text:
Three Dog Night
From Wikipedia, the free encyclopedia
Jump to: navigation, search
This article includes a list of references, but its sources remain unclear because it has insufficient inline citations. Please help to improve this article by introducing more precise citations. (December 2012) (Learn how and when to remove this template message)
Three Dog Night
Three Dog Night, 1972
Background information
Also known as
Redwood (1967-1968)
Origin
Los Angeles, California, United States
Genres
Pop rock,[1] soft rock,[2] blue-eyed soul[3]
Years active
1967–76, 1981–present
Labels
Dunhill, MGM, MCA, Epic, Columbia
Associated acts
The Enemys, Cory Wells Blues Band, SS Fools
Members
Danny Hutton
Michael Allsup
Paul Kingery
Pat Bautz
David Morgan
Howard Laravea
Past members
Cory Wells
Chuck Negron
Jimmy Greenspoon
Floyd Sneed
Joe Schermie
Ron Morgan
Jack Ryland
Skip Konte
Mickey McMeel
James "Smitty" Smith
Dennis Belfield
Al Ciner
Jay Gruska
Ron Stockert
Mike Seifrit
Richard Grossman
Mike Keeley
Scott Manzo
Steve Ezzo
Gary Moon
T.J. Parker
Richard Campbell
Mike Cuneo
Three Dog Night is an American rock band. They formed in 1967 with a line-up consisting of vocalists Danny Hutton, Cory Wells, and Chuck Negron. This lineup was soon augmented by Jimmy Greenspoon (keyboards), Joe Schermie (bass), Michael Allsup (guitar), and Floyd Sneed (drums). The band registered 21 Billboard Top 40 hits (with three hitting number one) between 1969 and 1975. It helped introduce mainstream audiences to the work of many songwriters, including Paul Williams ("An Old Fashioned Love Song"), Hoyt Axton ("Joy to the World", "Never Been to Spain"), Laura Nyro ("Eli's Comin'"), Harry Nilsson ("One"), Randy Newman ("Mama Told Me Not to Come"), and Leo Sayer ("The Show Must Go On").[4]
Contents
[hide]
1 Band name origin
2 Background
2.1 Early years
2.2 Success
2.3 Songs
3 History
3.1 1967–1972
3.2 1973–1976
3.3 1981–1990s
3.4 2000–present
3.4.1 Current activity
4 Personnel
4.1 Members
4.2 Timeline
4.3 Lead vocal credits
4.4 Lineups
5 Discography
6 Awards and recognition
7 Notes
8 References
9 External links
Band name origin[edit]
The official commentary included in the CD set Celebrate: The Three Dog Night Story, 1964–1975 states that vocalist Danny Hutton's girlfriend, actress June Fairchild (best known as the "Ajax Lady" from the Cheech and Chong movie Up In Smoke) suggested the name after reading a magazine article about indigenous Australians, in which it was explained that on cold nights they would customarily sleep in a hole in the ground while embracing a dingo, a native species of feral dog. On colder nights they would sleep with two dogs and, if the night were freezing, it was a "three dog night".[5]
Background[edit]
Early years[edit]
Negron, Wells and Hutton in 1969
The three vocalists, Danny Hutton (who got his start with Hanna-Barbera Records in 1964), Chuck Negron and Cory Wells (who landed a recording contract with Dunhill Records) first came together in 1967 and made some recordings with Brian Wilson while the Beach Boys were working on the album Wild Honey, and initially went by the name of Redwood. Shortly after abandoning the Redwood moniker in 1968, the vocalists hired a group of backing musicians – Ron Morgan on guitar, Floyd Sneed on drums, Joe Schermie from the Cory Wells Blues Band on bass, and Jimmy Greenspoon on keyboards – and soon took the name Three Dog Night, becoming one of the most successful bands in the United States during the late 1960s and early 1970s. Ron Morgan left the band early on and subsequently went on to join the Electric Prunes. Michael Allsup was quickly recruited to replace him on guitar.[6]
Success[edit]
Three Dog Night earned 12 gold albums and recorded 21 consecutive Billboard Top 40 hits, seven of which went gold. Their first gold record was "One" (US #5), which had been written and recorded by Harry Nilsson. The group had three US #1 songs, each of which featured a different lead singer: "Mama Told Me Not to Come" (Cory Wells on lead), which was also their only Top 10 hit in the UK; "Joy to the World" (Chuck Negron on lead); and "Black and White" (Danny Hutton on lead). Dunhill Records claimed that 40 million record albums were sold by the band during this time.
Songs[edit]
As its members wrote just a handful of songs on the albums, most songs Three Dog Night recorded were written by outside songwriters. Notable hits by outside writers include Harry Nilsson's "One" (US #5), the Gerome Ragni-James Rado-Galt MacDermot composition "Easy to Be Hard" (US #4) from the musical Hair, Laura Nyro's "Eli's Comin'" (US #10), Randy Newman's "Mama Told Me Not to Come" (US #1), Paul Williams' "Out in the Country" (US #15), "The Family Of Man" (US #12), and "An Old Fashioned Love Song" (US #4), Hoyt Axton's "Joy to the World" (US #1) and "Never Been to Spain" (US #5), Arkin & Robinson's "Black and White" (US #1), Argent's Russ Ballard's "Liar" (US #7), Elton John and Bernie Taupin's "Lady Samantha" and "Your Song", Daniel Moore's "Shambala" (#3), Leo Sayer's "The Show Must Go On" (US #4), John Hiatt's "Sure As I'm Sittin' Here" (US #16), and Bush's "I Can Hear You Calling".
History[edit]
1967–1972[edit]
Three Dog Night made its official debut in 1968 at the Whiskey a Go Go, at a 5 p.m. press party hosted by Dunhill Records. They were still in the process of making their first album Three Dog Night when they heard the favorable reactions from the hypercritical audience.[7]
The album Three Dog Night was a success with its hit songs "One" and "Nobody" and helped the band gain recognition and become one of the top drawing concert acts of their time.[7]
1973–1976[edit]
In 1973, Three Dog Night filed a $6 million lawsuit against their former booking agent, American Talent International (ATI) for continuing to advertise in the media that the band was still with their agency when in fact they signed with William Morris Agency in October 1972. Other damages were sought due to ATI taking deposits for booking Three Dog Night, whom they no longer represented.[8]
Joe Schermie was replaced by Jack Ryland in 1973, and the band then became an eight-piece with the inclusion of another keyboard player, Skip Konte (ex-Blues Image). In late 1974, Allsup and Sneed left to form a new band, SS Fools, with Schermie. New members James "Smitty" Smith and drummer Mickey McMeel were recruited, but by 1975, Smith was replaced by Al Ciner from Rufus and The American Breed and Ryland by Rufus bassist Dennis Belfield. By 1976, their run of hit records had ended and Hutton was succeeded by Jay Gruska.
Hours before their first concert of their 1975 tour, Chuck Negron was arrested for the possession of narcotics but was soon released on $10,000 bond.[9]
From JayGruska.com:
Over the years I've been asked if it's true that I toured with Three Dog Night, I thought this was a good place to set the record straight since Wikipedia has as much opinion as it does fact. After writing a couple of songs for them, and doing some background vocals on one of their albums, I was asked to do a national tour of 10 to 12 thousand seat venues as the '3rd Dog', as it were. They had been at it for the last 6 or 7 years as one of the biggest bands in the world, doing stadium tours, and now they were going to do smaller venues, a mere 10,000 people. Having played mostly clubs until then, these were giant venues for me and I was both thrilled and petrified. I had an incredibly great time singing with Cory Wells and Chuck Negron—both amazing singers. I had a chance to play piano on a couple of songs in the set and most amazingly, that band could do a 90 minute set of ALL HITS.
However, this lineup was short-lived. Another former Rufus band member, Ron Stockert, was recruited as second keyboardist after Konte left that same year. After a summer concert tour was cut short, the group played their final show at the Greek Theater in Los Angeles on July 26, 1976.[10]
1981–1990s[edit]
In 1981, Three Dog Night reunited and released the ska-inspired It's a Jungle in 1983 on the small Passport Records label, which garnered some airplay on the new wave circuit. The EP failed to sell after Passport went bankrupt. The reunion featured all of the original members, except Joe Schermie, who was succeeded by Mike Seifrit until 1982, and then by Richard Grossman, who stayed until 1984. Two guitarists, Paul Kingery and Steve Ezzo, occasionally played with the band, filling in for Allsup on dates he was not able to make between 1982 and 1984. Ezzo replaced Allsup when he departed in late 1984 to take care of some personal and family matters. Sneed was let go from the band at the same time. In early 1985, keyboardist Rick Serratte (formerly of Poco and later with Whitesnake and others) filled in for Greenspoon, who was ill, and the band hit the road with a revised lineup that included Serratte, Steve Ezzo, bassist Scott Manzo and drummer Mike Keeley.[11] But a spring and summer tour that same year was postponed after Negron and Greenspoon were both forced to enter drug rehab. By late 1985, Greenspoon and Negron were back touring with the group.
By December 1985, after a relapse into his drug habit, Negron was let go, and the group continued with Wells and Hutton fronting the band and Paul Kingery was brought back on guitar to cover Chuck's vocal harmonies. In 1986, their song "In My Heart" was featured in Robotech: The Movie.
More changes in personnel occurred when guitarist T.J. Parker and vocalist and bassist Gary Moon replaced Kingery and Manzo in 1988, and were replaced themselves by Mike Cuneo and Richard Campbell during 1989.
Allsup returned to the group to replace Cuneo in the spring of 1991. Negron entered drug rehab, but did not return to the band.
Pat Bautz succeeded Keeley as drummer in 1993.
In 1993, Three Dog Night performed for The Family Channel show Spotlight on Country, filmed in Myrtle Beach, South Carolina. Kingery returned to the band as their bass player in 1996 following Campbell's departure.
2000–present[edit]
In May 2002, Three Dog Night With The London Symphony Orchestra was released. The album was recorded in Los Angeles and in London at Abbey Road Studios. The album includes two new songs: "Overground" and "Sault Ste. Marie".
Original bassist Joe Schermie died on March 26, 2002.
In the summer of 2004, the band's 80s bassist, Scott Manzo, returned briefly to fill in for Paul Kingery.
In October 2004, Three Dog Night released The 35th Anniversary Hits Collection Featuring The London Symphony Orchestra. The album includes live versions of "Eli's Coming", "Brickyard Blues", "Try a Little Tenderness", and "Family of Man".
In 2007, Sky Television launched a new ad campaign in the UK, which promoted the company's aspirations to be seen as an environmentally friendly company, and used the band's song "Joy To The World".
In August 2008. Three Dog Night Greatest Hits Live was released, a compilation of previously unissued live 1972 and 1973 recordings from concerts in Frankfurt, Germany, and Edmonton, England.[12]
On October 24, 2009, Three Dog Night released three new songs – "Heart of Blues" and "Prayer of the Children", as well as "Two Lights In The Nighttime".
A new studio album, the group's first in 24 years, is being recorded during breaks from touring using producer Richie Podolor. Although an EP of five new songs was recorded and released in 1983, and two new songs were issued on Three Dog Night's 35th Anniversary Hits Collection Featuring The London Symphony Orchestra, Three Dog Night has not recorded a full-length album since 1976's American Pastime.
Current activity[edit]
In the late summer of 2012, guitarist Allsup was hospitalized for an intestinal disorder, forcing Kingery to temporarily move back to guitar, while Danny's son, Timothy Hutton, currently a Los Angeles music studio owner, manned the bass slot. This happened again during the summer of 2015 when Allsup was again forced to miss some shows.
On March 11, 2015, Jimmy Greenspoon died from cancer, aged 67. His place at the keyboards was taken by Eddie Reasoner. who had come in to sub for Jimmy when he'd first taken ill in mid-2014.[13]
On October 21, 2015 Cory Wells died at his home in Dunkirk, New York. He was 74. Wells' cause of death was sepsis while battling multiple myeloma. Funeral services were private, and he is buried in Dunkirk. When he was not performing on tour, he was often seen fishing at Lake Erie.
In November 2015 it was announced that singer David Morgan (a former member of The Association) would be joining Three Dog Night on the road.
In April 2017 Howard Laravea (formerly of Frankie Valli and The Four Seasons) replaced Eddie Reasoner on keyboards.
Personnel[edit]
Members[edit]
Current members
Danny Hutton - vocals (1967–1976, 1981–present)
Michael Allsup - guitar (1968–1974, 1981–1984, 1991-present)
