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Personal Public Service Number
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"PPSN" redirects here. For the political party, see Party for People with Special Needs.
Personal Public Service Number
Public Service identifier overview
Formed
April 1979
Jurisdiction
Ireland
Key document
Social Welfare (Consolidation) Act, 2005
The Personal Public Service Number (PPS No) (Irish: Uimhir Phearsanta Seirbhíse Poiblí, or Uimh. PSP) is an identifier issued by the Client Identity Services section of the Department of Social Protection, on behalf of the Minister for Social Protection in Ireland.
The PPSN was known as the Revenue and Social Insurance Number (RSI No) until 1998. RSI Numbers were first issued in April 1979 as a replacement for the separate PAYE Number and Social Welfare Insurance Number which had been used for income tax and social welfare purposes respectively until then. The PAYE Number was issued by the Revenue Commissioners and these numbers were transferred to the RSI No system as a basis for the unified system.
Contents
[hide]
1 Format
2 Check character
2.1 Calculation
2.2 Check digit calculation in software
3 Expansion
4 Usage
5 See also
6 References
7 External links
Format[edit]
The format of the number is a unique alphanumeric in the general form 8765432AA. The number is assigned at the registration of birth of the child and is issued on a "Public Services Card" often when a child reaches the legal age of employment, currently 16, otherwise a "Letter of Entitlement" is issued. The same format was used by the Department of Education and Skills as the "Pupil Number" since 1994 and this caused some concern and confusion as it was in the same format and used the same check character formula, but more often different from the PPS No. In August 2000 the department instigated a programme to remove the Pupil Number and replace it with the PPS No in future on records. By September 2001, the Pupil Number was fully withdrawn.
The format is seven numeric characters (including leading zeros), a check character and sometimes a second letter, which if it exists, will normally be an A (for individuals) or an H (for non-individuals, e.g., limited companies, trusts, etc.[1]) In some cases, this second letter may be a W, which was used for women - "W" from "wife" – who married and automatically adopted the same number as their husband, though this practice stopped in 1999 chiefly due to equal rights concerns.[2] The present policy is that these W numbers are eliminated when the bearer's husband dies, or when they become separated or divorced.
The Social Services Card, no longer in use, contained a number called the "Primary Account Number" (PAN), this is the long main sequence embossed near the centre of the card. This consists of the issuer number of the International Organization for Standardization, the PPS number and a card issue number; any letters are converted to numbers using the standard convention of A=1, B=2 and so forth. Basic personal information is encoded on the magnetic stripe on the rear of the card such as date of birth and sex. The Social Services Card was completely withdrawn by January 2014.
Since 2012, a new Public Services (National Identity) Card has been rolled out thus replacing the Social Services Card used to collect social welfare payments . It displays a passport-size photo, your PPS No, your date of birth and a Card Number. The Passport Service of the Department of Foreign Affairs and Trade has announced that as of 29 March 2016, all first-time passport applicants aged 18 and above who are resident in Ireland will need to have a Public Services Card (PSC) for identification purposes.
Separately, the old paper Free Travel Pass was replaced by the Public Services Card Free Travel (PSCFT) since 9 December 2013, with the paper version being completely phased out by 1 January 2016.
Check character[edit]
The format of the PPS number was defined as being nine characters in length, consisting of 7 digits in positions 1 to 7, followed by a check character in position 8, with either a space or the letter “W” in position 9. However, from 1 January 2013 a new range of PPS numbers were introduced by including an additional alphabetic character, other than “W”, in position 9.[3]
The character in position 8 still operates as the check character for all existing and new numbers, but the calculation used to decide this character has been revised to avoid any confusion between an “old” number and a “new” number using the same 7 numeric values in the first 7 positions.
The check character is calculated using a weighted addition of all the numbers and modulus calculation (known as Modulus 23). It therefore checks for incorrectly entered digits and for digit transposition (digits in the wrong order will alter the sum due to weightings).
Calculation[edit]
The modulus 23 calculation has been revised to take account of the extra character as follows:
A numeric value is assigned to the alphabetic character in position 9, with "A" = 1, "B" = 2, "C" = 3, etc. Where a "W" or a blank already exists (in numbers assigned before 1 January 2013) the assigned numeric value will be zero.
Each digit is multiplied by a weight, with a weighting of 9 assigned to the numeric equivalent of the alphabetic character in position 9. See the table for a sample calculation on the PPSN "1234567_A".
Digit
Weighting
Result
1 8 1 * 8 = 8
2 7 2 * 7 = 14
3 6 3 * 6 = 18
4 5 4 * 5 = 20
5 4 5 * 4 = 20
6 3 6 * 3 = 18
7 2 7 * 2 = 14
A(1) 9 1 * 9 = 9
The results are added together, and divided by 23. The remainder (modulus 23) indicate the check character position in the alphabet. In the example above, 121 divided by 23 leaves a remainder of 6, and "F" is the sixth character in the alphabet. The correct PPS number is therefore 1234567FA. Where the remainder is zero, the check letter is W.
Check digit calculation in software[edit]
The following are examples of software that provide checksum verification:
PHP: The Pear class Validate_IE contains a checksum algorithm.
Thesaurus Software Thesaurus Payroll Manager payroll software.
Sage QuickPay payroll software.
