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Coronary artery bypass surgery
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"Heart bypass" redirects here. For the technique to take over the function of the heart and lungs during surgery, see Cardiopulmonary bypass.
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Coronary artery bypass surgery
Early in a coronary artery bypass operation, during vein harvesting from the legs (left of image) and the establishment of cardiopulmonary bypass by placement of an aortic cannula (bottom of image). The perfusionist and heart-lung machine are on the upper right. The patient's head (not seen) is at the bottom.
ICD-10-PCS
021209W
ICD-9-CM
36.1
MeSH
D001026
MedlinePlus
002946
[edit on Wikidata]
Coronary artery bypass surgery, also known as coronary artery bypass graft (CABG, pronounced "cabbage") surgery, and colloquially heart bypass or bypass surgery, is a surgical procedure to restore normal blood flow to an obstructed coronary artery. A normal coronary artery transports blood to and from the heart muscle itself, not through the main circulatory system.
There are two main approaches. In one, the left internal thoracic artery, LITA (also called left internal mammary artery, LIMA) is diverted to the left anterior descending branch of the left coronary artery. In this method, the artery is "pedicled" which means it is not detached from the origin. In the other, a great saphenous vein is removed from a leg; one end is attached to the aorta or one of its major branches, and the other end is attached to the obstructed artery immediately after the obstruction to restore blood flow.
CABG is performed to relieve angina unsatisfactorily controlled by maximum tolerated anti-ischemic medication, prevent or relieve left ventricular dysfunction, and/or reduce the risk of death. CABG does not prevent myocardial infarction (heart attack). This surgery is usually performed with the heart stopped, necessitating the usage of cardiopulmonary bypass. However, two alternative techniques are also available, allowing CABG to be performed on a beating heart either without using the cardiopulmonary bypass, a procedure referred to as "off-pump" surgery, or performing beating surgery using partial assistance of the cardiopulmonary bypass, a procedure referred to as "on-pump beating" surgery. The latter procedure offers the advantages of the on-pump stopped and off-pump while minimizing their respective side-effects.
CABG is often indicated when coronary arteries have a 50 to 99 percent obstruction. The obstruction being bypassed is typically due to arteriosclerosis, atherosclerosis, or both. Arteriosclerosis is characterized by thickening, loss of elasticity, and calcification of the arterial wall, most often resulting in a generalized narrowing in the affected coronary artery. Atherosclerosis is characterized by yellowish plaques of cholesterol, lipids, and cellular debris deposited into the inner layer of the wall of a large or medium-sized coronary artery, most often resulting in a partial obstruction in the affected artery. Either condition can limit blood flow if it causes a cross-sectional narrowing of at least 50 percent.
Contents
1 Terminology
1.1 Number of arteries bypassed
2 Medical uses
2.1 Benefits
2.2 Results compared to stent placement
2.3 Outcomes
3 Complications
3.1 CABG associated
3.2 Open heart surgery associated
3.3 General surgery associated
4 Procedure
4.1 Minimally invasive technique
4.2 Choice of source of grafts
4.3 Follow up
5 Number performed
6 History
7 Cost
8 See also
9 References
10 External links
Terminology[edit]
Three coronary artery bypass grafts, a LIMA to LAD and two saphenous vein grafts – one to the right coronary artery system and one to the obtuse marginal system.
There are many variations in terminology, in which one or more of "artery", "bypass" or "graft" is left out. The most frequently used acronym for this type of surgery is CABG (pronounced 'cabbage'),[1] pluralized as CABGs (pronounced 'cabbages'). Initially the term aortocoronary bypass (ACB) was more popularly used to describe this procedure.[2] CAGS (coronary artery graft surgery, pronounced phonetically) should not be confused with coronary angiography (CAG).
Number of arteries bypassed[edit]
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Illustration depicting single, double, triple, and quadruple bypass
The terms single bypass, double bypass, triple bypass, quadruple bypass and quintuple bypass refer to the number of coronary arteries bypassed in the procedure. In other words, a double bypass means two coronary arteries are bypassed (e.g., the left anterior descending (LAD) coronary artery and right coronary artery (RCA)); a triple bypass means three vessels are bypassed (e.g., LAD, RCA and left circumflex artery (LCX)); a quadruple bypass means four vessels are bypassed (e.g., LAD, RCA, LCX and first diagonal artery of the LAD) while quintuple means five. Left main coronary artery obstruction requires two bypasses, one to the LAD and one to the LCX.
A coronary artery may be unsuitable for bypass grafting if it is small (< 1 mm or < 1.5 mm), heavily calcified, or located within the heart muscle rather than on the surface. A single obstruction of the left main coronary artery is associated with a higher risk for a cardiac death and usually receives a double bypass.[citation needed]
The surgeon reviews the coronary angiogram prior to surgery and identifies the number of obstructions, the percent obstruction of each, and the suitability of the arteries beyond the obstruction(s) as targets. The presumed number of bypass grafts needed as well as the location for graft attachment is determined in a preliminary fashion prior to surgery, but the final decision as to number and location is made during surgery by direct examination of the heart.
Medical uses[edit]
The 2004 ACC/AHA CABG guidelines state CABG is the preferred treatment for:[3]
Disease of the left main coronary artery (LMCA).
Disease of all three coronary arteries (LAD, LCX and RCA).
Diffuse disease not amenable to treatment with a PCI.
