin is determined mainly by the bluish-white connective tissue under the dermis and by the hemoglobin circulating in the veins of the dermis. The red color underlying the skin becomes more visible, especially in the face, when, as consequence of physical exercise or the stimulation of the nervous system (anger, fear), arterioles dilate.[17]
There are at least five different pigments that determine the color of the skin.[18][19] These pigments are present at different levels and places.
Melanin: It is brown in color and present in the basal layer of the epidermis.
Melanoid: It resembles melanin but is present diffusely throughout the epidermis.
Carotene: This pigment is yellow to orange in color. It is present in the stratum corneum and fat cells of dermis and superficial fascia.
Hemoglobin (also spelled haemoglobin): It is found in blood and is not a pigment of the skin but develops a purple color.
Oxyhemoglobin: It is also found in blood and is not a pigment of the skin. It develops a red color.
There is a correlation between the geographic distribution of UV radiation (UVR) and the distribution of indigenous skin pigmentation around the world. Areas that highlight higher amounts of UVR reflect darker-skinned populations, generally located nearer towards the equator. Areas that are far from the tropics and closer to the poles have lower concentration of UVR, which is reflected in lighter-skinned populations.[20]
In the same population it has been observed that adult human females are considerably lighter in skin pigmentation than males. Females need more calcium during pregnancy and lactation, and vitamin D which is synthesized from sunlight helps in absorbing calcium. For this reason it is thought that females may have evolved to have lighter skin in order to help their bodies absorb more calcium.[21]
The Fitzpatrick scale[22][23] is a numerical classification schema for human skin color developed in 1975 as a way to classify the typical response of different types of skin to ultraviolet (UV) light:
I Always burns, never tans Pale, Fair, Freckles
II Usually burns, sometimes tans Fair
III May burn, usually tans Light Brown
IV Rarely burns, always tans Olive brown
V Moderate constitutional pigmentation Brown
VI Marked constitutional pigmentation Black
Aging[edit]
Further information: senescence
Further information: Intrinsic and extrinsic aging
A typical rash
Skin infected with scabies
As skin ages, it becomes thinner and more easily damaged. Intensifying this effect is the decreasing ability of skin to heal itself as a person ages.
Among other things, skin aging is noted by a decrease in volume and elasticity. There are many internal and external causes to skin aging. For example, aging skin receives less blood flow and lower glandular activity.
A validated comprehensive grading scale has categorized the clinical findings of skin aging as laxity (sagging), rhytids (wrinkles), and the various facets of photoaging, including erythema (redness), and telangiectasia, dyspigmentation (brown discoloration), solar elastosis (yellowing), keratoses (abnormal growths) and poor texture.[24]
Cortisol causes degradation of collagen,[25] accelerating skin aging.[26]
Anti-aging supplements are used to treat skin aging.
Photoaging[edit]
Main article: Photoaging
Photoaging has two main concerns: an increased risk for skin cancer and the appearance of damaged skin. In younger skin, sun damage will heal faster since the cells in the epidermis have a faster turnover rate, while in the older population the skin becomes thinner and the epidermis turnover rate for cell repair is lower which may result in the dermis layer being damaged.[27]
Functions[edit]
Skin performs the following functions:
Protection: an anatomical barrier from pathogens and damage between the internal and external environment in bodily defense; Langerhans cells in the skin are part of the adaptive immune system.[5][6] Perspiration contains lysozyme that break the bonds within the cell walls of bacteria.[28]
Sensation: contains a variety of nerve endings that react to heat and cold, touch, pressure, vibration, and tissue injury; see somatosensory system and haptics.
Heat regulation: the skin contains a blood supply far greater than its requirements which allows precise control of energy loss by radiation, convection and conduction. Dilated blood vessels increase perfusion and heatloss, while constricted vessels greatly reduce cutaneous blood flow and conserve heat.
Control of evaporation: the skin provides a relatively dry and semi-impermeable barrier to fluid loss.[6] Loss of this function contributes to the massive fluid loss in burns.