Expansion[edit]
As the system allows for a maximum of ten million numbers to be issued, and with numbers having been issued to both the Irish and the legal immigrant population, expatriates, and many people who are now deceased, the current system will be in need of expansion in the not distant future.
Since January 2013, the format uses a letter after the current check character.[3] This has the advantage that all current PPS numbers remain valid. The letter after the check character would have a weighting of nine. The letter value would be assigned the same as the check character's. A=1, B=2 ... W=0.
Examples of valid new PPSN
1234567TW
1234567FA
Usage[edit]
The number is currently used for a number of public services including education, health, housing, social welfare and tax however the net is widening raising concern about functionality creep.[4] The number is underpinned in legislation by the Social Welfare (Consolidation) Act, 2005 (Section 262) and a number of amendments, including data protection, have expanded its legal use as well as defining improper usage.
The number has already been issued automatically to everyone born in the Republic of Ireland since January 1971 and those who commenced or were in employment since April 1979 – the primary trigger today for the numbers' issue is birth registration. A PPS number can be applied for at a PPS Number allocation centre. Applicants should show the reason for requiring a PPS Number, and provide Photographic ID and proof of address.
See also[edit]
NHI Number (a similar number in New Zealand)
National Insurance number (a similar number in the United Kingdom)
Social Insurance Number (a similar number in Canada)
Tax file number (a similar number in Australia)
Social Security number (a similar number in the United States)
CPF (a similar number in Brazil)
References[edit]
Jump up ^ "Personal Public Service Number". Citizens Information. Retrieved 24 October 2014.
Jump up ^ http://www.citizensinformation.ie/en/social_welfare/irish_social_welfare_system/personal_public_service_number.html
^ Jump up to: a b "Extension of the Personal Public Service Number Range". welfare.ie. Retrieved 24 October 2014.
Jump up ^ McMahon, Rossa. "Biometric national ID cards for Ireland on the way?". A Clatter of the Law. Retrieved 24 October 2014. the PPS number – an epitome of function creep if ever there were.
External links[edit]
Personal Public Service Number
Personal Public Service Number Algorithim
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Biotechnology
From Wikipedia, the free encyclopedia
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For other uses, see Biotechnology (disambiguation).
Insulin crystals
Biotechnology is the broad area of science involving living systems and organisms to develop or make products, or "any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify products or processes for specific use" (UN Convention on Biological Diversity, Art. 2).[1] Depending on the tools and applications, it often overlaps with the (related) fields of molecular biology, bio-engineering, biomedical engineering, biomanufacturing, molecular engineering, etc.
For thousands of years, humankind has used biotechnology in agriculture, food production, and medicine.[2] The term is largely believed to have been coined in 1919 by Hungarian engineer Károly Ereky. In the late 20th and early 21st centuries, biotechnology has expanded to include new and diverse sciences such as genomics, recombinant gene techniques, applied immunology, and development of pharmaceutical therapies and diagnostic tests.[2]
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Contents
1 Definitions
2 History
3 Examples
3.1 Medicine
3.2 Agriculture
3.3 Industrial
3.4 Environmental
3.5 Regulation
4 Learning
5 See also
6 References and notes
7 Further reading
8 External links
Definitions[edit]
The wide concept of "biotech" or "biotechnology" encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials and organisms such as pharmaceuticals, crops, and livestock.[3] As per European Federation of Biotechnology, biotechnology is the integration of natural science and organisms, cells, parts thereof, and molecular analogues for products and services.[4] Biotechnology is based on the basic biological sciences (e.g. molecular biology, biochemistry, cell biology, embryology, genetics, microbiology) and conversely provides methods to support and perform basic research in biology.
Biotechnology is the research and development in the laboratory using bioinformatics for exploration, extraction, exploitation and production from any living organisms and any source of biomass by means of biochemical engineering where high value-added products could be planned (reproduced by biosynthesis, for example), forecasted, formulated, developed, manufactured, and marketed for the purpose of sustainable operations (for the return from bottomless initial investment on R & D) and gaining durable patents rights (for exclusives rights for sales, and prior to this to receive national and international approval from the results on animal experiment and human experiment, especially on the pharmaceutical branch of biotechnology to prevent any undetected side-effects or safety concerns by using the products).[5][6][7]
By contrast, bioengineering is generally thought of as a related field that more heavily emphasizes higher systems approaches (not necessarily the altering or using of biological materials directly) for interfacing with and utilizing living things. Bioengineering is the application of the principles of engineering and natural sciences to tissues, cells and molecules. This can be considered as the use of knowledge from working with and manipulating biology to achieve a result that can improve functions in plants and animals.[8] Relatedly, biomedical engineering is an overlapping field that often draws upon and applies biotechnology (by various definitions), especially in certain sub-fields of biomedical or chemical engineering such as tissue engineering, biopharmaceutical engineering, and genetic engineering.
History[edit]
Brewing was an early application of biotechnology
Main article: History of biotechnology
Although not normally what first comes to mind, many forms of human-derived agriculture clearly fit the broad definition of "'utilizing a biotechnological system to make products". Indeed, the cultivation of plants may be viewed as the earliest biotechnological enterprise.