The 2005 ACC/AHA guidelines further state that CABG is the preferred treatment with other high-risk patients such as those with severe ventricular dysfunction (i.e. low ejection fraction), or diabetes mellitus.[3]
Benefits[edit]
Bypass surgery can provide relief of angina when the location of partial obstructions precludes improving blood flow with stents.
There is no survival benefit with bypass surgery vs. medical therapy in stable angina patients.
Bypass surgery does not prevent future myocardial infarctions.[4]
Age per se is not a factor in determining risk vs benefit of CABG.[5]
Results compared to stent placement[edit]
CABG or stent placement is indicated when medical management - anti-anginal medications, statins, antihypertensives, smoking cessation, and /or tight blood sugar control in diabetics - do not satisfactorily relieve ischemic symptoms.
Both PCI and CABG are more effective than medical management at relieving symptoms,[6] (e.g. angina, dyspnea, fatigue).
CABG is superior to PCI for some patients with multivessel CAD[7][8]
The Surgery or Stent (SoS) trial was a randomized controlled trial that compared CABG to PCI with bare-metal stents. The SoS trial demonstrated CABG is superior to PCI in multivessel coronary disease.[7]
The SYNTAX trial was a randomized controlled trial of 1800 patients with multivessel coronary disease, comparing CABG versus PCI using drug-eluting stents (DES). The study found that rates of major adverse cardiac or cerebrovascular events at 12 months were significantly higher in the DES group (17.8% versus 12.4% for CABG; P=0.002).[8] This was primarily driven by higher need for repeat revascularization procedures in the PCI group with no difference in repeat infarctions or survival. Higher rates of strokes were seen in the CABG group.
The FREEDOM (Future Revascularization Evaluation in Patients With Diabetes Mellitus—Optimal Management of Multivessel Disease) trial will compare CABG and DES in patients with diabetes. The registries of the nonrandomized patients screened for these trials may provide as much robust data regarding revascularization outcomes as the randomized analysis.[9]
A study comparing the outcomes of all patients in New York state treated with CABG or percutaneous coronary intervention (PCI) demonstrated CABG was superior to PCI with DES in multivessel (more than one diseased artery) coronary artery disease (CAD). Patients treated with CABG had lower rates of death and of death or myocardial infarction than treatment with a coronary stent. Patients undergoing CABG also had lower rates of repeat revascularization.[10] The New York State registry included all patients undergoing revascularization for coronary artery disease, but was not a randomized trial, and so may have reflected other factors besides the method of coronary revascularization.
A meta-analysis with over 6000 patients showed that coronary artery bypass was associated with lower risk for major adverse cardiac events compared to drug-eluting stenting. However, patients had a higher risk of stroke events.[11]
Outcomes[edit]
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Prognosis following CABG depends on a variety of factors, and successful grafts typically last 8–15 years.[citation needed] In general, CABG improves the chances of survival of patients who are at high risk (generally triple or higher bypass), though statistically after about five years the difference in survival rate between those who have had surgery and those treated by drug therapy diminishes. Age at the time of CABG is critical to the prognosis, younger patients with no complicating diseases doing better, while older patients can usually be expected to suffer further blockage of the coronary arteries.[12]
Grafts can become diseased and may partially or completely occlude—that is, lose their patency—in the months to years after bypass surgery is performed. A graft is considered patent if there is normal flow through the graft; flow begins to diminish with around a 70 percent stenosis in the graft.
Graft patency is dependent on a number of factors, including the type of graft used (internal thoracic artery, radial artery, or great saphenous vein), the size of the coronary artery that the graft is anastomosed with, and, of course, the skill of the surgeon(s) performing the procedure. Arterial grafts (e.g. LITA, radial) are far more sensitive to rough handling than the saphenous veins and may go into spasm if handled improperly.
Generally the best patency rates are achieved with the in-situ left internal thoracic artery (the proximal end is left connected to the subclavian artery) with the distal end being anastomosed with the coronary artery (typically the left anterior descending artery or a diagonal branch artery). Lesser patency rates can be expected with radial artery grafts and "free" internal thoracic artery grafts (where the proximal end of the thoracic artery is excised from its origin from the subclavian artery and re-anastomosed with the ascending aorta). Saphenous vein grafts may undergo vein graft failure and have worse patency rates, but are more available, as the patients can have multiple segments of the saphenous vein used to bypass different arteries.
Veins that are used either have their valves removed or are turned around so that the valves in them do not occlude blood flow in the graft. External support may be placed on the vein prior to grafting into the coronary circulation of the patient. LITA grafts are longer-lasting than vein grafts, both because the artery is more robust than a vein and because, being already connected to the arterial tree, the LITA need only be grafted at one end. The LITA is usually grafted to the left anterior descending coronary artery (LAD) because of its superior long-term patency when compared to saphenous vein grafts.[13][14]
Complications[edit]
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CABG associated[edit]
Postperfusion syndrome (pumphead), a transient neurocognitive impairment associated with cardiopulmonary bypass. Some research shows the incidence is initially decreased by off-pump coronary artery bypass, but with no difference beyond three months after surgery. A neurocognitive decline over time has been demonstrated in people with coronary artery disease regardless of treatment (OPCAB, conventional CABG or medical management). However, a 2009 research study suggests that longer term (over 5 years) cognitive decline is not caused by CABG but is rather a consequence of vascular disease.[15] Loss of mental function is a complication of bypass surgery in elderly people, and might influence procedure cost benefit considerations.[16] Several factors may contribute to immediate cognitive decline. The heart-lung blood circulation system and the surgery itself release a variety of debris, including bits of blood cells, tubing, and plaques. For example, when surgeons clamp and connect the aorta to tubing, resulting emboli block blood flow and cause mini strokes. Other heart surgery factors related to mental damage may be events of hypoxia, high or low body temperature, abnormal blood pressure, irregular heart rhythms, and fever after surgery.[17]
Nonunion of the sternum; internal thoracic artery harvesting increases the sternum devascularization risk.[18]
Myocardial infarction due to embolism, hypoperfusion, or graft failure.
