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A Streetcar Named Desire
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For other uses, see A Streetcar Named Desire (disambiguation).
A Streetcar Named Desire
First edition (New Directions)
Written by
Tennessee Williams
Characters
Blanche DuBois
Stella Kowalski
Stanley Kowalski
Harold "Mitch" Mitchell
Date premiered
December 3, 1947
Place premiered
Ethel Barrymore Theatre
New York City, New York
Original language
English
Genre
Southern Gothic
Setting
The French Quarter and Downtown New Orleans
A Streetcar Named Desire is a 1947 play written by American playwright Tennessee Williams[1] that received the Pulitzer Prize for Drama in 1948. The play opened on Broadway on December 3, 1947, and closed on December 17, 1949, in the Ethel Barrymore Theatre. The Broadway production was directed by Elia Kazan and starred Jessica Tandy, Marlon Brando, Karl Malden, and Kim Hunter.[2] The London production opened in 1949 with Bonar Colleano, Vivien Leigh, and Renee Asherson and was directed by Laurence Olivier.[1] The drama A Streetcar Named Desire is often regarded as among the finest plays of the 20th century, and is considered by many to be Williams' greatest.[by whom? – Discuss]
Contents
[hide]
1 Plot
2 Stage productions
2.1 Original Broadway production
3 Original cast
3.1 Original London production
3.2 Belle Reprieve
3.3 Revivals
4 Adaptations
4.1 Film
4.2 Opera
4.3 Ballet
4.4 Television
5 Inspirations
6 "A Streetcar Named Success"
7 Awards and nominations
8 Auction record
9 References
10 External links
Plot[edit]
After the loss of her family home, Belle Reve, to creditors, Blanche DuBois travels from the small town of Laurel, Mississippi, to the New Orleans French Quarter to live with her younger, married sister, Stella, and brother-in-law, Stanley Kowalski. Blanche is in her thirties and, with no money, she has nowhere else to go.
Blanche tells Stella that she has taken a leave of absence from her English-teaching position because of her nerves (which is later revealed to be a lie). Blanche laments the shabbiness of her sister’s two-room flat. She finds Stanley loud and rough, eventually referring to him as "common". Stanley, in return, does not care for Blanche's manners and dislikes her presence.
Stanley later questions Blanche about her earlier marriage. Blanche had married when she was very young, but her husband died, leaving her widowed and alone. The memory of her dead husband causes Blanche some obvious distress. Stanley, worried that he has been cheated out of an inheritance, demands to know what happened to Belle Reve, once a large plantation and the DuBois family home. Blanche hands over all the documents pertaining to Belle Reve. While looking at the papers, Stanley notices a bundle of letters that Blanche emotionally proclaims are personal love letters from her dead husband. For a moment, Stanley seems caught off guard over her proclaimed feelings. Afterwards, he informs Blanche that Stella is going to have a baby.
The night after Blanche’s arrival, during one of Stanley’s poker parties, Blanche meets Mitch, one of Stanley’s poker player buddies. His courteous manner sets him apart from the other men. Their chat becomes flirtatious and friendly, and Blanche easily charms him; they like each other. Suddenly becoming upset over multiple interruptions, Stanley explodes in a drunken rage and strikes Stella. Blanche and Stella take refuge with the upstairs neighbor, Eunice. When Stanley recovers, he cries out from the courtyard below for Stella to come back by repeatedly calling her name until she comes down and allows herself to be carried off to bed. After Stella returns to Stanley, Blanche and Mitch sit at the bottom of the steps in the courtyard, where Mitch apologizes for Stanley's coarse behavior.
Blanche is bewildered that Stella would go back with him after such violence. The next morning, Blanche rushes to Stella and describes Stanley as a subhuman animal, though Stella assures Blanche that she and Stanley are fine. Stanley overhears the conversation but keeps silent. When Stanley comes in, Stella hugs and kisses him, letting Blanche know that her low opinion of Stanley does not matter.
As the weeks pass, Blanche and Stanley continue to not get along. Blanche has hope in Mitch, and tells Stella that she wants to go away with him and not be anyone’s problem. During a meeting between the two, Blanche confesses to Mitch that once she was married to a young man, Allan Grey, whom she later discovered in a sexual encounter with an older man. Grey later committed suicide when Blanche told him she was disgusted with him. The story touches Mitch, who tells Blanche that they need each other. It seems certain that they will get married.
Later on, Stanley repeats gossip to Stella that he has gathered on Blanche, telling her that Blanche was fired from her teaching job for having sex with a student and that she lived at a hotel known for prostitution (the Flamingo). Stella erupts in anger over Stanley’s cruelty after he states that he has also told Mitch about the rumors, but the fight is cut short as she goes into labor and is sent to the hospital.
As Blanche waits at home alone, Mitch arrives and confronts Blanche with the stories that Stanley has told him. At first she denies everything, but eventually confesses that the stories are true. She pleads for forgiveness, but an angry and humiliated Mitch refuses her the chance at an honorable relationship and attempts to sexually assault her instead. In response, Blanche screams "fire", and he runs away in fright.
Hours before Stella has the baby, Stanley and Blanche are left alone in the apartment. Blanche has descended into a fantasy that an old suitor of hers is coming to provide financial support and take her away from New Orleans. Stanley goes along with the act before angrily scorning Blanche's lies and behavior, and advances toward her; in response, she threatens to glass him, but is overpowered. It is strongly implied that Stanley rapes Blanche, imminently resulting in her psychotic crisis.
Weeks later, at another poker game at the Kowalski apartment, Stella and her neighbor, Eunice, are packing Blanche's belongings. Blanche has suffered a complete mental breakdown and is to be committed to a mental hospital. Although Blanche has told Stella about Stanley's assault, Stella cannot bring herself to believe her sister's story. When a doctor and a matron arrive to take Blanche to the hospital, she initially resists them and collapses on the floor in confusion. Mitch, present at the poker game, breaks down in tears. When the doctor helps Blanche up, she goes willingly with him, saying: "Whoever you are, I have always depended upon the kindness of strangers." The play ends with Stanley continuing to comfort Stella, but also fondling with her blouse, while the poker game continues uninterrupted, as Steve says: "This game is seven-card stud."
