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List of One Piece episodes (season 19)
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One Piece (season 19)
The cover of the first DVD compilation released by Toei Animation of the nineteenth season.
Country of origin
Japan
No. of episodes
57
Release
Original network
Fuji Television
Original release
April 9, 2017 (2017-04-09) – present (present)
Season chronology
← Previous
Season 18
List of One Piece episodes (seasons 15–current)
The nineteenth season of the One Piece anime series was produced by Toei Animation, and directed by Toshinori Fukuzawa. The season began broadcasting in Japan on Fuji Television on April 9, 2017. Like the rest of the series, it follows the adventures of Monkey D. Luffy and his Straw Hat Pirates. The story arc, called "Whole Cake Island", adapts material from the rest of the 82nd volume onwards of the manga by Eiichiro Oda. It deals with Luffy and his small team rescuing Sanji from his arranged marriage to finalize a political alliance between his own family, the Vinsmoke's, and Big Mom's family.
As of October 2017, two pieces of theme music are used for this season. The opening themes are "We Can" (ウィーキャン!, Wī Kyan!) sung by Kishidan and Hiroshi Kitadani for episodes 784 to 806, and "Hope" performed by Namie Amuro beginning with episode 807.
Contents
[hide]
1 Episode list
1.1 "Whole Cake Island"
2 Home releases
2.1 Japanese
3 Notes
4 References
Episode list[edit]
"Whole Cake Island"[edit]
No.[n 1]
Title[n 2]
Original airdate[n 3]
783
"Sanji's Homecoming! Into Big Mom's Territory!"
"Sanji Kikyō – Biggu Mamu no Nawabari e!" (サンジ 帰郷　ビッグ・マムの海域へ！) April 9, 2017
As the Sanji Retrieval Team fight off a storm, they're still weak from hunger. Meanwhile, Tamago tries to convince Sanji to join Big Mom but he refuses. When Vito shows him a picture of fiancée, Pudding, he is immediately love struck. However, Sanji ignores Vito and gets angry when he's grouped in with Germa 66. After returning to his room, Sanji's refusal to cooperate and disrespect causes Gotti to try to attack him but is stopped by a woman, who seems familiar to Sanji. After passing through the storm and days without food, Luffy catches a giant fish while people on a sail ship begin looking for someone.
784
"Zero and Four! Encountering Germa 66!"
"Rei to Yon - Sōgū! Jeruma Daburu Shikkusu" (0と4　遭遇！ジェルマ66 (ダブリシックス)) April 16, 2017
After going days without food, Luffy finally manages to catch a giant fish. However, he starts eating it before Chopper discovers its skin is extremely poisonous, causing him to collapse. The Sanji Retrieval Team enters Big Mom's territory, where they come across a Germa 66 ship. They see a man on the ship who resembles Sanji, but the man reveals himself to be Sanji's younger brother Yonji, and coldly refuses the team's pleas for an antidote to save Luffy. However, Yonji's sister Reiju berates him for his attitude, kicking him off their ship before leaping onto the Thousand Sunny.
785
"A Deadly Poison Crisis! Luffy and Reiju!"
"Mōdoku no Kiki - Rufi to Reiju!" (猛毒の危機　ルフィとレイジュ！) April 23, 2017
Brook recognizes Sanji's brother Yonji and his sister Reiju as members of the Vinsmoke Family which used to rule over the entire North Blue, and Reiju reveals that they still hold royal status despite losing their physical territory. Reiju then presses her mouth to Luffy's and sucks all the poison out of him, curing him. She and Yonji return to their ship, agreeing to not say anything about their encounter in order to ensure Sanji's wedding happens smoothly. Meanwhile, Aladine sees the scene from underwater and reports the Straw Hats' presence to Jinbe. The Sanji Retrieval Team later docks at an island, and despite Pekoms' orders to wait, Luffy and Chopper run out immediately, and they come to a town made entirely out of chocolate.
786
"Totto Land! Emperor Big Mom Appears!"
"Totto Rando! Yonkō Biggu Mamu Tōjō!" (万国！　四皇ビッグ・マム登場) April 30, 2017
The Sanji retrieval team disembarks on Cacao Island, an island close to Whole Cake Island in which everything on it is made of chocolate. Luffy and Chopper eat an entire café and are nearly arrested, but are saved by the cafe's owner, Charlotte Pudding. They converse with her, but Luffy accidentally reveals who he is. On Whole Cake Island, Big Mom oversees the preparation for the wedding tea party, which will occur in three days.
787
"The Emperor's Daughter! Sanji's Fiancée - Pudding!"
"Yonkō no Musume - Sanji no Fianse Purin" (四皇の娘　サンジの婚約者プリン) May 7, 2017
In Pudding's cafe on Cacao Island, Pudding and the Sanji Retrieval Team recognize each other. Together, they discuss the Charlotte Family and the upcoming wedding, and Pudding offers to secretly help the team retrieve Sanji. Meanwhile, an agitated Sanji arrives at the Germa Kingdom. Another section of Germa 66, led by his two elder brothers, arrive at the war-torn Brock Collie Island and confer with one of its sides. Back on the Thousand Sunny, the Sanji Retrieval Team discover that Pekoms is missing, and find a warning scrawled in the bathroom. An excited Luffy nonetheless declares that they will push on.
788
"A Massive Attack! Mom's Hunger Pangs!"
"Dai-shingeki! Kui-wazurai no Mamu" (大進撃! 食いわずらいのマム) May 14, 2017
On Brock Collie Island, Sanji's two older brothers end a two-year war in four hours. They then prepare to make the two-day voyage to Whole Cake Island to attend their brother's wedding. Meanwhile, the Sanji Retrieval Team sails through Totto Land, marveling at the archipelago's sweet scenery. However, they are attacked by two giant centipedes, but Luffy manages to defeat them both. The team gets suspicious at Pedro's advanced knowledge of the area, and he reveals that he has been here once before. Meanwhile, Big Mom gets a craving for croquembouche that causes her to fall into madness, and she leaves a path of destruction in her wake as she searches for the treat. The ministers begin to panic as she enters Sweet City, and order the citizens to evacuate as Big Mom mindlessly wrecks the city.
789
"The Capital City Falls?! Big Mom and Jimbei"
"Shuto Hōkai!? Biggu Mamu to Jinbē" (首都崩壊！？ ビッグ・マムとジンベエ) May 21, 2017
Big Mom continues her murderous rampage through Sweet City, still searching for croquembouche. Her 16th son Charlotte Moscato tries to stop her, but she kills him in a blind rage. However, before she can reach the castle, Jimbei races in with a pile of croquembouche tourists and feeds them to her, satiating her. With Big Mom in a good mood, Jimbei formally requests to leave her crew. Big Mom takes Jimbei to her castle in order to discuss Jimbei's request, and as they walk, Jimbei recalls his past experiences with Luffy and how they have caused him to want to join the Straw Hat Pirates. Meanwhile, the Sanji Retrieval Team sails into the Mixed Juice Current, where the sea is composed of several juices. The team is attacked by fruit footballfish which resemble giant fruits, but Luffy kills several of them and the team feasts on their fruit bodies.
790
"The Emperor's Castle! Arriving at the Whole Cake Island!"
"Yonkō no Shiro Hōru Kēki Airando Tōchaku" (四皇の城 ホールケーキアイランド到着) May 28, 2017
Before he went to Whole Cake Island, Jimbei consulted his crew about leaving to join the Straw Hat Pirates. His crew supported him, but Aladine's wife and Big Mom's daughter Charlotte Praline warned him that no one who tried to leave her mother's crew has emerged alive. In the present, Big Mom takes Jimbei to her castle, and seems fine with him leaving, but then says he will have to lose something in return. She then takes out a roulette wheel to determine what he will lose. As night falls, the Sanji Retrieval Team gets stuck in a sea of mizuame. While they try to free themselves, Pedro reveals that he once sailed with Pekoms as explorers looking for Poneglyphs. However, he met his defeat here, though is now willing to return because he knows how highly Duke Dogstorm and Master Cat Viper think of the Straw Hats. He now wants to help the Straw Hats get ahold of Big Mom's Road Poneglyph, and offers to sneak in and get it while the others rescue Sanji. The next morning, the team finally reaches Whole Cake Island. They approach the coast, and to their shock they see Sanji standing on it.
791
"A Mysterious Forest Full of Candies! Luffy vs. Luffy?!"
"Okashi na Mori! Rufi tai Rufi" (お菓子な森！ルフィＶＳルフィ) June 4, 2017
While Pedro and Brook take the Shark Submerge III into Whole Cake Island to look for Big Mom's Road Poneglyph, the rest of the Sanji Retrieval Team makes landfall on the island. Despite seeing Sanji multiple times, they are forced to chase after him as he constantly runs away and eludes them. They end up inside a forest made mostly of sweets, and encounter a talking crocodile that nearly eats them. While they chase after Sanji, Luffy suddenly encounters a mirrored copy of himself that perfectly reflects his movements. Not knowing what is happening, Luffy attacks his duplicate, who counters with the exact same attacks.
792
"Mom's Assassin! Luffy and the Seducing Woods!"
"Mamu no Shikaku - Rufi to Yūwaku no Mori!" (マムの刺客 ルフィと誘惑の森!) June 11, 2017
Nami, Chopper, and Carrot run from the anthropomorphic rabbit Randolph as he relentlessly attacks them, and also encounter a very large and strange man who is buried in the ground up to his neck. Unbeknownst to the trio, everything in the Seducing Woods is alive and trying to trap and kill them. Meanwhile, Sanji has arrived at his family's castle, where he reunites with Yonji. Yonji tries to berate his brother for trying to resist his arranged marriage, and the two's argument results in them attacking each other. Back in the forest, the Sanji Retrieval Team reunites with Luffy as they attempt to run back to the shore. However, each time they run back to where they came from, they end up back in the same clearing. They then realize that everything is alive, and the Luffy with them is revealed to be the mirror duplicate he was fighting earlier. Mirrored Luffy returns to her true appearance: the eighth daughter of the Charlotte Family, Charlotte Brûlée. Brûlée captures Nami and prepares to slice up her and Carrot's faces with her fingernails.
793
"A Seafaring Kingdom! Germa's King Judge!"
