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HIV-1 protease
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HIV-1 Protease (Retropepsin)
HIV-1 protease dimer in white and grey, with peptide substrate in black and active site aspartate side chains in red. (PDB: 1KJF)
Identifiers
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3.4.23.16
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144114-21-6
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HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS.[1][2] HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at the appropriate places to create the mature protein components of an infectious HIV virion. Without effective HIV protease, HIV virions remain uninfectious.[4][5] Thus, mutation of HIV protease's active site or inhibition of its activity disrupts HIV’s ability to replicate and infect additional cells,[6] making HIV protease inhibition the subject of considerable pharmaceutical research. [7]
Contents
[hide]
1 Structure and function
2 HIV-1 protease as a drug target
3 See also
4 External links
5 References
Structure and function[edit]
HIV-1 protease labelled according to its resemblance to an English Bulldog or a fat cat.[8] The blue and cyan-green ribbons depict the peptide backbone of a wild-type (1D4S) and a mutant (1KZK) structure, respectively.
HIV protease's protein structure has been investigated using X-ray crystallography. It exists as a homodimer, with each subunit made up of 99 amino acids.[1]
The active site lies between the identical subunits and has the characteristic Asp-Thr-Gly (Asp25, Thr26 and Gly27) sequence common to aspartic proteases. The two Asp25 residues (one from each chain) act as the catalytic residues. According to the mechanism for HIV protease protein cleavage proposed by Mariusz Jaskolski and colleagues, water acts as a nucleophile, which acts in simultaneous conjunction with a well-placed aspartic acid to hydrolyze the scissile peptide bond.[9] Additionally, HIV protease has two molecular "flaps" which move a distance of up to 7 Å when the enzyme becomes associated with a substrate.[10]
HIV-1 protease as a drug target[edit]
The HIV-1 protease dimer (green and cyan) with active site Asp-25 in red.
Complexed with a polypeptide substrate (magenta). (PDB: 1KJF)
Complexed with inhibitor BEA369 (depicted as a sticks with carbon in white, nitrogen in blue, oxygen in red). (PDB: 1EBY)
With its integral role in HIV replication, HIV protease has been a prime target for drug therapy. HIV protease inhibitors work by specifically binding to the active site by mimicking the tetrahedral intermediate of its substrate and essentially becoming “stuck,” disabling the enzyme. After assembly and budding, viral particles lacking active protease cannot mature into infectious virions. Several protease inhibitors have been licensed for HIV therapy.[11]
HIV-1 Protease has the classic AspThrGly of Aspartyl Proteases. These amino acids are located at position 25, 26, and 27, and are responsible for the catalytic activity.
However, due to the high mutation rates of retroviruses, and considering that changes to a few amino acids within HIV protease can render it much less visible to an inhibitor, the active site of this enzyme can change rapidly when under the selective pressure of replication-inhibiting drugs.[12]
One approach to minimizing the development of drug-resistance in HIV is to administer a combination of drugs which inhibit several key aspects of the HIV replication cycle simultaneously, rather than one drug at a time. Other drug therapy targets include reverse transcriptase, virus attachment, membrane fusion, cDNA integration and virion assembly.[13][14]
See also[edit]
Management of HIV/AIDS
Discovery and development of HIV-protease inhibitors
External links[edit]
The MEROPS online database for peptidases and their inhibitors: A02.001
Proteopedia HIV-1_protease - the HIV-1 protease structure in interactive 3D
HIV-1 Protease at the US National Library of Medicine Medical Subject Headings (MeSH)
References[edit]
^ Jump up to: a b Davies DR (1990). "The structure and function of the aspartic proteinases". Annu Rev Biophys Biophys Chem. 19 (1): 189–215. PMID 2194475. doi:10.1146/annurev.bb.19.060190.001201.
Jump up ^ Brik A, Wong CH (January 2003). "HIV-1 protease: mechanism and drug discovery". Org. Biomol. Chem. 1 (1): 5–14. PMID 12929379. doi:10.1039/b208248a.
Jump up ^ Huang, X; Britto, MD; Kear-Scott, JL; Boone, CD; Rocca, JR; Simmerling, C; Mckenna, R; Bieri, M; Gooley, PR; Dunn, BM; Fanucci, GE (13 June 2014). "The role of select subtype polymorphisms on HIV-1 protease conformational sampling and dynamics.". The Journal of Biological Chemistry. 289 (24): 17203–14. PMC 4059161  . PMID 24742668. doi:10.1074/jbc.M114.571836.