Paul Kingery - bass, guitar, vocals (1985–1988, 1996–present; substitute - 1982-1983)
Pat Bautz - drums (1993–present)
David Morgan - vocals (2015–present)
Howard Laravea - keyboards (2017-present)
Former members
Cory Wells - vocals (1967–1976, 1981–2015; his death)
Chuck Negron - vocals (1967–1976, 1981–1985)
Jimmy Greenspoon - keyboards (1968–1976, 1981–2015; his death)
Floyd Sneed - drums (1968–1974, 1981–1984)
Joe Schermie - bass (1968–1973; died 2002)
Jack Ryland - bass (1973–1975)
Skip Konte - keyboards (1973–1976)
Mickey McMeel - drums (1974–1976)
James "Smitty" Smith - guitar (1974–1975)
Dennis Belfield - bass (1975–1976)
Al Ciner - guitar (1975–1976)
Jay Gruska - vocals (1976)
Ron Stockert - keyboards (1976)
Mike Seifrit - bass (1981–1982)
Richard Grossman - bass (1982–1984)
Mike Keeley - drums (1985–1993)
Scott Manzo - bass (1985–1988, 2004)
Steve Ezzo - guitar (fill-in for Allsup 1983-1984, 1985)
Gary Moon - bass, vocals (1988–1989)
T.J. Parker - guitar (1988–1989)
Richard Campbell - bass, vocals (1989–1996)
Eddie Reasoner - keyboards (2015–2017; substitute - 2014-2015)
Mike Cuneo - guitar (1989–1991)
Timeline[edit]
Lead vocal credits[edit]
"An Old Fashioned Love Song" - Negron
"Black and White" - Hutton
"Celebrate" - Hutton (Verse 1), Negron (Verse 2), Wells (Verse 3), who sings melody through the end refrain
"Easy to Be Hard" - Negron
"Eli's Coming" - Wells
"Joy to the World" - Negron
"Let Me Serenade You" - Wells
"Liar" - Hutton
"Mama Told Me (Not to Come)" - Wells
"Never Been to Spain" - Wells
"One" - Negron
"One Man Band" - Hutton sings melody with Negron on harmony on verses, then Negron takes the lead through the end refrain
"Out in the Country" - Group vocal in unison
"Pieces of April" - Negron
"Play Something Sweet (Brickyard Blues)" - Wells
"Shambala" - Wells
"Sure As I'm Sittin' Here" - Wells
"The Family of Man" - Hutton (Verse 1), Negron (Verse 2), Wells (Verse 3)
"The Show Must Go On" - Negron
"Til the World Ends" - Negron
"Try a Little Tenderness" - Wells
"Your Song" - Hutton
Lineups[edit]
1967-1968
(Redwood)
1968-1973
(Three Dog Night)
1973
1973-1974
Danny Hutton - vocals
Chuck Negron - vocals
Cory Wells - vocals
Henry Vestine - guitar
Goldy McJohn - keyboards
Larry Taylor - bass
Frank Cook - drums
Danny Hutton - vocals
Chuck Negron - vocals
Cory Wells - vocals
Michael Allsup - guitar
Jimmy Greenspoon - keyboards
Joe Schermie - bass
Floyd Sneed - drums
Danny Hutton - vocals
Chuck Negron - vocals
Cory Wells - vocals
Michael Allsup - guitar
Jimmy Greenspoon - keyboards
Floyd Sneed - drums
Jack Ryland - bass
Danny Hutton - vocals
Chuck Negron - vocals
Cory Wells - vocals
Michael Allsup - guitar
Jimmy Greenspoon - keyboards
Floyd Sneed - drums
Jack Ryland - bass
Skip Konte - keyboards
1974-1975
1975-1976
1976
1976
Danny Hutton - vocals
Chuck Negron - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Jack Ryland - bass
Skip Konte - keyboards
Mickey McMeel - drums
James "Smitty" Smith - guitar
Danny Hutton - vocals
Chuck Negron - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Skip Konte - keyboards
Mickey McMeel - drums
Dennis Belfield - bass
Al Ciner - guitar
Chuck Negron - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Skip Konte - keyboards
Mickey McMeel - drums
Dennis Belfield - bass
Al Ciner - guitar
Jay Gruska - vocals
Chuck Negron - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Mickey McMeel - drums
Dennis Belfield - bass
Al Ciner - guitar
Jay Gruska - vocals
Ron Stockert - keyboards
1976-1981
1981-1982
1982-1984
1985
Disbanded
Danny Hutton - vocals
Chuck Negron - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Michael Allsup - guitar
Mike Seifrit - bass
Floyd Sneed - drums
Danny Hutton - vocals
Chuck Negron - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Michael Allsup - guitar
Floyd Sneed - drums
Richard Grossman - bass
Paul Kingery - guitar, vocals (fill in for Allsup 1982-1983)
Steve Ezzo - guitar (fill in for Allsup 1983-1984)
Danny Hutton - vocals
Chuck Negron - vocals
Cory Wells - vocals
Rick Serratte - keyboards
Mike Keeley - drums
Steve Ezzo - guitar
Scott Manzo - bass
1985
1985-1988
1988-1989
1989-1991
Danny Hutton - vocals
Chuck Negron - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Mike Keeley - drums
Steve Ezzo - guitar
Scott Manzo - bass
Danny Hutton - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Mike Keeley - drums
Paul Kingery - guitar, vocals
Scott Manzo - bass
Danny Hutton - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Mike Keeley - drums
Gary Moon - bass, vocals
T.J. Parker - guitar
Danny Hutton - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Mike Keeley - drums
Richard Campbell - bass
Mike Cuneo - guitar
1991-1993
1993-1996
1996–2015
2015
Danny Hutton - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Mike Keeley - drums
Richard Campbell - bass
Michael Allsup - guitar
Danny Hutton - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Richard Campbell - bass
Michael Allsup - guitar
Pat Bautz - drums
Danny Hutton - vocals
Cory Wells - vocals
Jimmy Greenspoon - keyboards
Michael Allsup - guitar
Pat Bautz - drums
Paul Kingery - bass, vocals
Danny Hutton - vocals
Cory Wells - vocals
Michael Allsup - guitar
Pat Bautz - drums
Paul Kingery - bass, vocals
Eddie Reasoner - keyboards
2015–present
Danny Hutton - vocals
David Morgan - vocals
Michael Allsup - guitar
Pat Bautz - drums
Paul Kingery - bass, vocals
Eddie Reasoner - keyboards
Discography[edit]
Main article: Three Dog Night discography
Three Dog Night (1968)
Suitable for Framing (1969)
It Ain't Easy (1970)
Naturally (1970)
Harmony (1971)
Seven Separate Fools (1972)
Cyan (1973)
Hard Labor (1974)
Coming Down Your Way (1975)
American Pastime (1976)
It's a Jungle (1983)
Awards and recognition[edit]
Three Dog Night was inducted into The Vocal Group Hall of Fame in 2000.
Notes[edit]
Jump up ^ George-Warren, Holly; Romanowski, Patricia, eds. (2001). The Rolling Stone Encyclopedia of Rock & Roll (3rd ed.). Fireside. p. 990. ISBN 0-7432-9201-4.
Jump up ^ Hoffmann, Frank, ed. (2005). "Soft Rock And Related Styles". Encyclopedia of Recorded Sound. 2. Routledge. pp. 1011–12. ISBN 0-415-93835-X.
Jump up ^ Negron, Chuck (2008). Three Dog Nightmare: The Continuing Chuck Negron Story. Literary Architects. p. 68. ISBN 978-1-9336-6913-7.
Jump up ^ Beckerman, Jim. "A ROUGH YEAR FOR BAND, BUT THE SHOW MUST GO ON." The Record, Jan 26 2016
Jump up ^ Chawkins, Steve (2015-02-18). "June Fairchild dies at 68; former actress lived on skid row". Los Angeles Times. Retrieved 2015-03-15.
Jump up ^ Jimmy Greenspoon; Mark Bego (1991). One Is the Loneliest Number: On the Road and Behind the Scenes With the Legendary Rock Band Three Dog Night. Amazon.co.uk. ISBN 9780886876470. Retrieved 2015-03-11.
^ Jump up to: a b Orloff, Kathy. "Three Dog Night—A Howling Success Story". Los Angeles Times (1923–Current file), May 23 1971, pp. 1-q16.
Jump up ^ "Billboard - Google Books". Books.google.co.uk. 1973-02-03. Retrieved 2015-08-26.
Jump up ^ Wirephoto, A. P. "Arrested just before Concert Tour." Chicago Tribune (1963-Current file), Jul 04 1975, p. 5.
Jump up ^ Jimmy Greenspoon; Mark Bego (1991). One Is the Loneliest Number: On the Road and Behind the Scenes With the Legendary Rock Band Three Dog Night. Amazon.co.uk. ISBN 9780886876470. Retrieved 2015-03-11.
Jump up ^ Jimmy Greenspoon; Mark Bego (1991). One Is the Loneliest Number: On the Road and Behind the Scenes With the Legendary Rock Band Three Dog Night. Amazon.co.uk. ISBN 9780886876470. Retrieved 2015-03-11.
Jump up ^ "Three Dog Night – Chart history". Billboard.com. Retrieved March 12, 2015.
Jump up ^ Vanmetre, Elizabeth (March 11, 2015). "Jimmy Greenspoon of Three Dog Night has died from cancer at age 67". Daily News. Retrieved March 12, 2015.
References[edit]
Three Dog Nightmare. Chuck Negron. Renaissance Books 1st edition (June 1999) ISBN 1-58063-040-5
One Is the Loneliest Number: On the Road and Behind the Scenes With the Legendary Rock Band Three Dog Night. Greenspoon, Jimmy and Bago, Mark. Pharos Books (January 1991). ISBN 0-88687-647-8
Lawrence, Guy (2006). Yogi Bear's Nuggets: A Hanna-Barbera 45 Guide. Spectropop.com
Bubblegum University https://web.archive.org/web/20090224002810/http://www.bubblegum-music.com/categories/artists
External links[edit]
Book: Three Dog Night
Wikimedia Commons has media related to Three Dog Night.
Three Dog Night official website
Three Dog Night on IMDb
Three Dog Night at Allmusic
'Three Dog Night Vocal Group Hall of Fame
[show]
v
t
e
Three Dog Night
Danny Hutton
Michael Allsup
Paul Kingery
Pat Bautz
Eddie Reasoner
David Morgan
Cory Wells
Chuck Negron
Jimmy Greenspoon
Floyd Sneed
Joe Schermie
Skip Konte
Al Ciner
Gary Moon
Richard Campbell
Studio albums
Three Dog Night (1968)
Suitable for Framing (1969)
It Ain't Easy (1970)
Naturally (1970)
Harmony (1971)
Seven Separate Fools (1972)
Cyan (1973)
Hard Labor (1974)
Coming Down Your Way (1975)
American Pastime (1976)
It's a Jungle (1983)
Live albums
Captured Live at the Forum (1969)
Around the World with Three Dog Night (1973)
Compilations
Golden Bisquits (1971)
Joy to the World: Their Greatest Hits (1975)
The Best of 3 Dog Night (1982)
Celebrate: The Three Dog Night Story, 1965–1975 (1993)
20th Century Masters – The Millennium Collection: The Best of Three Dog Night (1999)
Singles
"Nobody"
"Try a Little Tenderness"
"One"
"Easy to Be Hard"
"Eli's Coming"
"Celebrate"
"Mama Told Me (Not to Come)"
"Out in the Country"
"One Man Band"
"Joy to the World"
"Liar"
"An Old Fashioned Love Song"
"Never Been to Spain"
"The Family of Man"
"Black & White"
"Pieces of April"
"Shambala"
"Let Me Serenade You"
"The Show Must Go On"
"Sure As I'm Sittin' Here"
"Play Something Sweet (Brickyard Blues)"
"Til the World Ends"
"Everybody Is a Masterpiece"
"It's a Jungle Out There"
Discography
Book
[show]
v
t
e
Billboard Year-End number one singles (1960–1979)
1960: "Theme from A Summer Place" – Percy Faith
1961: "Tossin' and Turnin'" – Bobby Lewis
1962: "Stranger on the Shore" – Mr. Acker Bilk
1963: "Sugar Shack" – Jimmy Gilmer and the Fireballs
1964: "I Want to Hold Your Hand" – The Beatles
1965: "Wooly Bully" – Sam the Sham & the Pharaohs
1966: "Ballad of the Green Berets" – S/Sgt. Barry Sadler
1967: "To Sir, with Love" – Lulu
1968: "Hey Jude" – The Beatles
1969: "Sugar, Sugar" – The Archies
1970: "Bridge over Troubled Water" – Simon & Garfunkel
1971: "Joy to the World" – Three Dog Night
1972: "The First Time Ever I Saw Your Face" – Roberta Flack
1973: "Tie a Yellow Ribbon Round the Ole Oak Tree" – Tony Orlando and Dawn
1974: "The Way We Were" – Barbra Streisand
1975: "Love Will Keep Us Together" – Captain & Tennille
1976: "Silly Love Songs" – Wings
1977: "Tonight's the Night (Gonna Be Alright)" – Rod Stewart
1978: "Shadow Dancing" – Andy Gibb
1979: "My Sharona" – The Knack
Complete list
(1946–1959)
(1960–1979)
(1980–1999)
(2000–2019)
Authority control
WorldCat Identities
VIAF: 154915089
LCCN: nr89008937
ISNI: 0000 0001 2298 6681
GND: 4380946-7
BNF: cb13907027v (data)
MusicBrainz: 1a48176d-1414-4a18-9792-50ba585d4d59
NKC: xx0025411
Retrieved from "https://en.wikipedia.org/w/index.php?title=Three_Dog_Night&oldid=833722720"
Categories:
American pop rock music groups
American soft rock music groups
Columbia Records artists
Dunhill Records artists
Epic Records artists
MCA Records artists
MGM Records artists
Musical groups established in 1967
Musical groups disestablished in 1976
Musical groups reestablished in 1981
Musical groups from Los Angeles
Hidden categories:
Articles lacking in-text citations from December 2012
All articles lacking in-text citations
Articles with hCards
Wikipedia articles with VIAF identifiers
Wikipedia articles with LCCN identifiers
Wikipedia articles with ISNI identifiers
Wikipedia articles with GND identifiers
Wikipedia articles with BNF identifiers
Wikipedia articles with MusicBrainz identifiers
Navigation menu
Personal tools
Not logged in
Talk
Contributions
Create account
Log in
Namespaces
Article
Talk
Variants
Views
Read
Edit
View history
More
Search
Navigation
Main page
Contents
Featured content
Current events
Random article
Donate to Wikipedia
Wikipedia store
Interaction
Help
About Wikipedia
Community portal
Recent changes
Contact page
Tools
What links here
Related changes
Upload file
Special pages
Permanent link
Page information
Wikidata item
Cite this page
Print/export
Create a book
Download as PDF
Printable version
In other projects
Wikimedia Commons
Languages
Čeština
Deutsch
Español
Français
한국어
Italiano
Nederlands
日本語
Norsk
Português
Русский
Simple English
Suomi
Svenska
Türkçe
Українська
7 more
Edit links
This page was last edited on 2 April 2018, at 02:47.
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.
Privacy policy
About Wikipedia
Disclaimers
Contact Wikipedia
Developers
Cookie statement
Mobile view
Enable previews