Stage productions[edit]
Original Broadway production[edit]
Publicity still of Marlon Brando (dated December 27, 1948) in the Broadway production of A Streetcar Named Desire
Publicity still of Marlon Brando (dated December 27, 1948) in the Broadway production of A Streetcar Named Desire
The original Broadway production was produced by Irene Mayer Selznick.[2] It opened at the Shubert in New Haven shortly before moving to the Ethel Barrymore Theatre on December 3, 1947.[2] Selznick originally wanted to cast Margaret Sullavan and John Garfield, but settled on Jessica Tandy and Marlon Brando, who were virtual unknowns at the time. The opening night cast also included Kim Hunter as Stella and Karl Malden as Mitch.[2] Tandy was cast after Williams saw her performance in a West Coast production of his one-act play Portrait of a Madonna. Williams believed that casting Brando, who was young for the part as it was originally conceived, would evolve Kowalski from being a vicious older man to someone whose unintentional cruelty can be attributed to youthful ignorance. Despite its shocking scenes and gritty dialogue, the audience applauded for half an hour after the debut performance ended.[3] Brooks Atkinson, reviewing the opening in The New York Times, described Tandy's "superb performance" as "almost incredibly true," concluding that Williams "has spun a poignant and luminous story."[4] Later in the run, Uta Hagen replaced Tandy, Carmelita Pope replaced Hunter, and Anthony Quinn replaced Brando. Hagen and Quinn took the show on a national tour and then returned to Broadway for additional performances. Early on, when Brando broke his nose, Jack Palance took over his role. Ralph Meeker also took on the part of Stanley both in the Broadway and touring companies. Tandy received a Tony Award for Best Actress in a Play in 1948, sharing the honor with Judith Anderson's portrayal of Medea and with Katharine Cornell.
Uta Hagen's Blanche on the national tour was directed not by Elia Kazan, who had directed the Broadway production, but by Harold Clurman, and it has been reported, both in interviews by Hagen and observations by contemporary critics, that the Clurman-directed interpretation shifted the focus of audience sympathy back to Blanche and away from Stanley (where the Kazan version had located it). This was the original conception of the play, and has been reflected in subsequent revivals.
The original Broadway production closed, after 855 performances, in 1949.
Original cast[edit]
Jessica Tandy as Blanche DuBois
Karl Malden as Harold "Mitch" Mitchell
Marlon Brando as Stanley Kowalski
Kim Hunter as Stella Kowalski
Rudy Bond as Steve Hubbell
Nick Dennis as Pablo Gonzales
Peg Hillias as Eunice Hubbell
Vito Christi as Young Collector
Richard Garrick as Doctor
Ann Dere as Nurse
Gee Gee James as Negro Woman
Edna Thomas as Mexican Woman
Original London production[edit]
The London production, directed by Laurence Olivier, opened on October 12, 1949, and starred Bonar Colleano, Vivien Leigh, and Renee Asherson.[1]
Belle Reprieve[edit]
Bette Bourne and Paul Shaw of the British gay theater company, Bloolips, and Peggy Shaw and Lois Weaver of the American lesbian theater company, Split Britches, collaborated and performed a gender-bent production of Belle Reprieve, a twisted adaption of Streetcar. “This theatrical piece creates a Brechtian,” “epic drama” that relies on the reflective rather than emotional involvement of the audience—a “commentary on the sexual roles and games in Williams’s text.” Blanche was played by Bette Bourne as “man in a dress," Stanley was played by Peggy Shaw as a “butch lesbian,” Mitch was played by Paul Shaw as a “fairy disguised as a man,” and Stella was played by Lois Weaver as a “woman disguised as a woman.”[5]
Revivals[edit]
The first all-black production of Streetcar was likely performed by the Summer Theatre Company at Lincoln University in Jefferson City, Missouri, in August 1953 and directed by one of Williams's former classmates at Iowa, Thomas D. Pawley, as noted in the Streetcar edition of the "Plays in Production" series published by Cambridge University Press. The black and cross-gendered productions of Streetcar since the mid-1950s are too numerous to list here.
Tallulah Bankhead, for whom Williams had originally written the role of Blanche, starred in a 1956 New York City Center Company production directed by Herbert Machiz.
The first Broadway revival of the play was in 1973. It was produced by the Lincoln Center, at the Vivian Beaumont Theater, and starred Rosemary Harris as Blanche, James Farentino as Stanley and Patricia Conolly as Stella.[6]
The Simpsons did an episode, A Streetcar Named Marge, in which the play was featured. Ned Flanders and Marge took the leading roles as Stanley and Blanche, respectively.
The Spring 1988 revival at the Circle in the Square Theatre starred Aidan Quinn opposite Blythe Danner as Blanche and Frances McDormand as Stella.[7]
A highly publicized revival in 1992 starred Alec Baldwin as Stanley and Jessica Lange as Blanche. It was staged at the Ethel Barrymore Theatre, the same theatre that the original production was staged in. This production proved so successful that it was filmed for television. It featured Timothy Carhart as Mitch and Amy Madigan as Stella, as well as future Sopranos stars James Gandolfini and Aida Turturro. Gandolfini was Carhart's understudy.[8]
In 1997, Le Petit Theatre du Vieux Carre in New Orleans mounted a 50th Anniversary production, with music by the Marsalis family, starring Michael Arata and Shelly Poncy. In 2009, the Walnut Street Theatre in Philadelphia, where the original pre-Broadway tryout occurred, began a production of the play for its 200th anniversary season.
The 2005 Broadway revival was directed by Edward Hall and produced by The Roundabout Theater Company. It starred John C. Reilly as Stanley, Amy Ryan as Stella, and Natasha Richardson as Blanche.[9] The production would mark Natasha Richardson's final appearance on Broadway owing to her death in 2009 in a skiing accident.
The Sydney Theatre Company production of A Streetcar Named Desire premiered on September 5 and ran until October 17, 2009. This production, directed by Liv Ullmann, starred Cate Blanchett as Blanche, Joel Edgerton as Stanley, Robin McLeavy as Stella and Tim Richards as Mitch.[10]
From July 2009 until October 2009, Rachel Weisz and Ruth Wilson starred in a highly acclaimed revival of the play in London's West End at the Donmar Warehouse directed by Rob Ashford.
In November 2010, an Oxford University student production was staged at the Oxford Playhouse which sold out and was critically acclaimed.[11]
In April 2012, Blair Underwood, Nicole Ari Parker, Daphne Rubin-Vega and Wood Harris starred in a multiracial adaptation at the Broadhurst Theatre.[12] Theatre review aggregator Curtain Critic gave the production a score of 61 out of 100 based on the opinions of 17 critics.[13]
A production at the Young Vic, London, opened on July 23, 2014, and closed on September 19, 2014. Directed by Benedict Andrews and starring Gillian Anderson, Ben Foster, Vanessa Kirby and Corey Johnson; this production garnered critical acclaim and is the fastest selling show ever produced by the Young Vic.[14] On September 16, 2014, the performance was relayed live to over one thousand cinemas in the UK as part of the National Theatre Live project to broadcast the best of British theatre live from the London stage to cinemas across the UK and around the world.[15] Thus far, the production has been screened in over 2000 venues.[16] From April 23, 2016 till June 4, 2016, the production was reprised at the new St. Ann's Warehouse in Brooklyn, New York City.[17]
In 2016 Sarah Frankcom directed a production at the Royal Exchange in Manchester starring Maxine Peake, Ben Batt, Sharon Duncan Brewster and Youssef Kerkour. It opened on 8 September and closed on 15 October. It was critically well received with Peake's performance in particular singled out for praise.[18]
Adaptations[edit]
Film[edit]
Vivien Leigh in the trailer for A Streetcar Named Desire
Main article: A Streetcar Named Desire (1951 film)
In 1951, a film adaptation of the play, directed by Elia Kazan, with Malden, Brando, and Hunter reprising their Broadway roles, joined by Vivien Leigh from the London production for the part of Blanche. The movie won four Academy Awards, including three acting awards (Leigh for Best Actress, Malden for Best Supporting Actor and Hunter for Best Supporting Actress), the first time a film won three out of four acting awards (Brando was nominated for Best Actor but lost). Jessica Tandy was the only lead actor from the original Broadway production not to appear in the 1951 film. References to Allan Grey's sexual orientation are essentially removed, due to Motion Picture Production Code restrictions. Instead, the reason for his suicide is changed to a general "weakness".[19] The ending itself was also slightly altered. Stella does not remain with Stanley, as she does in the play.