"Kaiyū Kokka - Jeruma no Ō Jajji" (海遊国家 ジェルマの王ジャッジ) June 18, 2017
The world's only seafaring nation, the Germa Kingdom sails into Whole Cake Island as Sanji wallows in its castle. There, he is approached by his father Vinsmoke Judge, who confronts him over his scuffle with Yonji, which resulted in Yonji's face getting bashed in. When Sanji gives him the cold shoulder, Judge challenges his estranged son to a duel. Sanji proves to unexpectedly be a match for his father, and as they fight he recalls being abused as a child by his brothers, which Judge did nothing to stop. Meanwhile, Luffy is hunted down by the anthropomorphic flora of the Seducing Woods as he searches for his teammates alone.
794
"A Battle Between Father and Son! Judge vs. Sanji!"
"Oyako Taiketsu - Jajji tai Sanji!" (父子対決　ジャッジVSサンジ！) June 25, 2017
Sanji and Judge continue fighting, and Sanji is overwhelmed by Judge's high-tech weapons. Judge then sacrifices one of his soldiers to get the jump on Sanji, defeating him. Reiju treats Sanji's wounds, and Judge has explosive cuffs placed on his son, forcing him to go through with the wedding with his cooking ability on the line. Meanwhile, Luffy continues racing through the Seducing Woods, and is attacked by the forest's anthropomorphic flora. He beats them all up, but suddenly finds his teammates, plus Sanji and Pudding, standing nearby. He chases after them, but none of them speak or acknowledge him. Meanwhile, Brook and Pedro reach Sweet City, and see a newspaper being handed out that has a picture of Jimbei on the front page.
795
"A Giant Ambition! Big Mom and Caesar!"
"Kyodai na Yabō - Biggu Mamu to Shīzā" (巨大な野望　ビッグ・マムとシーザー) July 2, 2017
Brook and Pedro infiltrate Sweet City, and discover in the newspaper that Jimbei has withdrawn his request to leave the Big Mom Pirates. They then encounter Pudding being forced to try on wedding dresses, as well as Tamago, who reveals that the Big Mom Pirates know everything about the Sanji Retrieval Team's locations, with the exception of Brook and Pedro's. Meanwhile, on the northwestern coast of Whole Cake Island, Capone Bege stands with his family and crew as he prepares to shoot the captured Pekoms for not complying with his wishes. He then shoots Pekoms into shark-infested waters. In the Whole Cake Chateau, Big Mom meets with Caesar Clown, as she seeks to find out the result of the gigantification research she hired him to perform. Caesar, knowing that it was impossible and having blown Big Mom's funds on hedonism, lies that Luffy and Law stalled his research when they destroyed his lab. However, Big Mom reveals that she had her son Charlotte Perospero make an identical lab out of candy, and gives Caesar two weeks to complete the research, threatening to have Perospero turn him into candy otherwise. In the Seducing Woods, Luffy discovers duplicates of Sanji and Pudding that act like animals. He catches them and throws them in a pile, but to his great confusion keeps finding more and more duplicates of his crewmates.
796
"The Land of Souls! Mom’s Fatal Ability!"
"Tamashī no Kuni - Mamu no Osorubeki Nōryoku!" (魂の国　マムの恐るべき能力！) July 9, 2017
Luffy finds Nami in the pile of his crewmates' duplicates, and she reveals what happened between them and Charlotte Brûlée. Brûlée used the Mirror-Mirror Fruit to trap Carrot in a mirror, and the anthropomorphic flora ambushed Nami and Chopper, subduing the latter as Nami ran away. In the present, Luffy and Nami confront the buried man over what he knows, and he reveals that all the flora and fauna is alive because of receiving soul fragments from Big Mom's Soru Soru no Mi ability; she takes a month's worth of lifespan from all Totto Land citizens as taxation and releases them into the wild. When inquired as to how he knows this, the man reveals that he was once one of Big Mom's husbands. Meanwhile, Big Mom orders Charlotte Cracker, her tenth son and one of the Three Sweet Commanders in her crew to go and attack the Straw Hats, and he stomps through the Seducing Woods as he draws closer to Luffy, Nami, and Big Mom's ex-husband.
797
"A Top Officer! The Sweet 3 General Cracker Appears!"
"Dai Kanbu! San Shōsei Kurakkā Tōjō" (大幹部！三将星クラッカー登場) July 16, 2017
Charlotte Cracker confronts Luffy and Nami and pulls the buried man, Pound, out of the ground. Cracker reveals to Pound that Big Mom gave permission to kill him, and Pound begs him to let him see his daughters Chiffon and Lola one last time. The mention of Lola's name shocks Nami, who recalls meeting her on Thriller Bark. She remembers getting a Vivre Card pointing to Lola's mother, and realizes that Lola's mother is Big Mom. Randolph, Charlotte Brûlée, and the giant tree homie King Baum arrive to finish the job against the Straw Hats, and Brûlée reveals that she has Carrot and Chopper trapped in a mirror, which she shatters. Cracker asserts that taking out their enemies is now his responsibility, and attempts to execute Pound. However, Luffy blocks his strike, and as the two fight, Nami and Pound run away. They are chased by Brûlée and the homies, but on her hunch, Nami pulls out Lola's Vivre Card. The Vivre Card emits the aura of Big Mom's powerful soul, rendering all of the homies unable to attack.
798
"An Enemy Worth 800 million! Luffy vs. Thousand Armed Cracker!"
"Hachi Oku no Teki Rufi tai Senju no Kurakkā" (8億の敵　ルフィVS千手のクラッカー) July 23, 2017
Cracker overpowers Luffy in battle, revealing that he can multiply his limbs and weapons just by tapping on his body. Meanwhile, Nami and Pound are confronted by Brûlée and King Baum, and Brûlée tells Nami that other members of the Worst Generation had invaded their territory before, only to be quickly dealt with without even meeting Big Mom. Urouge had managed to defeat one of their Sweet Commanders, but was later taken out by Cracker. Brûlée then attacks Nami and tries to drag her into the Mirro-World, but Pound gains the resolve to attack his stepdaughter, branding himself an enemy of the Big Mom Pirates. However, Nami hits Brûlée with a thunderbolt and sends her falling back into Mirro-World, and Luffy continues to fight Cracker with determination.
799
"An All-out Duel! Gear Four vs. the Bis-Bis Ability!"
"Zenryoku Shōbu Gia Fōsu tai Bisu Bisu no Chikara" (全力勝負　ギア 4VSビスビスの能力) July 30, 2017
Despite his most valiant efforts, Luffy cannot overwhelm Cracker's defenses. Cracker pins Luffy down, and the Sweet Commander claims that Sanji, as a royal, should appreciate his upcoming wedding and that Luffy is doing him no favors by rescuing him. This enrages Luffy, causing him to activate Gear Fourth, and he finally lands a harmful blow on Cracker. Cracker is powerless before Gear Fourth's might, and his body seemingly shatters after another attack. However, Cracker's body is revealed to just be a puppet made of biscuit, and the real Cracker reveals himself to Luffy, showcasing the powers of the Bis-Bis Fruit as he creates several of the biscuit puppets that Luffy had taken so long to bring down just one of. Meanwhile, Brook and Pedro encounter some Biscuit Soldiers as well in Sweet City, but as homies, and Pedro plans to use them to get into the Whole Cake Chateau. In the Mirro-World, Chopper and Carrot struggle to move around with chain balls around their feet, but they try to look into one of the mirrors. Elsewhere in the Seducing Woods, Nami decides to use the power of her Vivre Card to force the homies to attack Cracker, much to their shock.
800
"The First and the Second Join! The Vinsmoke Family"
"Ichi to Ni Shūketsu! Vinsumōku-ke" (1と2　集結！ヴィンスモーク家) August 6, 2017
Luffy continues struggling against Cracker's Biscuit Soldiers; every time he destroys them, Cracker just makes more, and the Sweet Commander keeps Luffy on his toes with occasional onslaughts. However, Nami has put the homies under her command and forces them to attack Cracker against their will, Chopper and Carrot decide to exploit the Mirro-World and gain access to all the mirrors on Whole Cake Island, and Brook and Pedro hide inside a biscuit soldier homie that is going into the Whole Cake Chateau. The next day, Sanji's older brothers Vinsmoke Ichiji and Niji return to the Germa Kingdom, and the three of them reunite. However, when the Vinsmoke Family eats a meal together, Sanji and Niji quickly get into a fight over Niji's treatment of his food and cooks.
801
"The Benefactor's Life! Sanji and Owner Zeff!"
"Onjin no Inochi Sanji to Ōnā Zefu" (恩人の命 サンジと料理長 (オーナー)ゼフ) August 13, 2017
Luffy cannot reach Cracker before Gear Fourth runs out, and he is forced to hide in the Seducing Woods for ten minutes while Cracker sends Biscuit Soldiers to look for him. Meanwhile, Sanji's argument against his family members is shut down when Judge reveals that with a single order, he can have the Baratie destroyed and Zeff killed. Sanji is deeply unnerved by this, as he remembers Zeff giving up his leg for him and acting as a real father figure to him.
802
"An Angry Sanji! The Secret of Germa 66!"
"Ikari no Sanji Jeruma Daburu Shikkusu no Himitsu" (怒りのサンジ ジェルマ66 (ダブルシックス)の秘密) August 20, 2017
Nami saves Luffy from Cracker's Biscuit Soldier with the help of King Baum and the homies she has enslaved, and forces the homies to undergo the suicidal mission of attacking the Biscuit Soldiers. As Luffy rests inside King Baum's mouth, Cracker catches up to the group, and in anger cuts off King Baum's top. Meanwhile, in the Mirro-World, Chopper and Carrot find out Sanji's location by spying through mirrors, unaware that Brûlée is hunting them down. In the Germa Kingdom, Niji beats up Cosette in retaliation for Sanji's actions, and Sanji becomes enraged when he finds Cosette. Yonji offers to take Sanji to Niji, and leads him to the kingdom's secret cloning facility, where he reveals that Germa 66's soldiers are bred through illegal cloning techniques that Judge worked on with Vegapunk. Sanji is appalled, but when Niji and Ichiji walk in, he wastes no time in kicking Niji in the face.
803
"The Past that He Let Go of! Vinsmoke Sanji!"
