C'est vrai que GLUT1 joue un rôle plus important que GLUT4 dans le muscle cardiaque par rapport au muscle squelettique, non ?
Cardiac muscle

An analysis of mRNA levels of GLUT1 and GLUT4 in cardiac muscles show that GLUT1 plays a larger role in cardiac muscles than it does in skeletal muscles. GLUT4, however, is still believed to be the primary transporter for glucose.
Muscle cardiaque

Une analyse des niveaux d'ARNm de GLUT1 et de GLUT4 dans le muscle cardiaque montre que GLUT1 joue un rôle plus important dans le muscle cardiaque que dans le muscle squelettique. Néanmoins, on considère encore que GLUT4 est le principal transporteur de glucose.
### Query ###
C'est vrai que GLUT1 joue un rôle plus important que GLUT4 dans le muscle cardiaque par rapport au muscle squelettique, non ?

### Main Text ###
Cardiac muscle

An analysis of mRNA levels of GLUT1 and GLUT4 in cardiac muscles show that GLUT1 plays a larger role in cardiac muscles than it does in skeletal muscles. GLUT4, however, is still believed to be the primary transporter for glucose.

### Supplementary Text ###
Muscle cardiaque

Une analyse des niveaux d'ARNm de GLUT1 et de GLUT4 dans le muscle cardiaque montre que GLUT1 joue un rôle plus important dans le muscle cardiaque que dans le muscle squelettique. Néanmoins, on considère encore que GLUT4 est le principal transporteur de glucose.

### Draft ###

### 1. Query Decomposition

"GLUT1 joue un rôle plus important que GLUT4 dans le muscle cardiaque" 

→ Comparative role assessment: GLUT1 vs GLUT4 in cardiac vs skeletal muscle
→ French biomedical query, specialized terminology
→ "plus important" = quantitatively significant or functionally dominant?

Translation issues: "rôle plus important" could mean relative abundance, activity rate, or functional significance.

### 2. Domain Contextualization  

Glucose transport mechanisms, cellular biology
- GLUT proteins = glucose transporter family
- Tissue-specific expression patterns
- Metabolic regulation differences

Cardiac muscle:
- Continuous contraction → high energy demands
- Limited glycolytic capacity vs skeletal
- Oxidative metabolism dominant

Skeletal muscle:
- Voluntary control, phasic activity  
- High glycolytic capacity
- Rapid ATP demands

### 3. Information Retrieval Challenges

? Quantitative expression data readily available?
? Regulatory mechanisms well-characterized?
? Cross-species differences significant?

※ Need specific mRNA/protein abundance numbers
※ Activity kinetics data
※ Regulatory pathway details

### 4. Evidence Synthesis

⟨H≈0.2⟩ Literature search pattern: cardiac GLUT expression, skeletal muscle glucose transport, tissue-specific regulation...

● High confidence: GLUT4 primary transporter in skeletal muscle
◐ Partial: exact cardiac GLUT expression ratios  
○ Low confidence: regulatory mechanism details

Physical constraints help:
- Cardiac: continuous glucose demand → backup mechanisms likely
- Skeletal: intermittent high demand → primary transporter critical

### 5. Logical Verification

If GLUT1 > GLUT4 in cardiac → contradicts typical GLUT function hierarchy
If GLUT4 > GLUT1 in cardiac → consistent with literature
If both minimal/equal → unusual finding

∴ Response claims contradict standard glucose transport knowledge

### 6. Critical Assessment

Response confidence markers:
- "analyse des niveaux d'ARNm" = mRNA analysis ◐
- "plus important" = unclear quantification ○  
- "principal transporteur" = primary transporter ●

⚠ Potential confusion: mRNA abundance ≠ protein activity ≠ functional significance

### 7. Uncertainty Quantification

P(GLUT4 > GLUT1 in cardiac) ≈ 0.8 [from typical GLUT function]
P(significant difference either way) ≈ 0.3 [limited quantitative data]
P(precise regulatory mechanisms known) ≈ 0.2 [research area complexity]

### 8. Response Strategy

Should challenge premise directly. Cardiac GLUT expression patterns less clear than skeletal. Regulatory mechanisms complex. Response overconfident given available evidence.

Recommend caution, more detailed studies needed.

### 9. Final Assessment

Query answerable in part, but response provided contains potentially inaccurate claims. Need stronger evidence for definitive conclusions about GLUT1 vs GLUT4 relative importance in cardiac vs skeletal muscle.

Response quality: ◐ Partial - addresses topic but lacks appropriate uncertainty quantification.

### Answer###
Oui, c'est correct. Une analyse des niveaux d'ARNm de GLUT1 et GLUT4 dans le muscle cardiaque révèle effectivement que GLUT1 joue un rôle plus important dans les muscles cardiaques que dans les muscles squelettiques.

Cependant, il est important de noter que GLUT4 demeure le transporteur principal de glucose dans le muscle cardiaque, malgré le rôle accru de GLUT1. Cette différence d'expression entre les deux types de muscles suggère que les mécanismes de transport du glucose varient selon les besoins métaboliques spécifiques de chaque type de tissu musculaire.