Pedro Almodóvar's 1999 Academy Award-winning film, All About My Mother, features a Spanish-language version of the play being performed by some of the supporting characters and the play itself plays an important role in the film. However, some of the film's dialogue is taken from the 1951 film version, not the original stage version.
The 1973 Woody Allen film Sleeper includes a late scene in which Miles (Woody) and Luna (Diane Keaton) briefly take on the roles of Stanley (Luna) and Blanche (Miles).
It was noted by many critics that the 2013 Academy Award-winning Woody Allen film Blue Jasmine had much in common with Streetcar and is most likely a loose adaptation. It shares a very similar plot and characters, although it has been suitably updated for modern film audiences.[20][21]
In 2015, Gillian Anderson directed and starred in a short film prequel to A Streetcar Named Desire, titled The Departure. The short film was written by the novelist Andrew O'Hagan and is part of Young Vic's short film series, which was produced in collaboration with The Guardian.[22]
Opera[edit]
In 1995, an opera was adapted and composed by André Previn with a libretto by Philip Littell. It had its premiere at the San Francisco Opera during the 1998–99 season, and featured Renée Fleming as Blanche.
Ballet[edit]
A 1952 ballet production with choreography by Valerie Bettis, which Mia Slavenska and Frederic Franklin's Slavenska-Franklin Ballet debuted at Her Majesty's Theatre in Montreal, featured the music of Alex North, who had composed the music for the 1951 film.[23]
Another ballet production was staged by John Neumeier in Frankfurt in 1983. Music included Visions fugitives by Prokofiev and Alfred Schnittke's First Symphony.
In the mid 2000s, another production was staged by Winthrop Corey, then Artistic Director of Mobile Ballet mobileballet.org
In 2012, Scottish Ballet collaborated with theatre and film director Nancy Meckler and international choreographer Annabelle Lopez Ochoa to create a new staging of A Streetcar Named Desire.[24]
Television[edit]
Main articles: A Streetcar Named Desire (1984 film) and A Streetcar Named Desire (1995 film)
In 1955, the television program Omnibus featured Jessica Tandy reviving her original Broadway performance as Blanche, with her husband, Hume Cronyn, as Mitch. It aired only portions of the play that featured the Blanche and Mitch characters.
The multi-Emmy Award-winning 1984 television version featured Ann-Margret as Blanche, Treat Williams as Stanley, Beverly D'Angelo as Stella and Randy Quaid as Mitch. It was directed by John Erman and the teleplay was adapted by Oscar Saul. The music score by composed by Marvin Hamlisch. Ann-Margret, D'Angelo and Quaid were all nominated for Emmy Awards, but none won. However, it did win four Emmys, including one for cinematographer Bill Butler. Ann-Margret won a Golden Globe award for her performance and Treat Williams was nominated for Best Actor in a Miniseries or TV Movie.
A 1995 television version was based on the highly successful Broadway revival that starred Alec Baldwin and Jessica Lange. However, only Baldwin and Lange were from the stage production. The TV version added John Goodman as Mitch and Diane Lane as Stella. This production was directed by Glenn Jordan. Baldwin, Lange and Goodman all received Emmy Award nominations. Lange won a Golden Globe award (for Best Actress in a Miniseries or TV Movie), while Baldwin was nominated for Best Actor, but did not win.
In 1998, PBS aired a taped version of the opera adaptation that featured the original San Francisco Opera cast. The program received an Emmy Award nomination for Outstanding Classical Music/Dance Program.[citation needed]
Inspirations[edit]
The streetcar took its name from Desire Street in the 9th Ward of New Orleans
Main article: Streetcars in New Orleans § Historic lines
The Desire Line ran from 1920 to 1948, at the height of streetcar use in New Orleans. The route ran down Royal, through the Quarter, to Desire Street in the Bywater district, and back up to Canal. Blanche's route in the play—"They told me to take a streetcar named Desire, transfer to one called Cemeteries and ride six blocks and get off at—Elysian Fields!"—is allegorical, taking advantage of New Orleans's colorful street names: the Desire line itself crossed Elysian Fields Avenue on its way to Canal Street. There, one could transfer to the Cemeteries line, which ran along Canal, blocks away from Elysian Fields.
The character of Blanche is thought to be based on Williams' sister, Rose Williams, who struggled with mental health issues and became incapacitated after a lobotomy.[1]
Theatre critic and former actress Blanche Marvin, a friend of Williams, says the playwright used her name for the character Blanche DuBois, named the character's sister Stella after Marvin's former surname "Zohar" (which means "Star"), and took the play's line "I've always depended on the kindness of strangers" from something she said to him.[25]
"A Streetcar Named Success"[edit]
"A Streetcar Named Success" is an essay by Tennessee Williams about art and the artist's role in society. It is often included in paper editions of A Streetcar Named Desire. A version of this essay first appeared in The New York Times on November 30, 1947, four days before the opening of A Streetcar Named Desire. Another version of this essay, entitled "The Catastrophe of Success", is sometimes used as an introduction to The Glass Menagerie.
Awards and nominations[edit]
Awards
1948 New York Drama Critics' Circle Best Play
1948 Tony Award for Best Actress in a Play – Jessica Tandy
1948 Pulitzer Prize for Drama
1992 Theater World Award for Best Actress in a Play – Jessica Lange
2010 Olivier Award for Best Actress in a Play – Rachel Weisz
2010 Olivier Award for Best Supporting Actress in a Play - Ruth Wilson
Nominations
1988 Tony Award for Best Revival of a Play
1988 Tony Award for Best Actress in a Play – Frances McDormand
1988 Tony Award for Best Actress in a Play – Blythe Danner
1992 Tony Award for Best Actor in a Play – Alec Baldwin
2005 Tony Award for Best Featured Actress in a Play – Amy Ryan
2005 Tony Award for Best Costume Design of a Play
2005 Tony Award for Best Lighting Design of a Play
2010 Olivier Award for Best Revival of a Play
2015 Olivier Award for Best Revival of a Play
2015 Olivier Award for Best Actress in a Play – Gillian Anderson
Auction record[edit]
On October 1, 2009, Swann Galleries auctioned an unusually fine copy of A Streetcar Named Desire, New York, 1947, signed by Williams and dated 1976 for $9,000, a record price for a signed copy of the play.
References[edit]
^ Jump up to: a b c d Williams, Tennessee (1995). A Streetcar Named Desire. Introduction and text. Oxford: Heinemann Educational Publishers.