"Suteta Kako - Vinsumōku Sanji" (捨てた過去 ヴィンスモーク・サンジ) August 27, 2017
Nami confronts Cracker and tries to use various tricks against him, but they prove ineffective and he overpowers her. However, Luffy regains his Haki and leaps back into the fray, taking Cracker by surprise with a Gear Second punch. In the Germa Kingdom, Sanji cannot continue fighting Niji due to the threat on Zeff, which allows Niji to pummel him. As his brothers stand over him, Sanji remembers his childhood in the Germa Kingdom. Judge had given him and his siblings superhuman abilities and had them train their skills, but Sanji continuously fell far behind his siblings' performances, causing him to be viciously bullied. Judge discovered that Sanji possessed no superhuman abilities after all, and he faked Sanji's death, locking his third son in a dungeon with an iron mask on to act like he never existed.
804
"To the East Blue! Sanji's Resolute Departure!"
"Īsuto Burū e Sanji Ketsui no Funade" (東の海 (イースト･ブルー)へ サンジ決意の船出) September 3, 2017
The terrible history of Sanji's family continue to unfold. From a rare moment of compassion he is able to escape, only to face his father's cruelty before setting out on his own.
805
"A Battle of Limits! Luffy and the Infinite Biscuits!"
"Genkai Shōbu - Rufi to Mugen Bisuketto" (限界勝負 ルフィと無限ビスケット) September 17, 2017
Nami produces rain to soften Cracker's Biscuit Soldiers, allowing Luffy to eat and disable them. This goes on for several hours, leaving Cracker exhausted and angry, although Luffy's stomach is nearly at its limit. Meanwhile, Brûlée finds Chopper and Carrot in Mirro-World and starts chasing them with a scythe. In the Germa Kingdom, Reiju gives Sanji a face mask to hide his swollen injuries as the Vinsmoke Family prepares to head for the Whole Cake Chateau. Sanji reveals to Reiju how he got his chivalry through Zeff's parental example on the Baratie.
806
"The Power of Satiety! A New Gear Four Form - Tank Man!"
"Manpuku no Chikara - Shin Gia Fōsu Tankuman" (満腹の力 新ギア４タンクマン！) September 24, 2017
Luffy is full to bursting from eating all of Cracker's biscuit creations for several hours, but refuses to give up, causing an enraged Cracker to attack him directly. However, Luffy activates another form of Gear Fourth known as Tankman: Full Version. Cracker is unable to penetrate Luffy and is instead sucked into his inflated body, getting shot out at high velocity and flying all the way into Sweet City. His unconscious body is discovered by his siblings, who put Sweet City into a state of emergency. Despite Luffy's victory, Pound and King Baum warn him that Big Mom will retaliate with even greater force. Meanwhile, Chopper and Carrot finally discover Sanji through a mirror and learn where he is going, but they are caught by Brûlée. The Vinsmoke Family heads out to meet Big Mom at the Whole Cake Chateau, and Sanji thinks about his crew as he reaches the point of no return.
807
"A Heartbreaking Duel! Luffy vs Sanji! - Part 1"
"Kanashiki Kettō - Rufi VS Sanji" (哀しき決闘　ルフィVSサンジ) October 1, 2017[n 4]
Sanji has memories of his escape from the Germa Kingdom, meeting Zeff, and later joining the Straw Hats as his family heads to the Whole Cake Chateau. Luffy and Nami ride King Baum out of the Seducing Woods, and they contact Chopper and Carrot, who reveal where Sanji is headed as they are pursued by Brûlée. They manage to hide again, but Brûlée brings Randolph, his crane, and the Noble Croc into the world to help her hunt the duo down, and Chopper gets the idea to gain control of Brûlée's power. Back in the real world, Luffy and Nami reach Sanji, and Luffy reunites with his crewmate. However, Sanji kicks Luffy out of the carriage, claiming to have accepted his royal heritage and disowning Luffy.
808
"A Heartbreaking Duel! Luffy vs Sanji! - Part 2"
"Kanashiki Kettō - Rufi VS Sanji" (哀しき決闘　ルフィVSサンジ) October 1, 2017[n 4]
Luffy refuses to back down from the hostile Sanji, causing Sanji to confront him and attack him with Diable Jambe. Despite Sanji's vicious attacks, Luffy refuses to fight back or retreat, and Nami pleads Sanji to stop to no avail. Finally, Sanji knocks Luffy out with a spinning midair kick, and returns to his family. Luffy yells out to Sanji as he leaves, saying that he will stay at this spot and not eat until Sanji returns, as he cannot become the Pirate King without Sanji. This causes Sanji to break down in tears as he is taken to Big Mom.
809
"A Storm of Revenge! An Enraged Army Comes to Attack!"
"Fukushū no Arashi! Ikari no Gundan Shūrai!" (復讐の嵐 怒りの軍団襲来！) October 15, 2017
After hearing about Cracker's defeat, Big Mom creates a big storm before sending a massive army out to take revenge on Luffy. She then goes to meet with the Vinsmoke Family for lunch, and as they exchange pleasantries, Pudding asks Sanji via note to meet her in private later. Outside, Luffy, Nami, and King Baum watch as the enraged army heads toward them, but a steadfast Luffy refuses to move from his waiting spot.
810
"The End of the Adventure! Sanji's Resolute Proposal!"
"Bōken no Owari - Sanji Ketsui no Puropōzu" (冒険の終わり サンジ決意のプロポーズ) October 22, 2017
Luffy faces Big Mom's enraged army with determination, and decimates their hordes of Chess Soldiers. He struggles against the higher-ranking Big Mom Pirates, but Nami and King Baum come back to help him and Nami decimates all the Chess Soldiers with a massive lightning strike. As this battle rages on, Sanji talks to Pudding in her room and, in order to make the best of his situation, agrees to marry her tomorrow and make a life together.
811
"I'll Wait Here! Luffy vs. the Enraged Army!"
"Koko de Matsu - Rufi tai Ikari no Gundan" (ここで待つ ルフィVS怒りの軍団) October 29, 2017
In the Mirro-World, Chopper and Carrot fight against Brûlée and her henchmen, but are subdued by their own reflections. In the Whole Cake Chateau, Sanji makes a deal with Big Mom to spare his friends if he gets married without resisting. In the battle with the enraged army, Amande kills King Baum by bisecting him, Galette immobilizes Nami, and although Luffy continues fighting here, he is eventually caught and defeated. He tries to remain in his waiting spot as the army drags him and Nami away, but is knocked out.
812
"Invading the Chateau! Reach the Road Ponegliff!"
"Shadō sen'nyũ - Ubae! Rōdo Pōnegurifu" (城内 (シャドー)潜入 奪え！ ロード歴史の本文 (ポーネグリフ)) November 5, 2017
Tamago increases security on the Big Mom Pirates' three Ponegliffs in the Room of Treasure by having Sweet Commander Charlotte Smoothie protect them. Brook spies on the room and goes back to tell Pedro about security, and they hatch a plan to get around it. In the Mirro-World, Brûlée and her henchmen finally capture Chopper and Carrot. However, the two devise a plan. They are taken to Brûlée's house and Carrot is about to be cooked in a pot of boiling water, but Chopper prepares to execute the plan. Big Mom shows the Vinsmoke Family her collection of rare creatures trapped inside giant books. Meanwhile, Luffy wakes up in another part of the library, and he and Nami are bound inside a book together. Big Mom departs from the Vinsmokes and calls Luffy and Nami to discuss their actions, but to her surprise Luffy responds defiantly.
813
"A Fateful Confrontation! Luffy and Big Mom!"
"Innen no Taimen - Rufi to Biggu Mamu!" (因縁の対面　ルフィとビッグ・マム！) November 12, 2017
Pekoms creates a diversion for Brook to set his plan into action. Meanwhile Luffy continues to goad Big Mom into a fight, and Pudding begins to have stirrings of rebellion herself!
814
"Shout of the Soul! Brook and Pedro's Lightning Operation!"
"Tamashī no Sakebi - Burukku & Pedoro Dengeki Sakusen" (魂の叫び　ブルック＆ペドロ電撃作戦) November 19, 2017
Thanks to Pedro's distraction, Brook manages to sneak into the Room of Treasure. With the power of his Devil Fruit, he overwhelms the Chess Soldier homies by the power of soul. In Brûlée's house, it is revealed that she and her henchmen captured a mirror clone of Carrot. The real Carrot then unleashes an ambush on the people in the house and kicks the pot of boiling water onto Brûlée. Chopper then frees himself and activates Monster Point as the two prepare a counterattack. While Sanji picks flowers for Pudding, she goes to the Prisoner Library to visit Luffy and Nami. She confesses her failure to bring Sanji to them like they had agreed, and Luffy and Nami gawk in shock as she continues speaking to them.
815
"Goodbye! Pudding's Tearful Determination!"
"Sayonara - Purin Namida no Ketsui" (さよなら プリン涙の決意) November 26, 2017
Pudding reveals a secret plan to prevent Sanji from marrying her, shocking Luffy and Nami. After she leaves, Luffy attempts to escape from their prison. In the Mirro-World, Chopper and Carrot successfully execute their counterattack and take out Brûlée and all of her henchmen. They then plot to use Brûlée's powers to explore Mirro-World and find all their crewmates. In the Room of Treasure, Brook defeats all the guards in it and begins transcribing the Ponegliffs. However, Big Mom breaks into the room and confronts him. Meanwhile, Tamago confronts Pedro in the third floor courtyard, and it is revealed that Pedro had 50 years of his life removed during his invasion five years ago, after he and Tamago had taken out each other's left eyes. Meanwhile, the Vinsmokes plot to keep Pudding in the Germa Kingdom after the wedding in order to prevent the Big Mom Pirates from taking advantage of their deal. Reiju is sneaking around the chateau, but is suddenly caught outside by someone and shot with a gun. She manages to head back inside, but collapses from her injuries.
816
"The History of the Left Eye! Pedro vs. Baron Tamago!"
"Hidarime no Innen - Pedoro VS Tamago Danshaku" (左眼の因縁 ペドロVSタマゴ男爵) December 3, 2017
Luffy tries desperately to free himself as the risk of his own well-being. Meanwhile, Chopper and Carrot continue to search the Mirro-World as Brook squares off against Big Mom and Pedro’s past is revealed.
