text:
Astronaut
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For other uses, see Astronaut (disambiguation).
"Cosmonaut" redirects here. For other uses, see Cosmonaut (disambiguation).
NASA Astronaut Bruce McCandless II using a Manned Maneuvering Unit outside Space Shuttle Challenger on shuttle mission STS-41-B in 1984.
An astronaut or cosmonaut is a person trained by a human spaceflight program to command, pilot, or serve as a crew member of a spacecraft. Although generally reserved for professional space travelers, the terms are sometimes applied to anyone who travels into space, including scientists, politicians, journalists, and tourists.[1][2]
Until 2002, astronauts were sponsored and trained exclusively by governments, either by the military or by civilian space agencies. With the suborbital flight of the privately funded SpaceShipOne in 2004, a new category of astronaut was created: the commercial astronaut.
Contents
1 Definition
2 Terminology
2.1 English
2.2 Russian
2.3 Chinese
2.4 Other terms
3 Space travel milestones
3.1 Age milestones
3.2 Duration and distance milestones
3.3 Civilian and non-government milestones
3.4 Self-funded travelers
4 Training
4.1 NASA candidacy requirements
4.1.1 Commander and Pilot
4.1.2 Mission Specialist
4.1.3 Mission Specialist Educator
5 Health risks of space travel
6 Food and drink
7 Insignia
8 Deaths
9 See also
10 References
11 External links
Definition
Alan Shepard aboard Freedom 7
The criteria for what constitutes human spaceflight vary. The Fédération Aéronautique Internationale (FAI) Sporting Code for astronautics recognizes only flights that exceed an altitude of 100 kilometers (62 mi).[3] In the United States, professional, military, and commercial astronauts who travel above an altitude of 50 miles (80 km)[4] are awarded astronaut wings.
As of 17 November 2016[update], a total of 552 people from 36 countries have reached 100 km (62 mi) or more in altitude, of which 549 reached low Earth orbit or beyond.[5] Of these, 24 people have traveled beyond low Earth orbit, either to lunar orbit, the lunar surface, or, in one case, a loop around the Moon.[6] Three of the 24–Jim Lovell, John Young and Eugene Cernan–did so twice.[7] The three current[when?] astronauts who have flown without reaching low Earth orbit are spaceplane pilots Joe Walker, Mike Melvill, and Brian Binnie, who participated in suborbital missions.
As of 17 November 2016[update], under the U.S. definition, 558 people qualify as having reached space, above 50 miles (80 km) altitude. Of eight X-15 pilots who exceeded 50 miles (80 km) in altitude, only one exceeded 100 kilometers (about 62 miles).[5] Space travelers have spent over 41,790 man-days (114.5 man-years) in space, including over 100 astronaut-days of spacewalks.[8][9] As of 2016[update], the man with the longest cumulative time in space is Gennady Padalka, who has spent 879 days in space.[10] Peggy A. Whitson holds the record for the most time in space by a woman, 377 days.[11]
Terminology
See also: Astronaut ranks and positions
In 1959, when both the United States and Soviet Union were planning, but had yet to launch humans into space, NASA Administrator T. Keith Glennan and his Deputy Administrator, Dr. Hugh Dryden, discussed whether spacecraft crew members should be called astronauts or cosmonauts. Dryden preferred "cosmonaut", on the grounds that flights would occur in the cosmos (near space), while the "astro" prefix suggested flight to the stars. Most NASA Space Task Group members preferred "astronaut", which survived by common usage as the preferred American term.[12] When the Soviet Union launched the first man into space, Yuri Gagarin in 1961, they chose a term which anglicizes to "cosmonaut".
English
In English-speaking nations, a professional space traveler is called an astronaut.[13] The term derives from the Greek words ástron (ἄστρον), meaning "star", and nautes (ναύτης), meaning "sailor". The first known use of the term "astronaut" in the modern sense was by Neil R. Jones in his 1930 short story "The Death's Head Meteor". The word itself had been known earlier; for example, in Percy Greg's 1880 book Across the Zodiac, "astronaut" referred to a spacecraft. In Les Navigateurs de l'Infini (1925) by J.-H. Rosny aîné, the word astronautique (astronautic) was used. The word may have been inspired by "aeronaut", an older term for an air traveler first applied in 1784 to balloonists. An early use of "astronaut" in a non-fiction publication is Eric Frank Russell's poem "The Astronaut", appearing in the November 1934 Bulletin of the British Interplanetary Society.[14]