Agriculture has been theorized to have become the dominant way of producing food since the Neolithic Revolution. Through early biotechnology, the earliest farmers selected and bred the best suited crops, having the highest yields, to produce enough food to support a growing population. As crops and fields became increasingly large and difficult to maintain, it was discovered that specific organisms and their by-products could effectively fertilize, restore nitrogen, and control pests. Throughout the history of agriculture, farmers have inadvertently altered the genetics of their crops through introducing them to new environments and breeding them with other plants — one of the first forms of biotechnology.
These processes also were included in early fermentation of beer.[9] These processes were introduced in early Mesopotamia, Egypt, China and India, and still use the same basic biological methods. In brewing, malted grains (containing enzymes) convert starch from grains into sugar and then adding specific yeasts to produce beer. In this process, carbohydrates in the grains broke down into alcohols, such as ethanol. Later, other cultures produced the process of lactic acid fermentation, which produced other preserved foods, such as soy sauce. Fermentation was also used in this time period to produce leavened bread. Although the process of fermentation was not fully understood until Louis Pasteur's work in 1857, it is still the first use of biotechnology to convert a food source into another form.
Before the time of Charles Darwin's work and life, animal and plant scientists had already used selective breeding. Darwin added to that body of work with his scientific observations about the ability of science to change species. These accounts contributed to Darwin's theory of natural selection.[10]
For thousands of years, humans have used selective breeding to improve production of crops and livestock to use them for food. In selective breeding, organisms with desirable characteristics are mated to produce offspring with the same characteristics. For example, this technique was used with corn to produce the largest and sweetest crops.[11]
In the early twentieth century scientists gained a greater understanding of microbiology and explored ways of manufacturing specific products. In 1917, Chaim Weizmann first used a pure microbiological culture in an industrial process, that of manufacturing corn starch using Clostridium acetobutylicum, to produce acetone, which the United Kingdom desperately needed to manufacture explosives during World War I.[12]
Biotechnology has also led to the development of antibiotics. In 1928, Alexander Fleming discovered the mold Penicillium. His work led to the purification of the antibiotic compound formed by the mold by Howard Florey, Ernst Boris Chain and Norman Heatley – to form what we today know as penicillin. In 1940, penicillin became available for medicinal use to treat bacterial infections in humans.[11]
The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced the new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the United States Supreme Court ruled that a genetically modified microorganism could be patented in the case of Diamond v. Chakrabarty.[13] Indian-born Ananda Chakrabarty, working for General Electric, had modified a bacterium (of the genus Pseudomonas) capable of breaking down crude oil, which he proposed to use in treating oil spills. (Chakrabarty's work did not involve gene manipulation but rather the transfer of entire organelles between strains of the Pseudomonas bacterium.
Revenue in the industry is expected to grow by 12.9% in 2008. Another factor influencing the biotechnology sector's success is improved intellectual property rights legislation—and enforcement—worldwide, as well as strengthened demand for medical and pharmaceutical products to cope with an ageing, and ailing, U.S. population.[14]
Rising demand for biofuels is expected to be good news for the biotechnology sector, with the Department of Energy estimating ethanol usage could reduce U.S. petroleum-derived fuel consumption by up to 30% by 2030. The biotechnology sector has allowed the U.S. farming industry to rapidly increase its supply of corn and soybeans—the main inputs into biofuels—by developing genetically modified seeds that resist pests and drought. By increasing farm productivity, biotechnology boosts biofuel production.[15]
Examples[edit]
A rose plant that began as cells grown in a tissue culture
Biotechnology has applications in four major industrial areas, including health care (medical), crop production and agriculture, non-food (industrial) uses of crops and other products (e.g. biodegradable plastics, vegetable oil, biofuels), and environmental uses.
For example, one application of biotechnology is the directed use of organisms for the manufacture of organic products (examples include beer and milk products). Another example is using naturally present bacteria by the mining industry in bioleaching. Biotechnology is also used to recycle, treat waste, clean up sites contaminated by industrial activities (bioremediation), and also to produce biological weapons.
A series of derived terms have been coined to identify several branches of biotechnology, for example:
Bioinformatics is an interdisciplinary field that addresses biological problems using computational techniques, and makes the rapid organization as well as analysis of biological data possible. The field may also be referred to as computational biology, and can be defined as, "conceptualizing biology in terms of molecules and then applying informatics techniques to understand and organize the information associated with these molecules, on a large scale."[16] Bioinformatics plays a key role in various areas, such as functional genomics, structural genomics, and proteomics, and forms a key component in the biotechnology and pharmaceutical sector.
Blue biotechnology is a term that has been used to describe the marine and aquatic applications of biotechnology, but its use is relatively rare.
Green biotechnology is biotechnology applied to agricultural processes. An example would be the selection and domestication of plants via micropropagation. Another example is the designing of transgenic plants to grow under specific environments in the presence (or absence) of chemicals. One hope is that green biotechnology might produce more environmentally friendly solutions than traditional industrial agriculture. An example of this is the engineering of a plant to express a pesticide, thereby ending the need of external application of pesticides. An example of this would be Bt corn. Whether or not green biotechnology products such as this are ultimately more environmentally friendly is a topic of considerable debate.
Red biotechnology is applied to medical processes. Some examples are the designing of organisms to produce antibiotics, and the engineering of genetic cures through genetic manipulation.
White biotechnology, also known as industrial biotechnology, is biotechnology applied to industrial processes. An example is the designing of an organism to produce a useful chemical. Another example is the using of enzymes as industrial catalysts to either produce valuable chemicals or destroy hazardous/polluting chemicals. White biotechnology tends to consume less in resources than traditional processes used to produce industrial goods.[17]
The investment and economic output of all of these types of applied biotechnologies is termed as "bioeconomy".