values: mw-page-base noprint

values: mw-head-base noprint

values: firstHeading firstHeading en

values: siteSub noprint

values: jump-to-nav mw-jump

values: Wikipedia:WikiProject Fact and Reference Check

value: span

value: small

values: plainlinks metadata ambox ambox-style ambox-More_footnotes

values:
/wiki/Cory_Wells_Blues_Band
mw-redirect
Cory Wells Blues Band

values:
/wiki/Cheech_and_Chong
mw-redirect
Cheech and Chong

values:
/wiki/Up_In_Smoke
mw-redirect
Up In Smoke

values:
/wiki/Electric_Prunes
mw-redirect
Electric Prunes

values:
/wiki/One_(Three_Dog_Night_song)
mw-redirect
One (Three Dog Night song)

values: Television networks preceding ABC Family

values:
/wiki/Frankfurt,_Germany
mw-redirect
Frankfurt, Germany

values: border-collapse: collapse; padding: 0; border: 0; background:transparent; width:100%;

values:
/wiki/Mama_Told_Me_Not_To_Come
mw-redirect
Mama Told Me Not To Come

values: The Family of Man (Three Dog Night song)

values: Til the World Ends (Three Dog Night song)

attrs: class border cellpadding cellspacing style

values: float:width:375px; margin:0 0 1em 1em; border-collapse:collapse; border:1px solid #e2e2e2; width:99%;

values:
/wiki/Fireside_Books
mw-redirect
Fireside Books

values:
/wiki/Daily_News_(New_York)
mw-redirect
Daily News (New York)

values:
nofollow
external text
http://www.spectropop.com/HBR/index.htm

values:
nofollow
http://www.threedognight.com/
external text

values:
nofollow
https://www.imdb.com/name/nm2061571/
external text

values:
nofollow
external text
https://www.allmusic.com/artist/p5648

values:
Three_Dog_Night
fn org
font-size:114%;margin:0 4em

values:
navbox-abovebelow
2
background: #EEEEEE;

values:
row
navbox-group
width:1%;background: #EEEEEE;

values: nowraplinks vcard hlist collapsible autocollapse navbox-inner

values: Template:Billboard Year-End number one singles 1960–1979

values: Template talk:Billboard Year-End number one singles 1960–1979

values:
/wiki/To_Sir_With_Love_(song)
mw-redirect
To Sir With Love (song)

values: Tie a Yellow Ribbon Round the Ole Oak Tree

values:
/wiki/Wings_(band)
mw-redirect
Wings (band)