Jump up ^ Kräusslich HG, Ingraham RH, Skoog MT, Wimmer E, Pallai PV, Carter CA (February 1989). "Activity of purified biosynthetic proteinase of human immunodeficiency virus on natural substrates and synthetic peptides". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 807–11. PMC 286566  . PMID 2644644. doi:10.1073/pnas.86.3.807.
Jump up ^ Kohl NE, Emini EA, Schleif WA, et al. (July 1988). "Active human immunodeficiency virus protease is required for viral infectivity". Proc. Natl. Acad. Sci. U.S.A. 85 (13): 4686–90. PMC 280500  . PMID 3290901. doi:10.1073/pnas.85.13.4686.
Jump up ^ Seelmeier S, Schmidt H, Turk V, von der Helm K (September 1988). "Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A". Proc. Natl. Acad. Sci. U.S.A. 85 (18): 6612–6. PMC 282027  . PMID 3045820. doi:10.1073/pnas.85.18.6612.
Jump up ^ McPhee F, Good AC, Kuntz ID, Craik CS (October 1996). "Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11477–81. PMC 56635  . PMID 8876160. doi:10.1073/pnas.93.21.11477.
Jump up ^ Perryman AL, Lin JH, McCammon JA (April 2004). "HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: possible contributions to drug resistance and a potential new target site for drugs" (PDF). Protein Sci. 13 (4): 1108–23. PMC 2280056  . PMID 15044738. doi:10.1110/ps.03468904. Retrieved 2008-06-27.
Jump up ^ Jaskólski M, Tomasselli AG, Sawyer TK, Staples DG, Heinrikson RL, Schneider J, Kent SB, Wlodawer A (February 1991). "Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor". Biochemistry. 30 (6): 1600–9. PMID 1993177. doi:10.1021/bi00220a023.
Jump up ^ Miller M, Schneider J, Sathyanarayana BK, Toth MV, Marshall GR, Clawson L, Selk L, Kent SB, Wlodawer A (December 1989). "Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution". Science. 246 (4934): 1149–52. PMID 2686029. doi:10.1126/science.2686029.
Jump up ^ H.P. Rang (2007). Rang and Dale's pharmacology (6th ed.). Philadelphia, Pa., U.S.A.: Churchill Livingstone/Elsevier. ISBN 9780808923541.
Jump up ^ Watkins T, Resch W, Irlbeck D, Swanstrom R (February 2003). "Selection of high-level resistance to human immunodeficiency virus type 1 protease inhibitors". Antimicrob. Agents Chemother. 47 (2): 759–69. PMC 151730  . PMID 12543689. doi:10.1128/AAC.47.2.759-769.2003.
Jump up ^ Moore JP, Stevenson M (October 2000). "New targets for inhibitors of HIV-1 replication". Nat. Rev. Mol. Cell Biol. 1 (1): 40–9. PMID 11413488. doi:10.1038/35036060.
Jump up ^ De Clercq E (December 2007). "The design of drugs for HIV and HCV". Nat Rev Drug Discov. 6 (12): 1001–18. PMID 18049474. doi:10.1038/nrd2424.
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Angel of the Morning
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"Angel of the Morning"
A-side label of U.S. vinyl single
Single by Merrilee Rush & The Turnabouts
from the album Angel of the Morning
B-side
"Reap What You Sow"[1]
Released
7 February 1968
Format
7" single
Recorded
American Sound Studios Memphis
January 1968
Genre
Pop, country
Length
3:19
Label
Bell
Songwriter(s)
Chip Taylor
Producer(s)
Chips Moman
Merrilee Rush singles chronology
"How's the Weather on Your Street"
(1967) "Angel of the Morning"
(1968) "That Kind of Woman"
(1968)
"How's the Weather on Your Street"
Merrilee & the Turnabouts
(1967) "Angel of the Morning"
Merrilee Rush & the Turnabouts
(1968) "That Kind of Woman"
(1968)
"Angel of the Morning" is a popular song, written and composed by Chip Taylor, that has been recorded numerous times by, or has been a hit single for, various artists including Evie Sands, Merrilee Rush, Juice Newton, Nina Simone, P. P. Arnold, Olivia Newton-John, The Pretenders/Chrissie Hynde, Dusty Springfield, Mary Mason, Melba Montgomery, Vagiant, Billie Davis, Bonnie Tyler, Rita Wilson, The New Seekers and Skeeter Davis.