Medicine[edit]
In medicine, modern biotechnology finds many applications in areas such as pharmaceutical drug discoveries and production, pharmacogenomics, and genetic testing (or genetic screening).
DNA microarray chip – some can do as many as a million blood tests at once
Pharmacogenomics (a combination of pharmacology and genomics) is the technology that analyses how genetic makeup affects an individual's response to drugs.[18] It deals with the influence of genetic variation on drug responses in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity.[19] By doing so, pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects.[20] Such approaches promise the advent of "personalized medicine"; in which drugs and drug combinations are optimized for each individual's unique genetic makeup.[21][22]
Computer-generated image of insulin hexamers highlighting the threefold symmetry, the zinc ions holding it together, and the histidine residues involved in zinc binding.
Biotechnology has contributed to the discovery and manufacturing of traditional small molecule pharmaceutical drugs as well as drugs that are the product of biotechnology – biopharmaceutics. Modern biotechnology can be used to manufacture existing medicines relatively easily and cheaply. The first genetically engineered products were medicines designed to treat human diseases. To cite one example, in 1978 Genentech developed synthetic humanized insulin by joining its gene with a plasmid vector inserted into the bacterium Escherichia coli. Insulin, widely used for the treatment of diabetes, was previously extracted from the pancreas of abattoir animals (cattle or pigs). The resulting genetically engineered bacterium enabled the production of vast quantities of synthetic human insulin at relatively low cost.[23][24] Biotechnology has also enabled emerging therapeutics like gene therapy. The application of biotechnology to basic science (for example through the Human Genome Project) has also dramatically improved our understanding of biology and as our scientific knowledge of normal and disease biology has increased, our ability to develop new medicines to treat previously untreatable diseases has increased as well.[24]
Genetic testing allows the genetic diagnosis of vulnerabilities to inherited diseases, and can also be used to determine a child's parentage (genetic mother and father) or in general a person's ancestry. In addition to studying chromosomes to the level of individual genes, genetic testing in a broader sense includes biochemical tests for the possible presence of genetic diseases, or mutant forms of genes associated with increased risk of developing genetic disorders. Genetic testing identifies changes in chromosomes, genes, or proteins.[25] Most of the time, testing is used to find changes that are associated with inherited disorders. The results of a genetic test can confirm or rule out a suspected genetic condition or help determine a person's chance of developing or passing on a genetic disorder. As of 2011 several hundred genetic tests were in use.[26][27] Since genetic testing may open up ethical or psychological problems, genetic testing is often accompanied by genetic counseling.
Agriculture[edit]
Genetically modified crops ("GM crops", or "biotech crops") are plants used in agriculture, the DNA of which has been modified with genetic engineering techniques. In most cases, the main aim is to introduce a new trait that does not occur naturally in the species.
Examples in food crops include resistance to certain pests,[28] diseases,[29] stressful environmental conditions,[30] resistance to chemical treatments (e.g. resistance to a herbicide[31]), reduction of spoilage,[32] or improving the nutrient profile of the crop.[33] Examples in non-food crops include production of pharmaceutical agents,[34] biofuels,[35] and other industrially useful goods,[36] as well as for bioremediation.[37][38]
Farmers have widely adopted GM technology. Between 1996 and 2011, the total surface area of land cultivated with GM crops had increased by a factor of 94, from 17,000 square kilometers (4,200,000 acres) to 1,600,000 km2 (395 million acres).[39] 10% of the world's crop lands were planted with GM crops in 2010.[39] As of 2011, 11 different transgenic crops were grown commercially on 395 million acres (160 million hectares) in 29 countries such as the USA, Brazil, Argentina, India, Canada, China, Paraguay, Pakistan, South Africa, Uruguay, Bolivia, Australia, Philippines, Myanmar, Burkina Faso, Mexico and Spain.[39]
Genetically modified foods are foods produced from organisms that have had specific changes introduced into their DNA with the methods of genetic engineering. These techniques have allowed for the introduction of new crop traits as well as a far greater control over a food's genetic structure than previously afforded by methods such as selective breeding and mutation breeding.[40] Commercial sale of genetically modified foods began in 1994, when Calgene first marketed its Flavr Savr delayed ripening tomato.[41] To date most genetic modification of foods have primarily focused on cash crops in high demand by farmers such as soybean, corn, canola, and cotton seed oil. These have been engineered for resistance to pathogens and herbicides and better nutrient profiles. GM livestock have also been experimentally developed; in November 2013 none were available on the market,[42] but in 2015 the FDA approved the first GM salmon for commercial production and consumption.[43]
There is a scientific consensus[44][45][46][47] that currently available food derived from GM crops poses no greater risk to human health than conventional food,[48][49][50][51][52] but that each GM food must be tested on a case-by-case basis before introduction.[53][54][55] Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.[56][57][58][59] The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.[60][61][62][63]
GM crops also provide a number of ecological benefits, if not used in excess.[64] However, opponents have objected to GM crops per se on several grounds, including environmental concerns, whether food produced from GM crops is safe, whether GM crops are needed to address the world's food needs, and economic concerns raised by the fact these organisms are subject to intellectual property law.