The first known formal use of the term astronautics in the scientific community was the establishment of the annual International Astronautical Congress in 1950, and the subsequent founding of the International Astronautical Federation the following year.[15]
NASA applies the term astronaut to any crew member aboard NASA spacecraft bound for Earth orbit or beyond. NASA also uses the term as a title for those selected to join its Astronaut Corps.[16] The European Space Agency similarly uses the term astronaut for members of its Astronaut Corps.[17]
Russian
Main article: Soviet space program
See also: List of cosmonauts
By convention, an astronaut employed by the Russian Federal Space Agency (or its Soviet predecessor) is called a cosmonaut in English texts.[16] The word is an anglicisation of the Russian word kosmonavt (Russian: космонавт Russian pronunciation: [kəsmɐˈnaft]), one who works in space outside the Earth's atmosphere, a space traveler,[18] which derives from the Greek words kosmos (κόσμος), meaning "universe", and nautes (ναύτης), meaning "sailor". Other countries of the former Eastern Bloc use variations of the Russian word kosmonavt, such as the Polish kosmonauta.
Coinage of the term kosmonavt has been credited to Soviet aeronautics pioneer Mikhail Tikhonravov (1900–1974).[19][20] The first cosmonaut was Soviet Air Force pilot Yuri Gagarin, also the first person in space. Valentina Tereshkova, a Russian factory worker, was the first woman in space, as well as the first civilian among the Soviet cosmonaut or NASA astronaut corps to make a spaceflight. On March 14, 1995, Norman Thagard became the first American to ride to space on board a Russian launch vehicle, and thus became the first "American cosmonaut".
Chinese
Main article: Chinese space program
See also: List of Chinese astronauts
"Yǔ háng yuán" (宇航员, "Space-universe navigating personnel") is used for astronauts and cosmonauts in general,[21][22] while "Hángtiān yuán" (航天员, "navigating outer space personnel") is used for Chinese astronauts. Here, "Hángtiān" (航天) is strictly defined as the navigation of outer space within the local star system, i.e. Solar system. The phrase "tài kōng rén" (太空人, "spaceman") is often used in Hong Kong and Taiwan.[23]
The term taikonaut is used by some English-language news media organizations for professional space travelers from China.[24] The word has featured in the Longman and Oxford English dictionaries, the latter of which describes it as "a hybrid of the Chinese term taikong (space) and the Greek naut (sailor)"; the term became more common in 2003 when China sent its first astronaut Yang Liwei into space aboard the Shenzhou 5 spacecraft.[25] This is the term used by Xinhua News Agency in the English version of the Chinese People's Daily since the advent of the Chinese space program.[26] The origin of the term is unclear; as early as May 1998, Chiew Lee Yih (趙裡昱) from Malaysia, used it in newsgroups.[27][28]
Other terms
With the rise of space tourism, NASA and the Russian Federal Space Agency agreed to use the term "spaceflight participant" to distinguish those space travelers from professional astronauts on missions coordinated by those two agencies.
While no nation other than the Russian Federation (and previously the former Soviet Union), the United States, and China have launched a manned spacecraft, several other nations have sent people into space in cooperation with one of these countries. Inspired partly by these missions, other synonyms for astronaut have entered occasional English usage. For example, the term spationaut (French spelling: spationaute) is sometimes used to describe French space travelers, from the Latin word spatium for "space", the Malay term angkasawan was used to describe participants in the Angkasawan program, and the Indian Space Research Organisation hope to launch a spacecraft in 2022 that would carry vyomanauts, coined from the Sanskrit word for space. In Finland, the NASA astronaut Timothy Kopra, a Finnish American, has sometimes been referred to as sisunautti, from the Finnish word sisu.[29]
Space travel milestones
Yuri Gagarin, first human in space (1961)