Late graft stenosis, particularly of saphenous vein grafts due to atherosclerosis causing recurrent angina or myocardial infarction.[19]
Acute renal failure due to embolism or hypoperfusion.[20][21]
Stroke, secondary to embolism or hypoperfusion.[22]
Vasoplegic syndrome, secondary to cardiopulmonary bypass and hypothermia
Graft failure: grafts last 8–15 years, and then need to be replaced.
Pneumothorax: An air collection around the lung that compresses the lung[21]
Hemothorax: Blood in the space around the lungs
Pericardial tamponade: Blood collection around the heart that compresses the heart and causes poor body and brain perfusion. Chest tubes are placed around the heart and lung to prevent this. If the chest tubes become clogged in the early post operative period when bleeding is ongoing this can lead to pericardial tamponade, pneumothorax or hemothorax.
Pleural effusion: Fluid in the space around the lungs. This can lead to hypoxia which can slow recovery.
Pericarditis
Lower extremity edema, extravasation, inflammation, and eccymoses from vein harvest; entrapment of up to 9 pounds (4.1 kg) of fluid in the extremity is common. This is managed with a thigh length compression stocking, elevation of the limb, and early and frequent slow walking; as well as avoidance of standing in place, sitting, and bending the leg at the knee more than a few degrees.
Open heart surgery associated[edit]
Post-operative atrial fibrillation and atrial flutter.[23]
Anemia - secondary to blood loss, plus the anemia of inflammation, inflammation being inevitable with opening the chest plus harvesting of leg vein(s) for grafting. A fall in the hemoglobin from normal preoperative levels (e.g. 15) to postoperative levels of 6 to 10 are inevitable. There is no benefit from transfusions until the hemoglobin falls below 7.5.[24] Institutions should establish protocols to ensure transfusions are not given unless the hemoglobin falls below 7.5 without some additional compelling reason(s).[25]
Delayed healing or refracture of sternum - the sternum is bifurcated logitudinally (a median sternotomy) and retracted to access the heart. Failure to follow "sternal precautions" following surgery could result in delayed healing or refracture of the sternum which was sutured at the closure of the chest wound:
Hold a pillow against the chest whenever getting out of or into a chair or bed; or coughing, sneezing, blowing nose, or laughing, in order to oppose the intrathoracic outward force created by these activities on the healing sternum.
Avoid using the pectoral muscles, such as by pushing on the chair arms to assist one's self out of a chair, or by using the arms to assist in sitting down. Proper standing technique is to rock three times in the chair and then stand to provide momentum for moving the center of gravity from the sitting to the standing position. Proper sitting technique is to slowly lower the bottom toward the chair seat using gluteus and quadriceps muscles ("legs only") without grabbing the chair arms. Second, patients should avoid lifting objects utilizing the pectoral muscles: carrying light objects with arms extended down at sides, and lifting light objects with the elbows pressed to the chest and using the biceps, are acceptable. Also, avoid using the arms overhead.
Avoid sitting in the car front seat (no driving) for at least four weeks: the explosion of the deployment of an airbag could refracture the sternal union.
General surgery associated[edit]
Infection at incision sites
Sepsis
Deep vein thrombosis
Anesthetic complications such as malignant hyperthermia
Keloid scarring
Chronic pain at incision sites
Chronic stress related illnesses
Procedure[edit]
Illustration of a typical coronary artery bypass surgery. A vein from the leg is removed and grafted to the coronary artery to bypass a blockage.
Coronary artery bypass surgery during mobilization (freeing) of the right coronary artery from its surrounding tissue, adipose tissue (yellow). The tube visible at the bottom is the aortic cannula (returns blood from the HLM). The tube above it (obscured by the surgeon on the right) is the venous cannula (receives blood from the body). The patient's heart is stopped and the aorta is cross-clamped. The patient's head (not seen) is at the bottom.
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The patient is brought to the operating room and moved onto the operating table.
An anaesthetist or anesthesiologist places intravenous and arterial lines and injects an analgesic, usually fentanyl, intravenously, followed within minutes by an induction agent (usually propofol or etomidate) to render the patient unconscious.
An endotracheal tube is inserted and secured by the anaesthetist and mechanical ventilation is started. General anaesthesia is maintained with an inhaled volatile anesthetic agent such as isoflurane.
The chest is opened via a median sternotomy and the heart is examined by the surgeon.
The bypass grafts are harvested – frequent vessels are the internal thoracic arteries, radial arteries and saphenous veins. When harvesting is done, the patient is given heparin to inhibit blood clotting.
In the case of "off-pump" surgery, the surgeon places devices to stabilize the heart.