Industrial[edit]
Industrial biotechnology (known mainly in Europe as white biotechnology) is the application of biotechnology for industrial purposes, including industrial fermentation. It includes the practice of using cells such as micro-organisms, or components of cells like enzymes, to generate industrially useful products in sectors such as chemicals, food and feed, detergents, paper and pulp, textiles and biofuels.[65] In doing so, biotechnology uses renewable raw materials and may contribute to lowering greenhouse gas emissions and moving away from a petrochemical-based economy.[66]
Environmental[edit]
The environment can be affected by biotechnologies, both positively and adversely. Vallero and others have argued that the difference between beneficial biotechnology (e.g.bioremediation is to clean up an oil spill or hazard chemical leak) versus the adverse effects stemming from biotechnological enterprises (e.g. flow of genetic material from transgenic organisms into wild strains) can be seen as applications and implications, respectively.[67] Cleaning up environmental wastes is an example of an application of environmental biotechnology; whereas loss of biodiversity or loss of containment of a harmful microbe are examples of environmental implications of biotechnology.
Regulation[edit]
Main articles: Regulation of genetic engineering and Regulation of the release of genetic modified organisms
The regulation of genetic engineering concerns approaches taken by governments to assess and manage the risks associated with the use of genetic engineering technology, and the development and release of genetically modified organisms (GMO), including genetically modified crops and genetically modified fish. There are differences in the regulation of GMOs between countries, with some of the most marked differences occurring between the USA and Europe.[68] Regulation varies in a given country depending on the intended use of the products of the genetic engineering. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety.[69] The European Union differentiates between approval for cultivation within the EU and approval for import and processing. While only a few GMOs have been approved for cultivation in the EU a number of GMOs have been approved for import and processing.[70] The cultivation of GMOs has triggered a debate about coexistence of GM and non GM crops. Depending on the coexistence regulations incentives for cultivation of GM crops differ.[71]
Learning[edit]
In 1988, after prompting from the United States Congress, the National Institute of General Medical Sciences (National Institutes of Health) (NIGMS) instituted a funding mechanism for biotechnology training. Universities nationwide compete for these funds to establish Biotechnology Training Programs (BTPs). Each successful application is generally funded for five years then must be competitively renewed. Graduate students in turn compete for acceptance into a BTP; if accepted, then stipend, tuition and health insurance support is provided for two or three years during the course of their Ph.D. thesis work. Nineteen institutions offer NIGMS supported BTPs.[72] Biotechnology training is also offered at the undergraduate level and in community colleges.
See also[edit]
Biotechnology portal
Agriculture portal
Food portal
Medicine portal
Bioculture
Bioeconomics (biophysical)
Biological engineering
Biomimetics
Bionic architecture
Biotechnology industrial park
Competitions and prizes in biotechnology
Cyborg art
C5SD
EHA101
Genetic engineering
Green Revolution
History of biotechnology
List of biotechnology articles
List of biotechnology companies
Metabolic engineering
NASDAQ Biotechnology Index
Outline of biotechnology
Pharmaceutical chemistry
Pharmaceutical companies
SWORD-financing
Timeline of biotechnology
Virotherapy
References and notes[edit]
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Jump up ^ Genetically Altered Potato Ok'd For Crops Lawrence Journal-World – 6 May 1995
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Jump up ^ Strange, Amy (20 September 2011) Scientists engineer plants to eat toxic pollution The Irish Times. Retrieved 20 September 2011
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^ Jump up to: a b c James C (2011). "ISAAA Brief 43, Global Status of Commercialized Biotech/GM Crops: 2011". ISAAA Briefs. Ithaca, New York: International Service for the Acquisition of Agri-biotech Applications (ISAAA). Retrieved 2012-06-02.
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Jump up ^ Nicolia A, Manzo A, Veronesi F, Rosellini D (March 2014). "An overview of the last 10 years of genetically engineered crop safety research" (PDF). Critical Reviews in Biotechnology. 34 (1): 77–88. doi:10.3109/07388551.2013.823595. PMID 24041244. We have reviewed the scientific literature on GE crop safety for the last 10 years that catches the scientific consensus matured since GE plants became widely cultivated worldwide, and we can conclude that the scientific research conducted so far has not detected any significant hazard directly connected with the use of GM crops.
The literature about Biodiversity and the GE food/feed consumption has sometimes resulted in animated debate regarding the suitability of the experimental designs, the choice of the statistical methods or the public accessibility of data. Such debate, even if positive and part of the natural process of review by the scientific community, has frequently been distorted by the media and often used politically and inappropriately in anti-GE crops campaigns.
Jump up ^ "State of Food and Agriculture 2003–2004. Agricultural Biotechnology: Meeting the Needs of the Poor. Health and environmental impacts of transgenic crops". Food and Agriculture Organization of the United Nations. Retrieved February 8, 2016. Currently available transgenic crops and foods derived from them have been judged safe to eat and the methods used to test their safety have been deemed appropriate. These conclusions represent the consensus of the scientific evidence surveyed by the ICSU (2003) and they are consistent with the views of the World Health Organization (WHO, 2002). These foods have been assessed for increased risks to human health by several national regulatory authorities (inter alia, Argentina, Brazil, Canada, China, the United Kingdom and the United States) using their national food safety procedures (ICSU). To date no verifiable untoward toxic or nutritionally deleterious effects resulting from the consumption of foods derived from genetically modified crops have been discovered anywhere in the world (GM Science Review Panel). Many millions of people have consumed foods derived from GM plants - mainly maize, soybean and oilseed rape - without any observed adverse effects (ICSU).