Valentina Tereshkova, first woman in space (1963)
Neil Armstrong, first human to walk on the Moon (1969)
Dr. Sally Ride, the first American female astronaut (1980s)
Yang Liwei, first person sent into space by China (2003)
See also: Spaceflight records and Timeline of space travel by nationality
The first human in space was Soviet Yuri Gagarin, who was launched on April 12, 1961, aboard Vostok 1 and orbited around the Earth for 108 minutes. The first woman in space was Soviet Valentina Tereshkova, who launched on June 16, 1963, aboard Vostok 6 and orbited Earth for almost three days.
Alan Shepard became the first American and second person in space on May 5, 1961, on a 15-minute sub-orbital flight. The first American to orbit the Earth was John Glenn, aboard Friendship 7 on February 20, 1962. The first American woman in space was Sally Ride, during Space Shuttle Challenger's mission STS-7, on June 18, 1983.[30] In 1992 Mae Jemison became the first African American woman to travel in space aboard STS-47.
Cosmonaut Alexei Leonov was the first person to conduct an extravehicular activity (EVA), (commonly called a "spacewalk"), on March 18, 1965, on the Soviet Union's Voskhod 2 mission. This was followed two and a half months later by astronaut Ed White who made the first American EVA on NASA's Gemini 4 mission.[31]
The first manned mission to orbit the Moon, Apollo 8, included American William Anders who was born in Hong Kong, making him the first Asian-born astronaut in 1968.
The Soviet Union, through its Intercosmos program, allowed people from other "socialist" (i.e. Warsaw Pact and other Soviet-allied) countries to fly on its missions, with the notable exception of France participating in Soyuz TM-7. An example is Czechoslovak Vladimír Remek, the first cosmonaut from a country other than the Soviet Union or the United States, who flew to space in 1978 on a Soyuz-U rocket.[32]
On July 23, 1980, Pham Tuan of Vietnam became the first Asian in space when he flew aboard Soyuz 37.[33] Also in 1980, Cuban Arnaldo Tamayo Méndez became the first person of Hispanic and black African descent to fly in space, and in 1983, Guion Bluford became the first African American to fly into space. In April 1985, Taylor Wang became the first ethnic Chinese person in space.[34][35] The first person born in Africa to fly in space was Patrick Baudry (France), in 1985.[36][37] In 1985, Saudi Arabian Prince Sultan Bin Salman Bin AbdulAziz Al-Saud became the first Arab Muslim astronaut in space.[38] In 1988, Abdul Ahad Mohmand became the first Afghan to reach space, spending nine days aboard the Mir space station.[39]
With the increase of seats on the Space Shuttle, the U.S. began taking international astronauts. In 1983, Ulf Merbold of West Germany became the first non-US citizen to fly in a US spacecraft. In 1984, Marc Garneau became the first of 8 Canadian astronauts to fly in space (through 2010).[40] In 1985, Rodolfo Neri Vela became the first Mexican-born person in space.[41] In 1991, Helen Sharman became the first Briton to fly in space.[42] In 2002, Mark Shuttleworth became the first citizen of an African country to fly in space, as a paying spaceflight participant.[43] In 2003, Ilan Ramon became the first Israeli to fly in space, although he died during a re-entry accident.
On October 15, 2003, Yang Liwei became China's first astronaut on the Shenzhou 5 spacecraft.
Age milestones
The youngest person to fly in space is Gherman Titov, who was 25 years old when he flew Vostok 2. (Titov was also the first person to suffer space sickness).[44][45] The oldest person who has flown in space is John Glenn, who was 77 when he flew on STS-95.[46]
Duration and distance milestones
438 days is the longest time spent in space, by Russian Valeri Polyakov.[8] As of 2006, the most spaceflights by an individual astronaut is seven, a record held by both Jerry L. Ross and Franklin Chang-Diaz. The farthest distance from Earth an astronaut has traveled was 401,056 km (249,205 mi), when Jim Lovell, Jack Swigert, and Fred Haise went around the Moon during the Apollo 13 emergency.[8]
Civilian and non-government milestones