values: Template:Billboard Year-End number one singles 1946–1959

values: Template:Billboard Year-End number one singles 1980–1999

values: Template:Billboard Year-End number one singles 2000–2019

values: nowraplinks collapsible autocollapse navbox-inner

values:
nofollow
external text
https://viaf.org/viaf/154915089

values:
nofollow
external text
http://isni.org/isni/0000000122986681

values:
nofollow
external text
https://d-nb.info/gnd/4380946-7

values: Category:American soft rock music groups

values: Category:Musical groups established in 1967

values: Category:Musical groups disestablished in 1976

values: Category:Musical groups reestablished in 1981

values: Category:Musical groups from Los Angeles

values: Category:Articles lacking in-text citations from December 2012

values: Category:All articles lacking in-text citations

values: Category:Wikipedia articles with VIAF identifiers

values: Category:Wikipedia articles with LCCN identifiers

values: Category:Wikipedia articles with ISNI identifiers

values: Category:Wikipedia articles with GND identifiers

values: Category:Wikipedia articles with BNF identifiers

values: Category:Wikipedia articles with MusicBrainz identifiers

values: Discussion about edits from this IP address [ctrl-alt-n]

values: A list of edits made from this IP address [ctrl-alt-y]

values: You are encouraged to create an account and log in; however, it is not mandatory

values: You're encouraged to log in; however, it's not mandatory. [ctrl-alt-o]

values:
/wiki/Three_Dog_Night
View the content page [ctrl-alt-c]
c

values: Discussion about the content page [ctrl-alt-t]

values: p-namespaces navigation vectorTabs p-namespaces-label

values: p-views navigation vectorTabs p-views-label

values:
p-cactions
navigation
vectorMenu emptyPortlet
p-cactions-label

values:
mw-wiki-logo
/wiki/Main_Page
Visit the main page

values:
/wiki/Main_Page
Visit the main page [ctrl-alt-z]
z

values: Featured content – the best of Wikipedia

values: Find background information on current events

values:
/wiki/Special:Random
Load a random article [ctrl-alt-x]
x

values: portal navigation p-navigation p-navigation-label

values: Guidance on how to use and edit Wikipedia

values:
interlanguage-link interwiki-cs
display: none;

values: 스리 도그 나이트 – Korean

values:
interlanguage-link interwiki-nl
display: none;

values: スリー・ドッグ・ナイト – Japanese

values:
interlanguage-link interwiki-no
display: none;

values:
interlanguage-link interwiki-simple
display: none;

values:
interlanguage-link interwiki-fi
display: none;

values:
interlanguage-link interwiki-sv
display: none;

values:
interlanguage-link interwiki-uk
display: none;

values: All languages (initial selection from common choices by you and others)

values: /static/images/wikimedia-button-1.5x.png 1.5x, /static/images/wikimedia-button-2x.png 2x

values: /static/images/poweredby_mediawiki_132x47.png 1.5x, /static/images/poweredby_mediawiki_176x62.png 2x

values:
suggestions
display: none; font-size: 13px;

values: mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject page-Three_Dog_Night rootpage-Three_Dog_Night skin-vector action-view


text:
U Sure Do
From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
"U Sure Do"
Single by Strike
from the album I Saw the Future
B-side
"Remix"
Released
1994
Format
7" single
12" single
CD single
Cassette single
Genre
Dance
house
Length
3:53
Label
Fresh Records
Songwriter(s)
Andy Gardner, Matt Cantor
Strike singles chronology
"U Sure Do"
(1994) "The Morning After (Free At Last)"
(1995)
"U Sure Do"
(1994) "The Morning After (Free At Last)"
(1995)
Music video
"U Sure Do" on YouTube
"U Sure Do" is a song by British electronic dance music band Strike.
Contents
1 Release
2 Critical reception
3 Track listing
3.1 12": Fresh Records / FRSHT19 (UK)
3.2 12": Fresh Records / FRSHTX19 (UK)
3.3 CD, Maxi-Single: Fresh Records / FRSHD19 (UK)
3.4 Cassette: Fresh Records / FRSHC19 (UK)
4 Charts
4.1 Weekly charts
4.2 Year-end charts
5 References
Release[edit]
Released in December 1994, it was Strike's second single and reached number 31 in the UK charts. The song was a big UK club hit and after receiving regular play in clubs throughout 1994/1995 it was re-released and re-entered the chart in April 1995 reaching number 4. It also peaked at number 1 on the UK Dance Singles. The track samples Donna Allen's "Serious" for the vocal, and Cubic 22's "Night in Motion" for the main synth. In 1999 it was remixed and released as "U Sure Do '99". This version peaked at number 53 in the UK. In 2006 it was remixed a third time and released to a handful of DJs solely for club use.
In 2011 MTV Dance ranked "U Sure Do" at #45 in their list of The 100 Biggest 90's Dance Anthems Of All Time.[1]
Critical reception[edit]
Music & Media wrote about the song: "The keyboard intro could've been Todd Rundgren's Can We Still Be Friends at double speed. But then the enthusiastic ladies start singing their ready-to-use-on-air pop dance one liner."[2]
Track listing[edit]
12": Fresh Records / FRSHT19 (UK)[edit]
"U Sure Do" (Guest List Mix)
"U Sure Do" (Formula 2 Mix)
12": Fresh Records / FRSHTX19 (UK)[edit]
"U Sure Do" (Strike's Raise The Roof Remix)
"U Sure Do" (Goodfella's Remix)
"U Sure Do" (Mr Roys Jinx Remix)
CD, Maxi-Single: Fresh Records / FRSHD19 (UK)[edit]
"U Sure Do" (Strike 7" Mix)
"U Sure Do" (Guest List Mix)
"U Sure Do" (Formula 2 Mix)
Cassette: Fresh Records / FRSHC19 (UK)[edit]
"U Sure Do" (Strike 7" Mix)
"U Sure Do" (Formula 2 Mix)
Charts[edit]
Weekly charts[edit]
Chart (1994-95)
Peak
position
Australia (ARIA)[3]
9
Europe (Eurochart Hot 100)[4]
10
Iceland (Íslenski Listinn Topp 40)[5]
22
Ireland (IRMA)[6]
20
Italy (FIMI)
19
Netherlands (Dutch Top 40)
13
Netherlands (Single Top 100)[7]
15
Scotland (Official Charts Company)[8]
7
UK Singles (Official Charts Company)[9]
4
UK Dance (Official Charts Company)[10]
1
Chart (1999)
Peak
position
Scotland (Official Charts Company)[11]
71
UK Singles (Official Charts Company)[12]
53
UK Dance (Official Charts Company)[13]
40
Year-end charts[edit]
Chart (1995)
Position
Australia (ARIA)[14] 70
References[edit]
Jump up ^ MTV Dance - Tuesday 27.12.2011
Jump up ^ "New Releases: Singles" (PDF). Music & Media. 1994-12-10. Retrieved 2018-04-10.
Jump up ^ "Australian Singles". australian-charts.com. Retrieved 2017-03-24.
Jump up ^ "Music & Media: Eurochart Hot 100" (PDF). Music & Media. Retrieved 2018-01-16.
Jump up ^ "Íslenski Listinn Topp 40 (27.05.1995 - 02.06.1995)" (PDF). Dagblaðið Vísir - Tónlist. Retrieved 2018-02-01.
Jump up ^ "Irish Singles". irishcharts.ie. Retrieved 2017-03-24.
Jump up ^ "Netherlands Singles". dutchcharts.nl. Retrieved 2017-03-24.
Jump up ^ "Scottish Singles Chart 02 April 1995 - 08 April 1995". Official Charts Company. Retrieved 2018-01-16.
Jump up ^ "UK Singles". Official Charts Company. Retrieved 2017-03-24.
Jump up ^ "UK Dance Singles". Official Charts Company. Retrieved 2017-03-24.
Jump up ^ "Official Scottish Singles Sales Chart Top 100". officialcharts.com. Retrieved 2018-07-05.
Jump up ^ "UK Singles". Official Charts Company. Retrieved 2017-03-24.
Jump up ^ "Official Dance Singles Chart Top 40". officialcharts.com.
Jump up ^ "The ARIA Australian Top 100 Singles 1995". Imgur.com (original document published by ARIA). Retrieved 2017-04-11.
Retrieved from "https://en.wikipedia.org/w/index.php?title=U_Sure_Do&oldid=848889454"
Categories:
1995 singles
1995 songs
Strike (band) songs
Debut singles
Electro songs
Hidden categories:
Articles with hAudio microformats
Navigation menu
Personal tools
Not logged in
Talk
Contributions
Create account
Log in
Namespaces
Article
Talk
Variants
Views
Read
Edit
View history
More
Search
Navigation
Main page
Contents
Featured content
Current events
Random article
Donate to Wikipedia
Wikipedia store
Interaction
Help
About Wikipedia
Community portal
Recent changes
Contact page
Tools
What links here
Related changes
Upload file
Special pages
Permanent link
Page information
Wikidata item
Cite this page
Print/export
Create a book
Download as PDF
Printable version
Languages
Add links
This page was last edited on 5 July 2018, at 01:58 (UTC).
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.
Privacy policy
About Wikipedia
Disclaimers
Contact Wikipedia
Developers
Cookie statement
Mobile view
Enable previews

key: html

type: local

value: div

attrs: id class

values: mw-page-base noprint

values: mw-head-base noprint

value: a

attrs: id class lang

values: firstHeading firstHeading en

values: siteSub noprint

attrs: class href

values: mw-jump-link #mw-head

values: mw-jump-link #p-search

value: th

attrs: colspan class style

value: tr

value: img

attrs: alt src width height srcset data-file-width data-file-height

attrs: href class

value: td

attrs: colspan style

attrs: href title

attrs: href class title

values:
/wiki/I_Saw_the_Future
mw-redirect
I Saw the Future

value: i

values:
/wiki/12%22_single
mw-redirect
12" single

values: width: 33%; text-align: center; vertical-align: top; padding: .2em .1em .2em 0;

values: width: 33%; text-align: center; vertical-align: top; padding:.2em .1em;

values: width: 33%; text-align: center; vertical-align: top; padding: .2em 0 .2em .1em;

values: background: transparent; width: 100%; min-width: 100%; border-collapse: collapse;

values: width:33%; padding:.2em .1em .2em 0; text-align: center;