Aesthetics and communication: others see our skin and can assess our mood, physical state and attractiveness.
Storage and synthesis: acts as a storage center for lipids and water, as well as a means of synthesis of vitamin D by action of UV on certain parts of the skin.
Excretion: sweat contains urea, however its concentration is 1/130th that of urine, hence excretion by sweating is at most a secondary function to temperature regulation.
Absorption: the cells comprising the outermost 0.25–0.40 mm of the skin are "almost exclusively supplied by external oxygen", although the "contribution to total respiration is negligible".[12] In addition, medicine can be administered through the skin, by ointments or by means of adhesive patch, such as the nicotine patch or iontophoresis. The skin is an important site of transport in many other organisms.
Water resistance: The skin acts as a water-resistant barrier so essential nutrients are not washed out of the body.
Skin flora[edit]
Main article: Skin flora
The human skin is a rich environment for microbes.[7][8] Around 1000 species of bacteria from 19 bacterial phyla have been found. Most come from only four phyla: Actinobacteria (51.8%), Firmicutes (24.4%), Proteobacteria (16.5%), and Bacteroidetes (6.3%). Propionibacteria and Staphylococci species were the main species in sebaceous areas. There are three main ecological areas: moist, dry and sebaceous. In moist places on the body Corynebacteria together with Staphylococci dominate. In dry areas, there is a mixture of species but dominated by b-Proteobacteria and Flavobacteriales. Ecologically, sebaceous areas had greater species richness than moist and dry ones. The areas with least similarity between people in species were the spaces between fingers, the spaces between toes, axillae, and umbilical cord stump. Most similarly were beside the nostril, nares (inside the nostril), and on the back.
Reflecting upon the diversity of the human skin researchers on the human skin microbiome have observed: "hairy, moist underarms lie a short distance from smooth dry forearms, but these two niches are likely as ecologically dissimilar as rainforests are to deserts."[7]
The NIH has launched the Human Microbiome Project to characterize the human microbiota which includes that on the skin and the role of this microbiome in health and disease.[29]
Microorganisms like Staphylococcus epidermidis colonize the skin surface. The density of skin flora depends on region of the skin. The disinfected skin surface gets recolonized from bacteria residing in the deeper areas of the hair follicle, gut and urogenital openings.
Clinical significance[edit]
The electrical activity map of the skin in normal subjects and diabetic subjects.[30]
Further information: skin disease
The electrical activity of the skin can be used for diagnosis and prediction of various metabolic diseases, such as diabetes mellitus.[30] Diseases of the skin include skin infections and skin neoplasms (including skin cancer).
Dermatology is the branch of medicine that deals with conditions of the skin.[4]
Society and culture[edit]
Hygiene and skin care[edit]
See also: Exfoliation (cosmetology)
The skin supports its own ecosystems of microorganisms, including yeasts and bacteria, which cannot be removed by any amount of cleaning. Estimates place the number of individual bacteria on the surface of one square inch (6.5 square cm) of human skin at 50 million, though this figure varies greatly over the average 20 square feet (1.9 m2) of human skin. Oily surfaces, such as the face, may contain over 500 million bacteria per square inch (6.5 cm²). Despite these vast quantities, all of the bacteria found on the skin's surface would fit into a volume the size of a pea.[31] In general, the microorganisms keep one another in check and are part of a healthy skin. When the balance is disturbed, there may be an overgrowth and infection, such as when antibiotics kill microbes, resulting in an overgrowth of yeast. The skin is continuous with the inner epithelial lining of the body at the orifices, each of which supports its own complement of microbes.
Cosmetics should be used carefully on the skin because these may cause allergic reactions. Each season requires suitable clothing in order to facilitate the evaporation of the sweat. Sunlight, water and air play an important role in keeping the skin healthy.