Jump up ^ Ronald P (May 2011). "Plant genetics, sustainable agriculture and global food security". Genetics. 188 (1): 11–20. doi:10.1534/genetics.111.128553. PMC 3120150  . PMID 21546547. There is broad scientific consensus that genetically engineered crops currently on the market are safe to eat. After 14 years of cultivation and a cumulative total of 2 billion acres planted, no adverse health or environmental effects have resulted from commercialization of genetically engineered crops (Board on Agriculture and Natural Resources, Committee on Environmental Impacts Associated with Commercialization of Transgenic Plants, National Research Council and Division on Earth and Life Studies 2002). Both the U.S. National Research Council and the Joint Research Centre (the European Union's scientific and technical research laboratory and an integral part of the European Commission) have concluded that there is a comprehensive body of knowledge that adequately addresses the food safety issue of genetically engineered crops (Committee on Identifying and Assessing Unintended Effects of Genetically Engineered Foods on Human Health and National Research Council 2004; European Commission Joint Research Centre 2008). These and other recent reports conclude that the processes of genetic engineering and conventional breeding are no different in terms of unintended consequences to human health and the environment (European Commission Directorate-General for Research and Innovation 2010).
Jump up ^ But see also:
Domingo JL, Giné Bordonaba J (May 2011). "A literature review on the safety assessment of genetically modified plants" (PDF). Environment International. 37 (4): 734–42. doi:10.1016/j.envint.2011.01.003. PMID 21296423. In spite of this, the number of studies specifically focused on safety assessment of GM plants is still limited. However, it is important to remark that for the first time, a certain equilibrium in the number of research groups suggesting, on the basis of their studies, that a number of varieties of GM products (mainly maize and soybeans) are as safe and nutritious as the respective conventional non-GM plant, and those raising still serious concerns, was observed. Moreover, it is worth mentioning that most of the studies demonstrating that GM foods are as nutritional and safe as those obtained by conventional breeding, have been performed by biotechnology companies or associates, which are also responsible of commercializing these GM plants. Anyhow, this represents a notable advance in comparison with the lack of studies published in recent years in scientific journals by those companies.
Krimsky S (2015). "An Illusory Consensus behind GMO Health Assessment" (PDF). Science, Technology, & Human Values. 40: 1–32. doi:10.1177/0162243915598381. I began this article with the testimonials from respected scientists that there is literally no scientific controversy over the health effects of GMOs. My investigation into the scientific literature tells another story.
And contrast:
Panchin AY, Tuzhikov AI (March 2017). "Published GMO studies find no evidence of harm when corrected for multiple comparisons". Critical Reviews in Biotechnology. 37 (2): 213–217. doi:10.3109/07388551.2015.1130684. PMID 26767435. Here, we show that a number of articles some of which have strongly and negatively influenced the public opinion on GM crops and even provoked political actions, such as GMO embargo, share common flaws in the statistical evaluation of the data. Having accounted for these flaws, we conclude that the data presented in these articles does not provide any substantial evidence of GMO harm.
The presented articles suggesting possible harm of GMOs received high public attention. However, despite their claims, they actually weaken the evidence for the harm and lack of substantial equivalency of studied GMOs. We emphasize that with over 1783 published articles on GMOs over the last 10 years it is expected that some of them should have reported undesired differences between GMOs and conventional crops even if no such differences exist in reality.
and
Yang YT, Chen B (April 2016). "Governing GMOs in the USA: science, law and public health". Journal of the Science of Food and Agriculture. 96 (6): 1851–5. doi:10.1002/jsfa.7523. PMID 26536836. It is therefore not surprising that efforts to require labeling and to ban GMOs have been a growing political issue in the USA (citing Domingo and Bordonaba, 2011).
Overall, a broad scientific consensus holds that currently marketed GM food poses no greater risk than conventional food... Major national and international science and medical associations have stated that no adverse human health effects related to GMO food have been reported or substantiated in peer-reviewed literature to date.
Despite various concerns, today, the American Association for the Advancement of Science, the World Health Organization, and many independent international science organizations agree that GMOs are just as safe as other foods. Compared with conventional breeding techniques, genetic engineering is far more precise and, in most cases, less likely to create an unexpected outcome.
Jump up ^ "Statement by the AAAS Board of Directors On Labeling of Genetically Modified Foods" (PDF). American Association for the Advancement of Science. October 20, 2012. Retrieved February 8, 2016. The EU, for example, has invested more than €300 million in research on the biosafety of GMOs. Its recent report states: "The main conclusion to be drawn from the efforts of more than 130 research projects, covering a period of more than 25 years of research and involving more than 500 independent research groups, is that biotechnology, and in particular GMOs, are not per se more risky than e.g. conventional plant breeding technologies." The World Health Organization, the American Medical Association, the U.S. National Academy of Sciences, the British Royal Society, and every other respected organization that has examined the evidence has come to the same conclusion: consuming foods containing ingredients derived from GM crops is no riskier than consuming the same foods containing ingredients from crop plants modified by conventional plant improvement techniques.