values: width:33%; padding:.2em .1em; text-align: center;

values: width:33%; padding:.2em 0 .2em .1em; text-align: center;

values: checkbox button toctogglecheckbox toctogglecheckbox display:none

values:
/wiki/Serious_(Donna_Allen_song)
mw-redirect
Serious (Donna Allen song)

values: Edit section: 12": Fresh Records / FRSHT19 (UK)

values: Edit section: 12": Fresh Records / FRSHTX19 (UK)

values: Edit section: CD, Maxi-Single: Fresh Records / FRSHD19 (UK)

values: Edit section: Cassette: Fresh Records / FRSHC19 (UK)

values:
col
headerSort
0
columnheader button
Sort ascending

values:
/wiki/Eurochart_Hot_100
mw-redirect
Eurochart Hot 100

values:
/wiki/Italian_Singles_Chart
mw-redirect
Italian Singles Chart

values:
/wiki/UK_Dance_Singles_Chart
mw-redirect
UK Dance Singles Chart

values: wikitable sortable plainrowheaders jquery-tablesorter

values: width: 50%;text-align: left; vertical-align: top;

values: border-collapse: collapse; padding: 0; border: 0; background:transparent; width:100%;

values:
nofollow
external text
http://www.irishcharts.ie

values:
nofollow
external text
http://i.imgur.com/aBqgAcE.jpg

values: Australian Recording Industry Association

values: Category:Articles with hAudio microformats

values: Discussion about edits from this IP address [ctrl-alt-n]

values: A list of edits made from this IP address [ctrl-alt-y]

values: You are encouraged to create an account and log in; however, it is not mandatory

values: You're encouraged to log in; however, it's not mandatory. [ctrl-alt-o]

values:
/wiki/U_Sure_Do
View the content page [ctrl-alt-c]
c

values: Discussion about the content page [ctrl-alt-t]

values: p-namespaces navigation vectorTabs p-namespaces-label

values:
p-variants
navigation
vectorMenu emptyPortlet
p-variants-label

values: Past revisions of this page [ctrl-alt-h]

values: p-views navigation vectorTabs p-views-label

values:
p-cactions
navigation
vectorMenu emptyPortlet
p-cactions-label

values:
mw-wiki-logo
/wiki/Main_Page
Visit the main page

values:
/wiki/Main_Page
Visit the main page [ctrl-alt-z]
z

values: Featured content – the best of Wikipedia

values: About the project, what you can do, where to find things

values: A list of recent changes in the wiki [ctrl-alt-r]

values: portal navigation p-interaction p-interaction-label

values: List of all English Wikipedia pages containing links to this page [ctrl-alt-j]

values: Recent changes in pages linked from this page [ctrl-alt-k]

values:
/wiki/Wikipedia:File_Upload_Wizard
Upload files [ctrl-alt-u]
u

values: A list of all special pages [ctrl-alt-q]

values: Permanent link to this revision of the page

values: Link to connected data repository item [ctrl-alt-g]

values: Printable version of this page [ctrl-alt-p]

values: mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject page-U_Sure_Do rootpage-U_Sure_Do skin-vector action-view