817
"Moist Cigarette! The Night Before Sanji's Wedding!"
"Shikemoku - Sanji no Kekkon Zenya" (シケモク サンジの結婚前夜) December 10, 2017
Luffy continues trying to escape the prison book by tearing off his hands. In a flashback, Pudding reveals to Luffy and Nami that she plans to kill Sanji during the wedding and that Big Mom does not intend to let them leave alive. Elsewhere, Sanji goes to Pudding's room and listens in on Pudding taunting Reiju as she reveals her sinister nature and a plot to assassinate the Vinsmoke Family. After hearing Pudding mocking him, Sanji becomes heartbroken.
818
"The Undaunted Soul! Brook vs. Big Mom!"
"Fukutsu no Souru - Burukku tai Biggu Mamu" (不屈の魂（ソウル） ブルックVSビック・マム) December 17, 2017
After revealing the truth about the wedding, Pudding removes Reiju's memories of their encounter and has her taken to medical help so she can meet her doom at the wedding tomorrow. In the Room of Treasure, Brook tries to use his speed to attack Big Mom, but she counters his attacks. Her homies prove to be resistant to his soul power, but even after taking multiple attacks from them, Brook keeps getting up. In the Mirro-World, Chopper and Carrot find out that the mirrors can tell them where they lead to, and they work on identifying their comrades to the mirrors. Meanwhile, Luffy gets closer to ripping his arms off as Opera prepares to torture Nami for Lola's location. Suddenly, Jinbe arrives and attacks Opera to free Luffy and Nami.
819
"Sora's Wish! Germa's Failure - Sanji!"
"Sora no Negai - Jeruma no Shippaisaku Sanji" (母 (ソラ) の願い ジェルマの失敗作サンジ) December 24, 2017
Jimbei arrives on the scene and works to free Luffy and Nami. Meanwhile Sanji confronts Reiju with the awful truth of Pudding, and she confides in him the powerful secret of their mother's undying love.
820
"To Reach Sanji! Luffy's Vengeful Hell-bent Dash!"
"Sanji no Moto e - Rufi Gyakushū no Dai Gekisō" (サンジの元へ　ルフィ逆襲の大激走) January 7, 2018
In the Chateau courtyard, Tamago regenerates into a stronger form with chicken features known as Viscount Hiyoko with his Devil Fruit power. Pedro fights Hiyoko and manages to defeat this form, but before Hiyoko regenerates into a stronger form, Pedro lights a string of bombs and attempts to take out all the surrounding enemies in a massive explosion. In the Room of Treasure, Brook's sword is unable to pierce Big Mom's skin, and he is finally defeated, but not before managing to injure Prometheus. Outside the room, Smoothie hears about Luffy's breakout and orders the floors below them to be blocked off so Big Mom does not find out. Pudding then comes in, and Big Mom reveals to Brook that she can awaken the ability to read the Ponegliffs with her third eye. Pudding asks Big Mom if they can talk in the latter's room. Below, Luffy fights against Charlotte Cadenza in his race to find Sanji, and knocks out the pirate after choking him for Sanji's location. In the infirmary, Reiju encourages Sanji to escape and leave their family to die, revealing that she replaced the explosive cuffs on his wrists with duds, which will allow him to leave without repercussions.
821
"The Chateau in Turmoil! Luffy, to the Rendezvous!"
"Shatō Dōran - Rufi Yakusoku no Basho e" (城内 (シャトー) 動乱 ルフィ約束の場所へ) January 14, 2018
As Pedro detonates a string of dynamite at the courtyard, Chopper grabs him into the Mirro-World. While traveling in the Mirro-World, Chopper and Carrot manage to locate Nami and Jinbe, who are evading the Big Mom Pirates. Meanwhile, Luffy continues running through the chateau and is confronted by Cabaletta, who intends to avenge Cadenza. After a furious clash, Luffy manages to defeat Cabaletta and continues onward. Luffy eventually comes across the infirmary, where Reiju hides him from the pursuing Big Mom Pirates. Reiju informs Luffy that Sanji has been made aware of Pudding's deception and Luffy decides to return to the place where he promised to wait for Sanji. After jumping out of the Chateau and landing in Sweet City, Luffy is confronted by Chess Soldiers as he is traveling to his intended destination. While wandering in the hallways of the Chateau, Sanji decides that he will not return to the Straw Hats.
822
"Deciding to Say Goodbye! Sanji and his Straw-Hat Bento!"
"Wakare no Ketsui - Sanji to Mugiwara Bentō" (別れの決意　サンジと麦わら弁当) January 21, 2018
Having brought Jinbe and Nami into the Mirro-World, the Sanji Retrieval Team begins searching for Luffy, Sanji, and Brook. Inside Big Mom's chamber, Big Mom continues holding Brook captive and goes over the Vinsmoke assassination plan with Pudding. The Charlotte Family and the Big Mom Pirates have a meeting and discuss the statuses of the intruders. Believing the intruders have been dealt with, the meeting adjourned. Inside Sweet City, Luffy battles against two chess soldiers and two members of the Big Mom Pirates. Due to his hunger, Luffy initially struggles but is able to muster enough strength to defeat his opponents. Back inside the chateau, Sanji sits alone in a hallway and decides to accept death. Bobbin runs into him and as he is about to eat a piece of meat from Sanji's bento box, Sanji kicks him and then flees the scene.
823
"The Emperor Rolls Over! Rescue Brook Mission!"
"Yonko no Negaeri - Burukku Kyūshutsu Dai Sakusen!" (四皇の寝返り　ブルック救出大作戦！) January 28, 2018
After Sanji fled, Bobbin decides to pursue him by himself. The Sanji Retrieval Team finds the mirror leading to Brook but also learns that the mirror also leads to Big Mom's bedroom. While Big Mom is sleeping, the team plans to retrieve Brook and replace him with another skeleton. After three unsuccessful attempts, the team manage to get Brook back. As Sanji hurries towards the place where Luffy promised to wait for him, Luffy is also approaching near his intended destination. However, Charlotte Counter ambushes Luffy.
824
"The Rendezvous! Luffy, a One-on-One at His Limit!"
"Yakusoku no Basho - Rufi Genkai no Ikkiuchi" (約束の場所 ルフィ限界の一騎打ち) February 4, 2018
Luffy fights against Charlotte Counter, but despite his best effort, his hunger causes him to be easily overpowered. Meanwhile, Brook reveals to the Sanji Retrieval Team that he successfully transcribed Big Mom's Ponegliffs. As the team prepares to find Sanji, Jinbe states that they should reach him before the wedding, as there is a plot going on behind the scenes that will plunge it into chaos. He reveals that Pekoms was caught up in this scheme, which resulted in him being shot by Bege. In the Whole Cake Chateau, the Vinsmokes celebrate by drinking lots of alcohol, and outside in Sweet City, Bobbin is shot by a mysterious gunman while pursuing Sanji. Sanji reaches the outskirts of Sweet City where Luffy promised to wait for him, but cannot find Luffy. However, he finally locates the unconscious Luffy by the remains of King Baum after hearing his stomach rumble.
825
"A Liar! Luffy and Sanji!!"
"Usotsuki - Rufi to Sanji" (ウソつき ルフィとサンジ) February 11, 2018
After a harsh struggle, Luffy finally manages to defeat Counter. He then rests besides King Baum's corpse. Sanji later arrives and finds Luffy, who wakes up from the smell of Sanji's bento. Sanji gives the bento to Luffy, relieving his hunger. Sanji once again attempts to convince Luffy to leave without him, but in response, Luffy punches him and forces him to say his true feelings. Sanji then tearfully admits that he wants to return to the Straw Hats but could not abandon his family. Happy to hear Sanji's answer, Luffy decides to help him crash the wedding.
826
"Sanji Comes Back! Crash! The Tea Party from Hell!"
"Sanji Fukkatsu Kowase! Jigoku no Ochakai" (サンジ復活　壊せ！地獄のお茶会) February 18, 2018
After Luffy and Sanji reconcile, the Sanji Retrieval Team manages to contact them through a mirror shard. Jinbe proceeds to talk about Bege's past before revealing that he plots to assassinate Big Mom during the tea party. Jinbe then proposes forming an alliance with him.
827
"A Secret Meeting! Luffy vs. the Fire Tank Pirates!"
"Mikkai! Rufi VS Faiatanku Kaizoku-dan" (密会！ルフィVSファイアタンク海賊団) March 4, 2018
The Sanji Retrieval Team goes to the Fire Tank Pirates' hideout to meet Capone Bege. Meanwhile, the Sun Pirates tend to an injured Pekoms and guard him to prevent him from reporting to Big Mom. While Nami and Carrot are bathing, they have a conversation with Charlotte Chiffon, who explains about Lola's arranged marriage with Loki, the prince of Elbaf, and how Lola running away from the marriage cost Big Mom an alliance with the giants. After finishing bathing and changing clothes, the Sanji Retrieval Team meets Bege in person.
828
"The Deadly Pact! Luffy & Bege's Allied Forces!"
"Shi no kyōtei Rufi & Bejji rengō-gun" (死の協定 ルフィ&ベッジ連合軍) March 18, 2018
The meeting between the Sanji Retrieval Team and the Fire Tank Pirates begins. Luffy wants to punch Bege for what he did to Pekoms and after a brief quarrel, Jinbe convinces everyone to put their differences aside. Bege reveals that he recruited Caesar for his assassination plot and goes over his plan to assassinate Big Mom. After Bege explains about an incident concerning the photo of Mother Carmel, Luffy agrees to be the bait.
829
"Luffy Engages in a Secret Maneuver! The Wedding Full of Conspiracies Starts Soon!"
"Rufi Anyaku Kaien Chokuzen! Inbō no Kekkonshiki" (ルフィ暗躍　開演直前！陰謀の結婚式) March 25, 2018
The meeting between the Sanji Retrieval Team and the Fire Tank Pirates continues. The groups review their plans for the Tea Party and intend to use a mirror and Brûlée to escape. After the meeting concludes, Sanji returns to his room in the Whole Cake Chateau to prepare for the wedding. Meanwhile, the Sun Pirates prepare to leave Whole Cake Island after tying Pekoms to a rock. The guests arrive and everyone prepares for the tea party, which is due in an hour.