The first civilian in space was Valentina Tereshkova[47] aboard Vostok 6 (she also became the first woman in space on that mission). Tereshkova was only honorarily inducted into the USSR's Air Force, which did not accept female pilots at that time. A month later, Joseph Albert Walker became the first American civilian in space when his X-15 Flight 90 crossed the 100 kilometers (54 nautical miles) line, qualifying him by the international definition of spaceflight.[48][49] Walker had joined the US Army Air Force but was not a member during his flight. The first people in space who had never been a member of any country's armed forces were both Konstantin Feoktistov and Boris Yegorov aboard Voskhod 1.
The first non-governmental space traveler was Byron K. Lichtenberg, a researcher from the Massachusetts Institute of Technology who flew on STS-9 in 1983.[50] In December 1990, Toyohiro Akiyama became the first paying space traveler as a reporter for Tokyo Broadcasting System, a visit to Mir as part of an estimated $12 million (USD) deal with a Japanese TV station, although at the time, the term used to refer to Akiyama was "Research Cosmonaut".[51][52][53] Akiyama suffered severe space sickness during his mission, which affected his productivity.[52]
The first self-funded space tourist was Dennis Tito on board the Russian spacecraft Soyuz TM-3 on April 28, 2001.
Self-funded travelers
Main article: Space tourism
The first person to fly on an entirely privately funded mission was Mike Melvill, piloting SpaceShipOne flight 15P on a suborbital journey, although he was a test pilot employed by Scaled Composites and not an actual paying space tourist.[54][55] Seven others have paid the Russian Space Agency to fly into space:
Dennis Tito (American): April 28 – May 6, 2001 (ISS)
Mark Shuttleworth (South African): April 25 – May 5, 2002 (ISS)
Gregory Olsen (American): October 1–11, 2005 (ISS)
Anousheh Ansari (Iranian / American): September 18–29, 2006 (ISS)
Charles Simonyi (Hungarian / American): April 7–21, 2007 (ISS), March 26 – April 8, 2009 (ISS)
Richard Garriott (British / American): October 12–24, 2008 (ISS)
Guy Laliberté (Canadian): September 30, 2009 – October 11, 2009 (ISS)
Training
Elliot See during water egress training with NASA (1965)
Main article: Astronaut Training
See also: Astronaut ranks and positions
The first NASA astronauts were selected for training in 1959.[56] Early in the space program, military jet test piloting and engineering training were often cited as prerequisites for selection as an astronaut at NASA, although neither John Glenn nor Scott Carpenter (of the Mercury Seven) had any university degree, in engineering or any other discipline at the time of their selection. Selection was initially limited to military pilots.[57][58] The earliest astronauts for both America and the USSR tended to be jet fighter pilots, and were often test pilots.
Once selected, NASA astronauts go through twenty months of training in a variety of areas, including training for extravehicular activity in a facility such as NASA's Neutral Buoyancy Laboratory.[1][57] Astronauts-in-training (astronaut candidates) may also experience short periods of weightlessness (microgravity) in an aircraft called the "Vomit Comet," the nickname given to a pair of modified KC-135s (retired in 2000 and 2004, respectively, and replaced in 2005 with a C-9) which perform parabolic flights.[56] Astronauts are also required to accumulate a number of flight hours in high-performance jet aircraft. This is mostly done in T-38 jet aircraft out of Ellington Field, due to its proximity to the Johnson Space Center. Ellington Field is also where the Shuttle Training Aircraft is maintained and developed, although most flights of the aircraft are conducted from Edwards Air Force Base.
Astronauts is training must learn how to control and fly the Space Shuttle and, it is vital that they are familiar with the International Space Station so they know what they must do when they get there.[59]
NASA candidacy requirements
Be citizens of the United States.[56][60]
Pass a strict physical examination, and have a near and distant visual acuity correctable to 20/20 (6/6). Blood pressure, while sitting, must be no greater than 140 over 90. There are currently no age restrictions.[61]
Commander and Pilot
A bachelor's degree in engineering, biological science, physical science or mathematics is required.
At least 1,000 hours' flying time as pilot-in-command in jet aircraft. Experience as a test pilot is desirable.
Height must be 5 ft 2 in to 6 ft 2 in (1.58 m to 1.88 m).
Distant visual acuity must be correctable to 20/20 in each eye.