text:
Protein kinase A
From Wikipedia, the free encyclopedia
Jump to: navigation, search
This article is about the enzyme. For the dissociation constant pKa, see acid dissociation constant. For other uses, see PKA.
"cAMP-dependent protein kinase" redirects here. It is not to be confused with AMP-activated protein kinase or cyclin-dependent kinases.
cAMP-dependent protein kinase (Protein kinase A)
Identifiers
EC number
2.7.11.11
CAS number
142008-29-5
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
[show]Search
PMC
articles
PubMed
articles
NCBI
proteins
In cell biology, protein kinase A (PKA[N 1]) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
Contents
[hide]
1 Background
2 Structure
3 Mechanism
3.1 Activation
3.2 Catalysis
3.3 Phosphorylation mechanism
3.4 Inactivation
3.5 Anchorage
4 Function
4.1 Overview table
4.2 In adipocytes and hepatocytes
4.3 In nucleus accumbens neurons
4.4 In skeletal muscle
4.5 In memory formation
5 See also
6 References
7 External links
8 Notes
Background[edit]
Protein kinase A, more precisely known as adenosine 3',5'-monophosphate (cyclic AMP)-dependent protein kinase was discovered by chemists H. Fischer and Edwin G. Krebs in 1968. They won the Nobel Prize in Physiology or Medicine in 1992 for their work on phosphorylation and dephosphorylation and how it relates to protein kinase A activity.[1]
PKA is one of the most widely researched protein kinases, in part because of its uniqueness; out of 540 different protein kinase genes that make up for human kinome, only one other protein kinase, Casein kinase 2, is known to exist in a physiological tetrameric complex.[2]
The diversity of mammalian PKA subunits was realized after Dr. Stan Knight and others identified possible four subunit C genes and presence of four R subunit genes. In 1991, Susan Taylor et al. crystallised the PKA Cα subunit, which revealed the bi-lobe structure of the protein kinase core for the very first time, providing a blueprint for all the other protein kinases in a genome ('the kinome').[3]
Structure[edit]
The PKA holoenzyme exists as a tetramer, although higher order structures form in cells, where PKA is targeted to specific components. The classical PKA holoenzyme structure consists of two regulatory subunits and two catalytic subunits. The catalytic subunit contains the active site, a series of canonical residues found in protein kinases that bind and hydrolyse ATP and a domain to bind the regulatory subunit. The regulatory subunit has domains to bind to cyclic AMP, a domain that interacts with catalytic subunit and an auto inhibitory domain. There are two major forms of regulatory subunit; RI and RII.[4]
The following human genes encode PKA subunits:
catalytic subunit – PRKACA, PRKACB, PRKACG
regulatory subunit type I - PRKAR1A, PRKAR1B
regulatory subunit type II - PRKAR2A, PRKAR2B
Mechanism[edit]
Overview: Activation and inactivation mechanisms of PKA
Activation[edit]
PKA is also commonly known as cAMP-dependent protein kinase, because it has traditionally been thought to be activated through release of the catalytic subunits when levels of the second messenger cAMP rise in response to a variety of signals. However, recent studies evaluating the intact holoenzyme complexes, including regulatory AKAP-bound signalling complexes, have suggested that the local sub cellular activation of the catalytic activity of PKA might proceed without physical separation of the regulatory and catalytic components, especially at physiological concentrations of cAMP.[5][6] In contrast, experimentally induced supra physiological concentrations of cAMP are able to cause separation of the holoenzymes, and release of the catalytic subunits.[5]
Extracellular hormones such as glucagon and epinephrine begin an intracellular signalling cascade that triggers protein kinase A activation by first binding to a G protein–coupled receptor (GPCR) on the target cell. When a GPCR is activated by its extracellular ligand, a conformational change is induced in the receptor that is transmitted to an attached intracellular heterotrimeric G protein complex by protein domain dynamics. The Gs alpha subunit of the stimulated G protein complex exchanges GDP for GTP and is released from the complex. The activated Gs alpha subunit binds to and activates an enzyme called adenylyl cyclase, which, in turn, catalyzes the conversion of ATP into cyclic adenosine monophosphate (cAMP), directly increasing the cAMP level. Four cAMP molecules are able to bind to the two R-subunits. This is done by two cAMP molecules binding to each of the two cAMP binding sites (CNB-B and CNB-A) which induces a conformational change in the regulatory subunits of PKA causing the subunits to detach and unleash the two (now activated) catalytic subunits.[7]
Once released from their inhibitory Regulatory subunit, the catalytic subunits can go on to phosphorylate a huge number of other proteins in the minimal substrate context Arg-Arg-X-Ser/Thr.,[8] although they are still subject to other layers of regulation, including modulation by the heat stable pseudosubstrate inhibitor of PKA, termed PKI.[6][9]
Below is a list of the steps involved in PKA activation:
Cytosolic cAMP increases
Two cAMP molecules bind to each PKA regulatory subunit
The regulatory subunits move out of the active sites of the catalytic subunits and the R2C2 complex dissociates
The free catalytic subunits interact with proteins to phosphorylate Ser or Thr residues.
Catalysis[edit]
The liberated catalytic subunits can then catalyze the transfer of ATP terminal phosphates to protein substrates at serine, or threonine residues. This phosphorylation usually results in a change in activity of the substrate. Since PKAs are present in a variety of cells and act on different substrates, PKA regulation and cAMP regulation are involved in many different pathways.
The mechanisms of further effects may be divided into direct protein phosphorylation and protein synthesis:
In direct protein phosphorylation, PKA directly either increases or decreases the activity of a protein.
In protein synthesis, PKA first directly activates CREB, which binds the cAMP response element, altering the transcription and therefore the synthesis of the protein. In general, this mechanism takes more time (hours to days).
Phosphorylation mechanism[edit]
The Serine/Threonine residue of the substrate peptide is orientated in such a way that the hydroxyl group faces towards the gamma phosphate group of the bound ATP molecule. Both the substrate, ATP, and two Mg2+ ions form intensive contacts with the catalytic subunit of PKA. In the active conformation, the C helix packs against the N-terminal lobe and the Aspartate residue of the conserved DFG motif chelates the Mg2+ ions, assisting in positioning the ATP substrate. The triphosphate group of ATP points out of the adenosine pocket for transfer of gamma-phosphate to the Serine/Threonine of the peptide substrate. There are several conserved residues, include Glutamate (E) 91 and Lysine (K) 72, that mediate the positioning of alpha- and beta-phosphate groups. The hydroxyl group the peptide substrate's Serine/Threonine attacks the gamma phosphate group at the phosphorus via an SN2 nucleophilic reaction, which results in the transfer of the terminal phosphate to the peptide substrate and cleavage of the phosphodiester bond between the beta-phosphate and the gamma-phosphate groups. PKA acts as a model for understanding protein kinase biology, with the position of the conserved residues helping to distinguish the active protein kinase and inactive pseudokinase members of the human kinome.
Inactivation[edit]
cAMP
Downregulation of protein kinase A occurs by a feedback mechanism and uses a number of cAMP hydrolyzing phosphodiesterase (PDE) enzymes, which belong to the substrates activated by PKA. Phosphodiesterase quickly converts cAMP to AMP, thus reducing the amount of cAMP that can activate protein kinase A. PKA is also regulated by a complex series of phosphorylation events, which can include modification by autophosphorylation and phosphorylation by regulatory kinases, such as PDK1.[6]
Thus, PKA is controlled, in part, by the levels cAMP. Also, the catalytic subunit itself can be down-regulated by phosphorylation.
Anchorage[edit]
The regulatory subunit dimer of PKA is important for localizing the kinase inside the cell. The dimerization and docking (D/D) domain of the dimer binds to the A-kinase binding (AKB) domain of A-kinase anchor protein (AKAP). The AKAPs localize PKA to various locations (e.g., plasma membrane, mitochondria, etc.) within the cell.
AKAPs bind many other signaling proteins, creating a very efficient signaling hub at a certain location within the cell. For example, an AKAP located near the nucleus of a heart muscle cell would bind both PKA and phosphodiesterase (hydrolyzes cAMP), which allows the cell to limit the productivity of PKA, since the catalytic subunit is activated once cAMP binds to the regulatory subunits.
Function[edit]
PKA phosphorylates proteins that have the motif Arginine-Arginine-X-Serine exposed, in turn (de)activating the proteins. As protein expression varies from cell type to cell type, the proteins that are available for phosphorylation will depend upon the cell in which PKA is present. Thus, the effects of PKA activation vary with cell type:
Overview table[edit]
Cell type
Organ/system
Stimulators
ligands → Gs-GPCRs
or PDE inhibitors
Inhibitors
ligands → Gi-GPCRs
or PDE stimulators
Effects
adipocyte
epinephrine → β-adrenergic receptor
glucagon → Glucagon receptor
enhance lipolysis
stimulate lipase[10]
myocyte (skeletal muscle) muscular system
epinephrine → β-adrenergic receptor
produce glucose
stimulate glycogenolysis
phosphorylate glycogen phosphorylase via phosphorylase kinase (activating it)[10]
phosphorylate Acetyl-CoA carboxylase (inhibiting it)
inhibit glycogenesis
phosphorylate glycogen synthase (inhibiting it)[10]
stimulate glycolysis
phosphorylate phosphofructokinase 2 (stimulating it, cardiomyocytes only)
myocyte (cardiac muscle) cardiovascular
norepinephrine → β-adrenergic receptor
sequester Ca2+ in sarcoplasmic reticulum
phosphorylates phospholamban[11]
myocyte (smooth muscle) cardiovascular
β2 adrenergic agonists → β-2 adrenergic receptor
histamine → Histamine H2 receptor
prostacyclin → prostacyclin receptor
Prostaglandin D2 → PGD2 receptor
Prostaglandin E2 → PGE2 receptor
VIP → VIP receptor
L-Arginine → imidazoline and α2 receptor? (Gi-coupled)
muscarinic agonists, e.g. acetylcholine → muscarinic receptor M2
NPY → NPY receptor
Contributes to vasodilation (phosphorylates, and thereby inactivates, Myosin light-chain kinase)
hepatocyte liver
epinephrine → β-adrenergic receptor
glucagon → Glucagon receptor
produce glucose
stimulate glycogenolysis
phosphorylate glycogen phosphorylase (activating it)[10]
phosphorylate Acetyl-CoA carboxylase (inhibiting it)
inhibit glycogenesis
phosphorylate glycogen synthase (inhibiting it)[10]
stimulate gluconeogenesis
phosphorylate fructose 2,6-bisphosphatase (stimulating it)
inhibit glycolysis
phosphorylate phosphofructokinase-2 (inactivating it)
phosphorylate fructose 2,6-bisphosphatase (stimulate it)
phosphorylate pyruvate kinase (inhibiting it)
neurons in nucleus accumbens nervous system dopamine → dopamine receptor Activate reward system
principal cells in kidney kidney
Vasopressin → V2 receptor
theophylline (PDE inhibitor)
exocytosis of aquaporin 2 to apical membrane.[12]
synthesis of aquaporin 2[12]
phosphorylation of aquaporin 2 (stimulating it)[12]
Thick ascending limb cell kidney Vasopressin → V2 receptor stimulate Na-K-2Cl symporter (perhaps only minor effect)[12]
Cortical collecting tubule cell kidney Vasopressin → V2 receptor stimulate Epithelial sodium channel (perhaps only minor effect)[12]
Inner medullary collecting duct cell kidney Vasopressin → V2 receptor
stimulate urea transporter 1
urea transporter 1 exocytosis[13]
proximal convoluted tubule cell kidney PTH → PTH receptor 1 Inhibit NHE3 → ↓H+ secretion[14]
juxtaglomerular cell kidney
adrenergic agonists → β-receptor[15]
agonists → α2 receptor[15]
dopamine → dopamine receptor[15]
glucagon → glucagon receptor[15]
renin secretion
In adipocytes and hepatocytes[edit]
Adrenaline and glucagon affect the activity of protein kinase A by changing the levels of cAMP in a cell via the G-protein mechanism, using adenylate cyclase. Protein kinase A acts to phosphorylate many enzymes important in metabolism. For example, protein kinase A phosphorylates acetyl-CoA carboxylase and pyruvate dehydrogenase. Such covalent modification has an inhibitory effect on these enzymes, thus inhibiting lipogenesis and promoting net gluconeogenesis. Insulin, on the other hand, decreases the level of phosphorylation of these enzymes, which instead promotes lipogenesis. Recall that gluconeogenesis does not occur in myocytes.
In nucleus accumbens neurons[edit]