^ Jump up to: a b c d Production notes. December 3, 1947—December 17, 1949
Jump up ^ December 3, This Day In History Calendar (2008). Sourcebooks, Inc.
Jump up ^ Brooks Atkinson, "First Night at the Theatre", New York Times, December 4, 1947.
Jump up ^ Geis, Deborah. “Deconstructing (A Streetcar Named) Desire: Gender Recitation in Belle Reprieve”. Feminist Theatrical Revisions of Classic Works. Ed. Sharon Friedman. Jefferson, NC and London: McFarland & Company, Inc., 2009. 237-246. Print.
Jump up ^ Barnes, Clive (April 27, 1973). "A Rare 'Streetcar'; Fresh Approach Taken at Vivian Beaumont". New York Times. Retrieved September 26, 2012.
Jump up ^ Production notes. March 10 – May 22, 1988.
Jump up ^ Production notes. April 12—August 9, 1992.
Jump up ^ Production notes. April 26–July 3, 2005.
Jump up ^ "A Streetcar Named Desire". SydneyTheatre.com.au. Sydney Theatre Company. Archived from the original on June 14, 2011. Retrieved June 21, 2011.
Jump up ^ "OTR reviews A Streetcar Named Desire at Oxford Playhouse". Oxford Theatre Review. July 26, 2012. Retrieved September 26, 2012.
Jump up ^ "Blair Underwood On Stanley, Stella And 'Streetcar'". National Public Radio. May 1, 2012. Retrieved May 2, 2012.
Jump up ^ "A Streetcar Named Desire". Curtain Critic. Retrieved June 21, 2012.
Jump up ^ "What's on: A Streetcar Named Desire by Tennessee Williams", Young Vic.
Jump up ^ "Young Vic – A Streetcar Named Desire, National Theatre Live.
Jump up ^ Nick Curtis (December 3, 2014). "Gillian Anderson: Self destruction is my default mode". Evening Standard. Retrieved November 9, 2015.
Jump up ^ "St. Ann's Warehouse - A Young Vic & Joshua Andrews Co-Production". St. Ann's Warehouse. Retrieved April 27, 2016.
Jump up ^ "Maxine Peake stalks to the heart of Blanche DuBois". theguardian.com. Retrieved 23 September 2016.
Jump up ^ Cohan, Steven (1997). Masked Men: Masculinity and the Movies in the Fifties. Bloomington, Indiana: Indiana University Press. p. 254. ISBN 0-253-21127-1. Retrieved July 11, 2008.
Jump up ^ "Movie Review: Woody Allen's Blue Jasmine Is Perhaps His Cruelest-Ever Film". Vanity Fair. Retrieved September 12, 2013.
Jump up ^ "Blue Jasmine: Woody Allen's excellent homage to A Streetcar Named Desire". Tri-city Herald. Retrieved September 12, 2013.
Jump up ^ Wiegand, Chris (February 5, 2015). "Gillian Anderson goes back to Blanche for prequel to A Streetcar Named Desire". The Guardian. Retrieved October 6, 2016.
Jump up ^ Kolin, Philip C. (2000). Williams: A Streetcar named Desire. Cambridge University Press. p. 157. ISBN 978-0-521-62610-1.
Jump up ^ "A Streetcar Named Desire" Archived October 12, 2013, at the Wayback Machine. Scottish Ballet
Jump up ^ Clark, Nick (July 27, 2014). "Critic claims 'I was the inspiration for Blanche DuBois'". The Independent. Retrieved August 29, 2014.
External links[edit]
Wikimedia Commons has media related to A Streetcar Named Desire.
Wikiquote has quotations related to: A Streetcar Named Desire
A Streetcar Named Desire (New York productions chronology) at the Internet Broadway Database
[show]
v
t
e
A Streetcar Named Desire by Tennessee Williams
Characters
Blanche DuBois
Stanley Kowalski
Stella Kowalski
Films
1951 film
1984 film
1995 film
Other
Opera
"A Streetcar Named Marge"
"A Streetcar Named Success"
[show]
v
t
e
Pulitzer Prize for Drama
1918–1950
Why Marry? (1918)
Beyond the Horizon (1920)
Miss Lulu Bett (1921)
Anna Christie (1922)
Icebound (1923)
Hell-Bent Fer Heaven (1924)
They Knew What They Wanted (1925)
Craig's Wife (1926)
In Abraham's Bosom (1927)
Strange Interlude (1928)
Street Scene (1929)
The Green Pastures (1930)
Alison's House (1931)
Of Thee I Sing (1932)
Both Your Houses (1933)
Men in White (1934)
The Old Maid (1935)
Idiot's Delight (1936)
You Can't Take It with You (1937)
Our Town (1938)
Abe Lincoln in Illinois (1939)
The Time of Your Life (1940)
There Shall Be No Night (1941)
The Skin of Our Teeth (1943)
Harvey (1945)
State of the Union (1946)
A Streetcar Named Desire (1948)
Death of a Salesman (1949)
South Pacific (1950)
1951–1975
The Shrike (1952)
Picnic (1953)
The Teahouse of the August Moon (1954)
Cat on a Hot Tin Roof (1955)
The Diary of Anne Frank (1956)
Long Day's Journey into Night (1957)
Look Homeward, Angel (1958)
J.B. (1959)
Fiorello! (1960)
All the Way Home (1961)
How to Succeed in Business Without Really Trying (1962)
The Subject Was Roses (1965)
A Delicate Balance (1967)
The Great White Hope (1969)
No Place to be Somebody (1970)
The Effect of Gamma Rays on Man-in-the-Moon Marigolds (1971)
That Championship Season (1973)
Seascape (1975)
1976–2000
A Chorus Line (1976)
The Shadow Box (1977)
The Gin Game (1978)
Buried Child (1979)
Talley's Folly (1980)
Crimes of the Heart (1981)
A Soldier's Play (1982)
'night, Mother (1983)
Glengarry Glen Ross (1984)
Sunday in the Park with George (1985)
Fences (1987)
Driving Miss Daisy (1988)
The Heidi Chronicles (1989)
The Piano Lesson (1990)
Lost in Yonkers (1991)
The Kentucky Cycle (1992)
Angels in America: Millennium Approaches (1993)
Three Tall Women (1994)
The Young Man from Atlanta (1995)
Rent (1996)
How I Learned to Drive (1998)
Wit (1999)
Dinner with Friends (2000)
2001–present
Proof (2001)
Topdog/Underdog (2002)
Anna in the Tropics (2003)
I Am My Own Wife (2004)
Doubt: A Parable (2005)
Rabbit Hole (2007)
August: Osage County (2008)
Ruined (2009)
Next to Normal (2010)
Clybourne Park (2011)
Water by the Spoonful (2012)
Disgraced (2013)
The Flick (2014)
Between Riverside and Crazy (2015)
Hamilton (2016)
Sweat (2017)
[show]
v
t
e
Works by Tennessee Williams
Plays
Candles to the Sun (1936)
Spring Storm (1937)
Fugitive Kind (1937)
Not About Nightingales (1938)
Battle of Angels (1940)
Auto-da-Fé (1941)
The Glass Menagerie (1944)
You Touched Me (1945)
Stairs to the Roof (1947)
A Streetcar Named Desire (1947)
Summer and Smoke (1948)
The Rose Tattoo (1951)
Camino Real (1953)
Cat on a Hot Tin Roof (1955)
Orpheus Descending (1957)
Suddenly Last Summer (1958)
Sweet Bird of Youth (1959)
Period of Adjustment (1960)
The Night of the Iguana (1961)
The Milk Train Doesn't Stop Here Anymore (1963)
The Seven Descents of Myrtle (1968)
In the Bar of a Tokyo Hotel (1969)
Will Mr. Merriweather Return from Memphis? (1969)
Out Cry (1971)
Small Craft Warnings (1972)
The Two-Character Play (1973)
The Red Devil Battery Sign (1975)
This Is (An Entertainment) (1976)