Oily skin[edit]
Oily skin is caused by over-active sebaceous glands, that produce a substance called sebum, a naturally healthy skin lubricant.[1] When the skin produces excessive sebum, it becomes heavy and thick in texture. Oily skin is typified by shininess, blemishes and pimples.[1] The oily-skin type is not necessarily bad, since such skin is less prone to wrinkling, or other signs of aging,[1] because the oil helps to keep needed moisture locked into the epidermis (outermost layer of skin).
The negative aspect of the oily-skin type is that oily complexions are especially susceptible to clogged pores, blackheads, and buildup of dead skin cells on the surface of the skin.[1] Oily skin can be sallow and rough in texture and tends to have large, clearly visible pores everywhere, except around the eyes and neck.[1]
Permeability[edit]
Human skin has a low permeability; that is, most foreign substances are unable to penetrate and diffuse through the skin. Skin's outermost layer, the stratum corneum, is an effective barrier to most inorganic nanosized particles.[32][33] This protects the body from external particles such as toxins by not allowing them to come into contact with internal tissues. However, in some cases it is desirable to allow particles entry to the body through the skin. Potential medical applications of such particle transfer has prompted developments in nanomedicine and biology to increase skin permeability. One application of transcutaneous particle delivery could be to locate and treat cancer. Nanomedical researchers seek to target the epidermis and other layers of active cell division where nanoparticles can interact directly with cells that have lost their growth-control mechanisms (cancer cells). Such direct interaction could be used to more accurately diagnose properties of specific tumors or to treat them by delivering drugs with cellular specificity.
Nanoparticles[edit]
Nanoparticles 40 nm in diameter and smaller have been successful in penetrating the skin.[34][35][36] Research confirms that nanoparticles larger than 40 nm do not penetrate the skin past the stratum corneum.[34] Most particles that do penetrate will diffuse through skin cells, but some will travel down hair follicles and reach the dermis layer.
The permeability of skin relative to different shapes of nanoparticles has also been studied. Research has shown that spherical particles have a better ability to penetrate the skin compared to oblong (ellipsoidal) particles because spheres are symmetric in all three spatial dimensions.[36] One study compared the two shapes and recorded data that showed spherical particles located deep in the epidermis and dermis whereas ellipsoidal particles were mainly found in the stratum corneum and epidermal layers.[37] Nanorods are used in experiments because of their unique fluorescent properties but have shown mediocre penetration.
Nanoparticles of different materials have shown skin’s permeability limitations. In many experiments, gold nanoparticles 40 nm in diameter or smaller are used and have shown to penetrate to the epidermis. Titanium oxide (TiO2), zinc oxide (ZnO), and silver nanoparticles are ineffective in penetrating the skin past the stratum corneum.[38][39] Cadmium selenide (CdSe) quantum dots have proven to penetrate very effectively when they have certain properties. Because CdSe is toxic to living organisms, the particle must be covered in a surface group. An experiment comparing the permeability of quantum dots coated in polyethylene glycol (PEG), PEG-amine, and carboxylic acid concluded the PEG and PEG-amine surface groups allowed for the greatest penetration of particles. The carboxylic acid coated particles did not penetrate past the stratum corneum.[37]
Increasing permeability[edit]
Scientists previously believed that the skin was an effective barrier to inorganic particles. Damage from mechanical stressors was believed to be the only way to increase its permeability.[40] Recently, however, simpler and more effective methods for increasing skin permeability have been developed. For example, ultraviolet radiation (UVR) has been used to slightly damage the surface of skin, causing a time-dependent defect allowing easier penetration of nanoparticles.[41] The UVR’s high energy causes a restructuring of cells, weakening the boundary between the stratum corneum and the epidermal layer.[41][42] The damage of the skin is typically measured by the transepidermal water loss (TEWL), though it may take 3–5 days for the TEWL to reach its peak value. When the TEWL reaches its highest value, the maximum density of nanoparticles is able to permeate the skin. Studies confirm that UVR damaged skin significantly increases the permeability.[41][42] The effects of increased permeability after UVR exposure can lead to an increase in the number of particles that permeate the skin. However, the specific permeability of skin after UVR exposure relative to particles of different sizes and materials has not been determined.[41]