The refractive surgical procedures of the eye, PRK (Photorefractive keratectomy) and LASIK, are now allowed, providing at least 1 year has passed since the date of the procedure with no permanent adverse after effects. For those applicants under final consideration, an operative report on the surgical procedure will be requested.
Mission Specialist
A bachelor's degree in engineering, biological science, physical science or mathematics, as well as at least three years of related professional experience (graduate work or studies) and an advanced degree, such as a master's degree (one to three years) or a doctoral degree (three years or more).
Applicant's height must be between 4 ft 10.5 in and 6 ft 4 in (1.49 m and 1.93 m).
Mission Specialist Educator
Main article: Educator Astronaut Project
Applicants must have a bachelor's degree with teaching experience, including work at the kindergarten through twelfth grade level. An advanced degree, such as a master's degree or a doctoral degree, is not required, but is strongly desired.[62]
Mission Specialist Educators, or "Educator Astronauts", were first selected in 2004, and as of 2007, there are three NASA Educator astronauts: Joseph M. Acaba, Richard R. Arnold, and Dorothy Metcalf-Lindenburger.[63][64] Barbara Morgan, selected as back-up teacher to Christa McAuliffe in 1985, is considered to be the first Educator astronaut by the media, but she trained as a mission specialist.[65] The Educator Astronaut program is a successor to the Teacher in Space program from the 1980s.[66][67]
Health risks of space travel
Gennady Padalka performing ultrasound on Michael Fincke during ISS Expedition 9.
See also: Effect of spaceflight on the human body and Space medicine
Astronauts are susceptible to a variety of health risks including decompression sickness, barotrauma, immunodeficiencies, loss of bone and muscle, loss of eyesight, orthostatic intolerance, sleep disturbances, and radiation injury.[68][69][70][71][72][73][74][75][76][77] A variety of large scale medical studies are being conducted in space via the National Space and Biomedical Research Institute (NSBRI) to address these issues. Prominent among these is the Advanced Diagnostic Ultrasound in Microgravity Study in which astronauts (including former ISS commanders Leroy Chiao and Gennady Padalka) perform ultrasound scans under the guidance of remote experts to diagnose and potentially treat hundreds of medical conditions in space. This study's techniques are now being applied to cover professional and Olympic sports injuries as well as ultrasound performed by non-expert operators in medical and high school students. It is anticipated that remote guided ultrasound will have application on Earth in emergency and rural care situations, where access to a trained physician is often rare.[78][79][80]
A 2006 Space Shuttle experiment found that Salmonella typhimurium, a bacterium that can cause food poisoning, became more virulent when cultivated in space.[81] More recently, in 2017, bacteria were found to be more resistant to antibiotics and to thrive in the near-weightlessness of space.[82] Microorganisms have been observed to survive the vacuum of outer space.[83][84]
On December 31, 2012, a NASA-supported study reported that manned spaceflight may harm the brain and accelerate the onset of Alzheimer's disease.[85][86][87]
In October 2015, the NASA Office of Inspector General issued a health hazards report related to space exploration, including a human mission to Mars.[88][89]
Over the last decade, flight surgeons and scientists at NASA have seen a pattern of vision problems in astronauts on long-duration space missions. The syndrome, known as visual impairment intracranial pressure (VIIP), has been reported in nearly two-thirds of space explorers after long periods spent aboard the International Space Station (ISS).
On November 2, 2017, scientists reported that significant changes in the position and structure of the brain have been found in astronauts who have taken trips in space, based on MRI studies. Astronauts who took longer space trips were associated with greater brain changes.[90][91]
Being in space can be physiologically deconditioning on the body. It can affect the otolith organs and adaptive capabilities of the central nervous system. Zero gravity and cosmic rays can cause many implications for astronauts.[92]