PKA helps transfer/translate the dopamine signal into cells in the nucleus accumbens, which mediates reward, motivation, and task salience. The vast majority of reward perception involves neuronal activation in the nucleus accumbens, some examples of which include sex, recreational drugs, and food. Protein Kinase A signal transduction pathway helps in modulation of ethanol consumption and its sedative effects. A mouse study reports that mice with genetically reduced cAMP-PKA signalling results into less consumption of ethanol and are more sensitive to its sedative effects.[16]
In skeletal muscle[edit]
Protein Kinase A is directed to specific sub cellular locations after tethering to Protein kinase A anchoring proteins (AKAPs). Sarcoplasmic Reticulum Ca2+ release channel or Ryanodine receptor (Ryr) co-localizes with the muscle AKAP. RyR phosphorylation and efflux of Ca 2+ is increased by localisation of PKA at RyR by mAKP.[17]
In memory formation[edit]
PKA has always been considered important in formation of a memory. Reductions in expression activity of DCO (PKA catalytic subunit encoding gene) can cause severe learning disabilities, middle term memory and short term memory. Long term memory is dependent on the CREB transcription factor, regulated by PKA. A study done on drosophila reported that an increase in PKA activity can effect short term memory. However, a decrease in PKA activity by 24% inhibited learning abilities and a decrease by 16% affected both learning ability and memory retention. Formation of a normal memory is highly sensitive to PKA levels.[18]
See also[edit]
Protein kinase
Signal transduction
G protein-coupled receptor
Serine/threonine-specific protein kinase
Myosin light-chain kinase
cAMP-dependent pathway
References[edit]
Jump up ^ Knighton, D. R.; Zheng, J. H.; Ten Eyck, L. F.; Xuong, N. H.; Taylor, S. S.; Sowadski, J. M. (1991-07-26). "Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science. 253 (5018): 414–420. doi:10.1126/science.1862343. ISSN 0036-8075. PMID 1862343.
Jump up ^ Turnham, Rigney E.; Scott, John D. (2016-02-15). "Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology". Gene. 577 (2): 101–108. doi:10.1016/j.gene.2015.11.052. PMC 4713328  . PMID 26687711.
Jump up ^ Manning, G.; Whyte, D. B.; Martinez, R.; Hunter, T.; Sudarsanam, S. (2002-12-06). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–1934. doi:10.1126/science.1075762. ISSN 1095-9203. PMID 12471243.
Jump up ^ Bauman AL, Scott JD (August 2002). "Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo". Nature Cell Biology. 4 (8): E203–6. doi:10.1038/ncb0802-e203. PMID 12149635.
^ Jump up to: a b Smith, FD; Esseltine, JL; Nygren, PJ; Veesler, D; Byrne, DP; Vonderach, M; Strashnov, I; Eyers, CE; Eyers, PA; Langeberg, LK; Scott, JD (2017). "Local protein kinase A action proceeds through intact holoenzymes". Science. 356: 1288–1293.
^ Jump up to: a b c Byrne, DP; Vonderach, M; Ferries, S; Brownridge, PJ; Eyers, CE; Eyers, PA (2016). "cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry". Biochemical Journal. 473: 3159–3175. doi:10.1042/bcj20160648. PMC 5095912  .
Jump up ^ Lodish; et al. (2016). "15.5". Molecular Cell Biology (8th ed.). W.H. Freeman and Company. p. 701. ISBN 978-1-4641-8339-3. CS1 maint: Explicit use of et al. (link)
Jump up ^ Voet, Voet & Pratt (2006). Fundamentals of Biochemistry. Wiley. Pg 492
Jump up ^ Scott, JD; Glaccum, MB; Fischer, EH; Krebs, EG (1986). "Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase". PNAS. 83: 1613–1616. doi:10.1073/pnas.83.6.1613. PMC 323133  .
^ Jump up to: a b c d e Rang HP (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 172
Jump up ^ Rodriguez P, Kranias EG (December 2005). "Phospholamban: a key determinant of cardiac function and dysfunction". Archives des Maladies du Coeur et des Vaisseaux. 98 (12): 1239–43. PMID 16435604.
^ Jump up to: a b c d e Boron WF, Boulpaep EL (2005). Medical Physiology: A Cellular And Molecular Approach (Updated ed.). Philadelphia, Pa.: Elsevier Saunders. p. 842. ISBN 978-1-4160-2328-9.
Jump up ^ Boron WF, Boulpaep EL (2005). Medical Physiology: A Cellular And Molecular Approaoch (Updated ed.). Philadelphia, Pa.: Elsevier Saunders. p. 844. ISBN 978-1-4160-2328-9.
Jump up ^ Boron WF, Boulpaep EL (2005). Medical Physiology: A Cellular And Molecular Approach (Updated ed.). Philadelphia, Pa.: Elsevier Saunders. p. 852. ISBN 978-1-4160-2328-9.
^ Jump up to: a b c d Boron WF, Boulpaep EL (2005). Medical Physiology: A Cellular And Molecular Approach (Updated ed.). Philadelphia, Pa.: Elsevier Saunders. p. 867. ISBN 978-1-4160-2328-9.
Jump up ^ Wand, Gary; Levine, Michael; Zweifel, Larry; Schwindinger, William; Abel, Ted (2001-07-15). "The cAMP–Protein Kinase A Signal Transduction Pathway Modulates Ethanol Consumption and Sedative Effects of Ethanol". Journal of Neuroscience. 21 (14): 5297–5303. ISSN 0270-6474. PMID 11438605.
Jump up ^ Ruehr, Mary L.; Russell, Mary A.; Ferguson, Donald G.; Bhat, Manju; Ma, Jianjie; Damron, Derek S.; Scott, John D.; Bond, Meredith (2003-07-04). "Targeting of Protein Kinase A by Muscle A Kinase-anchoring Protein (mAKAP) Regulates Phosphorylation and Function of the Skeletal Muscle Ryanodine Receptor". Journal of Biological Chemistry. 278 (27): 24831–24836. doi:10.1074/jbc.M213279200. ISSN 0021-9258. PMID 12709444.
Jump up ^ Horiuchi, Junjiro; Yamazaki, Daisuke; Naganos, Shintaro; Aigaki, Toshiro; Saitoe, Minoru (2008-12-30). "Protein kinase A inhibits a consolidated form of memory in Drosophila". Proceedings of the National Academy of Sciences. 105 (52): 20976–20981. doi:10.1073/pnas.0810119105. ISSN 0027-8424. PMC 2634933  . PMID 19075226.
External links[edit]
Cyclic AMP-Dependent Protein Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
Drosophila cAMP-dependent protein kinase 1 - The Interactive Fly
cAMP-dependent protein kinase: PDB Molecule of the Month
Notes[edit]
Jump up ^ Not to be confused with pKa, the symbol for the acid dissociation constant.
[show]
v
t
e
Intracellular signaling peptides and proteins
MAP
see MAP kinase pathway
Calcium
Intracellular calcium-sensing proteins
Calcineurin
Ca2+/calmodulin-dependent protein kinase
G protein
Heterotrimeric
cAMP:
Heterotrimeric G protein
Gs/Gi
Adenylate cyclase
cAMP
3',5'-cyclic-AMP phosphodiesterase
Protein kinase A
cGMP:
Transducin
Gustducin
Guanylate cyclase
cGMP
3',5'-cyclic-GMP phosphodiesterase
Protein kinase G
G alpha subunit Gα
GNAO1
GNAI1
GNAI2
GNAI3
GNAT1
GNAT2
GNAT3
GNAZ
GNAS
GNAL
GNAQ
GNA11
GNA12
GNA13
GNA14
GNA15/GNA16
G beta-gamma complex Gβ
GNB1
GNB2
GNB3
GNB4
GNB5
Gγ
GNGT1
GNGT2
GNG2
GNG3
GNG4
GNG5
GNG7
GNG8
GNG10
GNG11
GNG12
GNG13
BSCL2
G protein-coupled receptor kinase
AMP-activated protein kinase
Monomeric
ARFs
Rabs
Ras
HRAS
KRAS
NRAS
Rhos
Arfs
Ran
Rhebs
Raps
RGKs
Cyclin
Cyclin-dependent kinase inhibitor protein
Cyclin-dependent kinase
Cyclin
Lipid
Phosphoinositide phospholipase C
Phospholipase C
Other protein kinase
Serine/threonine:
Casein kinase
1
2
eIF-2 kinase
EIF2AK3
Glycogen synthase kinase
GSK1
GSK2
GSK-3
GSK3A
GSK3B
IκB kinase
CHUK
IKK2
IKBKG
Interleukin-1 receptor associated kinase
IRAK1
IRAK2
IRAK3
IRAK4
Lim kinase
LIMK1
LIMK2
p21-activated kinases
PAK1
PAK2
PAK3
PAK4
Rho-associated protein kinase
ROCK1
ROCK2
Ribosomal s6 kinase
RPS6KA1
Tyrosine:
ZAP70
Focal adhesion protein-tyrosine kinase
PTK2
PTK2B
BTK
both
Dual-specificity kinase
Other protein phosphatase
Serine/threonine:
Protein phosphatase 2
Tyrosine:
protein tyrosine phosphatase: Receptor-like protein tyrosine phosphatase
Sh2 domain-containing protein tyrosine phosphatase
both:
Dual-specificity phosphatase
Apoptosis
see apoptosis signaling pathway
GTP-binding protein regulators
see GTP-binding protein regulators
Other
Activating transcription factor 6
Signal transducing adaptor protein
I-kappa B protein
Mucin-4
Olfactory marker protein
Phosphatidylethanolamine binding protein
EDARADD
PRKCSH
see also deficiencies of intracellular signaling peptides and proteins
[show]
v
t
e
Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)
[show]
Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
LATS1
LATS2
MAST1
MAST2
STK38
STK38L
CIT
ROCK1
SGK
SGK2
SGK3
Protein kinase B
AKT1
AKT2
AKT3
Ataxia telangiectasia mutated
mTOR
EIF-2 kinases
PKR
HRI
EIF2AK3
EIF2AK4
Wee1
WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
PDK1
PDK2
PDK3
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
AMP-activated protein kinase α
PRKAA1
PRKAA2
β
PRKAB1
PRKAB2
γ
PRKAG1
PRKAG2
PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
BCKDK
BCKDHA
BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
IDH2
IDH3A
IDH3B
IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)
Aurora kinase
Aurora A kinase
Aurora B kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)
FASTK
STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
-
IκB kinase (EC 2.7.11.10)
CHUK
IKK2
TBK1
IKBKE
IKBKG
IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)
Protein kinase A
PRKACG
PRKACB
PRKACA
PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase G
PRKG1
Protein kinase C (EC 2.7.11.13)
Protein kinase C
Protein kinase Cζ
PKC alpha
PRKCB1
PRKCD
PRKCE
PRKCH
PRKCG
PRKCI
PRKCQ
Protein kinase N1
PKN2
PKN3
Rhodopsin kinase (EC 2.7.11.14)
Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)
Beta adrenergic receptor kinase
Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)
GRK4
GRK5
GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)
BRSK2
CAMK1
CAMK2A
CAMK2B
CAMK2D
CAMK2G
CAMK4
MLCK
CASK
CHEK1
CHEK2
DAPK1
DAPK2
DAPK3
STK11
MAPKAPK2
MAPKAPK3
MAPKAPK5
MARK1
MARK2
MARK3
MARK4
MELK
MKNK1
MKNK2
NUAK1
NUAK2
OBSCN
PASK
PHKG1
PHKG2
PIM1
PIM2
PKD1
PRKD2
PRKD3
PSKH1
SNF1LK2
KIAA0999
STK40
SNF1LK
SNRK
SPEG
TSSK2
Kalirin
TRIB1
TRIB2
TRIB3
TRIO
Titin
DCLK1
Myosin light-chain kinase (EC 2.7.11.18)
MYLK
MYLK2
MYLK3
MYLK4
Phosphorylase kinase (EC 2.7.11.19)
PHKA1
PHKA2
PHKB
PHKG1
PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)
EEF2K
STK19
Polo kinase (EC 2.7.11.21)
PLK1
PLK2
PLK3
PLK4
[show]
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
PLK1
PLK2
PLK3
PLK4
Cyclin-dependent kinase (EC 2.7.11.22)
CDK1
CDK2
CDKL2
CDK3
CDK4
CDK5
CDKL5
CDK6
CDK7
CDK8
CDK9
CDK10
CDK12
CDC2L5
PCTK1
PCTK2
PCTK3
PFTK1
CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
RPS6KA5
RPS6KA4
P70S6 kinase
P70-S6 Kinase 1
RPS6KB2
RPS6KA2
RPS6KA3
RPS6KA1
RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)
Extracellular signal-regulated
MAPK1
MAPK3
MAPK4
MAPK6
MAPK7
MAPK12
MAPK15
C-Jun N-terminal
MAPK8
MAPK9
MAPK10
P38 mitogen-activated protein
MAPK11
MAPK13
MAPK14
MAP3K (EC 2.7.11.25)
MAP kinase kinase kinases
MAP3K1
MAP3K2
MAP3K3
MAP3K4
MAP3K5
MAP3K6
MAP3K7
MAP3K8
RAFs
ARAF
BRAF
KSR1
KSR2
MLKs
MAP3K12
MAP3K13
MAP3K9
MAP3K10
MAP3K11
MAP3K7
ZAK
CDC7
MAP3K14
Tau-protein kinase (EC 2.7.11.26)
TPK1
TTK
GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
-
Tropomyosin kinase (EC 2.7.11.28)
-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
-
Receptor protein serine/threonine kinase (EC 2.7.11.30)
Bone morphogenetic protein receptors
BMPR1
BMPR1A
BMPR1B
BMPR2
ACVR1
ACVR1B
ACVR1C
ACVR2A
ACVR2B
ACVRL1
Anti-Müllerian hormone receptor
[show]
Dual-specificity kinases (EC 2.7.12)
MAP2K
MAP2K1
MAP2K2
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP2K7
[show]
v
t
e
Enzymes
Activity
Active site
Binding site
Catalytic triad
Oxyanion hole
Enzyme promiscuity
Catalytically perfect enzyme
Coenzyme
Cofactor
Enzyme catalysis
Regulation
Allosteric regulation
Cooperativity
Enzyme inhibitor
Enzyme activator
Classification
EC number
Enzyme superfamily
Enzyme family
List of enzymes
Kinetics
Enzyme kinetics
Eadie–Hofstee diagram
Hanes–Woolf plot
Lineweaver–Burk plot
Michaelis–Menten kinetics
Types
EC1 Oxidoreductases (list)
EC2 Transferases (list)
EC3 Hydrolases (list)
EC4 Lyases (list)
EC5 Isomerases (list)
EC6 Ligases (list)
Molecular and Cellular Biology portal
Retrieved from "https://en.wikipedia.org/w/index.php?title=Protein_kinase_A&oldid=842412940"
Categories:
Signal transduction
Protein kinases
EC 2.7.11
Hidden categories:
CS1 maint: Explicit use of et al.
Navigation menu
Personal tools
Not logged in
Talk
Contributions
Create account
Log in
Namespaces
Article
Talk
Variants
Views
Read
Edit
View history
More
Search
Navigation
Main page
Contents
Featured content
Current events
Random article
Donate to Wikipedia
Wikipedia store
Interaction
Help
About Wikipedia
Community portal
Recent changes
Contact page
Tools
What links here
Related changes
Upload file
Special pages
Permanent link
Page information
Wikidata item
Cite this page
Print/export
Create a book
Download as PDF
Printable version
Languages
العربية
Català
Čeština
Deutsch
Eesti
Español
فارسی
Français
Galego
Italiano
עברית
Русский
Српски / srpski
Srpskohrvatski / српскохрватски
Suomi
Tiếng Việt
中文
8 more
Edit links
This page was last edited on 22 May 2018, at 08:33.
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.
Privacy policy
About Wikipedia
Disclaimers
Contact Wikipedia
Developers
Cookie statement
Mobile view
Enable previews