In the case of "on-pump" surgery, the surgeon sutures cannulae into the heart and instructs the perfusionist to start cardiopulmonary bypass (CPB). Once CPB is established, there are two technical approaches: either the surgeon places the aortic cross-clamp across the aorta and instructs the perfusionist to deliver cardioplegia with a cooled potassium mixture to stop the heart and slow its metabolism or performing bypasses on beating state (on-pump beating).
One end of each vein graft is sewn on to the coronary arteries beyond the obstruction and the other end is attached to the aorta or one of its branches. For the internal thoracic artery, the artery is severed and the proximal intact artery is sewn to the LAD beyond the obstruction. Aside the latter classical approach, there are emerging techniques for construction of composite grafts as to avoiding connecting grafts on the ascending aorta (Un-Aortic) in view of decreasing neurologic complications.
The heart is restarted; or in "off-pump" surgery, the stabilizing devices are removed. In cases where the aorta is partially occluded by a C-shaped clamp, the heart is restarted and suturing of the grafts to the aorta is done in this partially occluded section of the aorta while the heart is beating.
Protamine is given to reverse the effects of heparin.
Chest tubes are placed in the mediastinal and pleural space to drain blood from around the heart and lungs.
The sternum is wired together and the incisions are sutured closed.
The patient is moved to an intensive care unit (ICU) or cardiac universal bed (CUB) to recover. Nurses in the ICU monitor blood pressure, urine output, respiratory status, and chest tubes for excessive or no drainage. Excessive drainage suggests continued bleeding which may require re-operation to manage; no drainage suggests an obstructed tube, which can result in cardiac tamponade and/or pneumothorax which can be lethal.
After awakening and stabilizing in the ICU for 18 to 24 hours, the person is transferred to the cardiac surgery ward. If the patient is in a CUB, equipment and nursing is "stepped down" appropriate to the patient's progress without having to move the patient. Vital sign monitoring, remote rhythm monitoring, early ambulation with assistance, breathing exercises, pain control, blood sugar monitoring with intravenous insulin administration by protocol, and anti-platelet agents are all standard of care.
The patient without complications is discharged in four or five days.
Minimally invasive technique[edit]
Alternate methods of minimally invasive coronary artery bypass surgery have been developed. Off-pump coronary artery bypass (OPCAB) is a technique of performing bypass surgery without the use of cardiopulmonary bypass (the heart-lung machine).[26] Avoidance of aortic manipulation may be achieved through the "anaortic" or no-touch OPCAB technique, which has been shown to reduce stroke and mortality compared to on-pump CABG.[27] Further refinements to OPCAB have resulted in minimally invasive direct coronary artery bypass surgery (MIDCAB), a technique of performing bypass surgery through a 5 to 10 cm incision.[28]
Hybrid Coronary Revascualrisation, where the LIMA-to-LAD anastomosis is combined with percutaneous stents in other atherosclerotic sites, has been shown to have significant advantages compared to conventional CABG, including a decrease in the incidence of blood transfusion, and a reduced intubation time. A 2018 meta-analysis has however demonstrated a greater financial cost when compared to conventional CABG.[29]
Choice of source of grafts[edit]
Heart bypass patient showing almost invisible residual scarring. Left: days after operation. Middle: chest scar, two years later. Right: leg scar from harvested vein, two years later.
The choice of vessel(s) is highly dependent upon the particular surgeon and institution. Typically, the left internal thoracic artery (LITA) (previously referred to as left internal mammary artery or LIMA) is grafted to the left anterior descending artery and a combination of other arteries and veins is used for other coronary arteries.[30] The great saphenous vein from the leg is used approximately in 80% of all grafts for CABG.[31] The right internal thoracic (mammary) artery (RITA or RIMA) and the radial artery from the forearm are frequently used as well; in the U.S., these vessels are usually harvested either endoscopically, using a technique known as endoscopic vessel harvesting (EVH), or with the open-bridging technique, employing two or three small incisions. The right gastroepiploic artery from the stomach is infrequently used given the difficult mobilization from the abdomen.
Follow up[edit]
Acute - patients without complications are typically seen 3–4 weeks post operatively, at which time driving may be resumed and formal cardiac rehabilitation begun to increase aerobic endurance and muscular strength.
Chronic -
a cardiac stress test at five years is recommended, even in the absence of cardiac symptoms.[32][33]
an intensive medical regimen including statins, aspirin, and aerobic exercise is essential to delaying the progression of plaque formation in both the native and grafted vessels.