Contents
[hide]
1 Origins, the original recording, and subsequent versions
2 Versions by Chip Taylor
3 Non-charting versions
4 Translated versions
5 Film, television and literature
6 Versions (English language-chronology)
7 Chart history
7.1 Weekly charts
7.1.1 Merrilee Rush & The Turnabouts version
7.2 Year-end charts
7.2.1 Juice Newton version
8 See also
9 References
10 External links
Origins, the original recording, and subsequent versions[edit]
Written and composed by New York City-born songwriter Chip Taylor, actor Jonathan "Jon" Voight's brother, "Angel of the Morning" was originally offered to Connie Francis to sing, but she turned it down because she thought that it was too risqué for her career.[citation needed] The song's narrator describes her feelings about a one-night stand: "If morning's echo says we've sinned, well, it was what I wanted now."
Taylor produced a recording of the song with Evie Sands, but the financial straits of Cameo-Parkway Records, which had Sands on their roster, reportedly prevented either that version's release or its distribution.
Other early recordings of the song were made in 1967 by Danny Michaels for Lee Hazlewood's LHI label and by UK vocalist Billie Davis.
The song finally became a hit in 1968 through a recording by Merrilee Rush, made that January at American Sound Studios in Memphis, with Chips Moman and Tommy Cogbill producing. Rush had come to Memphis through the group she fronted, the Turnabouts, being the opening act for a Paul Revere and the Raiders tour. While in Memphis, the Raiders recorded the album Going to Memphis at American Sound Studios, an association which led to Rush's discovery by Tommy Cogbill, who had been hoping to find the right voice for "Angel of the Morning"—he had kept a tape of the demo of that song constantly in his pocket for several months.
Rush recorded the song and the tracks which would comprise her Angel of the Morning album with the American Sound house band, even though the single and the album would be credited to the group "Merrilee Rush & the Turnabouts."[2]

The single version was released in February 1968, and reached the Top 10 on the Billboard Hot 100 that June, peaking at No. 7. A No. 1 hit in Canada,[3] Australia and New Zealand, and also gave Rush a hit in the Netherlands (No. 4). The song earned Rush a Grammy nomination for Best Contemporary-Pop Vocal Performance, Female.
Rush recorded a new version of the song for her 1977 eponymous album release. (Rush's version of "Angel of the Morning" would be featured on the soundtrack of the 1999 film Girl, Interrupted, whose time frame is 1967 and 1968, in which author-composer Chip Taylor's niece Angelina Jolie had a starring role.)
In the United Kingdom, where Rush's version stalled at No. 55, a rendition by P. P. Arnold,[4] who had sung background on the 1967 Billie Davis version, reached No. 29 in August 1968.
In 1970 a rendition by Connie Eaton reached No. 34 on the Billboard C&W charts.
In 1977, Mary Mason also had a UK Top 30 hit with her version, which was actually a medley of two Chip Taylor songs, "Angel of the Morning" and "Any Way That You Want Me," reaching No. 27.[5]
Also in 1977 the British act Guys 'n' Dolls had a hit in the Netherlands with the song, and their version reached No. 11 on the Dutch charts.
In 1978 a release by Melba Montgomery reached No. 22 on the Billboard C&W chart.
"Angel of the Morning"
Single by Juice Newton
from the album Juice
B-side
"Headin' for a Heartache"
Released
February 1981
Format
7" (45 rpm)
Recorded
4 September 1980
Genre
Soft rock,[6] Country rock
Length
3:49
3:57 (7")
Label
Capitol 4976
Songwriter(s)
Chip Taylor
Producer(s)
Richard Landis
Juice Newton singles chronology
"You Fill My Life"
(1980) "Angel of the Morning"
(1981) "Queen of Hearts"
(1981)
"You Fill My Life"
(1980) "Angel of the Morning"
(1981) "Queen of Hearts"
(1981)
The highest-charting and best-selling version in the United States was recorded and released in 1981 by country-rock singer Juice Newton for her album Juice. Newton re-interpreted the song at the suggestion of Steve Meyer, who promoted Capitol Records singles and albums to radio stations and felt a version of "Angel of the Morning" by Newton would be a strong candidate for airplay.[7] Newton would state that she would never have herself thought of recording "Angel of the Morning," and even though she immediately recognized the song when Meyer played it for her (quote): "I [hadn't been] really aware of that song because...when [it] was popular I was listening to folk music and R&B and not Pop, and that was a very Pop song." [8]
Newton's version reached No. 4 on the Billboard Hot 100, No. 22 on the Billboard country music chart, and spent three weeks at No. 1 on the Billboard adult contemporary chart in April of that year.[9][10] The recording also earned Newton a Grammy nomination, and in the same category as Rush's 1968 hit. More than 1 million units of Newton's single of the song were sold in the United States, and the single reached the Top 10 in a number of other countries, including Canada and Australia. Notably, Newton's video for "Angel of the Morning" was the first country-music music video aired on MTV; it first aired in 1981. In the UK, this recording reached No. 43 on the UK Singles Chart, marking the song's third appearance on that chart without becoming a truly major hit.[11] (Newton recorded the song again in 1998 for her The Trouble with Angels album.)