values: mw-page-base noprint

values: mw-head-base noprint

values: firstHeading firstHeading en

values: siteSub noprint

values: jump-to-nav mw-jump

value: sub

values:
/wiki/PKA_(disambiguation)
mw-redirect mw-disambig
PKA (disambiguation)

attrs: role class

values:
note
hatnote navigation-not-searchable

values:
/wiki/Cyclin-dependent_kinases
mw-redirect
Cyclin-dependent kinases

attrs: scope style

values:
row
background-color: #e7dcc3

values:
/wiki/CAS_registry_number
mw-redirect
CAS registry number

values:
nofollow
external text
http://www.expasy.org/enzyme/2.7.11.11

values:
/wiki/PRIAM_enzyme_specific_profiles
mw-redirect
PRIAM enzyme specific profiles

values: background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;

values: background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;

values: National Center for Biotechnology Information

values: width:22em;float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%

values:
nofollow
external text
https://enzyme.expasy.org/EC/2.7.11.11

values:
/wiki/Protein_kinases
mw-redirect
Protein kinases

attrs: alt src width height class srcset data-file-width data-file-height

values:
/wiki/Substrate_(biochemistry)
mw-redirect
Substrate (biochemistry)

values:
/wiki/CAMP_response_element
mw-redirect
CAMP response element

values:
/wiki/Transcription_(genetics)
mw-redirect
Transcription (genetics)

values:
/wiki/A-kinase_anchoring_protein
mw-redirect
A-kinase anchoring protein

values:
headerSort
0
columnheader button
Sort ascending

values:
/wiki/G_protein-coupled_receptor
mw-redirect
G protein-coupled receptor

values:
/wiki/Beta-adrenergic_receptor
mw-redirect
Beta-adrenergic receptor

values:
/wiki/Smooth_muscle
mw-redirect
Smooth muscle

values:
/wiki/NPY_receptor
mw-redirect
NPY receptor

values:
/wiki/Fructose_2,6-bisphosphatase
mw-redirect
Fructose 2,6-bisphosphatase

values:
/wiki/Principal_cell
mw-redirect
Principal cell

values:
/wiki/Arginine_vasopressin_receptor_2
mw-redirect
Arginine vasopressin receptor 2

values:
/wiki/Apical_membrane
mw-redirect
Apical membrane

values:
/wiki/Thick_ascending_limb_cell
mw-redirect
Thick ascending limb cell

values:
/wiki/Na-K-2Cl_symporter
mw-redirect
Na-K-2Cl symporter

values:
/wiki/Cortical_collecting_tubule_cell
mw-redirect
Cortical collecting tubule cell

values:
/wiki/Urea_transporter_1
mw-redirect
Urea transporter 1

values:
/wiki/Proximal_convoluted_tubule_cell
mw-redirect
Proximal convoluted tubule cell

values:
/wiki/PTH_receptor_1
mw-redirect
PTH receptor 1

values:
/wiki/Adrenergic_agonists
mw-redirect
Adrenergic agonists

values: Edit section: In adipocytes and hepatocytes

values:
/wiki/Adenylate_cyclase
mw-redirect
Adenylate cyclase

values: Edit section: In nucleus accumbens neurons

values:
nofollow
external text
//doi.org/10.1126%2Fscience.1862343

values:
nofollow
external text
//www.worldcat.org/issn/0036-8075

values:
/wiki/PubMed_Identifier
mw-redirect
PubMed Identifier

values:
nofollow
external text
//www.ncbi.nlm.nih.gov/pubmed/1862343

values:
nofollow
external text
//doi.org/10.1016%2Fj.gene.2015.11.052

attrs: alt src title width height srcset data-file-width data-file-height

values:
nofollow
external text
//www.ncbi.nlm.nih.gov/pubmed/26687711

values:
nofollow
external text
//doi.org/10.1126%2Fscience.1075762

values:
nofollow
external text
//www.worldcat.org/issn/1095-9203

values:
nofollow
external text
//www.ncbi.nlm.nih.gov/pubmed/12471243

values:
nofollow
external text
//doi.org/10.1038%2Fncb0802-e203

values:
nofollow
external text
//www.ncbi.nlm.nih.gov/pubmed/12149635

values:
nofollow
external text
//doi.org/10.1042%2Fbcj20160648

values: Category:CS1 maint: Explicit use of et al.

values:
nofollow
external text
//doi.org/10.1073%2Fpnas.83.6.1613

values:
nofollow
external text
//www.ncbi.nlm.nih.gov/pubmed/16435604

values:
nofollow
external text
//www.worldcat.org/issn/0270-6474

values:
nofollow
external text
//www.ncbi.nlm.nih.gov/pubmed/11438605

values:
nofollow
external text
http://www.jbc.org/content/278/27/24831

values:
nofollow
external text
//doi.org/10.1074%2Fjbc.M213279200

values:
nofollow
external text
//www.worldcat.org/issn/0021-9258

values:
nofollow
external text
//www.ncbi.nlm.nih.gov/pubmed/12709444

values:
nofollow
external text
//doi.org/10.1073%2Fpnas.0810119105

values:
nofollow
external text
//www.worldcat.org/issn/0027-8424

values:
nofollow
external text
//www.ncbi.nlm.nih.gov/pubmed/19075226

values:
reflist mw-references-wrap
list-style-type: decimal;

values: Template:Intracellular signaling peptides and proteins

values: Template talk:Intracellular signaling peptides and proteins

values: Intracellular signaling peptides and proteins

values:
row
navbox-group
width:1%;background-color: AntiqueWhite

values: Neuroblastoma RAS viral oncogene homolog

values: Cyclin-dependent kinase inhibitor protein

values: Interleukin-1 receptor associated kinase

values: Focal adhesion protein-tyrosine kinase (page does not exist)

values: Receptor-like protein tyrosine phosphatase (page does not exist)

values: Sh2 domain-containing protein tyrosine phosphatase (page does not exist)

values: Template:Deficiencies of intracellular signaling peptides and proteins

values:
navbox-abovebelow
2
background-color: AntiqueWhite

values: nowraplinks collapsible autocollapse navbox-inner

values: Template talk:Serine/threonine-specific protein kinases

values: Non-specific serine/threonine protein kinase

values:
/wiki/Ataxia_telangiectasia_mutated
mw-redirect
Ataxia telangiectasia mutated

values: Pyruvate dehydrogenase lipoamide kinase isozyme 1

values: (isocitrate dehydrogenase (NADP+)) kinase

values: nowraplinks collapsible collapsed navbox-subgroup

values:
/wiki/P70S6_kinase
mw-redirect
P70S6 kinase

values: Cell division cycle 7-related protein kinase

values: Receptor protein serine/threonine kinase

values: Bone morphogenetic protein receptor, type 1

values: nowraplinks collapsible collapsed navbox-inner

values:
/wiki/Catalytically_perfect_enzyme
mw-redirect
Catalytically perfect enzyme

values:
/wiki/Enzyme_superfamily
mw-redirect
Enzyme superfamily

values:
/wiki/Enzyme_family
mw-redirect
Enzyme family

values: Discussion about edits from this IP address [ctrl-alt-n]

values: A list of edits made from this IP address [ctrl-alt-y]

values: You are encouraged to create an account and log in; however, it is not mandatory

values: You're encouraged to log in; however, it's not mandatory. [ctrl-alt-o]

values:
/wiki/Protein_kinase_A
View the content page [ctrl-alt-c]
c

values: Discussion about the content page [ctrl-alt-t]

values: p-namespaces navigation vectorTabs p-namespaces-label

values:
p-variants
navigation
vectorMenu emptyPortlet
p-variants-label

values: Past revisions of this page [ctrl-alt-h]

values: Find background information on current events

values:
/wiki/Special:Random
Load a random article [ctrl-alt-x]
x

values: portal navigation p-navigation p-navigation-label

values: Guidance on how to use and edit Wikipedia

values: بروتين كيناز ألفا – Arabic

values:
interlanguage-link interwiki-ca
display: none;

values:
interlanguage-link interwiki-cs
display: none;

values:
interlanguage-link interwiki-et
display: none;

values:
https://es.wikipedia.org/wiki/PKA
PKA – Spanish
es
es
interlanguage-link-target

values: پروتئین کیناز آ – Persian

values:
interlanguage-link interwiki-gl
display: none;

values: פרוטאין קינאז A – Hebrew

values:
interlanguage-link interwiki-he
display: none;

values: Протеинкиназа A – Russian

values:
interlanguage-link interwiki-sr
display: none;

values:
interlanguage-link interwiki-sh
display: none;

values:
interlanguage-link interwiki-fi
display: none;

values: All languages (initial selection from common choices by you and others)

values: /static/images/wikimedia-button-1.5x.png 1.5x, /static/images/wikimedia-button-2x.png 2x

values: /static/images/poweredby_mediawiki_132x47.png 1.5x, /static/images/poweredby_mediawiki_176x62.png 2x

values:
suggestions
display: none; font-size: 13px;

values: mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject page-Protein_kinase_A rootpage-Protein_kinase_A skin-vector action-view