Illustration depicting coronary artery bypass surgery (double bypass)
Illustration of Single bypass
Illustration of Double bypass
Illustration of Triple bypass
Illustration of Quadruple bypass
Number performed[edit]
CABG is one of the most common procedures performed during U.S. hospital stays; it accounted for 1.4% of all operating room procedures performed in 2011.[34] Between 2001 and 2011, however, its volume decreased by 46%, from 395,000 operating procedures performed in 2001 to 213,700 procedures in 2011.[35]
Between 2000 and 2012, the number of CABG procedures carried out decreased across the majority of OECD countries. However, there remained substantial variation in the rate of procedures, with the U.S. carrying out four times as many CABG operations per 100,000 people as Spain.[36] These differences do not appear to be closely related to the incidence of heart disease, but may be due to variation in financial resources, capacity, treatment protocols and reporting methods.[37]
History[edit]
The first coronary artery bypass surgery was performed in the United States on May 2, 1960, at the Albert Einstein College of Medicine-Bronx Municipal Hospital Center by a team led by Robert H. Goetz and the thoracic surgeon, Michael Rohman with the assistance of Jordan Haller and Ronald Dee.[38][39] In this technique the vessels are held together with circumferential ligatures over an inserted metal ring. The internal mammary artery was used as the donor vessel and was anastomosed to the right coronary artery. The actual anastomosis with the Rosenbach ring took fifteen seconds and did not require cardiopulmonary bypass. The disadvantage of using the internal mammary artery was that, at autopsy nine months later, the anastomosis was open, but an atheromatous plaque had occluded the origin of the internal mammary that was used for the bypass.[citation needed][verification needed]
Soviet cardiac surgeon, Vasilii Kolesov, performed the first successful internal mammary artery–coronary artery anastomosis in 1964.[40][41] However, Goetz has been cited by others, including Kolesov,[42] as the first successful human coronary artery bypass.[43][44][45][46][47][48] Goetz's case has frequently been overlooked. Confusion has persisted for over 40 years and seems to be due to the absence of a full report and to misunderstanding about the type of anastomosis that was created. The anastomosis was intima-to-intima, with the vessels held together with circumferential ligatures over a specially designed metal ring. Kolesov did the first successful coronary bypass using a standard suture technique in 1964, and over the next five years he performed 33 sutured and mechanically stapled anastomoses in Leningrad (now St. Petersburg), USSR.[49][50]
René Favaloro, an Argentine surgeon, achieved a physiologic approach in the surgical management of coronary artery disease—the bypass grafting procedure—at the Cleveland Clinic in May 1967.[41][51] His new technique used a saphenous vein autograft to replace a stenotic segment of the right coronary artery. Later, he successfully used the saphenous vein as a bypassing channel, which has become the typical bypass graft technique we know today; in the U.S., this vessel is typically harvested endoscopically, using a technique known as endoscopic vessel harvesting (EVH).
Soon Dudley Johnson extended the bypass to include left coronary arterial systems.[41]
In 1968, doctors Charles Bailey, Teruo Hirose and George Green used the internal mammary artery instead of the saphenous vein for the grafting.[41]
Cost[edit]
According to the CDC, the average cost of hospitalization (only) associated with a coronary bypass operation in the United States in 2013 was $38,707, for an aggregate hospitalization cost of $6.4 billion.[52] The International Federation of Healthcare Plans[53] has estimated the average cost of hospitalization and physician fees for a coronary bypass operation in various countries as shown in the Table below.[54]
Country
Cost
United States $75,345
Australia $42,130
New Zealand $40,368
Switzerland $36,509
Argentina $16,492
Spain $16,247
Netherlands $15,742
India $1,583[55]
See also[edit]
Angioplasty
Cardiothoracic surgery
Dressler's syndrome
Hybrid coronary revascularization
Totally endoscopic coronary artery bypass surgery
Chest tube
References[edit]
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^ Jump up to: a b Silber, JH; Rosenbaum, PR; Schwartz, JS; Ross, RN; Williams, SV (1995). "Evaluation of the Complication Rate as a Measure of Quality of Care in Coronary Artery Bypass Graft Surgery". JAMA. 274 (4): 317–23. doi:10.1001/jama.1995.03530040045039. PMID 7609261.
Jump up ^ Selnes, OA; Gottesman, Rebecca F.; Grega, Maura A.; Baumgartner, William A.; Zeger, Scott L.; McKhann, Guy M. (2012). "Cognitive and neurologic outcomes after coronary-artery bypass surgery". NEJM. 366 (3): 250–7. doi:10.1056/NEJMra1100109. PMID 22256807.
Jump up ^ Leitch, JW; Thomson, D; Baird, DK; Harris, PJ (1990). "The importance of age as a predictor of atrial fibrillation and flutter after coronary artery bypass grafting". The Journal of Thoracic and Cardiovascular Surgery. 100 (3): 338–42. PMID 2391970.
Jump up ^ Murphy, GJ.; Pike, K; Rogers, C. A.; Wordsworth, S.; Stokes, E. a.; Angelini, G. D.; Reeves, B. C. (March 12, 2015). "Liberal or restrictive transfusion after cardiac surgery". New England Journal of Medicine. 372 (11): 997–1008. doi:10.1056/NEJMoa1403612. hdl:2381/36005. PMID 25760354.
Jump up ^ Spertus, J. (March 12, 2015). ""TITRe"ing the Approach to Transfusions after Cardiac Surgery". New England Journal of Medicine. 372 (11): 1069–1070. doi:10.1056/NEJMe1415394. PMID 25760360.
Jump up ^ Sabik, Joseph (2010). "Off Pump Bypass Surgery: Improving outcomes for coronary artery bypass surgery". Clevelandclinic.com. Retrieved February 28, 2011.
Jump up ^ Zhao, Dong Fang (February 28, 2017). "Coronary Artery Bypass Grafting With and Without Manipulation of the Ascending Aorta: A Network Meta-Analysis". Journal of the American College of Cardiology. 69 (8): 924–936. doi:10.1016/j.jacc.2016.11.071. PMID 28231944.
Jump up ^ Sabik, Joseph (2010). "Minimally Invasive Bypass Surgery". Clevelandclinic.com. Retrieved February 28, 2011.