The song "Angel," released by reggae artist Shaggy, heavily samples "Angel of the Morning," using the melody, but with different words, for the sung refrain. It reached #1 on the Billboard Hot 100 for the week ending March 31, 2001.
Swedish singer Jill Johnson released "Angel of the Morning," with lyrics in English, in 2007 from her album of cover versions, Music Row. This version peaked at No. 30 at the Swedish singles chart.
Versions by Chip Taylor[edit]
In 1972, Taylor released a version on Buddah 325. It reached #101 in the Record World survey.
In 1996, Taylor released a version on the album Hit Man.[12]
In 1999, a version by Taylor appeared on the KGSR fundraiser CD Broadcasts Vol. 7.[13]
In 2004, Taylor released a version of the song with his singer/songwriter partner Carrie Rodriguez on the album of the same name.[14]
Non-charting versions[edit]
In 1968, the American singer Joya Landis recorded a late rocksteady/early reggae version of this song in Jamaica for producer Arthur "Duke" Reid and his Treasure Isle label. The UK release (Trojan TR-622) had "Love Letters" by Phyllis Dillon and Alton Ellis as the B-side. It also appeared on the compilation album Soul Of Jamaica a.k.a. Come Rock With Me In Jamaica, and on the Trojan compilation album, Tighten Up, Volume 1 (both 1968).
The Chicks, a female New Zealand pop duo, released their version on their 1968 album C'mon Chicks.
Allison Durbin, who was dubbed "Australia's Queen of Pop" in the 1960s, released a version on her 1968 album I Have Loved Me a Man.
Soul singer Bettye Swann had a single release of "Angel of the Morning" in 1969.
The New Seekers included "Angel of the Morning" on their self-titled debut album (1969).
Nina Simone recorded the song in 1971 on Here Comes the Sun.
Norwegian singer Ellen Nikolaysen recorded the song for her 1973 English language album Freckles.
Soul singer Thelma Jones recorded the song for her eponymous 1978 album.
Reggae singer Samantha Rose recorded a Lover's rock version on the In Person LP in 1979.
Vintage British Invasion group The Tremeloes recorded the song in 1987 as an attempted comeback single.
In 1991, horror punk band Haunted Garage included the chorus of "Angel of the Morning" in the bridge of their song "Theme" on the album Possession Park, changing the lyrics to "Satan of the morning".
In 1995, Chrissie Hynde and The Pretenders sang their own version on the Friends soundtrack album. The song was released as a single, but it did not chart.
The short-lived British girl band Thunderbugs recorded an upbeat version of the song for their 1999 debut album, Delicious.
In 2003 Maggie Reilly recorded "Angel of the Morning" for her album Save It for a Rainy Day.
The Boston-based band Tijuana Sweetheart (then named VAGIANT) released a cover on their debut album, Public Display of Infection.
The Atlanta-based band Girlyman released a cover on its 2007 live album Somewhere Different Now.
Melinda Schneider and Beccy Cole covered the song on their album Great Women of Country, which they released in 2014.
Ray Conniff recorded a version found on the album "Turn Around Look at Me" in 1968.
Translated versions[edit]
A number of non-English versions of "Angel of the Morning" have been recorded including the following:
In Czech as "Dál jen vejdi" a 1989 single by Věra Martinová
In Dutch as "Vlinder van een zomer" a 1968 single by Willeke Alberti.
In French as "Au revoir et à demain" (literally: "goodbye and see you tomorrow") a 1967 single by Liliane Saint-Pierre.
In Finnish as "Kaipuu" a 1968 single by Pepe Willberg and also as "Jos Itket Silloin" recorded by Pirjo Lehti for her 1985 Se On Rakkautta Oikeaa album.
In Italian as "Gli occhi verdi dell'amore" (literally: "the green eyes of love") which was a 1968 hit in Italy at No. 9 for I Profeti.