Other skin damaging methods used to increase nanoparticle penetration include tape stripping, skin abrasion, and chemical enhancement. Tape stripping is the process in which tape is applied to skin then lifted to remove the top layer of skin. Skin abrasion is done by shaving the top 5-10 micrometers off the surface of the skin. Chemical enhancement is the process in which chemicals such as polyvinylpyrrolidone (PVP), dimethyl sulfoxide (DMSO), and oleic acid are applied to the surface of the skin to increase permeability.[43][44]
Electroporation is the application of short pulses of electric fields on skin and has proven to increase skin permeability. The pulses are high voltage and on the order of milliseconds when applied. Charged molecules penetrate the skin more frequently than neutral molecules after the skin has been exposed to electric field pulses. Results have shown molecules on the order of 100 micrometers to easily permeate electroporated skin.[44]
Applications[edit]
A large area of interest in nanomedicine is the transdermal patch because of the possibility of a painless application of therapeutic agents with very few side effects. Transdermal patches have been limited to administer a small number of drugs, such as nicotine, because of the limitations in permeability of the skin. Development of techniques that increase skin permeability has led to more drugs that can be applied via transdermal patches and more options for patients.[44]
Increasing the permeability of skin allows nanoparticles to penetrate and target cancer cells. Nanoparticles along with multi-modal imaging techniques have been used as a way to diagnose cancer non-invasively. Skin with high permeability allowed quantum dots with an antibody attached to the surface for active targeting to successfully penetrate and identify cancerous tumors in mice. Tumor targeting is beneficial because the particles can be excited using fluorescence microscopy and emit light energy and heat that will destroy cancer cells.[45]
Sunblock and sunscreen[edit]
Sunblock and sunscreen are different important skin-care products though both offer full protection from the sun.[46][47]
Sunblock—Sunblock is opaque and stronger than sunscreen, since it is able to block most of the UVA/UVB rays and radiation from the sun, and does not need to be reapplied several times in a day. Titanium dioxide and zinc oxide are two of the important ingredients in sunblock.[48]
Sunscreen—Sunscreen is more transparent once applied to the skin and also has the ability to protect against UVA/UVB rays, although the sunscreen's ingredients have the ability to break down at a faster rate once exposed to sunlight, and some of the radiation is able to penetrate to the skin. In order for sunscreen to be more effective it is necessary to consistently reapply and use one with a higher sun protection factor.
Diet[edit]
Vitamin A, also known as retinoids, benefits the skin by normalizing keratinization, downregulating sebum production which contributes to acne, and reversing and treating photodamage, striae, and cellulite.
Vitamin D and analogs are used to downregulate the cutaneous immune system and epithelial proliferation while promoting differentiation.
Vitamin C is an antioxidant that regulates collagen synthesis, forms barrier lipids, regenerates vitamin E, and provides photoprotection.
Vitamin E is a membrane antioxidant that protects against oxidative damage and also provides protection against harmful UV rays. [49]
Several scientific studies confirmed that changes in baseline nutritional status affects skin condition. [50]
The Mayo Clinic lists foods they state help the skin: fruits and vegetables, whole-grains, dark leafy greens, nuts, and seeds.[51]
See also[edit]
Acid mantle
Anthropodermic bibliopegy
Artificial skin
Callus, thick area of skin
List of cutaneous conditions
Cutaneous structure development
Fingerprint, skin on fingertips
Hyperpigmentation, about excess skin color
Intertriginous
Meissner's corpuscle
Pacinian corpuscle
Polyphenol antioxidant
Skin lesion
Skin repair
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Jump up ^ Cutroneo, Kenneth R.; Kenneth M. Sterling (2004). "How do glucocorticoids compare to oligo decoys as inhibitors of collagen synthesis and potential toxicity of these therapeutics?". Journal of Cellular Biochemistry. 92 (1): 6–15. doi:10.1002/jcb.20030. ISSN 0730-2312. PMID 15095399. (subscription required)
Jump up ^ Oikarinen, A. (2004). "Connective tissue and aging". International Journal of Cosmetic Science. 26 (2): 107. doi:10.1111/j.1467-2494.2004.213_6.x. ISSN 0142-5463. (subscription required)
Jump up ^ Gilchrest, BA (1990). "Skin aging and photoaging". Dermatology Nursing / Dermatology Nurses' Association. 2 (2): 79–82. PMID 2141531.