Jump up ^ Reynolds, AC; King, N (2018). "Hybrid coronary revascularization versus conventional coronary artery bypass grafting: Systematic review and meta-analysis". Medicine (Baltimore). 97 (33): e11941. doi:10.1097/MD.0000000000011941. PMID 30113498.
Jump up ^ Head, Stuart J.; Milojevic, Milan; Taggart, David P.; Puskas, John D. (2 October 2017). "Current Practice of State-of-the-Art Surgical Coronary Revascularization". Circulation. 136 (14): 1331–1345. doi:10.1161/CIRCULATIONAHA.116.022572. PMID 28972063.
Jump up ^ Mawhinney, Jamie A; Mounsey, Craig A; Taggart, David P (8 December 2017). "The potential role of external venous supports in coronary artery bypass graft surgery†". European Journal of Cardio-Thoracic Surgery. 53 (6): 1127–1134. doi:10.1093/ejcts/ezx432. PMID 29228235.
Jump up ^ American College of Cardiology. "Five Things Physicians and Patients Should Question" (PDF). Choosing Wisely: An Initiative of the ABIM Foundation. Retrieved August 17, 2012
Jump up ^ Douglas, P. S.; Garcia, M. J.; Haines, D. E.; Lai, W. W.; Manning, W. J.; Patel, A. R.; Picard, M. H.; Polk, D. M.; Ragosta, M.; Ward, R. P.; Douglas, R. B.; Weiner, R. B.; Society for Cardiovascular Angiography Interventions; Society of Critical Care Medicine; American Society of Echocardiography; American Society of Nuclear Cardiology; Heart Failure Society of America; Society for Cardiovascular Magnetic Resonance; Society of Cardiovascular Computed Tomography; American Heart Association; Heart Rhythm Society (2011). "ACCF/ASE/AHA/ASNC/HFSA/HRS/SCAI/SCCM/SCCT/SCMR 2011 Appropriate Use Criteria for Echocardiography". Journal of the American College of Cardiology. 57 (9): 1126–1166. doi:10.1016/j.jacc.2010.11.002. PMID 21349406.
Jump up ^ Weiss AJ, Elixhauser A, Andrews RM (February 2014). "Characteristics of Operating Room Procedures in U.S. Hospitals, 2011". HCUP Statistical Brief #170. Rockville, MD: Agency for Healthcare Research and Quality.
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Jump up ^ "Indicator: International comparisons of surgical procedures". QualityWatch. Nuffield Trust & Health Foundation. Retrieved 5 May 2015.
Jump up ^ Lafortune, Gaetan. "Comparing activities and performance of the hospital sector in Europe: how many surgical procedures performed as inpatient and day cases?" (PDF). OECD. OECD. Retrieved 5 May 2015.
Jump up ^ Dee, R (2003). "Who Assisted Whom?". Tex Heart Inst J. 30 (1): 90. PMC 152850. PMID 12638685.
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Jump up ^ Kolessov, VI (October 1967). "Mammary artery-coronary artery anastomosis as method of treatment for angina pectoris". J Thorac Cardiovasc Surg. 54 (4): 535–44. PMID 6051440.
^ Jump up to: a b c d Mehta, NJ; Khan, IA (2002). "Cardiology's 10 Greatest Discoveries of the 20th Century". Tex Heart Inst J. 29 (3): 164–71. PMC 124754. PMID 12224718.
Jump up ^ Kolesov, VI; Potashov, LV (1965). "Surgery of coronary arteries". Eksp Khir Anesteziol (in Russian). 10 (2): 3–8. PMID 5851057.
Jump up ^ Olearchyk, AS (1988). "Coronary revascularization: past, present and future". J Ukr Med Assoc North Am. 1 (117): 3–34.
Jump up ^ Olearchyk, AS; Olearchyk, RM (January 1999). "Reminiscences of Vasilii I. Kolesov". Ann Thorac Surg. 67 (1): 273–6. doi:10.1016/S0003-4975(98)01225-9. PMID 10086577.
Jump up ^ Glenn, WW (April 1972). "Some reflections on the coronary bypass operation". Circulation. 45 (4): 869–77. doi:10.1161/01.CIR.45.4.869. PMID 5016019.
Jump up ^ Ochsner JL, Mills NL (1978). Coronary artery surgery. Philadelphia: Lea & Febiger.
Jump up ^ Cushing, WJ; Magovern, GJ; Olearchyk, AS (November 1986). "Internal mammary artery graft: retrospective report with 17 years' survival". J Thorac Cardiovasc Surg. 92 (5): 963–4. PMID 3773554.
Jump up ^ Konstantinov, IE (June 2000). "Robert H. Goetz: the surgeon who performed the first successful clinical coronary artery bypass operation". Ann Thorac Surg. 69 (6): 1966–72. doi:10.1016/S0003-4975(00)01264-9. PMID 10892969.
Jump up ^ Kolesov, VI; Kolesov, EV (February 1991). "Twenty years' results with internal thoracic artery-coronary artery anastomosis". J Thorac Cardiovasc Surg. 101 (2): 360–1. PMID 1992247.