In German as "Der Engel der Verdammten" by Juliane Werding on her 1975 album Wenn du denkst, dass du denkst, dann denkst du nur, du denkst and also as " "Ich bin dein Engel bis zum Morgen" a 1981 single by Suzanne Klee.
In Spanish as "Ángel de la Mañana" by Enrique Guzmán in 1975.
In Swedish as "En enda morgon" recorded by Elisabeth Andreassen for her 1981 album Angel of the Morning and also as "Nattens sista ängel" recorded by Wizex for their 1982 album Nattfjäril. These respective lyricists for these versions were Mats Rådberg and Roine Carlsson.
In Russian as "Нелегальный Ангел" (Nelegal'nyj Angel) by Julia Kova in 2005.
Film, television and literature[edit]
The Merrilee Rush version of the song is featured in the soundtrack of the films Girl, Interrupted (as noted above) and Violet and Daisy.
Rush's version is also played during a scene in the 1978 film Fingers, where it is used to accentuate the conflicted nature of the main character played by Harvey Keitel.
The song was performed live by Chrissie Hynde in a 1995 episode of Friends titled "The One with the Baby on the Bus," and that version also appears in that show's soundtrack album. (As noted above, though released as a single, it did not chart.)
The song also makes an appearance in the 1996 film Jerry Maguire, with Tom Cruise's titular character singing what appears to be the original version, enthusiastically if badly.
More recently, Conan O'Brien has referenced the track, during periodic ironic pledges to cease his show's use of arbitrary and stupid humor in which he presents a gorilla dressed as a nurse who uses an old-fashioned abdominal exerciser while enjoying the song.
In "Branch Closing", an episode of The Office, Michael Scott sings "Levinson in the morning" to his supervisor, Jan Levinson.
The song plays a central role in Graeme Simsion's 2016 novel The Best of Adam Sharp[15] (optioned to Vocab Films in 2017).[16]
Juice Newton's version is heard during Drew Barrymore's first scene in the film Charlie's Angels, in the film Charlie Wilson's War (in which it is also sung by Emily Blunt), the opening titles of Deadpool, and the ending of The Meddler. It is also featured in Season 1 of HBO's True Detective.
The Toyota Highlander "Kid Cave" commercial, aired from late 2010, features a young boy who is embarrassed by his parents's singing of the song while he is riding with them in a car.[17]
The song features in an episode of ABC's sitcom Modern Family, "Regrets Only" (Series/Season 2, Ep 16), when Gloria, portrayed by Sofia Vergara, is singing along to it on a karaoke machine. A karaoke version of the song is also featured in the second-season finale of the HBO series The Leftovers.
The song also features a parody version in Family Guy with Peter Griffin portraying himself as Deadpool.
Versions (English language-chronology)[edit]
1967: Evie Sands (original recording), Billie Davis
1968: Merrilee Rush and The Turnabouts, Asha Puthli and The Surfers,[18] P. P. Arnold, Percy Faith, Ray Conniff
1969: Dusty Springfield (TV performance on Decidedly Dusty), Skeeter Davis, Bettye Swann, the New Seekers, the Tremeloes, Connie Eaton
1970: The Aggressors, on their album Reggae Steadae Go
1971: Nina Simone
1973: Olivia Newton-John
1977: Merrilee Rush (re-recording for United Artists Records), Guys 'n' Dolls, Mary Mason ("Angel of the Morning"/"Any Way That You Want Me" medley)
1978: Melba Montgomery, Thelma Jones, Pat Kelly
1981: Elisabeth Andreassen, Juice Newton, the States[19]
1987: The Tremeloes
1995: The Pretenders
1995: Annie Schilder BZN
1998: Juice Newton (re-recording), Bonnie Tyler
1998: Gitte Haenning (Gitte Hænning) WEA Records Warner music Germany
1998: Bonnie Tyler
1999: Thunderbugs
2000: Joya Landis
2001: Maggie Reilly
2003: The Shocker
2006: Chip Taylor & Carrie Rodriguez
2007: Girlyman, Jill Johnson, Vagiant
2008: Barb Jungr, Randy Crawford (with Joe Sample)
2011: Hanne Boel
2012: Rita Wilson
Chart history[edit]
Weekly charts[edit]
Merrilee Rush & The Turnabouts version[edit]
Chart (1968)
Peak
position
Canada RPM Top Singles [20] 1
Netherlands (Single Top 100)[21] 5
US Billboard Hot 100[22] 7
US Adult Contemporary (Billboard)[23] 32
US Cash Box Top 100[24] 3
Year-end charts[edit]
Chart (1968)
Rank
Canada [25] 70
US Billboard Hot 100[26] 28
US Cash Box [27] 45
Juice Newton version[edit]
Chart (1981)
Peak
position
Australia (Kent Music Report)[28] 2
Austria (Ö3 Austria Top 40)[29] 7
Canada RPM Top Singles [30] 1
Denmark (Tracklisten)[31] 23
South Africa (Springbok Radio)[32] 3
Switzerland (Schweizer Hitparade)[33] 4
New Zealand (Recorded Music NZ)[34] 5
UK Singles (Official Charts Company)[35] 43
US Billboard Hot 100[36] 4
US Adult Contemporary (Billboard)[37] 1
US Hot Country Songs (Billboard)[38] 22
US Cash Box Top 100[39] 2
Chart (1981)
Rank
Australia [40] 26
Canada [41] 8
New Zealand [42] 50
US Billboard Hot 100[26] 25
US Cash Box [43] 21
See also[edit]
List of number-one singles in Australia during the 1960s
List of number-one singles in 1968 (New Zealand)
List of number-one adult contemporary singles of 1981 (U.S.)