Jump up ^ WI, Kenneth Todar, Madison,. "Immune Defense against Bacterial Pathogens: Innate Immunity". textbookofbacteriology.net. Retrieved 2017-04-19.
Jump up ^ NIH Human Microbiome Project.
^ Jump up to: a b Ionescu-Tirgoviste, Constantin; Gagniuc, Paul A.; Gagniuc, Elvira (2018-11-30). "The electrical activity map of the human skin indicates strong differences between normal and diabetic individuals: A gateway to onset prevention". Biosensors & Bioelectronics. 120: 188–194. doi:10.1016/j.bios.2018.08.057. ISSN 1873-4235. PMID 30193191.
Jump up ^ Theodor Rosebury. Life on Man: Secker & Warburg, 1969 ISBN 0-670-42793-4
Jump up ^ Baroli, Biancamaria (2010). "Penetration of nanoparticles and nanomaterials in the skin: Fiction or reality?". Journal of Pharmaceutical Sciences. 99 (1): 21–50. doi:10.1002/jps.21817. ISSN 0022-3549. PMID 19670463.
Jump up ^ Filipe, P.; J.N. Silva; R. Silva; J.L. Cirne de Castro; M. Marques Gomes; L.C. Alves; R. Santus; T. Pinheiro (2009). "Stratum Corneum Is an Effective Barrier to TiO2 and ZnO Nanoparticle Percutaneous Absorption". Skin Pharmacology and Physiology. 22 (5): 266–275. doi:10.1159/000235554. ISSN 1660-5535. PMID 19690452.
^ Jump up to: a b Vogt, A.; Combadiere, B.; Hadam, S.; Stieler, K.; Lademann, J.; Schaefer, H.; et al. (June 2006). "40 nm, but not 750 or 1,500 nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin". Journal of Investigative Dermatology. 126 (6): 1316–22. doi:10.1038/sj.jid.5700226. PMID 16614727.
Jump up ^ Sonavane, Ganeshchandra; Keishiro Tomoda; Akira Sano; Hiroyuki Ohshima; Hiroshi Terada; Kimiko Makino (2008). "In vitro permeation of gold nanoparticles through rat skin and rat intestine: Effect of particle size". Colloids and Surfaces B: Biointerfaces. 65 (1): 1–10. doi:10.1016/j.colsurfb.2008.02.013. ISSN 0927-7765. PMID 18499408.
^ Jump up to: a b Ryman-Rasmussen, J. P. (2006). "Penetration of Intact Skin by Quantum Dots with Diverse Physicochemical Properties". Toxicological Sciences. 91 (1): 159–165. doi:10.1093/toxsci/kfj122. ISSN 1096-6080. PMID 16443688.
^ Jump up to: a b Ryman-Rasmussen, J.P., Riviere, J.E. and Monteiro-Riviere, N.A. Penetration of Intact Skin by Quantum Dots with Diverse Physicochemical Properties. Toxicological Sciences 2006;91(1):159-165
Jump up ^ Felipe, P.; Silva, J.N.; Silva, R.; Cirne de Castro, J.L.; Gomes, M.; Alves, L.C.; et al. (2009). "Stratum Corneum Is an Effective Carrier to TiO2 and ZnO Nanoparticle Percutaneous Absorption". Skin Pharmacology and Physiology. 22: 266–275. CS1 maint: Explicit use of et al. (link)
Jump up ^ Larese, Francesca Filon; Flavia D’Agostin; Matteo Crosera; Gianpiero Adami; Nadia Renzi; Massimo Bovenzi; Giovanni Maina (2009). "Human skin penetration of silver nanoparticles through intact and damaged skin". Toxicology. 255 (1–2): 33–37. doi:10.1016/j.tox.2008.09.025. ISSN 0300-483X. PMID 18973786.