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Jump up ^ Favaloro, RG; Effler, DB; Cheanvechai, C; Quint, RA; Sones Jr, FM (November 1971). "Acute coronary insufficiency (impending myocardial infarction and myocardial infarction): surgical treatment by the saphenous vein graft technique". Am J Cardiol. 28 (5): 598–607. doi:10.1016/0002-9149(71)90104-4. PMID 5116978.
Jump up ^ "www.cdc.gov" (PDF).
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External links[edit]
A BBC film showing a patient undergoing a double bypass operation.
Cleveland Clinic page on coronary artery bypass surgery
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Ashley Williams (actress)
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Not to be confused with Ashley C. Williams.
This article is an autobiography or has been extensively edited by the subject or by someone connected to the subject. It may need editing to conform to Wikipedia's neutral point of view policy. There may be relevant discussion on the talk page. (March 2018) (Learn how and when to remove this template message)
Ashley Williams Dodson
Born
Ashley Churchill Williams
(1978-11-12) November 12, 1978 (age 39)
Westchester County, New York, United States
Occupation
Actress
Years active
1993 – present
Spouse(s)
Neal Dodson (m. 2011)
Children
2
Ashley Williams Dodson (professional name Ashley Williams) (born November 12, 1978) is an American film, television, and theater actress. She is best known for her starring in the television series The Jim Gaffigan Show on TV Land and in the NBC series Good Morning Miami. Over the many years of its run, Williams played fan favorite Victoria on the hit CBS series How I Met Your Mother opposite Josh Radnor. She has starred in more than a dozen different television pilots over the years and done over 150 episodes of television in addition to television movies for The Hallmark Channel, Lifetime Television, and ABC Family. She's worked in studio and independent films, regional theater, Off-Broadway, and on Broadway. Williams is also a certified birth doula.
Contents
[hide]
1 Personal life
2 Career
3 Filmography
4 References
5 External links
Personal life[edit]
Williams was born in Westchester County, New York, the daughter of Linda Barbara (née Payne), a fundraiser for The Michael J. Fox Foundation, and Gurney Williams III, a freelance health and science writer. She is the younger sister of actress Kimberly Williams-Paisley and is sister-in-law to country music star Brad Paisley.[1]
Williams attended Rye High School in Rye, New York. In May 2001 she received her Bachelor of Fine Arts from the Boston University College of Fine Arts School of Theatre.[2]
Williams married independent film producer Neal Dodson on May 29, 2011. They have two sons: Gus Williams Dodson (b. October 5, 2014)[3] and Odie Sal Dodson (b. May 17, 2017).[4] In the summer of 2016, Williams was two months pregnant and suffered a miscarriage. She partnered with the Human Development Project to speak publicly about the experience, in hopes of reducing the stigma of miscarriage and encouraging more women to talk openly about it.[5]
Career[edit]
Williams made her big-screen acting debut in a non-speaking role in the 1993 drama Indian Summer, which also featured her sister Kimberly. She then spent from 1994 to 1996 playing teenage Danielle Andropoulos on the soap opera As the World Turns.
Williams starred in the television series Good Morning, Miami (2002–2004). Since then she has also appeared in episodes of Psych, How I Met Your Mother, multiple episodes of E-Ring, multiple episodes of Huff, Law & Order: Special Victims Unit, multiple episodes of Side Order of Life, The Mentalist, Monk, C.S.I., Royal Pains, multiple episodes of Saving Grace, Love Bites, The Protector, The Mentalist, Retired at 35, and multiple episodes of Warehouse 13. Williams also had a guest-starring role on American Dreams, playing singer Sandie Shaw and performing Shaw's 1964 hit "(There's) Always Something There to Remind Me" on American Bandstand.
In 2006, she starred in the Off Broadway play Burleigh Grime$[6][7] and appeared as Victoria, a cupcake baker, on six episodes of the television series How I Met Your Mother; a role she reprised in the concluding seasons of the show.
In 2010, she starred in the made-for-TV Lifetime movies, Patricia Cornwell's The Front and At Risk, which premiered on the channel on April 17, 2010. She also won an on-line straw poll conducted by the How I Met Your Mother production staff as to which ex-girlfriend of Ted Mosby, the show's main character, is the fans' favorite. Her character, Victoria, won 128 to 117 over Robin Scherbatsky, with a smattering of votes for other candidates.[8]
In 2011 and 2012, she played the role of Claire in a film adaptation of Something Borrowed opposite Kate Hudson, John Krasinski, and her college roommate Ginnifer Goodwin, and she also reprised her role as Victoria on How I Met Your Mother.
She made her Broadway debut in John Grisham's A Time To Kill playing law student Ellen Roarke, on September 28, 2013, with the opening night on October 20, 2013. She had previously worked at the Williamstown Theater Festival, and also worked as the understudy for both Rachel Weisz and Gretchen Mol opposite Paul Rudd in the world premiere Off-Broadway production of Neil LaBute's play The Shape of Things. She performed both lead female roles multiple times during the run.