References[edit]
Jump up ^ "Merrilee Rush & The Turnabouts -- "Angel of the Morning"/"Reap What You Sow"". Discogs. Retrieved 25 December 2014.
Jump up ^ Jones, Roben (2010). Memphis Boys: the story of American Studios (1st ed.). Jackson, Mississippi: University Press of Mississippi. pp. 126–130. ISBN 1-60473-401-9.
Jump up ^ "Item Display – RPM v Library and Archives Canada". Collectionscanada.gc.ca. Retrieved 2016-10-01.
Jump up ^ Arnold UK Singles Chart info Archived August 19, 2011, at the Wayback Machine. Chartstats.com. Retrieved 12 September 2009
Jump up ^ Mason UK Singles Chart info Archived March 5, 2012, at the Wayback Machine. Chartstats.com. Retrieved 12 September 2009.
Jump up ^ "VH1's 40 Most Softsational Soft-Rock Songs". Stereogum. SpinMedia. May 31, 2007. Retrieved July 31, 2016.
Jump up ^ Lewiston Daily Sun April 15, 1981 p. 4
Jump up ^ Kentucky New Era p.2
Jump up ^ Hyatt, Wesley (1999). The Billboard Book of No. 1 Adult Contemporary Hits (Billboard Publications), page 250.
Jump up ^ Whitburn, Joel (2004). The Billboard Book of Top 40 Hits, 8th Edition (Billboard Publications), page 454.
Jump up ^ Newton UK Singles Chart info Archived March 4, 2012, at the Wayback Machine. Chartstats.com. Retrieved 12 September 2009.
Jump up ^ Hit Man – Chip Taylor. Amazon.com.
Jump up ^ KGSR BROADCASTS CDS – Volume 7 Archived December 26, 2010, at the Wayback Machine.. KGSR.com.
Jump up ^ Angel of the Morning – Chip Taylor, Carrie Rodriguez Amazon.com.
Jump up ^ Best of Adam Sharp Playlist, Penguin
Jump up ^ Anita Busch. Toni Collette Options Graeme Simsion Novel ‘The Best of Adam Sharp’ For Her Vocab Films, Deadline Hollywood
Jump up ^ Beth Harpaz. What Embarrasses a Teen? A Parent's Mere Existence, Associated Press, 2010-12-20
Jump up ^ "Discography". Asha Puthli official website. Archived from the original on 3 January 2013. Retrieved 16 February 2013.
Jump up ^ "MusicMight :: Artists :: THE STATES". Rockdetector.com. Retrieved 2016-10-01.
Jump up ^ Canada, Library and Archives (17 July 2013). "Image : RPM Weekly".
Jump up ^ "Dutchcharts.nl – Merrilee Rush – Angel of the Morning" (in Dutch). Single Top 100.
Jump up ^ "Merrilee Rush & the Turnabouts Chart History (Hot 100)". Billboard.
Jump up ^ "Merrilee Rush & the Turnabouts Chart History (Adult Contemporary)". Billboard.
Jump up ^ "Cash Box Top 100 Singles, July 13, 1968".