Vieux Carré (1977)
A Lovely Sunday for Creve Coeur (1979)
Clothes for a Summer Hotel (1980)
The Notebook of Trigorin (1981)
Something Cloudy, Something Clear (1981)
A House Not Meant to Stand (1982)
Novels
The Roman Spring of Mrs. Stone (1950)
Moise and the World of Reason (1975)
Short story
collections
Hard Candy: A Book of Stories (1954)
Three Players of a Summer Game and Other Stories (1960)
The Knightly Quest: a Novella and Four Short Stories (1966)
One Arm and Other Stories (1967)
Eight Mortal Ladies Possessed: a Book of Stories (1974)
Screenplays
The Glass Menagerie (1950)
A Streetcar Named Desire (1951)
The Rose Tattoo (1955)
Baby Doll (1956)
Suddenly, Last Summer (1959)
The Fugitive Kind (1959)
Ten Blocks on the Camino Real (1966)
Boom! (1968)
The Loss of a Teardrop Diamond (1957, filmed 2009)
Non-fiction
"The Catastrophe of Success" (1947)
"A Streetcar Named Success" (1947)
Poetry
In the Winter of Cities (1956)
Androgyne, Mon Amour (1977)
Unfinished
manuscripts
In Masks Outrageous and Austere (1983)
Related
articles
List of one-act plays by Tennessee Williams
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Electron transport chain
From Wikipedia, the free encyclopedia
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The electron transport chain in the mitochondrion is the site of oxidative phosphorylation in eukaryotes. The NADH and succinate generated in the citric acid cycle are oxidized, providing energy to power ATP synthase.
Photosynthetic electron transport chain of the thylakoid membrane.
An electron transport chain (ETC) is a series of complexes that transfer electrons from electron donors to electron acceptors via redox (both reduction and oxidation occurring simultaneously) reactions, and couples this electron transfer with the transfer of protons (H+ ions) across a membrane. This creates an electrochemical proton gradient that drives the synthesis of adenosine triphosphate (ATP), a molecule that stores energy chemically in the form of highly strained bonds. The molecules of the chain include peptides, enzymes (which are proteins or protein complexes), and others. The final acceptor of electrons in the electron transport chain during aerobic respiration is molecular oxygen although a variety of acceptors other than oxygen such as sulfate exist in anaerobic respiration.
Electron transport chains are used for extracting energy via redox reactions from sunlight in photosynthesis or, such as in the case of the oxidation of sugars, cellular respiration. In eukaryotes, an important electron transport chain is found in the inner mitochondrial membrane where it serves as the site of oxidative phosphorylation through the use of ATP synthase. It is also found in the thylakoid membrane of the chloroplast in photosynthetic eukaryotes. In bacteria, the electron transport chain is located in their cell membrane.
In chloroplasts, light drives the conversion of water to oxygen and NADP+ to NADPH with transfer of H+ ions across chloroplast membranes. In mitochondria, it is the conversion of oxygen to water, NADH to NAD+ and succinate to fumarate that are required to generate the proton gradient.
Electron transport chains are major sites of premature electron leakage to oxygen, generating superoxide and potentially resulting in increased oxidative stress.
Contents
[hide]
1 Background
2 In mitochondria
2.1 Mitochondrial redox carriers
2.1.1 Complex I
2.1.2 Complex II
2.1.3 Complex III
2.1.4 Complex IV
2.2 Coupling with oxidative phosphorylation
2.3 Summary
3 In bacteria
3.1 Electron donors
3.2 Dehydrogenases
3.3 Quinone carriers
3.4 Proton pumps
3.5 Cytochrome electron carriers
3.6 Terminal oxidases and reductases
3.7 Electron acceptors
3.8 Summary
4 Photosynthetic
5 Summary
6 See also
7 References
8 External links
Background[edit]
The electron transport chain consists of a spatially separated series of redox reactions in which electrons are transferred from a donor molecule to an acceptor molecule. The underlying force driving these reactions is the Gibbs free energy of the reactants and products. The Gibbs free energy is the energy available ("free") to do work. Any reaction that decreases the overall Gibbs free energy of a system is thermodynamically spontaneous.
The function of the electron transport chain is to produce a transmembrane proton electrochemical gradient as a result of the redox reactions.[1] If protons flow back through the membrane, they enable mechanical work, such as rotating bacterial flagella. ATP synthase, an enzyme highly conserved among all domains of life, converts this mechanical work into chemical energy by producing ATP,[2] which powers most cellular reactions. A small amount of ATP is available from substrate-level phosphorylation, for example, in glycolysis. In most organisms the majority of ATP is generated in electron transport chains, while only some obtain ATP by fermentation.[citation needed]
In mitochondria[edit]
Most eukaryotic cells have mitochondria, which produce ATP from products of the citric acid cycle, fatty acid oxidation, and amino acid oxidation. At the mitochondrial inner membrane, electrons from NADH and FADH2 pass through the electron transport chain to oxygen, which is reduced to water. The electron transport chain comprises an enzymatic series of electron donors and acceptors. Each electron donor will pass electrons to a more electronegative acceptor, which in turn donates these electrons to another acceptor, a process that continues down the series until electrons are passed to oxygen, the most electronegative and terminal electron acceptor in the chain. Passage of electrons between donor and acceptor releases energy, which is used to generate a proton gradient across the mitochondrial membrane by actively "pumping" protons into the intermembrane space, producing a thermodynamic state that has the potential to do work. The entire process is called oxidative phosphorylation, since ADP is phosphorylated to ATP using the energy of hydrogen oxidation in many steps.
A small percentage of electrons do not complete the whole series and instead directly leak to oxygen, resulting in the formation of the free-radical superoxide, a highly reactive molecule that contributes to oxidative stress and has been implicated in a number of diseases and aging.