Pinholster G (October 25, 2012). "AAAS Board of Directors: Legally Mandating GM Food Labels Could "Mislead and Falsely Alarm Consumers"". American Association for the Advancement of Science. Retrieved February 8, 2016.
Jump up ^ A decade of EU-funded GMO research (2001–2010) (PDF). Directorate-General for Research and Innovation. Biotechnologies, Agriculture, Food. European Commission, European Union. 2010. doi:10.2777/97784. ISBN 978-92-79-16344-9. Retrieved February 8, 2016.
Jump up ^ "AMA Report on Genetically Modified Crops and Foods (online summary)". American Medical Association. January 2001. Retrieved March 19, 2016. A report issued by the scientific council of the American Medical Association (AMA) says that no long-term health effects have been detected from the use of transgenic crops and genetically modified foods, and that these foods are substantially equivalent to their conventional counterparts. (from online summary prepared by ISAAA)" "Crops and foods produced using recombinant DNA techniques have been available for fewer than 10 years and no long-term effects have been detected to date. These foods are substantially equivalent to their conventional counterparts. (from original report by AMA: [1])
"REPORT 2 OF THE COUNCIL ON SCIENCE AND PUBLIC HEALTH (A-12): Labeling of Bioengineered Foods" (PDF). American Medical Association. 2012. Archived from the original on September 7, 2012. Retrieved March 19, 2016. Bioengineered foods have been consumed for close to 20 years, and during that time, no overt consequences on human health have been reported and/or substantiated in the peer-reviewed literature. CS1 maint: BOT: original-url status unknown (link)
Jump up ^ "Restrictions on Genetically Modified Organisms: United States. Public and Scholarly Opinion". Library of Congress. June 9, 2015. Retrieved February 8, 2016. Several scientific organizations in the US have issued studies or statements regarding the safety of GMOs indicating that there is no evidence that GMOs present unique safety risks compared to conventionally bred products. These include the National Research Council, the American Association for the Advancement of Science, and the American Medical Association. Groups in the US opposed to GMOs include some environmental organizations, organic farming organizations, and consumer organizations. A substantial number of legal academics have criticized the US's approach to regulating GMOs.
Jump up ^ "Genetically Engineered Crops: Experiences and Prospects". The National Academies of Sciences, Engineering, and Medicine (US). 2016. p. 149. Retrieved May 19, 2016. Overall finding on purported adverse effects on human health of foods derived from GE crops: On the basis of detailed examination of comparisons of currently commercialized GE with non-GE foods in compositional analysis, acute and chronic animal toxicity tests, long-term data on health of livestock fed GE foods, and human epidemiological data, the committee found no differences that implicate a higher risk to human health from GE foods than from their non-GE counterparts.
Jump up ^ "Frequently asked questions on genetically modified foods". World Health Organization. Retrieved February 8, 2016. Different GM organisms include different genes inserted in different ways. This means that individual GM foods and their safety should be assessed on a case-by-case basis and that it is not possible to make general statements on the safety of all GM foods.
GM foods currently available on the international market have passed safety assessments and are not likely to present risks for human health. In addition, no effects on human health have been shown as a result of the consumption of such foods by the general population in the countries where they have been approved. Continuous application of safety assessments based on the Codex Alimentarius principles and, where appropriate, adequate post market monitoring, should form the basis for ensuring the safety of GM foods.
Jump up ^ Haslberger AG (July 2003). "Codex guidelines for GM foods include the analysis of unintended effects". Nature Biotechnology. 21 (7): 739–41. doi:10.1038/nbt0703-739. PMID 12833088. These principles dictate a case-by-case premarket assessment that includes an evaluation of both direct and unintended effects.
Jump up ^ Some medical organizations, including the British Medical Association, advocate further caution based upon the precautionary principle:
"Genetically modified foods and health: a second interim statement" (PDF). British Medical Association. March 2004. Retrieved March 21, 2016. In our view, the potential for GM foods to cause harmful health effects is very small and many of the concerns expressed apply with equal vigour to conventionally derived foods. However, safety concerns cannot, as yet, be dismissed completely on the basis of information currently available.
When seeking to optimise the balance between benefits and risks, it is prudent to err on the side of caution and, above all, learn from accumulating knowledge and experience. Any new technology such as genetic modification must be examined for possible benefits and risks to human health and the environment. As with all novel foods, safety assessments in relation to GM foods must be made on a case-by-case basis.
Members of the GM jury project were briefed on various aspects of genetic modification by a diverse group of acknowledged experts in the relevant subjects. The GM jury reached the conclusion that the sale of GM foods currently available should be halted and the moratorium on commercial growth of GM crops should be continued. These conclusions were based on the precautionary principle and lack of evidence of any benefit. The Jury expressed concern over the impact of GM crops on farming, the environment, food safety and other potential health effects.
The Royal Society review (2002) concluded that the risks to human health associated with the use of specific viral DNA sequences in GM plants are negligible, and while calling for caution in the introduction of potential allergens into food crops, stressed the absence of evidence that commercially available GM foods cause clinical allergic manifestations. The BMA shares the view that that there is no robust evidence to prove that GM foods are unsafe but we endorse the call for further research and surveillance to provide convincing evidence of safety and benefit.