830
"The Family Gets Together! The Hellish Tea Party Starts!"
"Famirī Shūketsu Kaien! Jigoku no Ochakai" (家族集結　開演！地獄のお茶会) April 1, 2018
The Underworld emperors arrive at the Whole Cake Chateau to attend Big Mom's tea party. Bege and his crew act as security for the wedding. When the Vinsmoke Family arrives, they are asked to relinquish their weapons and raid suits. As the Sanji Retrieval Team prepares for Bege's operation, Luffy goes to the Seducing Woods to catch animals. At the venue, an angry guest Jigra is trying to force his way in only to be shot down by Charlotte Katakuri. Shortly afterwards, the Organ Trading Assassin Group attacks the venue but they are easily defeated by Daifuku and Oven. After all the guests arrive at the venue, Big Mom appears and the tea party begins.
831
"The Broken Couple! Sanji and Pudding Enter!"
"Kamen Fūfu Sanji ♡ Purin Nyūjō!" (仮面夫婦　サンジ♡プリン入場！) April 8, 2018
As the Tea Party begins, the Fire Tank Pirates and Caesar Clown make preparations to commit their assassination attempt on Big Mom. Inside the venue, Big Mom receives the portrait of Mother Carmel as well as presents from her guests, and she reveals that she will be opening the Tamatebako she got from Fishman Island after the wedding. Meanwhile, Sanji struggles to not be fooled by Pudding's facade as the two of them practice their vows before being flown out to the venue.
832
"A Deadly Kiss! The Mission to Assassinate the Emperor Kicks Off!"
"Shi no Kisu - Yonkō Ansatsu Sakusen Kaishi!" (死のキス 四皇暗殺作戦開始!) April 15, 2018
The wedding has begun and after Sanji and Pudding arrive at the venue, Streusen brings out the wedding cake with the altar at the top. After arriving at the altar, Sanji and Pudding begin the exchange of vows. Following Big Mom's plan, Pudding reveals her third eye to him. Sanji says that her third eye is beautiful, something that no one else has said to her before. Pudding breaks down in tears, causing Big Mom's plan to go awry. Katakuri tries to assassinate Sanji himself but fails. Afterwards, Luffy and his duplicates intrude into the venue by bursting out of the wedding cake.
833
"Returning the Sake Cup! The Manly Jimbei Pays His Debt!"
"Sakazuki Henjō! Otoko Jinbei no Otoshimae" (盃返上! 侠客(おとこ)ジンベエの落とし前) April 22, 2018
Luffy's duplicates burst out of the wedding cake and they run amok at the wedding venue as the cake collapses. Following Bege's plan, Luffy goes after Carmel's photo. However, his attempt is thwarted by Katakuri. Jinbe steps in and saves Luffy from Katakuri's clutches. He then confronts Big Mom and declares his intention to leave her crew and join the Straw Hats. Big Mom then attempts to take Jinbe's lifespan, but his lack of fear towards her causes her powers to have no effect. As Big Mom attacks Jinbe in a fit of rage, Brook destroys the photo of Carmel.
834
"The Mission Failed?! The Big Mom Pirates Strike Back!"
"Sakusen Shippai!? Hangeki no Biggu Mamu Kaizoku-dan" (作戦失敗!? 反撃のビッグ・マム海賊団) April 29, 2018
Brook successfully destroys the picture of Carmel. Even though Big Mom is having a mental crisis, she does not start screaming as Bege had planned. Luffy and Jinbe defend themselves against the attacking Big Mom Pirates. Pudding attempts to shoot Sanji but fails, prompting Daifuku to attack him with his genie. As Bege's plan goes awry, Perospero traps the Vinsmokes in candy and they are held at gunpoint. Brook notices that Big Mom is not screaming because she is confused on what to be angry about. He then tells Luffy to show her the broken picture again, which Luffy prepares to do.
835
"Run, Sanji! SOS! Germa 66!"
"Hashire Sanji - SOS! Jeruma Daburu Shikkusu" (走れサンジ SOS!ジェルマ66(ダブルシックス)) May 6, 2018
Knowing what he needs to do, Luffy takes the fragments of Carmel's picture and runs towards Big Mom. With his family in a dire situation, Sanji runs towards them but is stopped by Daifuku's genie. Despite Katakuri's attempt to stop Luffy, the latter manages to show Carmel's broken picture to Big Mom. She starts screaming and incapacitates her family and crew, allowing Sanji to free his family. With Big Mom vulnerable, Bege, Vito, and Gotti prepare to assassinate her.
836
"Mom's Secret! The Giant's Island Elbaph and a Little Monster!"
"Mamu no Himitsu - Erubafu no Shima to Chīsana Kaibutsu" (マムの秘密 巨人の島と小さな怪物) May 13, 2018
A flashback begins, showing 63 years ago when Linlin was five years old. Her parents left her at Elbaf and she met Carmel, a woman who saved some of the Giant Warrior Pirates from execution after Dory and Brogy began their duel on Little Garden. Carmel ran an orphanage called the Sheep's House and she took Linlin in. The Elbaf village prepares for the Winter Solstice Festival. The villagers and the Sheep's House children feast on semla prior to the twelve-day fast. On the seventh day of the fast, Linlin lost control and goes on a rampage for semla.
837
"The Birth of Mom! The Day That Carmel Vanished!"
"Mamu Tanjō - Karumeru Ga Kieta Hi" (マム誕生 カルメルが消えた日) May 20, 2018
Furious at Linlin's actions, Jorl tried to strike down Linlin, only to be mortally wounded by the rampaging child. Linlin's rampage finally stopped when the giants gave her the semla. Jarl prepared to avenge Jorl, but Carmel begged him to spare Linlin, saying that she would leave Elbaf with her. Jorl died and this incident earned Linlin the hatred of the giants. Carmel and the children of the Sheep's House moved to a different island. Carmel had a secret meeting with Cipher Pol, negotiating on selling Linlin to the World Government. The Sheep's House children later celebrated Linlin's sixth birthday. After feasting on some sweets, Linlin discovered that Carmel and the other orphans disappeared.
838
"The Launcher Blasts! The Moment of Big Mom's Assassination!"
"Heiki Sakuretsu! Biggu Mamu Ansatsu no Shunkan" (兵器炸裂! ビッグ·マム暗殺の瞬間) May 27, 2018
Linlin cried from Carmel's disappearance, and two people witnessed what really happened. One of the witnesses was an Elbaf giant, who quickly fled back to Elbaf to tell the other giants what he saw. The other witness was Streusen, who decided to take advantage of Linlin's potential. Streusen befriended Linlin and they began creating Linlin's ideal country. Back in the present, Bege, Vito, and Gotti fire their KX Launchers. However, their assassination attempt ends in failure as Big Mom's scream destroys the rockets before they could reach her. Caesar Clown brings in the escape mirror, but it is shattered by Big Mom's scream. Katakuri creates earplugs for his family and crew and the Big Mom Pirates proceed to surround the alliance.
839
"The Evil Army! Transform! Germa 66!"
"Aku no Gundan - Henshin! Jeruma 66" (悪の軍団 変身!ジェルマ66(ダブルシックス)) June 3, 2018[1]
Home releases[edit]
Japanese[edit]
Toei Animation (Japan, Region 2 DVD)
Volume
Episodes
Release date
Ref.
19thシーズン ドレスローザ編 piece.01 783-786 September 6, 2017 [2]
piece.02 787-790 October 4, 2017 [3]
piece.03 791-794 November 1, 2017 [4]
piece.04 795-798 December 6, 2017 [5]
piece.05 799-802 January 10, 2018 [6]
piece.06 803-806 February 7, 2018 [7]
piece.07 807-810 March 7, 2018 [8]
piece.08 811-814 April 4, 2018 [9]
piece.09 815-818 May 2, 2018 [10]
piece.10 819-822 June 6, 2018 [11]
piece.11 824-826 July 4, 2018 [12]
piece.12 827-830 August 1, 2018 [13]
Notes[edit]
Jump up ^ Episode number by Toei Animation's count
Jump up ^ Title of the episode: literally translated, romanized using Hepburn romanization, and in kanji form
Jump up ^ Date the episode originally aired on Fuji Television
^ Jump up to: a b Episodes 807 and 808 aired together as a 1-hour television special.
References[edit]
General
ワンピース 公式サイト 東映アニメーション (in Japanese). Toei Animation. Retrieved August 24, 2011.
ワンピース (in Japanese). Fuji Television. Retrieved August 12, 2011.
Specific
Jump up ^ "ワンピース - フジテレビ" (in Japanese). Fuji Television. Retrieved October 15, 2017.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.01". Amazon.co.jp. Retrieved 2017-06-11.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.02". Amazon.co.jp. Retrieved 2017-08-03.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.03". Amazon.co.jp. Retrieved 2017-09-02.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.04". Amazon.co.jp. Retrieved 2017-09-15.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.05". Amazon.co.jp. Retrieved 2017-12-05.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.06". Amazon.co.jp. Retrieved 2017-12-05.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.07". Amazon.co.jp. Retrieved 2018-01-01.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.08". Amazon.co.jp. Retrieved 2018-02-12.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.09". Amazon.co.jp. Retrieved 2018-04-02.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.10". Amazon.co.jp. Retrieved 2018-04-02.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.11". Amazon.co.jp. Retrieved 2018-05-26.
Jump up ^ ワンピース (出演). "ONE PIECE ワンピース 19THシーズン ドレスローザ編 piece.12". Amazon.co.jp. Retrieved 2018-05-26.
[show]
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One Piece by Eiichiro Oda
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Ligand-gated ion channel
From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
"Ionotropic" redirects here, not to be confused with inotropic.
Neurotransmitter-gated ion-channel transmembrane region
Ligand-gated ion channel
Identifiers
Symbol
Neur_chan_memb
Pfam
PF02932
InterPro
IPR006029
PROSITE
PDOC00209
SCOP
1cek
SUPERFAMILY
1cek
TCDB
1.A.9
OPM superfamily
14
OPM protein
2bg9
showAvailable protein structures:
Pfam
structures
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Ion-channel-linked receptor
Ions
Ligand (such as acetylcholine)
When ligands bind to the receptor, the ion channel portion of the receptor opens, allowing ions to pass across the cell membrane.
Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.[1][2][3]
When a presynaptic neuron is excited, it releases a neurotransmitter from vesicles into the synaptic cleft. The neurotransmitter then binds to receptors located on the postsynaptic neuron. If these receptors are ligand-gated ion channels, a resulting conformational change opens the ion channels, which leads to a flow of ions across the cell membrane. This, in turn, results in either a depolarization, for an excitatory receptor response, or a hyperpolarization, for an inhibitory response.
These receptor proteins are typically composed of at least two different domains: a transmembrane domain which includes the ion pore, and an extracellular domain which includes the ligand binding location (an allosteric binding site). This modularity has enabled a 'divide and conquer' approach to finding the structure of the proteins (crystallising each domain separately). The function of such receptors located at synapses is to convert the chemical signal of presynaptically released neurotransmitter directly and very quickly into a postsynaptic electrical signal. Many LICs are additionally modulated by allosteric ligands, by channel blockers, ions, or the membrane potential. LICs are classified into three superfamilies which lack evolutionary relationship: cys-loop receptors, ionotropic glutamate receptors and ATP-gated channels.
Contents
1 Cys-loop receptors
1.1 Structure
1.2 Cationic cys-loop receptors
1.3 Anionic cys-loop receptors
2 Ionotropic glutamate receptors
2.1 AMPA receptor
2.2 NMDA receptors
3 GABA receptors
3.1 GABAA receptor
4 5-HT3 receptor
5 ATP-gated channels
6 PIP2-gated channels
7 Indirect modulation
7.1 G-protein-linked receptors
7.1.1 GABAB receptor
7.1.2 Gα signaling
7.1.3 Gβγ signaling
8 Clinical relevance
9 See also
10 References
11 External links
Cys-loop receptors[edit]
Nicotinic acetylcholine receptor in closed state with predicted membrane boundaries shown, PDB 2BG9
The cys-loop receptors are named after a characteristic loop formed by a disulfide bond between two cysteine residues in the N terminal extracellular domain. They are part of a larger family of pentameric ligand-gated ion channels that usually lack this disulfide bond, hence the tentative name "Pro-loop receptors".[4][5] A binding site in the extracellular N-terminal ligand-binding domain gives them receptor specificity for (1) acetylcholine (AcCh), (2) serotonin, (3) glycine, (4) glutamate and (5) γ-aminobutyric acid (GABA) in vertebrates. The receptors are subdivided with respect to the type of ion that they conduct (anionic or cationic) and further into families defined by the endogenous ligand. They are usually pentameric with each subunit containing 4 transmembrane helices constituting the transmembrane domain, and a beta sheet sandwich type, extracellular, N terminal, ligand binding domain.[6] Some also contain an intracellular domain like shown in the image.
The prototypic ligand-gated ion channel is the nicotinic acetylcholine receptor. It consists of a pentamer of protein subunits (typically ααβγδ), with two binding sites for acetylcholine (one at the interface of each alpha subunit). When the acetylcholine binds it alters the receptor's configuration (twists the T2 helices which moves the leucine residues, which block the pore, out of the channel pathway) and causes the constriction in the pore of approximately 3 angstroms to widen to approximately 8 angstroms so that ions can pass through. This pore allows Na+ ions to flow down their electrochemical gradient into the cell. With a sufficient number of channels opening at once, the inward flow of positive charges carried by Na+ ions depolarizes the postsynaptic membrane sufficiently to initiate an action potential.
While single-cell organisms like bacteria would have little apparent need for the transmission of an action potential, a bacterial homologue to an LIC has been identified, hypothesized to act nonetheless as a chemoreceptor.[4] This prokaryotic nAChR variant is known as the GLIC receptor, after the species in which it was identified; Gloeobacter Ligand-gated Ion C channel.
Structure[edit]
Cys-loop receptors have structural elements that are well conserved, with a large extracellular domain (ECD) harboring an alpha-helix and 10 beta-strands. Following the ECD, four transmembrane segments (TMSs) are connected by intracellular and extracellular loop structures.[7] Except the TMS 3-4 loop, their lengths are only 7-14 residues. The TMS 3-4 loop forms the largest part of the intracellular domain (ICD) and exhibits the most variable region between all of these homologous receptors. The ICD is defined by the TMS 3-4 loop together with the TMS 1-2 loop preceding the ion channel pore.[7] Crystallization has revealed structures for some members of the family, but to allow crystallization, the intracellular loop was usually replaced by a short linker present in prokaryotic cys-loop receptors, so their structures as not known. Nevertheless, this intracellular loop appears to function in desensitization, modulation of channel physiology by pharmacological substances, and posttranslational modifications. Motifs important for trafficking are therein, and the ICD interacts with scaffold proteins enabling inhibitory synapse formation.[7]
Cationic cys-loop receptors[edit]
Type
Class
IUPHAR-recommended
protein name [8]
Gene
Previous names
Serotonin
(5-HT) 5-HT3 5-HT3A
5-HT3B
5-HT3C
5-HT3D
5-HT3E HTR3A
HTR3B
HTR3C
HTR3D
HTR3E 5-HT3A
5-HT3B
5-HT3C
5-HT3D
5-HT3E
Nicotinic acetylcholine
(nAChR) alpha α1
α2
α3
α4
α5
α6
α7
α9
α10 CHRNA1
CHRNA2
CHRNA3
CHRNA4
CHRNA5
CHRNA6
CHRNA7
CHRNA9
CHRNA10 ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS

beta β1
β2
β3
β4 CHRNB1
CHRNB2
CHRNB3
CHRNB4 CMS2A, SCCMS, ACHRB, CHRNB, CMS1D
EFNL3, nAChRB2

gamma γ CHRNG ACHRG
delta δ CHRND ACHRD, CMS2A, FCCMS, SCCMS
epsilon ε CHRNE ACHRE, CMS1D, CMS1E, CMS2A, FCCMS, SCCMS
Zinc-activated ion channel
(ZAC) ZAC ZACN ZAC1, L2m LICZ, LICZ1
Anionic cys-loop receptors[edit]
Type
Class
IUPHAR-recommended
protein name[8]
Gene
Previous names
GABAA alpha α1
α2
α3
α4
α5
α6 GABRA1
GABRA2
GABRA3
GABRA4
GABRA5
GABRA6 EJM, ECA4
beta β1
β2
β3 GABRB1
GABRB2
GABRB3

ECA5
gamma γ1
γ2
γ3
GABRG1
GABRG2
GABRG3 CAE2, ECA2, GEFSP3
delta δ GABRD
epsilon ε GABRE
pi π GABRP
theta θ GABRQ
rho ρ1
ρ2
ρ3 GABRR1
GABRR2
GABRR3 GABAC[9]
Glycine
(GlyR) alpha α1
α2
α3
α4 GLRA1
GLRA2
GLRA3
GLRA4 STHE

beta β GLRB
Ionotropic glutamate receptors[edit]
The ionotropic glutamate receptors bind the neurotransmitter glutamate. They form tetramers with each subunit consisting of an extracellular amino terminal domain (ATD, which is involved tetramer assembly), an extracellular ligand binding domain (LBD, which binds glutamate), and a transmembrane domain (TMD, which forms the ion channel). The transmembrane domain of each subunit contains three transmembrane helices as well as a half membrane helix with a reentrant loop. The structure of the protein starts with the ATD at the N terminus followed by the first half of the LBD which is interrupted by helices 1,2 and 3 of the TMD before continuing with the final half of the LBD and then finishing with helix 4 of the TMD at the C terminus. This means there are three links between the TMD and the extracellular domains. Each subunit of the tetramer has a binding site for glutamate formed by the two LBD sections forming a clamshell like shape. Only two of these sites in the tetramer need to be occupied to open the ion channel. The pore is mainly formed by the half helix 2 in a way which resembles an inverted potassium channel.
Type
Class
IUPHAR-recommended
protein name [8]
Gene
Previous names
AMPA GluA GluA1
GluA2
GluA3
GluA4 GRIA1
GRIA2
GRIA3
GRIA4 GLUA1, GluR1, GluRA, GluR-A, GluR-K1, HBGR1
GLUA2, GluR2, GluRB, GluR-B, GluR-K2, HBGR2
GLUA3, GluR3, GluRC, GluR-C, GluR-K3
GLUA4, GluR4, GluRD, GluR-D
Kainate GluK GluK1
GluK2
GluK3
GluK4
GluK5 GRIK1
GRIK2
GRIK3
GRIK4
GRIK5 GLUK5, GluR5, GluR-5, EAA3
GLUK6, GluR6, GluR-6, EAA4
GLUK7, GluR7, GluR-7, EAA5
GLUK1, KA1, KA-1, EAA1
GLUK2, KA2, KA-2, EAA2
NMDA GluN GluN1
NRL1A
NRL1B GRIN1
GRINL1A
GRINL1B GLUN1, NMDA-R1, NR1, GluRξ1

GluN2A
GluN2B
GluN2C
GluN2D GRIN2A
GRIN2B
GRIN2C
GRIN2D GLUN2A, NMDA-R2A, NR2A, GluRε1
GLUN2B, NMDA-R2B, NR2B, hNR3, GluRε2
GLUN2C, NMDA-R2C, NR2C, GluRε3
GLUN2D, NMDA-R2D, NR2D, GluRε4
GluN3A
GluN3B GRIN3A
GRIN3B GLUN3A, NMDA-R3A, NMDAR-L, chi-1
GLU3B, NMDA-R3B
‘Orphan’ (GluD) GluD1
GluD2 GRID1
GRID2 GluRδ1
GluRδ2
AMPA receptor[edit]
The AMPA receptor bound to a glutamate antagonist showing the amino terminal, ligand binding, and transmembrane domain, PDB 3KG2
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, or quisqualate receptor) is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS). Its name is derived from its ability to be activated by the artificial glutamate analog AMPA. The receptor was first named the "quisqualate receptor" by Watkins and colleagues after a naturally occurring agonist quisqualate and was only later given the label "AMPA receptor" after the selective agonist developed by Tage Honore and colleagues at the Royal Danish School of Pharmacy in Copenhagen.[10] AMPARs are found in many parts of the brain and are the most commonly found receptor in the nervous system. The AMPA receptor GluA2 (GluR2) tetramer was the first glutamate receptor ion channel to be crystallized.