Jump up ^ Mortensen, Luke J.; Gunter Oberdörster; Alice P. Pentland; Lisa A. DeLouise (2008). "In Vivo Skin Penetration of Quantum Dot Nanoparticles in the Murine Model: The Effect of UVR". Nano Letters. 8 (9): 2779–2787. doi:10.1021/nl801323y. ISSN 1530-6984. PMC 4111258. PMID 18687009.
^ Jump up to: a b c d Osinski, Marek; Luke Mortensen; Hong Zheng; Renea Faulknor; Anna De Benedetto; Lisa Beck; Lisa A. DeLouise; Thomas M. Jovin; Kenji Yamamoto (2009). "Increased in vivo skin penetration of quantum dots with UVR and in vitro quantum dot cytotoxicity". Colloidal Quantum Dots for Biomedical Applications IV. 7189: 718919–718919–12. doi:10.1117/12.809215. ISSN 0277-786X.
^ Jump up to: a b Mortensen, L.; Oberdorster, G.; Pentland, A.; DeLoiuse, L. (2008). "In Vivo Skin Penetration of Quantum Dot Nanoparticles in the Murine Model: The Effects of UVR". Nano Letters. 8 (9): 2779–2787. doi:10.1021/nl801323y. PMC 4111258. PMID 18687009.
Jump up ^ Sokolov, K.; Follen, M.; Aaron, J.; Pavlova, I.; Malpica, A.; Lotan, R.; et al. (May 2003). "Real-Time Vital Optical Imaging of Precancer Using Anti-Epidermal Growth Factor Receptor Antibodies Conjugated to Gold Nanoparticles". Cancer Research. 63: 199.
^ Jump up to: a b c Prausnitz, M.; Mitragotri, S.; Langer, R. (February 2004). "Current Status and Future Potential of Transdermal Drug Delivery". Drug Discovery. 3 (2): 115–124. doi:10.1038/nrd1304. PMID 15040576.
Jump up ^ Gao, X.; Cui, Y.; Levenson, R.; Chung, L.; Nie, S. (2005). "In vivo cancer targeting and imaging with semiconductor quantum dots". Nature Biotechnology. 22 (8): 969–976. doi:10.1038/nbt994. PMID 15258594.
Jump up ^ "Sunscreen or sunblock". Retrieved July 2015. Check date values in: |accessdate= (help)
Jump up ^ An update on Suncreens; 2007; P 23- 29. Available at www.aocd.org/resource/resmgr/jaocd/2007aug.pdf
Jump up ^ "Nanotechnology Information Center: Properties, Applications, Research, and Safety Guidelines". American Elements.
Jump up ^ Shapiro SS, Saliou C (2001). "Role of vitamins in skin care". Nutrition. 17 (10): 839–844. doi:10.1016/S0899-9007(01)00660-8. PMID 11684391.
Jump up ^ Esther Boelsma, Lucy PL van de Vijver, R Alexandra Goldbohm; et al. (February 2003). "Role of vitamins in skin care". The American Journal of Clinical Nutrition. 77 (2): 348–355. doi:10.1093/ajcn/77.2.348. PMID 12540393. CS1 maint: Multiple names: authors list (link)
Jump up ^ "Foods for healthy skin".
External links[edit]
Look up human skin in Wiktionary, the free dictionary.
MedlinePlus Skin Conditions National Library of Medicine retrieved November 12, 2013.
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Holden Caulfield
From Wikipedia, the free encyclopedia
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Holden Caulfield
An interpretation of Holden Caulfield on the cover of the 2012 book The Catcher in the Rye and Philosophy by Heather Salter and Keith Dromm.