Food and drink
Main article: Space food
An astronaut on the International Space Station requires about 0.83 kilograms (1.83 pounds) weight of food inclusive of food packaging per meal each day. (The packaging for each meal weighs around 0.12 kilograms - 0.27 pounds) Longer-duration missions require more food.
Shuttle astronauts worked with nutritionists to select menus that appeal to their individual tastes. Five months before flight, menus are selected and analyzed for nutritional content by the shuttle dietician. Foods are tested to see how they will react in a reduced gravity environment. Caloric requirements are determined using a basal energy expenditure (BEE) formula. On Earth, the average American uses about 35 gallons (132 liters) of water every day. On board the ISS astronauts limit water use to only about three gallons (11 liters) per day.[93]
Insignia
In Russia, cosmonauts are awarded Pilot-Cosmonaut of the Russian Federation upon completion of their missions, often accompanied with the award of Hero of the Russian Federation. This follows the practice established in the USSR where cosmonauts were usually awarded the title Hero of the Soviet Union.
At NASA, those who complete astronaut candidate training receive a silver lapel pin. Once they have flown in space, they receive a gold pin. U.S. astronauts who also have active-duty military status receive a special qualification badge, known as the Astronaut Badge, after participation on a spaceflight. The United States Air Force also presents an Astronaut Badge to its pilots who exceed 50 miles (80 km) in altitude.
Space Mirror Memorial
Deaths
Main article: List of spaceflight-related accidents and incidents § Astronaut fatalities
Eighteen astronauts (fourteen men and four women) have lost their lives during four space flights. By nationality, thirteen were American (including one born in India), four were Russian (Soviet Union), and one was Israeli.
Eleven people (all men) have lost their lives training for spaceflight: eight Americans and three Russians. Six of these were in crashes of training jet aircraft, one drowned during water recovery training, and four were due to fires in pure oxygen environments.
The Space Mirror Memorial, which stands on the grounds of the John F. Kennedy Space Center Visitor Complex, commemorates the lives of the men and women who have died during spaceflight and during training in the space programs of the United States. In addition to twenty NASA career astronauts, the memorial includes the names of a U.S. Air Force X-15 test pilot, a U.S. Air Force officer who died while training for a then-classified military space program, and a civilian spaceflight participant.
See also
Spaceflight portal
Airman
Boundary of Space
Commercial astronaut
Cosmonautics Day
Fallen Astronaut
J-Wear
List of astronauts by name
List of astronauts by year of selection
List of cosmonauts
Lists of fictional astronauts
List of human spaceflights
List of space travelers by name
List of space travelers by nationality
Lists of spacewalks and moonwalks
Mercury 13 - 13 inactive women astronauts
North American X-15 program
Shirley Thomas - author, Men of Space (1960–1968)
List of spaceflight records
Space food
Space suit
Timeline of space travel by nationality
U.S. space exploration history on U.S. stamps
United States Astronaut Hall of Fame
Women in space
Yuri's Night
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^ Jump up to: a b BBC News (1990). "Mir Space Station 1986–2001". BBC News. Retrieved October 4, 2007.
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Jump up ^ Cherry, Jonathan D.; Frost, Jeffrey L.; Lemere, Cynthia A.; Williams, Jacqueline P.; Olschowka, John A.; O'Banion, M. Kerry; Liu, Bin (2012). Feinstein, Douglas L, ed. "Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer's Disease". PLoS ONE. 7 (12): e53275. Bibcode:2012PLoSO...753275C. doi:10.1371/journal.pone.0053275. PMC 3534034  . PMID 23300905. Retrieved January 7, 2013.
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Jump up ^ "Human Needs: Sustaining Life During Exploration". www.nasa.gov.
External links
Look up cosmonaut, spationaut, astronaut, or taikonaut in Wiktionary, the free dictionary.
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Encyclopedia Astronautica: Phantom cosmonauts
collectSPACE: Astronaut appearances calendar
spacefacts Spacefacts.de
Manned astronautics: facts and figures
Astronaut Candidate Brochure online
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text:
Oral mucosa
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Oral mucosa
Details
Latin
tunica mucosa oris
Dorlands
/Elsevier
t_22/12832012
Anatomical terminology
[edit on Wikidata]
The oral mucosa is the mucous membrane lining the inside of the mouth and consists of stratified squamous epithelium termed oral epithelium and an underlying connective tissue termed lamina propria.[1] The oral cavity has sometimes been described as a mirror that reflects the health of the individual.[2] Changes indicative of disease are seen as alterations in the oral mucosa lining the mouth, which can reveal systemic conditions, such as diabetes or vitamin deficiency, or the local effects of chronic tobacco or alcohol use.[3]