Jump up ^ http://www.collectionscanada.gc.ca/rpm/028020-119.01-e.php?brws_s=1&file_num=nlc008388.5867&type=1&interval=24&PHPSESSID=mhe12pta2k83e08udtq66ot062
^ Jump up to: a b "Top 100 Hits of 1981/Top 100 Songs of 1981". www.musicoutfitters.com.
Jump up ^ "Cash Box YE Pop Singles - 1968". tropicalglen.com.
Jump up ^ Kent, David (1993). Australian Chart Book 1970–1992 (Illustrated ed.). Sydney: Australian Chart Book. ISBN 0-646-11917-6.
Jump up ^ "Austriancharts.at – Juice Newton – Angel of the Morning" (in German). Ö3 Austria Top 40.
Jump up ^ Canada, Library and Archives (17 July 2013). "Image : RPM Weekly".
Jump up ^ "Danishcharts.com – Juice Newton – Angel of the Morning". Tracklisten.
Jump up ^ {http://www.rock.co.za/files/sa_charts_1969_1989_songs_(A-B).html%7Caccessdate=17 January 2018}
Jump up ^ "Swisscharts.com – Juice Newton – Angel of the Morning". Swiss Singles Chart.
Jump up ^ "Charts.org.nz – Juice Newton – Angel of the Morning". Top 40 Singles.
Jump up ^ "Juice Newton: Artist Chart History". Official Charts Company.
Jump up ^ "Juice Newton Chart History (Hot 100)". Billboard.
Jump up ^ "Juice Newton Chart History (Adult Contemporary)". Billboard.
Jump up ^ "Juice Newton Chart History (Hot Country Songs)". Billboard.
Jump up ^ "Cash Box Top 100 5/16/81". tropicalglen.com.
Jump up ^ "Forum – ARIA Charts: Special Occasion Charts – Top 100 End of Year AMR Charts – 1980s". Australian-charts.com. Hung Medien. Retrieved 13 January 2017.
Jump up ^ http://www.collectionscanada.gc.ca/rpm/028020-119.01-e.php?brws_s=1&file_num=nlc008388.4689&type=1&interval=24&PHPSESSID=mhe12pta2k83e08udtq66ot062
Jump up ^ http://nztop40.co.nz/chart/?chart=3870
Jump up ^ "Cash Box YE Pop Singles - 1981". tropicalglen.com.
Preceded by
"This Guy's in Love with You" by Herb Alpert Canadian RPM 100 number-one single
(Merrilee Rush version)
July 6, 1968 (one week) Succeeded by
"Lady Willpower" by Gary Puckett and the Union Gap
Preceded by
"What Kind of Fool" by Barbra Streisand and Barry Gibb Billboard Adult Contemporary (chart) number-one single
(Juice Newton version)
April 11-April 25, 1981 (three weeks) Succeeded by
"Morning Train (Nine to Five)" by Sheena Easton
External links[edit]
Newton 1981 U.S. single release info Discogs
Lyrics of this song at MetroLyrics
[show]
v
t
e
Juice Newton
Studio albums
Juice Newton & Silver Spur
After the Dust Settles
Come to Me
Well Kept Secret
Take Heart
Juice
Quiet Lies
Dirty Looks
Can't Wait All Night
Old Flame
Emotion
Ain't Gonna Cry
The Trouble with Angels
American Girl
The Gift of Christmas
Duets: Friends & Memories
Live albums
Every Road Leads Back to You
Compilation albums
Greatest Hits
Emotions
Anthology
Country Classics
The Ultimate Hits Collection
Notable singles
"It's a Heartache"
"Hey! Baby"
"Sunshine"
"Angel of the Morning"
"Queen of Hearts"
"The Sweetest Thing (I've Ever Known)"
"Love's Been a Little Bit Hard on Me"
"Break It to Me Gently"
"Tell Her No"
"You Make Me Want to Make You Mine"
"Hurt"
"Old Flame"
"Both to Each Other (Friends and Lovers)" (with Eddie Rabbitt)
"Cheap Love"
"What Can I Do with My Heart"
"First Time Caller"
"Tell Me True"
"When Love Comes Around the Bend"
"Funny How Time Slips Away" (with Willie Nelson)
Guest appearances
"Ebony Eyes" (Bob Welch song)
Have Harmony, Will Travel (Carla Olson album)
Related topics
Discography
Otha Young
Book:Juice Newton
[show]
v
t
e
Melba Montgomery
Discography
Collaborative and solo studio albums
What's in Our Heart
Bluegrass Hootenanny
Don't Let the Good Times Fool You
Compilation albums
A King & Two Queens
Famous Country Duets
Collaborative singles
"We Must Have Been Out of Our Minds"
"Let's Invite Them Over"
"What's in Our Heart"
"Blue Moon of Kentucky"
"Baby Ain't That Fine"
"Something to Brag About"