First appearance
"I'm Crazy"
Last appearance
The Catcher in the Rye
Created by
J. D. Salinger
Information
Gender
Male
Occupation
Student
Family
D. B. Caulfield (brother)
Phoebe Caulfield (sister)
Allie Caulfield (deceased brother)
Nationality
American
Holden Caulfield is a fictional character in author J. D. Salinger's 1951 novel The Catcher in the Rye. Since the book's publication, Holden has become an icon for teenage rebellion and angst, and now stands among the most important characters of 20th-century American literature. The name Holden Caulfield was used in an unpublished short story written in 1942 and first appeared in print in 1945.
Although it has been conjectured that J. D. Salinger got the name for Holden Caulfield in The Catcher in the Rye when he saw a marquee for the 1947 film Dear Ruth, starring William Holden and Joan Caulfield,[1] Salinger's first Holden Caulfield story, "I'm Crazy," appeared in Collier's on December 22, 1945, a year and a half before this movie was released.
Contents
[hide]
1 Explanation of teenage narrative
2 In The Catcher in the Rye
3 In other works
4 Caulfield family in other works
5 Cultural impact
6 References
7 External links
Explanation of teenage narrative[edit]
Holden is naive and at the same time resentful of the adult world.[2] One of Holden's most striking and quintessential qualities is his powerful revulsion for "phony" qualities, a catch-all term for the perceived hypocrisy that irritates Holden. It is this cynicism that causes him to distance himself from other people, despite wanting connection as well. Holden is very much a character of contradiction; at seventeen years of age he is six feet two-and-a-half inches (189 cm) tall, and already has some grey hair – though he himself admits that he sometimes acts more like a 13-year-old than an adult. He continually fails classes.
In The Catcher in the Rye[edit]
Holden Caulfield is the narrator and main character of The Catcher in the Rye. The novel recounts Holden's week in New York City during Christmas break following his expulsion from Pencey Prep, a preparatory school in Pennsylvania based loosely on Salinger's alma mater Valley Forge Military Academy. Holden Caulfield tells his story with surprising honesty from a hospital in California in a cynical and jaded language.
In other works[edit]
The character, as Holden Morrisey Caulfield, also appears in Salinger's "Slight Rebellion off Madison", published in the December 21, 1946, issue of The New Yorker. An earlier version of this story, titled "Are You Banging Your Head Against a Wall?" was accepted for publication by The New Yorker in October 1941, but was not published then because editors found the tone to be too desolate for its readership. An edited version of this short story later became the basis of several chapters in the middle-late section of The Catcher in the Rye dealing with Caulfield's date with Sally Hayes, during which he confesses his desire to run away with her, he meets Carl Luce for drinks, and he makes a drunken phone call to the Hayes home. Unlike the similar sequence in the novel, Caulfield is on a Christmas break from school, and, in the story, the interlude with Sally is split into two occurrences. Also, the meeting with Carl Luce is considerably briefer in the story than in the novel.
Caulfield also figures as a character in the short story "I'm Crazy", published in Colliers (December 22, 1945), and other members of the Caulfield family are featured in "Last Day of the Last Furlough", published in The Saturday Evening Post (July 15, 1944) and the unpublished short stories "The Last and Best of the Peter Pans" (c. 1942) and "The Ocean Full of Bowling Balls" (c. 1945). "I'm Crazy" is closely related to the first chapter of The Catcher in the Rye. It begins with Caulfield standing on a hill at "Pencey Prep" watching a football game below, and develops as Holden visits with his history teacher, Mr. Spencer, for a talk about his expulsion from school and his future. Several other details match those found in the first chapter of Catcher, including a reference to the mother of one of Caulfield's schoolmates and to his own mother sending him a gift of ice skates, but the story ends with his returning home instead of running away from school. Once home, he is not shown confronting his parents, who, according to the maid, are playing bridge. Instead, he goes to speak to Phoebe. Their dialogue is similar to that which appears in the later chapters of The Catcher in the Rye. The other notable feature of the story is that his sister Viola gets her first, and only, mention in the Caulfield saga.