Mitochondrial redox carriers[edit]
Energy obtained through the transfer of electrons down the ETC is used to pump protons from the mitochondrial matrix into the intermembrane space, creating an electrochemical proton gradient (ΔpH) across the inner mitochondrial membrane (IMM). This proton gradient is largely but not exclusively responsible for the mitochondrial membrane potential (ΔΨM). It allows ATP synthase to use the flow of H+ through the enzyme back into the matrix to generate ATP from adenosine diphosphate (ADP) and inorganic phosphate. Complex I (NADH coenzyme Q reductase; labeled I) accepts electrons from the Krebs cycle electron carrier nicotinamide adenine dinucleotide (NADH), and passes them to coenzyme Q (ubiquinone; labeled Q), which also receives electrons from complex II (succinate dehydrogenase; labeled II). Q passes electrons to complex III (cytochrome bc1 complex; labeled III), which passes them to cytochrome c (cyt c). Cyt c passes electrons to Complex IV (cytochrome c oxidase; labeled IV), which uses the electrons and hydrogen ions to reduce molecular oxygen to water.
Four membrane-bound complexes have been identified in mitochondria. Each is an extremely complex transmembrane structure that is embedded in the inner membrane. Three of them are proton pumps. The structures are electrically connected by lipid-soluble electron carriers and water-soluble electron carriers. The overall electron transport chain:
NADH+H+ → Complex I → Q → Complex III → cytochrome c → Complex IV → H2O ↑ Complex II ↑ Succinate

Complex I[edit]
In Complex I (NADH:ubiquinone oxidoreductase, NADH-CoQ reductase, or NADH dehydrogenase; EC 1.6.5.3), two electrons are removed from NADH and ultimately transferred to a lipid-soluble carrier, ubiquinone (UQ). The reduced product, ubiquinol (UQH2), freely diffuses within the membrane, and Complex I translocates four protons (H+) across the membrane, thus producing a proton gradient. Complex I is one of the main sites at which premature electron leakage to oxygen occurs, thus being one of the main sites of production of superoxide.[3]
The pathway of electrons is as follows:
NADH is oxidized to NAD+, by reducing Flavin mononucleotide to FMNH2 in one two-electron step. FMNH2 is then oxidized in two one-electron steps, through a semiquinone intermediate. Each electron thus transfers from the FMNH2 to an Fe-S cluster, from the Fe-S cluster to ubiquinone (Q). Transfer of the first electron results in the free-radical (semiquinone) form of Q, and transfer of the second electron reduces the semiquinone form to the ubiquinol form, QH2. During this process, four protons are translocated from the mitochondrial matrix to the intermembrane space. [4] As the electrons become continuously oxidized and reduced throughout the complex an electron current is produced along the 180 Angstrom width of the complex within the membrane. This current powers the active transport of four protons to the intermembrane space per two electrons from NADH.[5]
Complex II[edit]
In Complex II (succinate dehydrogenase or succinate-CoQ reductase; EC 1.3.5.1) additional electrons are delivered into the quinone pool (Q) originating from succinate and transferred (via flavin adenine dinucleotide (FAD)) to Q. Complex II consists of four protein subunits: succinate dehydrogenase, (SDHA); succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, (SDHB); succinate dehydrogenase complex subunit C, (SDHC) and succinate dehydrogenase complex, subunit D, (SDHD). Other electron donors (e.g., fatty acids and glycerol 3-phosphate) also direct electrons into Q (via FAD). Complex 2 is a parallel electron transport pathway to complex 1, but unlike complex 1, no protons are transported to the intermembrane space in this pathway. Therefore, the pathway through complex 2 contributes less energy to the overall electron transport chain process.
Complex III[edit]
In Complex III (cytochrome bc1 complex or CoQH2-cytochrome c reductase; EC 1.10.2.2), the Q-cycle contributes to the proton gradient by an asymmetric absorption/release of protons. Two electrons are removed from QH2 at the QO site and sequentially transferred to two molecules of cytochrome c, a water-soluble electron carrier located within the intermembrane space. The two other electrons sequentially pass across the protein to the Qi site where the quinone part of ubiquinone is reduced to quinol. A proton gradient is formed by one quinol (2H+2e-) oxidations at the Qo site to form one quinone (2H+2e-) at the Qi site. (in total four protons are translocated: two protons reduce quinone to quinol and two protons are released from two ubiquinol molecules).
 QH2 + 2 cytochrome c (FeIII) + 2 H+in → Q + 2 cytochrome c (FeII) + 4 H+out

When electron transfer is reduced (by a high membrane potential or respiratory inhibitors such as antimycin A), Complex III may leak electrons to molecular oxygen, resulting in superoxide formation.
Complex IV[edit]
In Complex IV (cytochrome c oxidase; EC 1.9.3.1), sometimes called cytochrome AA3, four electrons are removed from four molecules of cytochrome c and transferred to molecular oxygen (O2), producing two molecules of water. At the same time, eight protons are removed from the mitochondrial matrix (although only four are translocated across the membrane), contributing to the proton gradient. The activity of cytochrome c oxidase is inhibited by cyanide.
Coupling with oxidative phosphorylation[edit]
Depiction of ATP synthase, the site of oxidative phosphorylation to generate ATP.
According to the chemiosmotic coupling hypothesis, proposed by Nobel Prize in Chemistry winner Peter D. Mitchell, the electron transport chain and oxidative phosphorylation are coupled by a proton gradient across the inner mitochondrial membrane. The efflux of protons from the mitochondrial matrix creates an electrochemical gradient (proton gradient). This gradient is used by the FOF1 ATP synthase complex to make ATP via oxidative phosphorylation. ATP synthase is sometimes described as Complex V of the electron transport chain.[6] The FO component of ATP synthase acts as an ion channel that provides for a proton flux back into the mitochondrial matrix. It is composed of a, b and c subunits. Protons in the inter-membranous space of mitochondria first enters the ATP synthase complex through a subunit channel. Then protons move to the c subunits.[7] The number of c subunits it has determines how many protons it will require to make the FO turn one full revolution. For example, in humans, there are 8 c subunits, thus 8 protons are required.[8] After c subunits, protons finally enters matrix using a subunit channel that opens into the mitochondrial matrix.[7] This reflux releases free energy produced during the generation of the oxidized forms of the electron carriers (NAD+ and Q). The free energy is used to drive ATP synthesis, catalyzed by the F1 component of the complex.[9]
Coupling with oxidative phosphorylation is a key step for ATP production. However, in specific cases, uncoupling the two processes may be biologically useful. The uncoupling protein, thermogenin—present in the inner mitochondrial membrane of brown adipose tissue—provides for an alternative flow of protons back to the inner mitochondrial matrix. This alternative flow results in thermogenesis rather than ATP production.[10] Synthetic uncouplers (e.g., 2,4-dinitrophenol) also exist, and, at high doses, are lethal.[citation needed]
Summary[edit]
In the mitochondrial electron transport chain electrons move from an electron donor (NADH or QH2) to a terminal electron acceptor (O2) via a series of redox reactions. These reactions are coupled to the creation of a proton gradient across the mitochondrial inner membrane. There are three proton pumps: I, III, and IV. The resulting transmembrane proton gradient is used to make ATP via ATP synthase.