AMPA receptor trafficking
Ligands:
Agonists: Glutamate, AMPA, 5-Fluorowillardiine, Domoic acid, Quisqualic acid, etc.
Antagonists: CNQX, Kynurenic acid, NBQX, Perampanel, Piracetam, etc.
Positive allosteric modulators: Aniracetam, Cyclothiazide, CX-516, CX-614, etc.
Negative allosteric modulators: Ethanol, Perampanel, Talampanel, GYKI-52,466, etc.
NMDA receptors[edit]
Stylized depiction of an activated NMDAR
The N-methyl-D-aspartate receptor (NMDA receptor) – a type of ionotropic glutamate receptor – is a ligand-gated ion channel that is gated by the simultaneous binding of glutamate and a co-agonist (i.e., either D-serine or glycine).[11] Studies show that the NMDA receptor is involved in regulating synaptic plasticity and memory.[12][13]
The name "NMDA receptor" is derived from the ligand N-methyl-D-aspartate (NMDA), which acts as a selective agonist at these receptors. When the NMDA receptor is activated by the binding of two co-agonists, the cation channel opens, allowing Na+ and Ca2+ to flow into the cell, in turn raising the cell's electric potential. Thus, the NMDA receptor is an excitatory receptor. At resting potentials, the binding of Mg2+ or Zn2+ at their extracellular binding sites on the receptor blocks ion flux through the NMDA receptor channel. "However, when neurons are depolarized, for example, by intense activation of colocalized postsynaptic AMPA receptors, the voltage-dependent block by Mg2+ is partially relieved, allowing ion influx through activated NMDA receptors. The resulting Ca2+ influx can trigger a variety of intracellular signaling cascades, which can ultimately change neuronal function through activation of various kinases and phosphatases".[14]
Ligands:
Primary endogenous co-agonists: glutamate and either D-serine or glycine
Other agonists : aminocyclopropanecarboxylic acid; D-cycloserine; L-aspartate; quinolinate, etc.
Partial agonists : N-methyl-D-aspartic acid (NMDA); NRX-1074; 3,5-dibromo-L-phenylalanine,[15] etc.
Antagonists: ketamine, PCP, dextropropoxyphene, ketobemidone, tramadol, kynurenic acid (endogenous), etc.
GABA receptors[edit]
GABA receptors are major inhibitory neurotransmitter expressed in the major interneurons in animal cortex.
GABAA receptor[edit]
GABAA receptor schematic
GABAA receptors are ligand-gated ion channels. GABA (gamma-aminobutyric acid), the endogenous ligand for these receptors, is the major inhibitory neurotransmitter in the central nervous system. When activated, it mediates Cl– flow into the neuron, hyperpolarizing the neuron. GABAA receptors occur in all organisms that have a nervous system. Due to their wide distribution within the nervous system of mammals, they play a role in virtually all brain functions.[16]
Various ligands can bind specifically to GABAA receptors, either activating or inhibiting the Cl– channel.
Ligands:
Agonists: GABA, muscimol, progabide, gaboxadol
Antagonists: bicuculine, gabazine
Partial agonist: piperidine-4-sulfonic acid
5-HT3 receptor[edit]
5-HT3 receptor
The pentameric 5-HT3 receptor is permeable to sodium (Na), potassium (K), and calcium (Ca) ions.
ATP-gated channels[edit]
Figure 1. Schematic representation showing the membrane topology of a typical P2X receptor subunit. First and second transmembrane domains are labeled TM1 and TM2.
Main article: P2X receptor
ATP-gated channels open in response to binding the nucleotide ATP. They form trimers with two transmembrane helices per subunit and both the C and N termini on the intracellular side.
Type
Class
IUPHAR-recommended
protein name [8]
Gene
Previous names
P2X N/A P2X1
P2X2
P2X3
P2X4
P2X5
P2X6
P2X7 P2RX1
P2RX2
P2RX3
P2RX4
P2RX5
P2RX6
P2RX7 P2X1
P2X2
P2X3
P2X4
P2X5
P2X6
P2X7
PIP2-gated channels[edit]
Phosphatidylinositol 4,5-bisphosphate (PIP2) binds to and directly activates inwardly rectifying potassium channels (Kir).[17] PIP2 is a cell membrane lipid, and its role in gating ion channels represents a novel role for the molecule.[18][19]
Indirect modulation[edit]
In contrast to ligand-gated ion channels, there are also receptor systems in which the receptor and the ion channel are separate proteins in the cell membrane, instead of a single molecule. In this case, ion channels are indirectly modulated by activation of the receptor, instead of being gated directly.
G-protein-linked receptors[edit]
G-protein-coupled receptor mechanism
Also called G protein-coupled receptor, seven-transmembrane domain receptor, 7 TM receptor, constitute a large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They pass through the cell membrane 7 times. G-protein-Linked receptors are a huge family that have hundreds of members identified. Ion-channel-linked receptors (e.g. GABAB, NMDA, etc.) are only a part of them.
Table 1. Three major families of Trimeric G Proteins[20]
FAMILY
SOME FAMILY MEMBERS
ACTION MEDIATED BY
FUNCTIONS
I GS α Activate adenylyl cyclase activates Ca2+ channels
Golf α Activates adenylyl cyclase in olfactory sensory neurons
II Gi α Inhibits adenylyl cyclase
βɣ Activates K+ channels
G0 βɣ Activates K+ channels; inactivate Ca2+ channels
α and βɣ Activates phospholipase C-β
Gt (transducin) α Activate cyclic GMP phosphodiesterase in vertebrate rod photoreceptors
III Gq α Activates phospholipase C-β
GABAB receptor[edit]
GABAB receptors are metabotropic transmembrane receptors for gamma-aminobutyric acid. They are linked via G-proteins to K+ channels, when active, they create hyperpolarized effect and lower the potential inside the cell.[21]
Ligands:
Agonists: GABA, Baclofen, gamma-Hydroxybutyrate, Phenibut etc.
Positive Allosteric Modulators: CGP-7930,[22] Fendiline, BSPP, etc.
Antagonists:2-OH-saclofen, Saclofen, SCH-50911
Gα signaling[edit]
The cyclic-adenosine monophosphate (cAMP)-generating enzyme adenylate cyclase is the effector of both the Gαs and Gαi/o pathways. Ten different AC gene products in mammals, each with subtle differences in tissue distribution and/or function, all catalyze the conversion of cytosolic adenosine triphosphate (ATP) to cAMP, and all are directly stimulated by G-proteins of the Gαs class. Interaction with Gα subunits of the Gαi/o type, on the contrary, inhibits AC from generating cAMP. Thus, a GPCR coupled to Gαs counteracts the actions of a GPCR coupled to Gαi/o, and vice versa. The level of cytosolic cAMP may then determine the activity of various ion channels as well as members of the ser/thr-specific protein kinase A (PKA) family. As a result, cAMP is considered a second messenger and PKA a secondary effector.
The effector of the Gαq/11 pathway is phospholipase C-β (PLCβ), which catalyzes the cleavage of membrane-bound phosphatidylinositol 4,5-biphosphate (PIP2) into the second messengers inositol (1,4,5) trisphosphate (IP3) and diacylglycerol (DAG). IP3 acts on IP3 receptors found in the membrane of the endoplasmic reticulum (ER) to elicit Ca2+ release from the ER, DAG diffuses along the plasma membrane where it may activate any membrane localized forms of a second ser/thr kinase called protein kinase C (PKC). Since many isoforms of PKC are also activated by increases in intracellular Ca2+, both these pathways can also converge on each other to signal through the same secondary effector. Elevated intracellular Ca2+ also binds and allosterically activates proteins called calmodulins, which in turn go on to bind and allosterically activate enzymes such as Ca2+/calmodulin-dependent kinases (CAMKs).
The effectors of the Gα12/13 pathway are three RhoGEFs (p115-RhoGEF, PDZ-RhoGEF, and LARG), which, when bound to Gα12/13 allosterically activate the cytosolic small GTPase, Rho. Once bound to GTP, Rho can then go on to activate various proteins responsible for cytoskeleton regulation such as Rho-kinase (ROCK). Most GPCRs that couple to Gα12/13 also couple to other sub-classes, often Gαq/11.
Gβγ signaling[edit]
The above descriptions ignore the effects of Gβγ–signalling, which can also be important, in particular in the case of activated Gαi/o-coupled GPCRs. The primary effectors of Gβγ are various ion channels, such as G-protein-regulated inwardly rectifying K+ channels (GIRKs), P/Q- and N-type voltage-gated Ca2+ channels, as well as some isoforms of AC and PLC, along with some phosphoinositide-3-kinase (PI3K) isoforms.
Clinical relevance[edit]
Ligand-gated ion channels are likely to be the major site at which anaesthetic agents and ethanol have their effects, although unequivocal evidence of this is yet to be established.[23][24] In particular, the GABA and NMDA receptors are affected by anaesthetic agents at concentrations similar to those used in clinical anaesthesia.[25]
By understanding the mechanism and exploring the chemical/biological/physical component that could function on those receptors, more and more clinical applications are proven by preliminary experiments or FDA.
Memantine
Memantine is approved by the U.S. F.D.A and the European Medicines Agency for the treatment of moderate-to-severe Alzheimer's disease,[26] and has now received a limited recommendation by the UK's National Institute for Health and Care Excellence for patients who fail other treatment options.[27]
Antidepressant treatment
Agomelatine, is a type of drug that acts on a dual melatonergic-serotonergic pathway, which have shown its efficacy in the treatment of anxious depression during clinical trails,[28][29] study also suggests the efficacy in the treatment of atypical and melancholic depression.[30]
See also[edit]
MCB portal
Neuroscience portal
Biology portal
Receptor (biochemistry)
Action potential
Voltage-dependent calcium channel
Calcium-activated potassium channel
Cyclic nucleotide-gated ion channel
Acid-sensing ion channel
Ryanodine receptor
Inositol trisphosphate receptor
References[edit]
Jump up ^ "Gene Family: Ligand gated ion channels". HUGO Gene Nomenclature Committee.