Contents
[hide]
1 Classification
2 Structure
3 Function
4 See also
5 References
6 External links
Classification[edit]
Oral mucosa can be divided into three main categories based on function and histology:
Masticatory mucosa, keratinized stratified squamous epithelium, found on the dorsum of the tongue, hard palate and attached gingiva.
Lining mucosa, nonkeratinized stratified squamous epithelium, found almost everywhere else in the oral cavity, including the:
Buccal mucosa refers to the inside lining of the cheeks and floor of the mouth and is part of the lining mucosa.
Labial mucosa refers to the inside lining of the lips and is part of the lining mucosa.
Alveolar mucosa refers to the lining between the buccal and labial mucosae. It is a brighter red, smooth and shiny with many blood vessels, and is not connected to underlying tissue by rete pegs.[4]
Specialized mucosa, specifically in the regions of the taste buds on lingual papillae on the dorsal surface of the tongue that contains nerve endings for general sensory reception and taste perception.[5]
Structure[edit]
Schematic illustration of the layers found in keratinized oral mucosa that include a deeper lamina propria and basement membrane in-between and superficial layers of strafied squamous epithelium that include from deepest to most superficial:
1: Stratum basale
2: Stratum spinosum
3: Stratum granulosum
4: Stratum corneum
Oral mucosa consists of two layers, the surface stratified squamous epithelium and the deeper lamina propria. In keratinized oral mucosa, the epithelium consists of four layers:
Stratum basale (basal layer)
Stratum spinosum (prickle layer)
Stratum granulosum (granular layer)
Stratum corneum (keratinized layer)
In nonkeratinised epithelium, the two deep layers (basale and spinosum) remain the same but the outer layers are termed the intermediate and superficial layers.
Depending on the region of the mouth, the epithelium may be nonkeratinized or keratinized. Nonkeratinized squamous epithelium covers the soft palate, inner lips, inner cheeks, and the floor of the mouth, and ventral surface of the tongue. Keratinized squamous epithelium is present in the attached gingiva and hard palate as well as areas of the dorsal surface of the tongue.[5][6]
Keratinization is the differentiation of keratinocytes in the stratum granulosum into nonvital surface cells or squames to form the stratum corneum. The cells terminally differentiate as they migrate to the surface from the stratum basale where the progenitor cells are located to the superficial surface.
Unlike keratinized epithelium, nonkeratinized epithelium normally has no superficial layers showing keratinization. Nonkeratinized epithelium may, however, readily transform into a keratinizing type in response to frictional or chemical trauma, in which case it undergoes hyperkeratinization.This change to hyperkeratinization commonly occurs on the usually nonkeratinized buccal mucosa when the linea alba forms, a white ridge of calloused tissue that extends horizontally at the level where the maxillary and mandibular teeth come together and occlude. Histologically, an excess amount of keratin is noted on the surface of the tissue, and the tissue has all the layers of an orthokeratinized tissue with its granular and keratin layers. In patients who have habits such as clenching or grinding (bruxism) their teeth, a larger area of the buccal mucosa than just the linea alba becomes hyperkeratinized. This larger white, rough, raised lesion needs to be recorded so that changes may be made in the dental treatment plan regarding the patient’s parafunctional habits.[7][8]
Even keratinized tissue can undergo further level of hyperkeratinization; an increase in the amount of keratin is produced as a result of chronic physical trauma to the region. Changes such as hyperkeratinization are reversible if the source of the injury is removed, but it takes time for the keratin to be shed or lost by the tissue. Thus, to check for malignant changes, a baseline biopsy and microscopic study of any whitened tissue may be indicated, especially if in a high-risk cancer category, such with a history of tobacco or alcohol use or are HPV positive. Hyperkeratinized tissue is also associated with the heat from smoking or hot fluids on the hard palate in the form of nicotinic stomatitis.[7]
The lamina propria is a fibrous connective tissue layer that consists of a network of type I and III collagen and elastin fibers in some regions. The main cells of the lamina propria are the fibroblasts, which are responsible for the production of the fibers as well as the extracellular matrix.
The lamina propria, like all forms of connective tissue proper, has two layers: papillary and dense. The papillary layer is the more superficial layer of the lamina propria. It consists of loose connective tissue within the connective tissue papillae, along with blood vessels and nerve tissue. The tissue has an equal amount of fibers, cells, and intercellular substance. The dense layer is the deeper layer of the lamina propria. It consists of dense connective tissue with a large amount of fibers. Between the papillary layer and the deeper layers of the lamina propria is a capillary plexus, which provides nutrition for the all layers of the mucosa and sends capillaries into the connective tissue papillae.[7]