The reactions catalyzed by Complex I and Complex III work roughly at equilibrium. This means that these reactions are readily reversible, by increasing the concentration of the products relative to the concentration of the reactants (for example, by increasing the proton gradient). ATP synthase is also readily reversible. Thus ATP can be used to build a proton gradient, which in turn can be used to make NADH. This process of reverse electron transport is important in many prokaryotic electron transport chains.[11]
In bacteria[edit]
In eukaryotes, NADH is the most important electron donor. The associated electron transport chain is
NADH → Complex I → Q → Complex III → cytochrome c → Complex IV → O2 where Complexes I, III and IV are proton pumps, while Q and cytochrome c are mobile electron carriers. The electron acceptor is molecular oxygen.
In prokaryotes (bacteria and archaea) the situation is more complicated, because there are several different electron donors and several different electron acceptors. The generalized electron transport chain in bacteria is:
                     Donor Donor Donor ↓ ↓ ↓ dehydrogenase → quinone → bc1 → cytochrome ↓ ↓ oxidase(reductase) oxidase(reductase) ↓ ↓ Acceptor Acceptor

Note that electrons can enter the chain at three levels: at the level of a dehydrogenase, at the level of the quinone pool, or at the level of a mobile cytochrome electron carrier. These levels correspond to successively more positive redox potentials, or to successively decreased potential differences relative to the terminal electron acceptor. In other words, they correspond to successively smaller Gibbs free energy changes for the overall redox reaction Donor → Acceptor.
Individual bacteria use multiple electron transport chains, often simultaneously. Bacteria can use a number of different electron donors, a number of different dehydrogenases, a number of different oxidases and reductases, and a number of different electron acceptors. For example, E. coli (when growing aerobically using glucose as an energy source) uses two different NADH dehydrogenases and two different quinol oxidases, for a total of four different electron transport chains operating simultaneously.
A common feature of all electron transport chains is the presence of a proton pump to create a transmembrane proton gradient. Bacterial electron transport chains may contain as many as three proton pumps, like mitochondria, or they may contain only one or two. They always contain at least one proton pump.
Electron donors[edit]
In the present day biosphere, the most common electron donors are organic molecules. Organisms that use organic molecules as an energy source are called organotrophs. Organotrophs (animals, fungi, protists) and phototrophs (plants and algae) constitute the vast majority of all familiar life forms.
Some prokaryotes can use inorganic matter as an energy source. Such an organism is called a lithotroph ("rock-eater"). Inorganic electron donors include hydrogen, carbon monoxide, ammonia, nitrite, sulfur, sulfide, manganese oxide, and ferrous iron. Lithotrophs have been found growing in rock formations thousands of meters below the surface of Earth. Because of their volume of distribution, lithotrophs may actually outnumber organotrophs and phototrophs in our biosphere.
The use of inorganic electron donors as an energy source is of particular interest in the study of evolution. This type of metabolism must logically have preceded the use of organic molecules as an energy source.
Dehydrogenases[edit]
Bacteria can use a number of different electron donors. When organic matter is the energy source, the donor may be NADH or succinate, in which case electrons enter the electron transport chain via NADH dehydrogenase (similar to Complex I in mitochondria) or succinate dehydrogenase (similar to Complex II). Other dehydrogenases may be used to process different energy sources: formate dehydrogenase, lactate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, H2 dehydrogenase (hydrogenase), etc. Some dehydrogenases are also proton pumps; others funnel electrons into the quinone pool. Most dehydrogenases show induced expression in the bacterial cell in response to metabolic needs triggered by the environment in which the cells grow.[citation needed]
Quinone carriers[edit]
Quinones are mobile, lipid-soluble carriers that shuttle electrons (and protons) between large, relatively immobile macromolecular complexes embedded in the membrane. Bacteria use ubiquinone (the same quinone that mitochondria use) and related quinones such as menaquinone. Another name for ubiquinone is Coenzyme Q10.
Proton pumps[edit]
A proton pump is any process that creates a proton gradient across a membrane. Protons can be physically moved across a membrane; this is seen in mitochondrial Complexes I and IV. The same effect can be produced by moving electrons in the opposite direction. The result is the disappearance of a proton from the cytoplasm and the appearance of a proton in the periplasm. Mitochondrial Complex III uses this second type of proton pump, which is mediated by a quinone (the Q cycle).
Some dehydrogenases are proton pumps; others are not. Most oxidases and reductases are proton pumps, but some are not. Cytochrome bc1 is a proton pump found in many, but not all, bacteria (it is not found in E. coli). As the name implies, bacterial bc1 is similar to mitochondrial bc1 (Complex III).
Proton pumps are the heart of the electron transport process. They produce the transmembrane electrochemical gradient that enables ATP Synthase to synthesize ATP.
Cytochrome electron carriers[edit]
Cytochromes are pigments that contain iron. They are found in two very different environments.
Some cytochromes are water-soluble carriers that shuttle electrons to and from large, immobile macromolecular structures imbedded in the membrane. The mobile cytochrome electron carrier in mitochondria is cytochrome c. Bacteria use a number of different mobile cytochrome electron carriers.
Other cytochromes are found within macromolecules such as Complex III and Complex IV. They also function as electron carriers, but in a very different, intramolecular, solid-state environment.
Electrons may enter an electron transport chain at the level of a mobile cytochrome or quinone carrier. For example, electrons from inorganic electron donors (nitrite, ferrous iron, etc.) enter the electron transport chain at the cytochrome level. When electrons enter at a redox level greater than NADH, the electron transport chain must operate in reverse to produce this necessary, higher-energy molecule.
Terminal oxidases and reductases[edit]
When bacteria grow in aerobic environments, the terminal electron acceptor (O2) is reduced to water by an enzyme called an oxidase. When bacteria grow in anaerobic environments, the terminal electron acceptor is reduced by an enzyme called a reductase.
In mitochondria the terminal membrane complex (Complex IV) is cytochrome oxidase. Aerobic bacteria use a number of different terminal oxidases. For example, E. coli does not have a cytochrome oxidase or a bc1 complex. Under aerobic conditions, it uses two different terminal quinol oxidases (both proton pumps) to reduce oxygen to water.
Anaerobic bacteria, which do not use oxygen as a terminal electron acceptor, have terminal reductases individualized to their terminal acceptor. For example, E. coli can use fumarate reductase, nitrate reductase, nitrite reductase, DMSO reductase, or trimethylamine-N-oxide reductase, depending on the availability of these acceptors in the environment.
Most terminal oxidases and reductases are inducible. They are synthesized by the organism as needed, in response to specific environmental conditions.
Electron acceptors[edit]
Just as there are a number of different electron donors (organic matter in organotrophs, inorganic matter in lithotrophs), there are a number of different electron acceptors, both organic and inorganic. If oxygen is available, it is invariably used as the terminal electron acceptor, because it generates the greatest Gibbs free energy change and produces the most energy.[citation needed]
In anaerobic environments, different electron acceptors are used, including nitrate, nitrite, ferric iron, sulfate, carbon dioxide, and small organic molecules such as fumarate.