In 2015 and 2016, Williams starred as a fictionalized version of comedian Jim Gaffigan's real life wife in The Jim Gaffigan Show on Comedy central, a sitcom about a couple raising their five young children in a two-bedroom New York City apartment which also starred Michael Ian Black and Adam Goldberg.[9]
Filmography[edit]
Film
Year
Title
Role
Notes
1993 Indian Summer Ida Heinken
2004 List, TheThe List Short film
2007 Numero Dos Ashleigh Short film
2009 Eight Percent, TheThe Eight Percent Laura Short film
2010 Heterosexuals Rhonda
2011 Scents and Sensibility Elinor Dashwood
Margin Call Heather Burke
Something Borrowed Claire
2012 Hearing Voices Short film
2013 Sequin Raze Rebecca Short film
Christmas in the City Wendy Carroll
2014 Lovesick Felicia
A Most Violent Year Lange
Television
Year
Title
Role
Notes
1994–1996 As the World Turns Danielle Andropoulos Recurring role
2002 Dawson's Creek Lory Glory Episode: "Swan Song"
2002–2004 Good Morning, Miami Dylan Messinger Main role, 39 episodes
2003 American Dreams Sandie Shaw Episode: "High Hopes"
2004 Snow Sandy Brooks Television film (ABC)
2005 Monk Darlene Coolidge / Theresa Scott Episode: "Mr. Monk Goes to a Wedding"
2005–2006 E-Ring Beth Wilkerson Recurring role, 6 episodes
2006 Amy Coyne Amy Coyne Television film (Fox)
Huff Alyssa Recurring role, 8 episodes
Him and Us Nina Television film (ABC)
2006–2014 How I Met Your Mother Victoria Recurring role (seasons 1, 7–9), 15 episodes
2007 Imperfect Union Ronnie Television film (TBS)
Making It Legal Julie Television film (ABC)
Psych Trish Connors Episode: "Forget Me Not"
Montana Sky Willa Mercy Television film (Lifetime)
Law & Order: Special Victims Unit Laura Kozlowski Episode: "Haystack"
Side Order of Life Becca Main role
2008 Night Life Jenny Television film (Fox)
Snow 2: Brain Freeze Sandy Brooks Television film (ABC Family)
Novel Adventures Lizzie McKenzie 8 episodes
2009–2010 Saving Grace Amanda Dewey Recurring role, 5 episodes
2010 New Adventures of Old Christine, TheThe New Adventures of Old Christine Store Clerk Amy Episode: "Sweet Charity"
At Risk Stump Television film (Lifetime)
The Front Stump Television film (Lifetime)
Untitled Adam Carolla Project N/A Unsold television pilot
2011 Retired at 35 Lilah Fabricant "Stuck in the Meddle"
Bird Dog Gail McGrath Television film (TNT)
Love Bites Bridget Episode: "Too Much Information"
Protector, TheThe Protector N/A Episode: "Rats"
Warehouse 13 Sally Stukowski 4 episodes
Mentalist, TheThe Mentalist Anna Dugan Episode: "The Redshirt"
2012 Wedding Band, TheThe Wedding Band Denise Episodes: "End of the World as We Know It", "99 Problems"
CSI: Crime Scene Investigation Debbie Hicks Episode: "Stealing Home"
Royal Pains Sydney Bartlett Episodes: "You Give Love a Bad Name", "About Face"
2014 The Good Wife Christina Barrett Episode: "We, the Juries"
2015–2016 The Jim Gaffigan Show Jeannie Gaffigan Main role
2015 October Kiss Poppy Summerall Television film (Hallmark)
2016 Love on a Limb Aimie Television film (Hallmark)
2017 Girls Ginny Episode: "All I Ever Wanted"
Christmas in Evergreen Allie Television film (Hallmark)
2018 Instinct Nora Cecchino Episode: "Wild Game"
References[edit]
Jump up ^ Karger, Dave (September 13, 2002). "Good Morning, Miami". Fall TV Preview. Entertainment Weekly. Archived from the original on November 28, 2006. Retrieved 2015-10-17.
Jump up ^ "Ashley Williams: Overview". TV.com. Retrieved 2015-10-17.
Jump up ^ Parker, Heidi; Enriquez, Justin (23 October 2014). "How I Met Your Mother star Ashley Williams welcomes first child Gus into the world". Daily Mail. Retrieved 2015-10-17.
Jump up ^ "It's a Boy! Ashley Williams Welcomes Son Odie Sal". PEOPLE.com. 2017-06-07. Retrieved 2017-08-18.
Jump up ^ Williams, Ashley (September 9, 2016). "I Need to Talk About My Miscarriage". Retrieved October 1, 2016.
Jump up ^ Isherwood, Charles (June 14, 2006). "Burleigh Grime$: A Vengeful Financier and His Clueless Apprentice". Theater Review. The New York Times. Retrieved 2015-10-17.
Jump up ^ Jones, Kenneth (13 June 2006). "Burleigh Grimes, Wall Street Comedy With Music, Opens June 13". Playbill. Retrieved 2015-10-17.
Jump up ^ HIMYM Production [@himymprod] (26 Aug 2010). "Victoria has 128 votes! Robin follows closely with 117, Stella rolls in with 26 and Blah Blah rounds out the top four with 22. :)" (Tweet) – via Twitter.
Jump up ^ "TV Land releases extended scene from new comedy "Younger" featuring Sutton Foster and Hilary Duff" (PDF) (Press release). Viacom. December 4, 2014. Retrieved 2015-10-17.
External links[edit]
Ashley Williams on IMDb
Authority control
WorldCat Identities
VIAF: 165510702
LCCN: no2007094754
ISNI: 0000 0001 1464 3355
GND: 141657316
BNF: cb16253596b (data)
Retrieved from "https://en.wikipedia.org/w/index.php?title=Ashley_Williams_(actress)&oldid=832564705"
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