Jump up ^ Funk C, Rainie L (January 29, 2015). "Public and Scientists' Views on Science and Society". Pew Research Center. Retrieved February 24, 2016. The largest differences between the public and the AAAS scientists are found in beliefs about the safety of eating genetically modified (GM) foods. Nearly nine-in-ten (88%) scientists say it is generally safe to eat GM foods compared with 37% of the general public, a difference of 51 percentage points.
Jump up ^ Marris C (July 2001). "Public views on GMOs: deconstructing the myths. Stakeholders in the GMO debate often describe public opinion as irrational. But do they really understand the public?". EMBO Reports. 2 (7): 545–8. doi:10.1093/embo-reports/kve142. PMC 1083956  . PMID 11463731.
Jump up ^ Final Report of the PABE research project (December 2001). "Public Perceptions of Agricultural Biotechnologies in Europe". Commission of European Communities. Retrieved February 24, 2016.
Jump up ^ Scott SE, Inbar Y, Rozin P (May 2016). "Evidence for Absolute Moral Opposition to Genetically Modified Food in the United States" (PDF). Perspectives on Psychological Science. 11 (3): 315–24. doi:10.1177/1745691615621275. PMID 27217243.
Jump up ^ "Restrictions on Genetically Modified Organisms". Library of Congress. June 9, 2015. Retrieved February 24, 2016.
Jump up ^ Bashshur R (February 2013). "FDA and Regulation of GMOs". American Bar Association. Retrieved February 24, 2016.
Jump up ^ Sifferlin A (October 3, 2015). "Over Half of E.U. Countries Are Opting Out of GMOs". Time.
Jump up ^ Lynch D, Vogel D (April 5, 2001). "The Regulation of GMOs in Europe and the United States: A Case-Study of Contemporary European Regulatory Politics". Council on Foreign Relations. Retrieved February 24, 2016.
Jump up ^ Pollack A (April 13, 2010). "Study Says Overuse Threatens Gains From Modified Crops". New York Times.
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Jump up ^ Industrial biotechnology, A powerful, innovative technology to mitigate climate change
Jump up ^ Daniel A. Vallero, Environmental Biotechnology: A Biosystems Approach, Academic Press, Amsterdam, NV; ISBN 978-0-12-375089-1; 2010.
Jump up ^ Gaskell G, Bauer MW, Durant J, Allum NC (July 1999). "Worlds apart? The reception of genetically modified foods in Europe and the U.S". Science. 285 (5426): 384–7. doi:10.1126/science.285.5426.384. PMID 10411496.
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Jump up ^ Beckmann VC, Soregaroli J, Wesseler J (2011). "Coexistence of genetically modified (GM) and non-modified (non GM) crops: Are the two main property rights regimes equivalent with respect to the coexistence value?". In Carter C, Moschini G, Sheldon I. Genetically modified food and global welfare. Frontiers of Economics and Globalization Series. 10. Bingley, UK: Emerald Group Publishing. pp. 201–224.
Jump up ^ "Biotechnology Predoctoral Training Program". National Institute of General Medical Sciences. 18 December 2013. Retrieved 28 October 2014.
Further reading[edit]
Friedman Y (2008). Building Biotechnology: Starting, Managing, and Understanding Biotechnology Companies. Washington, DC: Logos Press. ISBN 978-0-9734676-3-5.
Oliver RW. The Coming Biotech Age. ISBN 0-07-135020-9.
Powell WW, White DR, Koput KW, Owen-Smith J (2005). "Network Dynamics and Field Evolution: The Growth of Interorganizational Collaboration in the Life Sciences". American Journal of Sociology. 110 (4): 1132–1205. CiteSeerX 10.1.1.319.1227  . doi:10.1086/421508. Viviana Zelizer Best Paper in Economic Sociology Award (2005–2006), American Sociological Association.
Rasmussen N (2014). Gene Jockeys: Life Science and the rise of Biotech Enterprise. Baltimore, MD: Johns Hopkins University Press.
Zaid A, Hughes HG, Porceddu E, Nicholas F (2001). Glossary of Biotechnology for Food and Agriculture — A Revised and Augmented Edition of the Glossary of Biotechnology and Genetic Engineering. Available in English, French, Spanish, Chinese, Arabic, Russian, Polish, Serbian, Vietnamese and Kazakh. Rome: FAO. ISBN 92-5-104683-2.
Caswell MF, Fuglie KO, Klotz CA (1998). "Agricultural Biotechnology: An Economic Perspective". Agricultural Economic Report. United States Department of Agriculture Economic Research Service.
External links[edit]
Wikibooks has a book on the topic of: Genes, Technology and Policy
At Wikiversity, you can learn more and teach others about Biotechnology at the Department of Biotechnology
Look up biotechnology in Wiktionary, the free dictionary.
Media related to Biotechnology at Wikimedia Commons
Foundation for Biotechnology Awareness and Education,
A report on Agricultural Biotechnology focusing on the impacts of "Green" Biotechnology with a special emphasis on economic aspects. fao.org.
US Economic Benefits of Biotechnology to Business and Society NOAA Economics, economics.noaa.gov
Database of the Safety and Benefits of Biotechnology – a database of peer-reviewed scientific papers and the safety and benefits of biotechnology.
What is Biotechnology? – A curated collection of resources about the people, places and technologies that have enabled biotechnology to transform the world we live in today
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values:
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values: ביאטעכנאלאגיע – Yiddish

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values:
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values:
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values: All languages (initial selection from common choices by you and others)

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