Jump up ^ "ligand-gated channel" at Dorland's Medical Dictionary
Jump up ^ Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008). Neuroscience. 4th ed. Sinauer Associates. pp. 156–7. ISBN 978-0-87893-697-7. CS1 maint: Multiple names: authors list (link)
^ Jump up to: a b Tasneem A, Iyer LM, Jakobsson E, Aravind L (2004). "Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels". Genome Biology. 6 (1): R4. doi:10.1186/gb-2004-6-1-r4. PMC 549065. PMID 15642096.
Jump up ^ Jaiteh M, Taly A, Hénin J (2016). "Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors". PLOS One. 11 (3): e0151934. Bibcode:2016PLoSO..1151934J. doi:10.1371/journal.pone.0151934. PMC 4795631. PMID 26986966.
Jump up ^ Cascio M (May 2004). "Structure and function of the glycine receptor and related nicotinicoid receptors". The Journal of Biological Chemistry. 279 (19): 19383–6. doi:10.1074/jbc.R300035200. PMID 15023997.
^ Jump up to: a b c Langlhofer G, Villmann C (2016-01-01). "The Intracellular Loop of the Glycine Receptor: It's not all about the Size". Frontiers in Molecular Neuroscience. 9: 41. doi:10.3389/fnmol.2016.00041. PMC 4891346. PMID 27330534.
^ Jump up to: a b c d Collingridge GL, Olsen RW, Peters J, Spedding M (January 2009). "A nomenclature for ligand-gated ion channels". Neuropharmacology. 56 (1): 2–5. doi:10.1016/j.neuropharm.2008.06.063. PMC 2847504. PMID 18655795.
Jump up ^ Olsen RW, Sieghart W (September 2008). "International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update". Pharmacological Reviews. 60 (3): 243–60. doi:10.1124/pr.108.00505. PMC 2847512. PMID 18790874.
Jump up ^ Honoré T, Lauridsen J, Krogsgaard-Larsen P (January 1982). "The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes". Journal of Neurochemistry. 38 (1): 173–8. doi:10.1111/j.1471-4159.1982.tb10868.x. PMID 6125564.
Jump up ^ Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 5: Excitatory and Inhibitory Amino Acids". In Sydor A, Brown RY. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York, USA: McGraw-Hill Medical. pp. 124–125. ISBN 9780071481274. At membrane potentials more negative than approximately −50 mV, the Mg2+ in the extracellular fluid of the brain virtually abolishes ion flux through NMDA receptor channels, even in the presence of glutamate. ... The NMDA receptor is unique among all neurotransmitter receptors in that its activation requires the simultaneous binding of two different agonists. In addition to the binding of glutamate at the conventional agonist-binding site, the binding of glycine appears to be required for receptor activation. Because neither of these agonists alone can open this ion channel, glutamate and glycine are referred to as coagonists of the NMDA receptor. The physiologic significance of the glycine binding site is unclear because the normal extracellular concentration of glycine is believed to be saturating. However, recent evidence suggests that D-serine may be the endogenous agonist for this site.
Jump up ^ Li F, Tsien JZ (July 2009). "Memory and the NMDA receptors". The New England Journal of Medicine. 361 (3): 302–3. doi:10.1056/NEJMcibr0902052. PMC 3703758. PMID 19605837.
Jump up ^ Cao X, Cui Z, Feng R, Tang YP, Qin Z, Mei B, Tsien JZ (March 2007). "Maintenance of superior learning and memory function in NR2B transgenic mice during ageing". The European Journal of Neuroscience. 25 (6): 1815–22. doi:10.1111/j.1460-9568.2007.05431.x. PMID 17432968.
Jump up ^ Dingledine R, Borges K, Bowie D, Traynelis SF (March 1999). "The glutamate receptor ion channels". Pharmacological Reviews. 51 (1): 7–61. PMID 10049997.
Jump up ^ Yarotskyy V, Glushakov AV, Sumners C, Gravenstein N, Dennis DM, Seubert CN, Martynyuk AE (May 2005). "Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine". Molecular Pharmacology. 67 (5): 1648–54. doi:10.1124/mol.104.005983. PMID 15687225.
Jump up ^ Wu C, Sun D (April 2015). "GABA receptors in brain development, function, and injury". Metabolic Brain Disease. 30 (2): 367–79. doi:10.1007/s11011-014-9560-1. PMC 4231020. PMID 24820774.
Jump up ^ Hansen SB, Tao X, MacKinnon R (August 2011). "Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2". Nature. 477 (7365): 495–8. Bibcode:2011Natur.477..495H. doi:10.1038/nature10370. PMC 3324908. PMID 21874019.
Jump up ^ Hansen SB (May 2015). "Lipid agonism: The PIP2 paradigm of ligand-gated ion channels". Biochimica et Biophysica Acta. 1851 (5): 620–8. doi:10.1016/j.bbalip.2015.01.011. PMC 4540326. PMID 25633344.
Jump up ^ Gao Y, Cao E, Julius D, Cheng Y (June 2016). "TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action". Nature. 534 (7607): 347–51. Bibcode:2016Natur.534..347G. doi:10.1038/nature17964. PMC 4911334. PMID 27281200.
Jump up ^ Lodish, Harvey. Molecular cell biology. Macmillan, 2008.
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Jump up ^ Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, Bettler B, Kaupmann K (November 2001). "Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501". Molecular Pharmacology. 60 (5): 963–71. doi:10.1124/mol.60.5.963. PMID 11641424.
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External links[edit]
Wikimedia Commons has media related to Ligand-gated ion channel.
Ligand-Gated Ion Channel database at European Bioinformatics Institute. Verified availability April 11, 2007.
"Revised Recommendations for Nomenclature of Ligand-Gated Ion Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
www.esf.edu
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As of this edit, this article uses content from "1.A.9 The Neurotransmitter Receptor, Cys loop, Ligand-gated Ion Channel (LIC) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. All relevant terms must be followed.
show
v
t
e
Membrane transport protein: ion channels (TC 1A)
show
Ca2+: Calcium channel
Ligand-gated
Inositol trisphosphate receptor
1
2
3
Ryanodine receptor
1
2
3
Voltage-gated
L-type/Cavα
1.1
1.2
1.3
1.4
N-type/Cavα2.2
P-type/Cavα
2.1
Q-type/Cavα2.1
R-type/Cavα2.3
T-type/Cavα
3.1
3.2
3.3
α2δ-subunits
1
2
β-subunits
β1
β2
β3
β4
γ-subunits
γ1
γ2
γ3
γ4
Cation channels of sperm
1
2
3
4
Two-pore channel
1
2
show
Na+: Sodium channel
Constitutively active
Epithelial sodium channel
α
β
γ
δ
Proton-gated
Amiloride-sensitive cation channel
1
2
3
4
Voltage-gated
Navα
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
7A
Navβ
1
2
3
4
show
K+: Potassium channel
Calcium-activated
BK channel
α1
β1
β2
β3
β4
SK channel
SK1
SK2
SK3
IK channel
IK1
KCa
1.1
2.1
2.2
2.3
3.1
4.1
4.2
5.1
Inward-rectifier
KATP
Kir
1.1
2.1
2.2
2.3
2.4
2.6
GIRK/Kir
3.1
3.2
3.3
3.4
Kir
4.1
4.2
5.1
6.1
6.2
7.1
Tandem pore domain
K2P
1
2
3
4
5
6
7
9
10
12
13
15
16
17
18
Voltage-gated
Kvα1-6
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
2.1
2.2
3.1
3.2
3.3
3.4
4.1
4.2
4.3
5.1
6.1
6.2
6.3
6.4
Kvα7-12
7.1
7.2
7.3
7.4
7.5
8.1
8.2
9.1
9.2
9.3
10.1
10.2
11.1/hERG
11.2
11.3
12.1
12.2
12.3
Kvβ
1
2
3
KCNIP
1
2
3
4
minK/ISK
minK/ISK-like
MiRP
1
2
3
Shaker gene
show
Miscellaneous
Cl−: Chloride channel
Calcium-activated chloride channels
Anoctamin
ANO1
Bestrophin
1
2
Chloride Channel Accessory
1
2
3
4
CFTR
CLCN
1
2
3
4
5
6
7
KA
KB
CLIC
1
2
3
4
5
6
L1
CLNS
1A
1B
H+: Proton channel
HVCN1
M+: CNG cation channel
α
1
2
3
4
β
1
2
3
HCN
FC
1
2
3
4
M+: TRP cation channel
TRPA (1)
TRPC
1
2
3
4
4AP
5
6
7
TRPM
1
2
3
4
5
6
7
8
TRPML
1
2
3
TRPN
TRPP
1
2
TRPV
1
2
3
4
5
6
H2O (+ solutes): Porin
Aquaporin
0
1
2
3
4
5
6
7
8
9
Voltage-dependent anion channel
1
2
3
General bacterial porin family
Cytoplasm: Gap junction
Connexin
A
GJA1
GJA3
GJA4
GJA5
GJA8
GJA9
GJA10
B
GJB1
GJB2
GJB3
GJB4
GJB5
GJB6
GJB7
C
GJC1
GJC2
GJC3
D
GJD2
GJD3
GJD4
Innexin
hide
By gating mechanism
Ion channel class
Ligand-gated
Light-gated
Voltage-gated
Stretch-activated
see also disorders
show
v
t
e
Ion channel, cell surface receptor: ligand-gated ion channels
Cys-loop receptors
5-HT/serotonin
5-HT3
A
B
C
D
E
GABA
GABAA
α1
α2
α3
α4
α5
α6
β1
β2
β3
γ1
γ2
γ3
δ
ε
π
θ
GABAA-ρ
ρ1
ρ2
ρ3
Glycine
α1
α2
α3
α4
β
Nicotinic acetylcholine
monomers: α1
α2
α3
α4
α5
α6
α7
α9
α10
β1
β2
β3
β4
δ
ε
pentamers: (α3)2(β4)3
(α4)2(β2)3
(α7)5
(α1)2(β4)3 - Ganglion type
(α1)2β1δε - Muscle type
Zinc
Zinc-activated
Ionotropic glutamates
Ligand-gated only
AMPA (1
2
3
4)
Kainate
1
2
3
4
5
Voltage- and ligand-gated
NMDA
1
2A
2B
2C
2D
3A
3B
L1A
L1B
‘Orphan’
GluD
δ1
δ2
ATP-gated channels
Purinergic receptors
P2X
1
2
3
4
5
6
7
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