Solo singles
"No Charge"
"Don't Let the Good Times Fool You"
"Angel of the Morning"
See also
George Jones
Gene Pitney
Charlie Louvin
Retrieved from "https://en.wikipedia.org/w/index.php?title=Angel_of_the_Morning&oldid=834239201"
Categories:
1967 songs
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Number-one singles in Australia
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Pop ballads
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Hidden categories:
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text:
Carol Ann Susi
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Carol Ann Susi
Born
(1952-02-02)February 2, 1952
Brooklyn, New York, U.S.[1]
Died
November 11, 2014(2014-11-11) (aged 62)
Los Angeles, California, U.S.[2]
Cause of death
Cancer
Nationality
American
Occupation
Actress
Years active
1974–2014
Carol Ann Susi (February 2, 1952 – November 11, 2014) was an American actress. She was known for providing the voice of recurring unseen character Mrs. Wolowitz, mother of Howard Wolowitz, on the television series The Big Bang Theory.[3][4][5]
Contents
[hide]
1 Career
2 Personal life
3 References
4 External links
Career[edit]
Susi made her first screen appearance in Kolchak: The Night Stalker. Other television and film credits included: McMillan & Wife, Coyote Ugly, Just Go with It, The Big Bang Theory, Becker, Grey's Anatomy, That '70s Show, Out of Practice, Cats & Dogs, Just Shoot Me, Married... with Children, Night Court, The King of Queens, Death Becomes Her, Seinfeld, The Secret of My Success, My Blue Heaven, and Sabrina, the Teenage Witch.[6] She also had extensive experience in live theatre[7][8] and voiced a character on the video game installment of CSI: NY.
Personal life[edit]
Carol Ann Susi was born in Brooklyn,[1] of Italian descent.[9] She studied acting at HB Studio in New York City before moving to Los Angeles in the 1970s.[1]
Susi died of cancer on November 11, 2014, in Los Angeles, California, at age 62.[2][10]
References[edit]
^ Jump up to: a b c Hughes, Jason (November 11, 2014). "Carol Ann Susi, 'Big Bang Theory's' Mrs. Wolowitz, Dead at 62". The Wrap. Retrieved November 12, 2014.
^ Jump up to: a b "Big Bang Theory actress dies at 62". The Globe and Mail. November 12, 2014. Retrieved November 13, 2014.
Jump up ^ Morris, Joan (March 14, 2009). "Who's the Voice of 'Big Bang' Mother?". Contra Costa Times. p. 2A. Retrieved June 2, 2012.
Jump up ^ Salem, Rob (January 24, 2009). "Nerd herd doing a bang-up job". Toronto Star. Retrieved June 2, 2012.
Jump up ^ Owen, Rob (March 16, 2012). "TV Q&A with Rob Owen". Pittsburgh Post-Gazette. Retrieved June 2, 2012.
Jump up ^ Robinson, Johnny (September 27, 1974). "Radio and TV plus Video Versions". Lewiston Evening Journal. p. 21. Retrieved June 2, 2012.
Jump up ^ Drake, Sylvie (September 16, 1988). "'Ladies' Room' Lives Up to Expectations of Racy Domain". Los Angeles Times. p. C6. Retrieved June 2, 2012.
Jump up ^ Collins, Scott (December 19, 1995). "Ollstein's 'Pot Roast' Is Rich in Flavor". Los Angeles Times. p. F8. Retrieved June 2, 2012.
Jump up ^ Andreeva, Nellie (November 11, 2014). "Carol Ann Susi, 'Big Bang Theory's Mrs. Wolowitz, Dead". Deadline. Retrieved November 12, 2014.
Jump up ^ Swift, Andy (November 11, 2014). "Carol Ann Susi, Voice Behind Big Bang Theory's Mrs. Wolowitz, Dead at 62". TV Line. Retrieved November 11, 2014.
External links[edit]
Carol Ann Susi on IMDb
Authority control
WorldCat Identities
VIAF: 311656933
GND: 1061791513
Retrieved from "https://en.wikipedia.org/w/index.php?title=Carol_Ann_Susi&oldid=823767932"
Categories:
1952 births
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Deaths from cancer in California
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