"This Sandwich Has No Mayonnaise" (Esquire, 1945) reveals that Holden went missing in action during the war.
A song by Green Day is titled "Who Wrote Holden Caulfield?" from their second studio album Kerplunk.
Caulfield family in other works[edit]
"Last Day of the Last Furlough" relates the final day of Babe Gladwaller before he leaves to fight in World War II. Gladwaller spends part of the day with his little sister before Vincent Caulfield (later renamed D.B. in the novel) arrives. At that point Vincent is a fellow soldier about to leave for the war. Vincent announces that his brother, Holden, has been declared missing in action. Gladwaller's relationship with his younger sister can be seen as a parallel to Caulfield's relationship with Phoebe.
"The Last and Best of the Peter Pans" relates the story of Vincent's (D.B.) draft questionnaire being hidden by his mother. The events occur just after the death of Kenneth (later renamed Allie) and reveal the anxiety of Mary Moriarity, an actress and Caulfield's mother. The story is notable for the appearance of Phoebe and Vincent's statements about a child crawling off a cliff.
In "The Ocean Full of Bowling Balls," Vincent (D.B.) recalls the day his brother Kenneth (Allie) died. The story is set at the Caulfield summer home on Cape Cod. Several details make their way from this story into Catcher, including the characterization of Allie; Allie's poetry-inscribed left-handed baseball mitt; Vincent's girlfriend, Helen, who keeps her kings in the back row (like Jane Gallagher); and Caulfield's critical view of others. While the cause of death in Catcher is leukemia, here it is due to an unspecified heart condition. Toward the end of the story, Kenneth and Vincent are on the beach. Kenneth decides to go swimming and is knocked out by a wave. Holden, just home from camp, is waiting on the porch with his suitcases as Vincent comes back with Kenneth's unconscious body. Kenneth passes away later the same night. The story was reportedly sold to a magazine, only to be taken back by Salinger before publication.
Another short story of note with relationship to Caulfield is "The Boy in the People Shooting Hat," which was submitted to The New Yorker sometime between 1948 and 1949 but was never published. It focuses on a fight between two characters named Bobby and Stradlater over Bobby's feelings about Jane Gallagher. This story appears to form the basis for several key scenes in the first several chapters of The Catcher in the Rye.
In Seymour: An Introduction a Curtis Caulfield is mentioned in passing as "an exceptionally intelligent and likable boy" who appeared on the same radio show as Seymour and the other Glass children. He is reportedly "killed during one of the landings in the Pacific."[3]
Cultural impact[edit]
Holden Caulfield is one of the most enduring characters in 20th-century American fiction. It has been suggested that Salinger himself related so closely to Holden that he was protective of the character. This was the reason he was unwilling to allow filming of the book or use of the character by other writers.[4] The Catcher in the Rye is required reading in many high school English courses, although it has been banned from some school libraries by parent and teacher groups opposed to its use of profanity and perceived glorification of rebellion.
References[edit]
Jump up ^ Saturday Evening Post, July 15, 1944
Jump up ^ Cliffs Notes: The Catcher in the Rye - Character Analysis: Holden Caulfield. Accessed 15 February 2013 Archived 17 February 2013 at the Wayback Machine.
Jump up ^ Salinger, J.D. (2001). Raise High the Roof Beam, Carpenters ; and Seymour : an introduction (1st Back Bay pbk. ed.). Boston: Back Bay books. p. 225. ISBN 0-316-76694-1.
Jump up ^ "Holden Caulfield, It's Time We Let Go", Atlantic Wire, October 16, 2012. Accessed 15 February 2013
External links[edit]
Salinger's uncollected short stories
Slight Rebellion off Madison.
In Japan, most of the short stories are already translated into Japanese (compiled in two volumes) and still commercially available with the approval of Salinger's agents (ISBN 4-7521-0001-0 / ISBN 4-7521-0002-9). Even Hapworth 16, 1924 is available (ISBN 4-7521-0004-5).
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