A submucosa may or may not be present deep in the dense layer of the lamina propria, depending on the region of the oral cavity. If present, the submucosa usually contains loose connective tissue and may also contain adipose tissue or salivary glands, as well as overlying bone or muscle within the oral cavity.[7]
A variable number of Fordyce spots or granules are scattered throughout the nonkeratinized tissue. These are a normal variant, visible as small, yellowish bumps on the surface of the mucosa. They correspond to deposits of sebum from misplaced sebaceous glands in the submucosa that are usually associated with hair follicles.[7]
A basal lamina (basement membrane without aid of the microscope) is at the interface between the oral epithelium and lamina propria similar to the epidermis and dermis.[9]
Function[edit]
Protection
Sensation
Secretion
Thermal regulation[9]
See also[edit]
Oral mucosa tissue engineering
Junctional epithelium
Oral cancer
Salivary glands
Basal lamina
Fibroblast
References[edit]
Jump up ^ Ten Cate's Oral Histology, Nanci, Elsevier, 2013, page 280
Jump up ^ Oral Manifestations of Systemic Diseases at eMedicine
Jump up ^ Squier, Christopher A.; Kremer, Mary J. (2001). "Biology of Oral Mucosa and Esophagus". Journal of the National Cancer Institute. Monographs (29): 7–15. PMID 11694559.
Jump up ^ Chandra (1 January 2004). Textbook of Dental and Oral Histology and Embryology with MCQs. Jaypee Brothers Publishers. pp. 180–. ISBN 978-81-8061-238-1.
^ Jump up to: a b University of Michigan Health System, Learning Resource Center at http://histology.med.umich.edu/node/2
Jump up ^ Luiz Carlos Junquiera et al (2005), Basic Histology, p. 282, ISBN 0-07-144116-6
^ Jump up to: a b c d e Illustrated Dental Embryology, Histology, and Anatomy, Bath-Balogh and Fehrenbach, Elsevier, 2011, page 106
Jump up ^ Ten Cate's Oral Histology, Nanci, Elsevier, 2013, page 285
^ Jump up to: a b Ten Cate's Oral Mucosa, Nanci, Elsevier, 2013, page 278
External links[edit]
Wikimedia Commons has media related to Tunica mucosa oris.
Histology image: 09601loa – Histology Learning System at Boston University – "Digestive System: Oral Cavity and Teeth – lip, oral mucosa"
Histology image: 95_04 at the University of Oklahoma Health Sciences Center – "Lip"
Histology image: 95_07 at the University of Oklahoma Health Sciences Center – "Lip"
Common Dental and Oral Mucosal Disorders, Duke University at http://pamodules.mc.duke.edu/Oral_Health/Print.asp?CourseNum=1&LessonNum=3
[show]
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Anatomy of the mouth
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[show]
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Oral mucosa – Lining of mouth
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[show]
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[show]
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[show]
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Median sulcus of the tongue

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Terminal sulcus of tongue

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Foramen cecum (tongue)

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Cunnilingus tongue

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Palatal cysts of the newborn

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Bohn's nodules

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Condyloma acuminatum

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/wiki/Focal_epithelial_hyperplasia
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Focal epithelial hyperplasia

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/wiki/Hand,_foot_and_mouth_disease
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Hand, foot and mouth disease

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Herpes zoster

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Basaloid squamous carcinoma

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Benign mucous membrane pemphigoid

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Verruca vulgaris

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Turner's hypoplasia

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Periodontal ligament

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Gingival cyst of the adult

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Gingival cyst of the newborn

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/wiki/Salivary_gland_disease
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Salivary gland disease

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Salivary gland diverticulum

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Salivary gland neoplasm

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