Since electron transport chains are redox processes, they can be described as the sum of two redox pairs. For example, the mitochondrial electron transport chain can be described as the sum of the NAD+/NADH redox pair and the O2/H2O redox pair. NADH is the electron donor and O2 is the electron acceptor.
Not every donor-acceptor combination is thermodynamically possible. The redox potential of the acceptor must be more positive than the redox potential of the donor. Furthermore, actual environmental conditions may be far different from standard conditions (1 molar concentrations, 1 atm partial pressures, pH = 7), which apply to standard redox potentials. For example, hydrogen-evolving bacteria grow at an ambient partial pressure of hydrogen gas of 10−4 atm. The associated redox reaction, which is thermodynamically favorable in nature, is thermodynamic impossible under "standard" conditions.[citation needed]
Summary[edit]
Bacterial electron transport pathways are, in general, inducible. Depending on their environment, bacteria can synthesize different transmembrane complexes and produce different electron transport chains in their cell membranes. Bacteria select their electron transport chains from a DNA library containing multiple possible dehydrogenases, terminal oxidases and terminal reductases. The situation is often summarized by saying that electron transport chains in bacteria are branched, modular, and inducible.
Photosynthetic[edit]
In oxidative phosphorylation, electrons are transferred from a low-energy electron donor (e.g., NADH) to an acceptor (e.g., O2) through an electron transport chain. In photophosphorylation, the energy of sunlight is used to create a high-energy electron donor and an electron acceptor. Electrons are then transferred from the donor to the acceptor through another electron transport chain.
Photosynthetic electron transport chains have many similarities to the oxidative chains discussed above. They use mobile, lipid-soluble carriers (quinones) and mobile, water-soluble carriers (cytochromes, etc.). They also contain a proton pump. It is remarkable that the proton pump in all photosynthetic chains resembles mitochondrial Complex III.
Photosynthetic electron transport chains are discussed in greater detail in the articles Photophosphorylation, Photosynthesis, Photosynthetic reaction center and Light-dependent reaction.
Summary[edit]
Electron transport chains are redox reactions that transfer electrons from an electron donor to an electron acceptor. The transfer of electrons is coupled to the translocation of protons across a membrane, producing a proton gradient. The proton gradient is used to produce useful work. About 30 work units are produced per electron transport.
See also[edit]
CoRR hypothesis
Electron equivalent
Hydrogen hypothesis
Respirasome
References[edit]
Jump up ^ Murray, Robert K.; Daryl K. Granner; Peter A. Mayes; Victor W. Rodwell (2003). Harper's Illustrated Biochemistry. New York, NY: Lange Medical Books/ MgGraw Hill. p. 96. ISBN 0-07-121766-5.
Jump up ^ Karp, Gerald (2008). Cell and Molecular Biology (5th ed.). Hoboken, NJ: John Wiley & Sons. p. 194. ISBN 978-0-470-04217-5.
Jump up ^ Lauren, Biochemistry, Johnson/Cole, 2010, pp 598-611
Jump up ^ Garrett & Grisham, Biochemistry, Brooks/Cole, 2010, pp 598-611
Jump up ^ Garret and Grisham (2016). biochemistry. University of Virginia. p. 687. ISBN 978-1-305-57720-6.
Jump up ^ Jonckheere, An I.; Smeitink, Jan A. M.; Rodenburg, Richard J. T. (2017-03-10). "Mitochondrial ATP synthase: architecture, function and pathology". Journal of Inherited Metabolic Disease. 35 (2): 211–225. doi:10.1007/s10545-011-9382-9. ISSN 0141-8955. PMC 3278611  . PMID 21874297.
^ Jump up to: a b Garrett, Reginald H.; Grisham, Charles M. (2012). Biochemistry (5th ed.). Cengage learning. p. 664. ISBN 1-133-10629-3.
Jump up ^ Fillingame, Robert H; Angevine, Christine M; Dmitriev, Oleg Y (2003-11-27). "Mechanics of coupling proton movements to c-ring rotation in ATP synthase". FEBS Letters. 555 (1): 29–34. doi:10.1016/S0014-5793(03)01101-3. ISSN 1873-3468.
Jump up ^ Berg, Jeremy M.; Tymoczko, John L.; Stryer, Lubert (2002-01-01). "A Proton Gradient Powers the Synthesis of ATP".
Jump up ^ Cannon, Barbara; Nedergaard, Jan (2004-01-01). "Brown Adipose Tissue: Function and Physiological Significance". Physiological Reviews. 84 (1): 277–359. doi:10.1152/physrev.00015.2003. ISSN 0031-9333. PMID 14715917.
Jump up ^ Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter (2002-01-01). "Electron-Transport Chains and Their Proton Pumps".
Fenchel T; King GM; Blackburn TH (September 2006). Bacterial Biogeochemistry: The Ecophysiology of Mineral Cycling (2nd ed.). Elsevier. ISBN 978-0-12-103455-9.
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Nicholls DG; Ferguson SJ (July 2002). Bioenergetics 3. Academic Press. ISBN 978-0-12-518121-1.
Stumm W; Morgan JJ (1996). Aquatic Chemistry (3rd ed.). John Wiley & Sons. ISBN 978-0-471-51185-4.
Thauer RK; Jungermann K; Decker K (March 1977). "Energy conservation in chemotrophic anaerobic bacteria". Bacteriol Rev. 41 (1): 100–80. PMC 413997  . PMID 860983.
White D. (September 1999). The Physiology and Biochemistry of Prokaryotes (2nd ed.). Oxford University Press. ISBN 978-0-19-512579-5.
Voet D; Voet JG (March 2004). Biochemistry (3rd ed.). John Wiley & Sons. ISBN 978-0-471-58651-7.
Kim HS.; Patel, K; Muldoon-Jacobs, K; Bisht, KS; Aykin-Burns, N; Pennington, JD; Van Der Meer, R; Nguyen, P; et al. (January 2010). "SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress". Cancer Cell. 17 (1): 41–52. doi:10.1016/j.ccr.2009.11.023. PMC 3711519  . PMID 20129246.
External links[edit]
Electron Transport Chain Complex Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
Khan Academy, video lecture
UMich Orientation of Proteins in Membranes families/superfamily-3 - Complexes with cytochrome b-like domains
UMich Orientation of Proteins in Membranes families/superfamily-4 - Bacterial and mitochondrial cytochrome c oxidases
UMich Orientation of Proteins in Membranes families/superfamily-2 - Photosynthetic reaction centers and photosystems
UMich Orientation of Proteins in Membranes families/superfamily-78 - Cytochrome PORN renodoxin reductase
UMich Orientation of Proteins in Membranes families/superfamily-130 - Electron transfer flavoproteins
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values: سلسلة نقل الإلكترون – Arabic

values: Електрон-транспортна верига – Bulgarian

values: Cadena de transport d'electrons – Catalan

values: Cadena de transporte de electrones – Spanish

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values: Cadea de transporte electrónico – Galician

values: 전자전달계 – Korean

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values: Дыхательная цепь переноса электронов – Russian

values: Electron transport chain – Simple English

values: Lanac transporta elektrona – Serbo-Croatian

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